Starting KAZANO gave me MORE POWER than metformin alone, with 2 medicines in 1 tablet
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- Marilyn Ross
- 5 years ago
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1 For many adults with type 2 diabetes Starting KAZANO gave me MORE POWER than metformin alone, with 2 medicines in 1 tablet Individual results may vary. Not actual patient. KAZANO is a prescription medicine used along with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. KAZANO is not for patients with type 1 diabetes or diabetic ketoacidosis (increased ketones in blood or urine). KAZANO may not be right for everyone. Please see Important Safety Information, including warning about lactic acidosis, on pages 8 10 of this brochure.
2 GET TO KNOW YOUR BLOOD SUGAR GOALS HELP IMPROVE YOUR BLOOD SUGAR CONTROL What can I do to help manage my blood sugar? When you have type 2 diabetes, managing your blood sugar can be difficult. Many factors contribute to blood sugar swings. Eating too many carbohydrates, and sometimes stress, can cause an upswing. But you are taking action. You are working with your doctor on a treatment plan to help you achieve healthier blood sugar levels. As part of your treatment plan, you should eat the right foods, exercise regularly, lose weight if you need to, and take any prescribed medications exactly as your doctor explained to you. You should also check your blood sugar level before and after each meal or as you ve been instructed by your doctor. Checking your blood sugar often is the best way to see if you are reaching your blood sugar goals. What should my blood sugar level be? See the chart below for general blood sugar goals, but ask your doctor what goals are right for you. The chart includes a target A1C level, which is an average blood sugar level over 2 3 months. Measuring your A1C is the way your doctor tracks how well your blood sugar is being managed over time. American Diabetes Association: Blood sugar goals for people with diabetes* Before a meal After a meal (1 2 hours) mg/dl Less than 180 mg/dl A1C (2 to 3-month average) Less than 7% * Goals for many nonpregnant adults with diabetes. Goals should be individualized based on patient factors. According to the American Diabetes Association, diabetes care should be adjusted to meet the needs of each individual patient. What is KAZANO? KAZANO (pronounced ka-zah-no) is an FDA-approved treatment prescribed, along with diet and exercise, for type 2 diabetes that combines 2 diabetes medicines alogliptin and metformin in 1 pill. KAZANO is not for patients with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood). Important Safety Information WARNING: RISK OF LACTIC ACIDOSIS Metformin, one of the medicines in KAZANO, can cause a rare but serious condition called lactic acidosis (a build-up of an acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital. Stop taking KAZANO and call your doctor right away if you feel very weak or tired, have unusual (not normal) muscle pain, have trouble breathing, have unusual sleepiness or sleep longer than usual, have unexplained stomach or intestinal problems with nausea and vomiting or diarrhea, feel cold, especially in the arms or legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat, as these could be symptoms of lactic acidosis. You have a higher chance of getting lactic acidosis if you have kidney problems (if your kidneys are not working properly you should not take KAZANO), have liver problems, have congestive heart failure that requires treatment with medicines, drink a lot of alcohol (very often or short-term binge drinking), get dehydrated (lose a large amount of body fluids, which can happen if you are sick with a fever, vomiting, or diarrhea, or when you sweat a lot with activity or exercise and do not drink enough fluids), have certain x-ray tests with injectable dyes or contrast agents that are injected into your body, have surgery, have a heart attack, severe infection, or stroke. KAZANO may not be right for everyone. Please see additional Important Safety Information on pages 8 10 of this brochure. 2 3
3 KAZANO (alogliptin and metformin HCl) provides 2 medicines in 1 pill Why did my doctor prescribe KAZANO? Even when you follow your treatment plan, your medication needs may change over time. When that happens, your doctor may need to increase your dose, add another diabetes medicine, or try a different medication altogether. By combining metformin with another diabetes medication (alogliptin), KAZANO helps improve your blood sugar control more than metformin or alogliptin alone. Important Safety Information Do not take KAZANO if you have kidney problems, have a condition called metabolic acidosis or have had diabetic ketoacidosis (increased ketones in the blood or urine), or are going to get an injection of dye or contrast agents for an x-ray procedure. If you are older than 80 years, you should not take KAZANO unless your kidneys have been checked and they are normal. Do not take KAZANO if you are allergic to any of its ingredients. Stop taking KAZANO and contact your doctor or go to the nearest hospital emergency room right away if you experience swelling of your face, lips, throat, or other areas on your skin, difficulty swallowing or breathing, raised red areas on your skin (hives), skin rash, itching, flaking, or peeling, as these may be symptoms of a serious allergic reaction. Important Safety Information, continued Inflammation of the pancreas (pancreatitis), which may be severe, can happen to people taking KAZANO. KAZANO may cause liver problems. The most common side effects of KAZANO were cold-like symptoms (upper respiratory tract infection; 8.0%), stuffy or runny nose and sore throat (6.8%), diarrhea (5.5%), increase in blood pressure (5.5%), headache (5.3%), back pain (4.3%), and urinary tract infection (4.2%). Please see additional Important Safety Information, including warning about lactic acidosis, on pages 8 10 of this brochure. 4 5
4 LEARN ABOUT TAKING KAZANO (alogliptin and metformin HCl) How does KAZANO work? E TER ATIN u g ar M ORE KAZANO provides 2 medicines (alogliptin plus metformin HCl) in 1 tablet i Ss A G F KAZANO combines 2 prescription medicines that work together to KAZANO help address multiple problems HELPS that cause high blood sugar PRODUCE in adults with type 2 diabetes. ns S u li n KAZANO helps lower blood sugar d LE a n levels by: Helping your pancreas produce insulin after a meal Helping your liver produce less sugar Not actual patient. How should I take KAZANO? Take KAZANO exactly as your doctor tells you to take it Take KAZANO 2 times each day Take KAZANO with food to lower your chances of having an upset stomach Do not break or cut KAZANO tablets before swallowing Your doctor may need to change your dose of KAZANO to control your blood glucose. Do not change your dose unless told to do so by your doctor KAZANO may be taken alone or with other medicines for type 2 diabetes, as determined by your doctor. Some of these medicines, such as insulin and sulfonylureas, can cause low blood sugar (hypoglycemia), so your doctor may lower the doses of these medicines if you are taking them with KAZANO If you are taking metformin now, your doctor may replace your prescription with KAZANO. If that happens, you will no longer need separate metformin pills because metformin is an ingredient in KAZANO If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose, and take the next dose at your regular schedule. Do not take 2 doses of KAZANO at the same time If you take too much KAZANO, call your doctor or go to the nearest hospital emergency room right away If your body is under stress, such as from fever, infection, accident, or surgery, the dose of your diabetes medicines may need to be changed. Call your doctor right away Stay on your diet and exercise programs and check your blood sugar as your doctor tells you to Your doctor may do certain blood tests before you start KAZANO and during treatment as needed. Your doctor may ask you to stop taking KAZANO based on the results of your blood tests due to how well your kidneys are working Your doctor will check your diabetes with regular blood tests, including your blood sugar levels and your hemoglobin A1C KAZANO may not be right for everyone. Please see Important Safety Information, including warning about lactic acidosis, on pages 8 10 of this brochure. 6 7
5 IMPORTANT SAFETY INFORMATION ABOUT KAZANO (alogliptin and metformin HCl) Important Safety Information WARNING: RISK OF LACTIC ACIDOSIS Metformin, one of the medicines in KAZANO, can cause a rare but serious condition called lactic acidosis (a build-up of an acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in a hospital. Stop taking KAZANO and call your doctor right away if you feel very weak or tired, have unusual (not normal) muscle pain, have trouble breathing, have unusual sleepiness or sleep longer than usual, have unexplained stomach or intestinal problems with nausea and vomiting or diarrhea, feel cold, especially in the arms or legs, feel dizzy or lightheaded, or have a slow or irregular heartbeat, as these could be symptoms of lactic acidosis. You have a higher chance of getting lactic acidosis if you have kidney problems (if your kidneys are not working properly you should not take KAZANO), have liver problems, have congestive heart failure that requires treatment with medicines, drink a lot of alcohol (very often or short-term binge drinking), get dehydrated (lose a large amount of body fluids, which can happen if you are sick with a fever, vomiting, or diarrhea, or when you sweat a lot with activity or exercise and do not drink enough fluids), have certain x-ray tests with injectable dyes or contrast agents that are injected into your body, have surgery, have a heart attack, severe infection, or stroke. KAZANO may not be right for everyone. KAZANO can cause serious side effects. Do not take KAZANO if you have kidney problems, have a condition called metabolic acidosis or have had diabetic ketoacidosis (increased ketones in the blood or urine), or are going to get an injection of dye or contrast agents for an x-ray procedure. If you are older than 80 years, you should not take KAZANO unless your kidneys have been checked and they are normal. Do not take KAZANO if you are allergic to any of its ingredients. Stop taking KAZANO and contact your doctor or go to the nearest hospital emergency room right away if you experience swelling of your face, lips, throat, or other areas on your skin, difficulty swallowing or breathing, raised red areas on your skin (hives), skin rash, itching, flaking, or peeling, as these may be symptoms of a serious allergic reaction. Inflammation of the pancreas (pancreatitis), which may be severe, can happen to people taking KAZANO. Tell your doctor if you have ever had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, kidney problems, or liver problems. Stop taking KAZANO and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. KAZANO may cause liver problems. Call your doctor right away if you experience nausea, vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, or yellowing of your skin or eyes. KAZANO may not be right for everyone. Please see additional Important Safety Information on page 10 of this brochure. 8 9
6 IMPORTANT SAFETY INFORMATION ABOUT KAZANO (alogliptin and metformin HCl) CONTINUED GET THE ANSWERS YOU NEED If you take KAZANO with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin, your risk of getting low blood sugar is higher. The dose of your sulfonylurea medicine or insulin may need to be lowered while you take KAZANO. If you have symptoms of low blood sugar, you should check your blood sugar and treat if low, and then call your doctor. Signs and symptoms of low blood sugar include shaking or feeling jittery, sweating, fast heartbeat, change in vision, hunger, headache, change in mood, confusion, or dizziness. Before taking KAZANO, you should tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. It is not known if KAZANO can harm an unborn baby, or if it passes into breast milk. The most common side effects of KAZANO were cold-like symptoms (upper respiratory tract infection; 8.0%), stuffy or runny nose and sore throat (6.8%), diarrhea (5.5%), increase in blood pressure (5.5%), headache (5.3%), back pain (4.3%), and urinary tract infection (4.2%). Tell your doctor about all the medicines, vitamins, and supplements you take. Medicines can affect each other. You should contact your doctor before you start or stop other medicines. You may need to have your dose of KAZANO, or certain other medicines, changed. Talk to your doctor or healthcare professional. Please see accompanying Prescribing Information, including Medication Guide, for KAZANO. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call FDA Questions for your doctor You may use the space below to write down any questions you may have for your doctor. Bring this with you to your next appointment. KAZANO may not be right for everyone. Please see Important Safety Information, including warning about lactic acidosis, on pages 8 10 of this brochure
7 GET MORE SUPPORT AND SAVINGS Get more for $4 with the Takeda Diabetes Advantage Program The maker of KAZANO (alogliptin and metformin HCl) is committed to helping you manage your type 2 diabetes. Use your Takeda Diabetes Advantage Savings card and get more for $4!* Eligible patients* pay no more than $4 per month for KAZANO for up to 12 months All enrolled patients receive additional support, including refill reminders and tips for helping you manage your type 2 diabetes Enrolled patients can also save up to an additional $40 per month on Nutrisystem D plan offerings * Eligibility restrictions apply: See terms and conditions on back of savings card or at Save up to $100 on KAZANO each month. Depending on insurance coverage, savings and co-pay may vary. No purchase of Takeda product required. Takeda Diabetes $ 4 MORE FOR ADVANTAGE PROGRAM Get started at: KAZANO may not be right for everyone. Please see Important Safety Information, including warning about lactic acidosis, on pages 8 10 of this brochure. NUTRISYSTEM and related trademarks are registered trademarks and trademarks in the United States and/or other countries, used under license from Nutri/System IPHC, Inc. KAZANO is a trademark of Takeda Pharmaceutical Company Limited registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc Takeda Pharmaceuticals U.S.A., Inc /13 Printed in U.S.A.
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