PROGRAM General Information

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1 Association for Quality Assessment in TDM and Clinical Toxicology Section of the Dutch Foundation for Quality Assessment in Medical Laboratories PROGRAM 2016 General Information P.O. Box 43100, 2504 AC The Hague, The Netherlands. Tel , Fax ,

2 Alcohols/GHB The program includes 4 tests per year. The samples (4 ml) contain the components listed below. Components Control serum Participation 176,75 Ethanol 1,8 g/l Control serum (per 5 tubes of 4 ml) 52,50 Ethylene glycol 0,5 g/l GHB 0,5 g/l Matrix: liquid bovine serum preserved with 0,1% Methanol 0,5 g/l sodiumazide Anti-epileptic drugs The program includes 4 tests per year. The samples (2 ml) contain the components listed below. It is also possible to subscribe for extra tests to analyse phenytoin free fraction (round 2 and round 4). Components Control serum Participation 237,35 Carbamazepine 8 mg/l Additional set of tests 50,- 10,11-epoxide-CBZ 2 mg/l Phenytoin free fraction 50,- Ethosuximide 70 mg/l Phenobarbital 30 mg/l Control serum (per vial of 2 ml) 12,50 Phenytoin 15 mg/l Lamotrigine 8 mg/l Matrix: lyophilised human serum Levetiracetam Monohydroxycarbazepine Valproic acid 15 mg/l 20 mg/l 70 mg/l Antibiotic drugs The program includes 4x2 tests per year. The samples (1 ml) contain the components listed below. Components Control serum Amikacin 10 mg/l Participation 277,75 Gentamicin 5 mg/l Additional set of tests 80,- Methotrexate 1 µmol/l Control serum (per vial of 1 ml) 10,- Tobramycin 5 mg/l Vancomycin 15 mg/l Matrix: lyophilised human serum For gentamicin, tobramycine and vancomycin the samples are accompanied by a casus and a recommendation about the next dosages is asked. 2

3 Benzodiazepines The program includes 4 tests per year. The samples (5 ml) contain the components listed below. Components Control serum Participation 202,- Clobazam 250 µg/l Control serum (per 5 vials of 5 ml) 45,- Desmethylclobazam 1500 µg/l Clonazepam 40 µg/l Matrix: lyophilised bovine serum Midazolam Hydroxymidazolam 250 µg/l 100 µg/l Cardiac drugs The program includes 4 tests per year. The samples (5 ml) contain the components listed below. Components Control serum* Participation 202,- Amiodarone 1,5 mg/l Control serum (per 5 vials of 5 ml) 42,50 Desethylamiodarone 1,5 mg/l Caffeine 12 mg/l Matrix: lyophilised bovine serum Digoxin Flecainide Theophylline 1 µg/l 0,7 mg/l 12 mg/l * Because of degradation of amiodarone and desethylamiodarone during the freeze drying process the values of these components in the control serum will be calculated on the consensus value of round 1. Analgesic drugs The program includes 4 tests per year. The samples (5 ml) contain the components listed below. Components Control serum Participation 176,75 Ibuprofen 100 mg/l Control serum (per 5 vials of 5 ml) 37,50 Acetaminophen 100 mg/l Salicylic acid 200 mg/l Matrix: lyophilised bovine serum 3

4 Psychotherapeutic drugs The program includes 4 tests per year. The samples (5 ml) contain the components listed below. Because of the size of this program we offer you the possibility to participate in a part of the program. You have the option to subscribe for the total program, only samples I and II, or only samples III, IV and V. Components Control serum Psychotherapeutic drugs I Participation (total program) 404,- Amitriptyline 100 µg/l Participation (I and II) 277,75 Nortriptyline 100 µg/l Participation (III, IV and V) 353,50 Clozapine 500 µg/l Psychotherapeutic drugs II Control serum (per 5 vials of 5 ml) 40,- Clomipramine Desmethylclomipramine Matrix: lyophilised bovine serum Imipramine Desipramine Lithium Clopentixol Psychotherapeutic drugs III Fluoxetine Desmethylfluoxetine Fluvoxamine Mirtazapine Desmethylmirtazepine Paroxetine Quetiapine Psychotherapeutic drugs IV Aripiprazol Citalopram Desmethylcitalopram Olanzapine Risperidon Hydroxyrisperidon Psychotherapeutic drugs V Haloperidol Sertraline Desmethylsertraline Venlafaxine Desmethylvenlafaxine 0,8 mmol/l 10 µg/l 200 µg/l 75 µg/l 75 µg/l 75 µg/l 250 µg/l 200 µg/l 90 µg/l 35 µg/l 50 µg/l 15 µg/l 35 µg/l 8 µg/l 60 µg/l 125 µg/l 60 µg/l 200 µg/l 4

5 Various drugs The program includes 4 test per year with 2 samples of 5 ml with different components The matrix depends on the components Componenten Participation 252,50 Round a Round b Round c Round a Round b Round c Round a Round b Round a Round b Mycofenolate Imatinib/Desmethylimatinib Pimozide Mycofenolate Flupentixol /Pipamperon, Bupropion/ Hydroxybupropion Mycofenolate Diuretics Mycofenolate Lacosamide/Pregabalin/Gabapentin/Felbamate "Drugs of Abuse" The program includes 4 tests of 2 urine samples per year. The presence or absence of amphetamines, opiates, cannabinoids, cocaine, benzodiazepines, ethanol, EtG, methadone, barbiturates and other drugs of abuse like GHB needs to be established. The matrix is human urine. Participation 303,- Toxicology The program includes 4 or 5 tests per year. The samples (5 ml) contain different components and are presented with a toxicological case. The participant is supposed to perform a toxicological screening and is asked to give an advice for treatment. The matrix is liquid of lyophilised bovine serum. Participation 287,85 5

6 Antiretroviral drugs This program includes 4 rounds with 1 sample Antiretroviral drugs I and Antiretroviral drugs II per year. The samples (4 ml) contain the components listed below. The samples of 2 rounds are accompanied with a casus. Components Control serum Participation (total program) 404,- Antiretroviral drugs I Control serum (per 5 tubes of 2,5 ml) 112,50 Atazanavir 1 mg/l Darunavir 5 mg/l Matrix: liquid human serum, preserved with 0,1% Lopinavir 7 mg/l sodiumazide Rilpivirine Ritonavir Saquinavir Antiretroviral drugs II Amprenavir Efavirenz Etravirine Nevirapine Raltegravir Tipranavir 0,3 mg/l 5 mg/l 1,5 mg/l 2 mg/l 2,5 mg/l 1 mg/l 4 mg/l 2 mg/l 15 mg/l Antifungal drugs This program includes 4 rounds with 1 sample per year. The samples (3 ml) contain the components listed below. The samples of 2 rounds are accompanied with a casus. Components Control serum Participation 252,50 Fluconazole 6 mg/l Control serum (per 5 tubes of 2,5 ml) 112,50 Flucytosine 60 mg/l Itraconazole 1 mg/l Matrix: liquid human serum, preserved with 0,1% Hydroxyitraconazole 1 mg/l sodiumazide Posaconazole Voriconazole 2 mg/l 3 mg/l 6

7 Antituberculosis drugs This program includes 2 rounds with 2 samples per year. The samples (1 ml) contain the components listed below. The samples of 1 round are accompanied with a casus. Components Participation 252,50 Ethambutol Isoniazid Matrix: lyophilised serum Levofloxacin Linezolid Moxifloxazin Pyrazinamide Rifampicin Antiviral drugs This program includes 2 rounds with 2 samples per year. The samples (2 ml) contain the components listed below. Components Participation 252,50 Aciclovir Ganciclovir Ribavirine Matrix: lyophilised bovine serum Other control samples Components Concentration Ethanol 1,5 g/l Control sample (per 5 tubes of 2 ml) 42,50 GHB 0,5 g/l Ketamine 1 mg/l Matrix: urine, preserved with 0,1% sodium azide 7

8 Price list 2016 Program Price (excl. VAT) Price (incl. VAT) Alcohols/GHB 176,75 213,87 Anti-epileptic drugs 237,35 287,19 Antiretroviral drugs 404,- 488,84 Antibiotic drugs 277,75 336,08 Antifungal drugs 252,50 305,53 Antituberculosis drugs 252,50 305,53 Antiviral drugs 252,50 305,53 Benzodiazepines 202,- 244,42 Cardiac drugs 202,- 244,42 Various drugs 252,50 305,53 "Drugs of Abuse" 303,- 366,63 Analgesic drugs 176,75 213,87 Psychotherapeutic drugs Total program 404,- 488,84 I and II 277,75 336,08 III, IV and V 353,50 427,73 Toxicology 287,85 348,30 Control samples Price (excl. VAT) Volume Matrix Alcohols/GHB 52,50 5 tubes of 4 ml Liquid bovine serum Anti-epileptic drugs 12,50 1 vial of 2 ml Lyophilised human serum Antiretroviral drugs 112,50 5 tubes of 2,5 ml (I or II) Liquid human serum Antibiotic drugs 10,- 1 vial of 1 ml Lyophilised human serum Antifungal drugs 112,50 5 tubes of 2,5 ml Liquid human serum Benzodiazepines 45,- 5 vials of 5 ml Lyophilised bovine serum Blank bovine serum 30,- 5 vials of 5 ml Lyophilised bovine serum Cardiac drugs 42,50 5 vials of 5 ml Lyophilised bovine serum Ethanol/GHB/ketamine 42,50 5 tubes of 2 ml Urine Analgetic drugs 37,50 5 vials of 5 ml Lyophilised bovine serum Psychotherapeutic drugs 40,- 5 vials of 5 ml (I, II, III, IV or V) Lyophilised bovine serum You can order your control samples simultaneous with your subscription for For late orders of control samples the KKGT will charge 17,50 for administrative expenses and shipping. It is only possible to order control samples of a specific program for participants who are subscribed for this program. The control samples should not be used as reference material. Antiretroviral and Antifungal drugs Since stability of the samples of Antiretroviral and Antifungal drugs has been proved at ambient temperature, shipping will take place by regular mail. If you want to receive your samples on dry-ice you will be charged extra, based on the extra costs of the shipment ( 350 or more). 8

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