Before a Step 2 medication is covered You get a prescription

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1 Step Therapy Most medical conditions have multiple medication options. Although their clinical effectiveness may be similar, prices can vary widely. With the Step Therapy program, you get the treatment you need, usually at a lower cost. Here s how it works: Before a Step 2 medication is covered You get a prescription Try a Step 1 medication first With this program, you need to try a Step 1 medication first, before a Step 2 medication may be covered. When you bring a prescription to the pharmacy, our system will automatically screen the medication for step therapy requirements. If your prior pharmacy claims show you have tried a Step 1 medication in the recent past, the Step 2 medication may be processed. If not, the pharmacist will contact your doctor for further explanation. There are some drugs that require three steps before a medication is covered. You must try Step 1 and Step 2 medications before receiving benefit coverage for a Step 3 medication. We encourage you to discuss your treatment and medication options with your doctor. If you have questions about the Step Therapy program, call the toll-free member phone number on the back of your ID card.

2 Step Therapy Program Step Therapy Medications (2 steps)* If you have a prescription for any of the following Step 2 medications, you will be required to first try a Step 1 medication(s) for benefit coverage. Attention Deficit Disorder Dextroamphetamine, Amphetaminedextroamphetamine, Methylphenidate, Dexmethylphenidate, Vyvanse Procentra/Dextroamphetamine, Desoxyn/Methamphetamine, Adderall XR/Amphetamine ER, Kapvay/Clonidine ER, Focalin XR/ Dexmethylphenidate ER, Metadate CD/Methylphenidate ER, Ritalin SR/Concerta/ Methylphenidate ER, Methylin/ Methylphenidate Solution, Ritalin LA/Methylphenidate ER, Daytrana, Methylin, Quillivant Antibiotics Doxycycline Acticlate, Adoxa, Doryx Bethkis Tobi Neb/Tobramycin Neb Antipsychotics Olanzapine, Risperidone, Geodon/Ziprasidone, Fanapt, Invega, Latuda Risperidone ODT, Quetiapine, Seroquel XR, Saphris, Abilify Asthma/COPD Striverdi Symbicort, Advair Diskus, Foradil, Serevent Dulera Advair Diskus, Advair HFA, Symbicort Anoro Ellipta Symbicort, Advair Diskus, Foradil, Serevent, Spiriva, Breo Ellipta Montelukast and any one of the following: Methylprednisolone, Prednisolone, Prednisone, Ventolin HFA,Proair HFA, Foradil, Serevent, Qvar, Pulmicort, Flovent Diskus, Flovent HFA, Asmanex, Advair Diskus, Advair HFA, Symbicort Zyflo, Zyflo CR OptumRx optumrx.com

3 Step Therapy Medications (2 steps)* Continued Cardiovascular Carvedilol Coreg CR Cholesterol Lowering Agents Depression Benazepril, Candesartan, Captopril, Enalopril, Fosinopril, Irbesartan, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril, Telmisartan, Trandolapril, Benazepril-amlodipine, Trandolapril-verapamil, Benazepril-HCTZ, Captopril-HCTZ, Enalapril-HCTZ, Fosinopril-HCTZ, Irbesartan-HCTZ, Lisinopril-HCTZ, Moexipril-HCTZ, Quinapril-HCTZ, Losartan, Losartan-HCTZ Amlodipine and any one of the following: Atorvastatin, Lovastatin, Pravastatin, Simvastatin, Crestor, Vytorin Lipofen and any one of the following: Fenofibric Acid, Fenofibrate Atorvastatin, Lovastatin, Pravastatin, Simvastatin, Crestor Atorvastatin, Lovastatin, Pravastatin, Simvastatin, Crestor, Vytorin Citalopram, Escitalopram, Fluoxetine, Paroxetine, Paroxetine ER, Sertraline, Venlafaxine, Venlafaxine ER, Bupropion SR, Mirtazapine, Mirtazapine ODT, Duloxetine, Pristiq Paroxetine or Sertraline Venlafaxine, Venlafaxine ER, Duloxetine, Pristiq Bupropion SR Edarbi, Edarbyclor, Azor, Exforge, Exforge HCT, Tribenzor Caduet/Amlodipine-atorvastatin Fibricor, Fenoglide, Triglide Lipitor, Lescol/Fluvastatin, Lescol XL, Mevacor, Altroprev, Livalo, Pravachol, Zocor Liptruzet Viibryd, Brintellix Luvox CR/Fluvoxamine ER Fetzima Aplenzin 3

4 Step Therapy Program Step Therapy Medications (2 steps)* Continued Diabetes Humalog or Novolog Apidra Metformin or Metformin ER Metformin, Metformin ER Metformin-glipizide, Metformin-glyburide, Metformin-pioglitazone, Chlorpropamide, Glimepiride, Glipizide, Glipizide ER, Glyburide, Tolazamide, Tolbutamide, Pioglitazone, Pioglitazone-glimepiride, Novolog, Lantus, Humalog, Levemir, Humulin, Novolin, Byetta Metformin-glipizide, Metformin-glyburide, Metformin-pioglitazone, Chlorpropamide, Glimepiride, Glipizide, Glipizide ER, Glyburide, Tolazamide, Tolbutamide, Pioglitazone, Pioglitazone-glimepiride, Novolog, Lantus, Humalog, Levemir, Humulin, Novolin, Byetta Amaryl, Diabeta, Duetact, Glucotrol, Glucotrol XR, Glucovance, Glynase, Metaglip, Prandimet, Prandin, Precose, Starlix Actoplus Met XR, Actos Glyset Riomet Ear Condition Ofloxacin Cetraxal/Ciprofloxacin Gastrointestinal Creon and Zenpep Viokace, Pancreaze, Pertzye, Ultresa (Miscellaneous) Polyethylene Glycol or Lactulose Amitiza, Linzess Gout Allopurinol Uloric Insomnia Zolpidem or Zolpidem CR Intermezzo, Edluar, Zolpimist OptumRx optumrx.com

5 Step Therapy Medications (2 steps)* Continued Migraine Rizatriptan (tablet)/rizatriptan RDT, Treximet Sumatriptan (tablet), Zolmitriptan (tablet)/zolmitriptan ODT Skin Conditions (Miscellaneous) Any one of the following topical corticosteroids: Alclometasone, Betamethasone Dipropionate (augmented), Betamethasone Dipropionate, Clobetasol, Desonide, Desoximetasone, Diflorasone, Fluocinolone, Fluocinonide, Fluticasone, Hydrocortisone, Mometasone, Triamcinolone, Pramosone Elidel, Protopic Narcotic Analgesics Nausea/ Vomiting Neurologic Non-Narcotic Analgesics Morphine Sulfate CR, Morphine Sulfate SR, Oxycontin Tramadol or Tramadol-acetaminophen Metoclopramide Amitriptyline, Cyclobenzaprine, Duloxetine, Lyrica Gabapentin Diclofenac, Etodolac, Fenoprofen, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Meloxicam, Nabumetone, Naproxen, Oxaprozin, Piroxicam, Sulindac, Tolmetin Exalgo Tramadol ER Metozolv ODT Savella Gralise Duexis Oncology Fluorouracil or Imiquimod Picato Opthalamic Bepreve, Lastacaft Agents Azelastine, Patanol, Pataday Osteoporosis Alendronate Atelvia 5

6 Step Therapy Program Step Therapy Medications (2 steps)* Continued Overactive Bladder Parkinson's Disease Prostatic Hypertrophy Severe Allergic Reaction Ulcer/Acid Reflux Oxybutynin, Vesicare, Oxytrol, Gelnique Ropinorole or Pramipexole Alfuzosin, Doxazosin, Terazosin, Tamsulosin, Rapaflo Epipen, Epipen Jr Omeprazole, Lansoprazole (capsule), Pantoprazole, Nexium, Dexilant Omeclamox or Pylera Detrol/Tolterodine, Sanctura/Trospium, Sanctura XR/Trospium ER, Detrol LA/ Tolterodine SR, Myrbetriq Requip XL/Ropinirole ER, Mirapex ER Cardura XL Epinephrine, Auvi-Q, Adrenaclick Esomeprazole Strontium, Lansoprazole Suspension, Prevacid, Prevacid ODT/Lanosprazole ODT, First-Omeprazole Suspension, Aciphex/Rabeprazole, Zegerid/ Omeprazole-sodium Bicarbonate, Prilosec, Protonix Prevpac/Lansoprazole-amoxicillinclarithromycin, Helidac Step Therapy Medications (3 steps)* If you have a prescription for any of the following Step 3 medications, you must first try Step 1 and Step 2 medications for benefit coverage. Step 3 Asthma /COPD Theophylline, Qvar, Pulmicort, Flovent Diskus, Flovent HFA, Asmanex, Tudorza, Atrovent HFA, Spiriva, Advair Diskus, Advair HFA, Symbicort, Theo-24 Foradil and Serevent Arcapta OptumRx optumrx.com

7 Step Therapy Medications (3 steps)* Continued Step 3 Cardiovascular Diabetes Benazepril, Candesartan, Captopril, Enalopril, Fosinopril, Irbesartan, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril, Telmisartan, Trandolapril, Benazepril-amlodipine, Trandolaprilverapamil, Benazepril-HCTZ, Captopril- HCTZ, Enalapril-HCTZ, Fosinopril-HCTZ, Irbesartan-HCTZ, Lisinopril-HCTZ, Moexipril-HCTZ, Quinapril-HCTZ, Losartan, Losartan-HCTZ Benazepril, Candesartan, Captopril, Enalopril, Fosinopril, Irbesartan, Irbesartan HCTZ, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril, Trandolapril, Benazepril-amlodipine, Trandolaprilverapamil, Telmisartan, Benazepril- HCTZ, Captopril-HCTZ, Enalapril-HCTZ, Fosinopril-HCTZ, Lisinopril-HCTZ, Moexipril-HCTZ, Quinapril-HCTZ, Losartan, Losartan-HCTZ Metformin-glipizide, Metformin-glyburide, Metformin-pioglitazone, Chlorpropamide, Glimepiride, Glipizide, Glipizide ER, Glyburide, Tolazamide, Tolbutamide, Pioglitazone, Pioglitazone-glimepiride, Novolog, Lantus, Humalog, Levemir, Humulin, Novolin, Byetta Any one of the following: Azor, Exforge, Exforge HCT Tekturna or Tekturna HCT Any two of the following: Benicar, Benicar HCT, Diovan, Micardis HCT Any one of the following: Tradjenta, Onglyza, Januvia, Jentadueto, Kombiglyze, Janumet Twynsta/ Telmisartanamlopidine Tekamlo, Amturnide Atacand, Atacand HCT/ Candesartan- HCTZ, Teveten/ Eprosartan, Teveten HCT, Avapro, Avalide, Cozaar, Hyzaar, Diovan HCT, Micardis Nesina, Kazano, Oseni 7

8 Step Therapy Medications (3 steps)* Continued Step 3 Diabetes Continued Metformin-glipizide, Metformin-glyburide, Metformin-pioglitazone, Chlorpropamide, Glimepiride, Glipizide, Glipizide ER, Glyburide, Tolazamide, Tolbutamide, Pioglitazone, Pioglitazone-glimepiride, Novolog, Lantus, Humalog, Levemir, Humulin, Novolin, Byetta Metformin-glipizide, Metformin-glyburide, Metformin-pioglitazone, Chlorpropamide, Glimepiride, Glipizide, Glipizide ER, Glyburide, Tolazamide, Tolbutamide, Pioglitazone, Pioglitazone-glimepiride, Novolog, Lantus, Humalog, Levemir, Humulin, Novolin Metformin, Metformin ER, Metformin-glipizide, Metformin-glyburide, Metforminpioglitazone, Chlorpropamide, Glimepiride, Glipizide, Glipizide ER, Glyburide, Tolazamide, Tolbutamide, Pioglitazone, Pioglitazone-glimepiride, Novolog, Lantus, Humalog, Levemir, Humulin, Novolin, Byetta Janumet Byetta, Victoza Invokamet, Invokana Janumet XR Bydureon, Tanzeum Fargixa, Jardiance * Step therapy requirements are effective as of January 1, The list of step therapy medications is subject to change without notice. Step therapy requirements may vary by benefit plan. Additional clinical programs, including quantity limits and prior authorization, may exist for the above medications which may affect your prescription drug coverage. optumrx.com OptumRx specializes in the delivery, clinical management and affordability of prescription medications and consumer health products. We are an Optum TM company a leading provider of integrated health services. Learn more at optum.com. All Optum TM trademarks and logos are owned by Optum, Inc. All other brand or product names are trademarks or registered marks of their respective owners OptumRx, Inc. A09934 ORX0785_150101

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