Chapter 16: Ketogenic Diets

Size: px
Start display at page:

Download "Chapter 16: Ketogenic Diets"

Transcription

1 Chapter 16: Ketogenic Diets 1. Wilder RM The effects of ketonuria on the course of epilepsy. Mayo Clin Bull, 1921, National Institute for Health and Clinical Excellence Clinical Guideline 20: The Epilepsies. London: NICE, Solomon NA Parent s Handbook Complex Childhood Epilepsy. National Centre for Young People with Epilepsy, Dudley RW, Penney SJ, Buckley DJ First drug treatment failures in children newly diagnosed with epilepsy. Paediatr Neurol, 2009, Leen WG, Klepper J, Verbeek MM et al. Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain, 2010, Wexler ID, Hemalatha SG, Kerr DS et al. Outcome of pyruvate dehydrogenase deficiency treated with ketogenic diets. Studies in patients with identical mutations. Neurology, 1997, Nabbout R, Mazzuca M, Hubert P Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia, 2010,

2 9. Nordli DR, De Vivo DC Effects of the ketogenic diet on cerebral energy metabolism. In: Stafstrom CE, Rho JM (eds) Epilepsy and the Ketogenic Diet. Totowa, NJ: Humana Press, Yudkoff M, Daikhin Y, Nissim I et al. Ketogenic diet, brain glutamate metabolism and seizure control. Prostagland, Leukotr Ess Fatty Acids, 2004, Weinshenker D Galanin and neuropeptide Y: orexigenic peptides link food intake, energy homeostasis, and seizure susceptibility. In: Stafstrom CE, Rho JM (eds) Epilepsy and the Ketogenic Diet. Totowa, NJ: Humana Press, Tabb K, Szot P, White SS et al. The ketogenic diet does not alter brain expression of orexigenic neuropeptides. Epilepsy Res, 2004, Szot P The role of norepinephrine in the anticonvulsant mechanism of action of the ketogenic diet. In: Stafstrom CE, Rho JM (eds) Epilepsy and the Ketogenic Diet. Totowa, NJ: Humana Press, Greene AE, Todorova MT, Seyfield TN Perspectives on metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies. J Neurochem, 2003, Huttenlocher PR, Wilbourn AJ, Signore JM Medium chain triglycerides as a therapy for intractable childhood epilepsy. Neurology, 1971, Kossoff EH, McGrogan JR, Vining EP et al. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia, 2006, Kang HC, Lee HS, You SJ et al. Use of a modified Atkins diet in intractable childhood epilepsy. Epilepsia, 2007, Kossoff EH, Dorward JL The modified Atkins diet. Epilepsia. 2008, 49(Suppl 8)

3 19. Pfeifer HH, Thiele EA Low glycaemic index treatment: liberalised ketogenic diet for treatment of intractable epilepsy. Neurology, 2005, Muzykewicz DA, Lyczkowski DA, Thiele EA et al. Efficacy, safety and tolerability of the low glycaemic index treatment in pediatric epilepsy. Epilepsia, 2009, Freeman JM, Vining EP, Pilas DJ et al. The efficacy of the ketogenic diet: a prospective evaluation of intervention in 150 children. Pediatrics, 1998, Lefevre F, Aronson N Ketogenic diet for the treatment of refractory epilepsy in children. A systematic review of efficacy. Pediatrics, 2000, 105 E Levy R, Cooper P Ketogenic diet for epilepsy. The Cochrane Library Issue 3. Chichester, UK: John Wiley, Neal EG, Chaffe H, Schwartz RH et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol, 2008, Neal EG, Chaffe H, Schwartz RH et al. A randomized trial of classical and mediumchain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia, 2009, Hong AM, Turner Z, Kossof EH et al. Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia, 2010, Eun SH, Kang HC, Kim HD et al. Ketogenic diet for treatment of infantile spasms. Brain Dev, 2006, Nordli DR Jr, Kuroda MM, De Vivo DC et al. Experience with the ketogenic diet in infants. Pediatrics, 2001,

4 29. Pulsifer MB, Gordon JM, Brandt J et al. Effects of the ketogenic diet on development and behaviour: preliminary report of a prospective study. Dev Med Child Neurol, 2001, 43, Dunlea O The cost benefit of the ketogenic diet in the treatment of epilepsy. King's College, University of London, Chandratre SR, Davison J, Whitehouse WP Ketogenic diet therapy: is it cost effective. Poster presentation at International Ketogenic Symposium, Edinburgh, Hallbook T, Lundgren J, Rosen I Ketogenic diet improves sleep quality in children with therapy resistant epilepsy. Epilepsia, 2007, Martinez CC, Pyzik PL, Kossoff EH Discontinuing the ketogenic diet in seizure free children: recurrence and risk factors. Epilepsia, 2007, Furth SL, Casey JC, Pyzik PL et al. Risk factors for urolithiasis in children on the ketogenic diet. Pediatr Nephrol, 2000, 15, Hertzberg GZ, Fivush BA, Kinsman SL et al. Urolithiaisis associated with the ketogenic diet. J Pediatr, 1990, Paul E, Conant KD, Dunne IE et al. Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy. Epilepsy Res, 2010, Bergqvist AG, Schall JI, Zemel BS Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet. Am J Clin Nutr, 2008, Delgado MR, Mills J, Sparagana S Hypercholesterolemia associated with the ketogenic diet. Epilepsia, 1996, 37(Suppl 5) Kwiterovitch PO, Vining EP, Pyzik P et al. Effect of high fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. J Am Med Assoc, 2003, Huttenlocher P Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976,

5 41. Nizamuddin J, Turner Z, Rubenstein JE et al. Management and risk factors for dyslipidaemia with the ketogenic diet. J Child Neurol, 2008, Couch SC, Schwarzman F, Carroll J et al. Growth and nutritional outcomes of children treated with the ketogenic diet. J Am Diet Assoc, 1999, Williams S, Basualdo-Hammond C, Curtis R et al. Growth retardation in children with epilepsy on the ketogenic diet: a retrospective chart review. J Am Diet Assoc, 2002, Vining EP, Pyzik P, McGrogan J et al. Growth of children on the ketogenic diet. Dev Med Child Neurol, 2002, Peterson SJ, Tangey CC, Pimentel-Zablah EM et al. Changes in growth and seizure reduction in children on the ketogenic diet as a treatment for intractable epilepsy. J Am Diet Assoc, 2005, Neal EG, Chaffe H, Edwards N et al. Growth of children on classical and medium chain triglyceride ketogenic diets. Pediatrics, 2008, 122 e Best TH, Franz DN, Gilbert DL et al. Cardiac complications in pediatric patients on the ketogenic diet. Neurology, 2000, Stewart WA, Gordon K, Camfield P Acute pancreatitis causing death in a child on the ketogenic diet. J Child Neurol, 2001, Ballaban-Gill K, Callahan C, O Dell C et al. Complications of the ketogenic diet. Epilepsia, 1998, Woody RC, Steele RW, Knapple WL et al. Impaired neutrophil function in children with seizures treated with the ketogenic diet. J Pediatr, 1989,

6 51. Berry-Kravis E, Booth G, Taylor A et al. Bruising and the ketogenic diet: evidence for diet-induced changes in platelet function. Ann Neurol, 2001, Kossoff EH, Zupec-Kania BA, Vining EP et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia, 2009, Vaisleib II, Buchalter JR, Zupanc ML Ketogenic diet: outpatient initiation, without fluid or caloric restrictions. Paed Neurol, 2004, Bergqvist AG, Schall JI, Stallings VA et al. Fasting versus gradual introduction of the ketogenic diet: a prospective, randomised clinical trial of efficacy. Epilepsia, 2005, Department of Health Report on Health and Social Subjects No. 41. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. London: TSO, World Health Organization. Energy and Protein Requirements. Reports of the Joint FAO/WHO/ UNU Meeting. Geneva: World Health Organization, 2007 (WHO Technical Report Series 724). 57. Dewy KG, Beaton G, Fjeld C et al. Protein requirements of infants and children. Eur J Clin Nutr, 1996, Suppl 1 S Kossoff EH, Freeman J, Turner Z et al. Ketogenic Diets Treatment for Epilepsy and Other Disorders, 5th edn. New York: Demos Health, Holland B, Welch AA, Unwin ID et al. McCance and Widdowson s Composition of Foods, 6th edn. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food. London: TSO, Huttenlocher, P Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976,

7 61. Schwartz RH, Eaton J, Bowyer BD et al. Ketogenic diets in the treatment of epilepsy: short-term clinical effects. Dev Med Child Neurol, 1989, Ranhotra GS, Gelroth JA, Glaser BK Levels of medium-chain triglycerides and their energy value. Cereal Chem, 1995, European Council Directive on Food Labelling (1990). Official Journal of the European Communities, No. L276/41, pp Kossoff EH, Turner Z, Vining EP et al. A randomized, crossover comparison of daily carbohydrate limits using the modified Atkins diet. Epilepsy Behav, 2007, Vaisleib LL, Buchalter JR, Zupanc ML Ketogenic diet: outpatient initiation, without fluid or caloric restrictions. Paed Neurol, 2004, McNally MA, Pyzik PL, Kossoff EH et al. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics, 2009, 124 e DeVivo DC, Bohan TP, Coulter DL et al. L-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia, 1998, Berry-Kravis E, Booth G, Sanchez AC et al. Carnitine levels and the ketogenic diet. Epilepsia, 2001, Gilbert D, Pyzik P, Freeman JM The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketone levels. J Child Neurol, 2000, Eltze C, Fitzsimmons GJ, Sewell M et al. Great Ormond Street Hospital Clinical Guidelines for the Ketogenic Diet,

8 professionals/clinical-guidelines/the-ketogenic-diet-in-the-management-of-epilepsy. Accessed 31 October Worden LT, Turner Z, Kossoff EH et al. Is there an ideal way to discontinue the ketogenic diet? 72. Epilepsy Res, 2011, Patel A, Pyzik PL, Kossoff EH et al. Long-term outcomes of children treated with the ketogenic diet in the past. Epilepsia, 2010,

Review Article A Systematic Review of the Use of the Ketogenic Diet in Childhood Epilepsy. Daniel L. Keene, MD, MA

Review Article A Systematic Review of the Use of the Ketogenic Diet in Childhood Epilepsy. Daniel L. Keene, MD, MA Review Article A Systematic Review of the Use of the Ketogenic Diet in Childhood Epilepsy Daniel L. Keene, MD, MA The ketogenic diet has been used in the treatment of intractable childhood epilepsy since

More information

Epilepsy & Behavior. Dietary therapies for epilepsy: Future research. Sudha K. Kessler, Elizabeth G. Neal, Carol S. Camfield, Eric H. Kossoff.

Epilepsy & Behavior. Dietary therapies for epilepsy: Future research. Sudha K. Kessler, Elizabeth G. Neal, Carol S. Camfield, Eric H. Kossoff. Epilepsy & Behavior 22 (2011) 17 22 Contents lists available at ScienceDirect Epilepsy & Behavior journal homepage: www.elsevier.com/locate/yebeh Review Dietary therapies for epilepsy: Future research

More information

Modified Atkins diet in adult with refractory epilepsy: A controlled randomized clinical trial

Modified Atkins diet in adult with refractory epilepsy: A controlled randomized clinical trial Iranian Journal of Neurology Original Paper Iran J Neurol 2017; 16(2): 72-7 Modified Atkins diet in adult with refractory epilepsy: A controlled randomized clinical trial Received: 17 Dec. 2016 Accepted:

More information

Dietary Approaches to Non-Lesional Epilepsy December 8, 2013

Dietary Approaches to Non-Lesional Epilepsy December 8, 2013 Dietary Approaches to Non-Lesional Epilepsy December 8, 2013 Eric H. Kossoff, MD Johns Hopkins University Baltimore, Maryland American Epilepsy Society Annual Meeting 1 Disclosures Nutricia, Inc. Atkins

More information

Use of the Modified Atkins Diet in Intractable Pediatric Epilepsy

Use of the Modified Atkins Diet in Intractable Pediatric Epilepsy Original Article Journal of Epilepsy Research pissn 2233-6249 / eissn 2233-6257 Use of the Modified Atkins Diet in Intractable Pediatric Epilepsy Eu Gene Park, MD, Jiwon Lee, MD, Jeehun Lee, MD, PhD Department

More information

The ketogenic diet; clinical update

The ketogenic diet; clinical update The ketogenic diet; clinical update J Helen Cross UCL-Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, & NCYPE, Lingfield, UK The ketogenic diet what is it? A high

More information

Long-term monitoring of the ketogenic diet: Do s and Don ts

Long-term monitoring of the ketogenic diet: Do s and Don ts Epilepsy Research (2012) 100, 261 266 jou rn al h om epa ge: www.elsevier.com/locate/epilepsyres Long-term monitoring of the ketogenic diet: Do s and Don ts A.G. Christina Bergqvist Division of Neurology/Department

More information

RESEARCH ARTICLE A MODIFIED ATKINS DIET FOR INTRACTABLE CHILDHOOD EPILEPSY

RESEARCH ARTICLE A MODIFIED ATKINS DIET FOR INTRACTABLE CHILDHOOD EPILEPSY RESEARCH ARTICLE A MODIFIED ATKINS DIET FOR INTRACTABLE CHILDHOOD EPILEPSY Mohammad BARZEGAR MD 1, Poupak IRANDOUST BSc 2, Mehrangiz EBRAHIMI MAMEGHANI PhD 3 1.Professor of Pediatric Neurology, Pediatric

More information

Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis

Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis Systematic Review Iran J Pediatr Dec 2013; Vol 23 (No 6), Pp: 613-620 Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis Hai-feng Li 1, MM; Yan Zou *2, MPH; Gangqiang

More information

Revisiting the Ketogenic Diet and Related Therapies in the Modern Era

Revisiting the Ketogenic Diet and Related Therapies in the Modern Era Revisiting the Ketogenic Diet and Related Therapies in the Modern Era Heung Dong Kim M.D., Ph.D. Pediatric Epilepsy Clinic, Division of Pediatric Neurology Severance Children s Hospital Yonsei University

More information

Combined Ketogenic Diet and Vagus Nerve Stimulation: Rational Polytherapy?

Combined Ketogenic Diet and Vagus Nerve Stimulation: Rational Polytherapy? Epilepsia, 48(1):77 81, 2007 Blackwell Publishing, Inc. C 2007 International League Against Epilepsy Combined Ketogenic Diet and Vagus Nerve Stimulation: Rational Polytherapy? Eric H. Kossoff, Paula L.

More information

Workshop Ketogenic diets. Christin Eltze Consultant Paediatric Neurologist Great Ormond Street Hospital for Children NHS Trust

Workshop Ketogenic diets. Christin Eltze Consultant Paediatric Neurologist Great Ormond Street Hospital for Children NHS Trust Workshop Ketogenic diets Christin Eltze Consultant Paediatric Neurologist Great Ormond Street Hospital for Children NHS Trust History Fasting suppresses seizure activity: Conklin (J Am Osteopatic Assoc

More information

Low Carbohydrate Diets and The Brain

Low Carbohydrate Diets and The Brain Low Carbohydrate Diets and The Brain Eric H. Kossoff, MD Medical Director, Ketogenic Diet Center Associate Professor, Neurology and Pediatrics Johns Hopkins Hospital Baltimore, Maryland July 9, 2010 Topics

More information

Ketogenic diet and other dietary therapies in epilepsy. Randa Jarrar, MD

Ketogenic diet and other dietary therapies in epilepsy. Randa Jarrar, MD Ketogenic diet and other dietary therapies in epilepsy Randa Jarrar, MD Ketogenic diet: History What is involved Efficacy Complications How does it work Variations: MCT ketogenic diet Low glycemic index

More information

Ketogenic Diet Neurology & Beyond J Helen Cross UCL-Great Ormond Street Institute of Child Health, London & Young Epilepsy, Lingfield

Ketogenic Diet Neurology & Beyond J Helen Cross UCL-Great Ormond Street Institute of Child Health, London & Young Epilepsy, Lingfield Ketogenic Diet Neurology & Beyond J Helen Cross UCL-Great Ormond Street Institute of Child Health, London & Young Epilepsy, Lingfield The ketogenic diet What is it? A high fat diet, designed to mimic the

More information

Ghee Whiz! The Growing Evidence for the Benefits of the Modified Atkins Diet

Ghee Whiz! The Growing Evidence for the Benefits of the Modified Atkins Diet Current Literature In Clinical Science Ghee Whiz! The Growing Evidence for the Benefits of the Modified Atkins Diet Use of the Modified Atkins Diet for Treatment of Refractory Childhood Epilepsy: A Randomized

More information

Diet therapy in refractory pediatric epilepsy: increased efficacy and tolerability

Diet therapy in refractory pediatric epilepsy: increased efficacy and tolerability Special article Epileptic Disord 2006; 8 (4): 309-16 Diet therapy in refractory pediatric epilepsy: increased efficacy and tolerability Hoon-Chul Kang 1, Heung Dong Kim 2 1 Department of Pediatrics, Epilepsy

More information

Ketogenic diet in patients with myoclonic-astatic epilepsy

Ketogenic diet in patients with myoclonic-astatic epilepsy Original article Epileptic Disord 2006; 8 (2): 151-5 Ketogenic diet in patients with myoclonic-astatic epilepsy Roberto Horacio Caraballo 1, Ricardo Oscar Cersósimo 1, Diego Sakr 1, Araceli Cresta 2, Nidia

More information

The Outcome of Children with Intractable Seizures: A 3- to 6-Year Follow-up of 67 Children Who Remained on the Ketogenic Diet Less Than One Year

The Outcome of Children with Intractable Seizures: A 3- to 6-Year Follow-up of 67 Children Who Remained on the Ketogenic Diet Less Than One Year Epilepsia, 47(2):425 430, 2006 Blackwell Publishing, Inc. C 2006 International League Against Epilepsy The Outcome of Children with Intractable Seizures: A 3- to 6-Year Follow-up of 67 Children Who Remained

More information

Dietary Treatments for Epilepsy From Minnesota to Scotland.and beyond!

Dietary Treatments for Epilepsy From Minnesota to Scotland.and beyond! Dietary Treatments for Epilepsy From Minnesota to Scotland.and beyond! Eric H. Kossoff, MD Associate Professor, Neurology & Pediatrics Medical Director, Ketogenic Diet Program Johns Hopkins Hospital 1921

More information

Ef cacy of the Atkins Diet as Therapy for Intractable Epilepsy in Children

Ef cacy of the Atkins Diet as Therapy for Intractable Epilepsy in Children Atkins Diet in Childhood Intractable Epilepsy Original Article Ef cacy of the Atkins Diet as Therapy for Intractable Epilepsy in Children Seyed Hassan Tonekaboni MD 1,2, Parvin Mostaghimi 3, Parvin Mirmiran

More information

Dietary Treatment for Patients With Epilepsy

Dietary Treatment for Patients With Epilepsy Dietary Treatment for Patients With Epilepsy Ketogenic diets are an effective treatment when used properly with medical supervision and support. By A.G. Christina Bergqvist, MD Introduction Dietary treatments

More information

Ketogenic Diet in Patients with Dravet Syndrome

Ketogenic Diet in Patients with Dravet Syndrome Epilepsia, 46(9):1539 1544, 2005 Blackwell Publishing, Inc. C 2005 International League Against Epilepsy Ketogenic Diet in Patients with Dravet Syndrome Roberto Horacio Caraballo, Ricardo Oscar Cersósimo,

More information

Growth of children on the ketogenic diet

Growth of children on the ketogenic diet Growth of children on the ketogenic diet Eileen P G Vining* MD, Associate Professor of Neurology and Pediatrics; Paula Pyzik BA, Research Coordinator; Jane McGrogan BS RD, Dietician; Heather Hladky BS

More information

ICAN: Infant, Child, & Adolescent Nutrition. Ketogenic Diet Patients Lipid Profiles Improved With KetoCal 4:1 Liquid

ICAN: Infant, Child, & Adolescent Nutrition. Ketogenic Diet Patients Lipid Profiles Improved With KetoCal 4:1 Liquid 580362CANXXX10.1177/1941406415580362Infant, Child, & Adolescent NutritionMONTH MONTH XXXXvol. X no. XInfant, Child, & Adolescent Nutrition research-articlexxxx Evidence-Based Practice Reports Ketogenic

More information

Effectiveness of Medium Chain Triglyceride Ketogenic Diet in Thai Children with Intractable Epilepsy

Effectiveness of Medium Chain Triglyceride Ketogenic Diet in Thai Children with Intractable Epilepsy Effectiveness of Medium Chain Triglyceride Ketogenic Diet in Thai Children with Intractable Epilepsy Krisnachai Chomtho MD*, Orapa Suteerojntrakool MD*, Sirinuch Chomtho MD* * Department of Pediatrics,

More information

Dietary Therapy For GLUT1 What are parents telling the experts?

Dietary Therapy For GLUT1 What are parents telling the experts? Dietary Therapy For GLUT1 What are parents telling the experts? Eric H. Kossoff, MD Professor, Neurology and Pediatrics Medical Director, Ketogenic Diet Program Johns Hopkins Hospital Baltimore, Maryland

More information

The Ketogenic Diet: Adolescents Can Do It, Too

The Ketogenic Diet: Adolescents Can Do It, Too Epilepsia, 44(6):847 851, 2003 Blackwell Publishing, Inc. C 2003 International League Against Epilepsy The Ketogenic Diet: Adolescents Can Do It, Too Mackenzie A. Mady, Eric H. Kossoff, Amy L. McGregor,

More information

Ketogenic diet for epilepsy

Ketogenic diet for epilepsy Ketogenic diet for epilepsy Published Jun 24, 1998 Version 1 Findings by SBU Alert The ketogenic diet has been used for intractable epilepsy in children, and is a method that has been used sporadically

More information

Dietary therapies for childhood epilepsy

Dietary therapies for childhood epilepsy Review 275 DOI: 10.4274/tpa.2083 Dietary therapies for childhood epilepsy Burak Tatlı 1, Ayşe Nurcan Cebeci 2, Barış Ekici 2 1Pediatric Neurology and Developmental Pediatrics 2Derince Education and Research

More information

WHY? 26/2/2010. Shimomura Y, Harris RA. J Nutr. 2006;136(1 suppl):232s-233s. BCAA buffer excessive amounts of Glutamate by converting it to Glutamine.

WHY? 26/2/2010. Shimomura Y, Harris RA. J Nutr. 2006;136(1 suppl):232s-233s. BCAA buffer excessive amounts of Glutamate by converting it to Glutamine. Branched Chain Amino Acids as Adjunctive Therapy to Ketogenic Diet Athanasios Evangeliou MD 4th Department of Pediatrics of the Aristotle University of Thessaloniki Papageorgiou Hospital Thessaloniki E-mail:

More information

27/08/58. Kwan, P. and M.J. Brodie, Early identification of refractory epilepsy. N Engl J Med, (5): p

27/08/58. Kwan, P. and M.J. Brodie, Early identification of refractory epilepsy. N Engl J Med, (5): p Pharmocologic Rx Other treatments: KD& VNS 1 st drug response - 47% 2 nd & 3 rd drug response - 14% Polytherapy response - 3% Dr Krisnachai Chomtho MD DCH MRCPCH Lecturer in pediatric neurology King Chulalongkorn

More information

E. Haritov, E. Angeleska and N. Boyadjieva Department of pharmacology and toxicology, Medical Faculty, Medical University So a

E. Haritov, E. Angeleska and N. Boyadjieva Department of pharmacology and toxicology, Medical Faculty, Medical University So a :.,..,, KETOGENIC DIET AND EPILEPSY: THE ROLE OF KETONE BODIES IN THE INFLUENCE N NEURONAL EXCITABILITY E. Haritov, E. Angeleska and N. Boyadjieva Department of pharmacology and toxicology, Medical Faculty,

More information

LILY FOUNDATION. An Introduction to Ketogenic Diets. Susan Wood. Matthew s Friends. Registered Dietitian Adults & Paediatrics

LILY FOUNDATION. An Introduction to Ketogenic Diets. Susan Wood. Matthew s Friends. Registered Dietitian Adults & Paediatrics LILY FOUNDATION An Introduction to Ketogenic Diets Susan Wood Registered Dietitian Adults & Paediatrics Matthew s Friends What is a ketogenic diet? A MEDICAL treatment. Mimics fasting metabolism Alters

More information

The Fat Is in the Fire: Ketogenic Diet for Refractory Status Epilepticus

The Fat Is in the Fire: Ketogenic Diet for Refractory Status Epilepticus Current Literature In Clinical Science The Fat Is in the Fire: Ketogenic Diet for Refractory Status Epilepticus Efficacy of Ketogenic Diet in Severe Refractory Status Epilepticus Initiating Fever Induced

More information

1.0 Introduction. Ketogenic Diet. Purpose:

1.0 Introduction. Ketogenic Diet. Purpose: 1.0 Introduction The therapy is a nonpharmacological treatment used to treat children with drug resistant epilepsy when traditional pharmacological treatments do not adequately control seizures. 1,2,3,4

More information

Document Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume numbers)

Document Version Publisher s PDF, also known as Version of Record (includes final page, issue and volume numbers) A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy Lambrechts, D.A.J.E.; de Kinderen, R.J.A.; Vles, J.S.H.; de Louw, A.J.A.; Aldenkamp, A.P.; Majoie, H.J.M. Published

More information

Dietary Therapy What are the parents actually doing?

Dietary Therapy What are the parents actually doing? Dietary Therapy What are the parents actually doing? Eric H. Kossoff, MD Professor, Neurology and Pediatrics Medical Director, Ketogenic Diet Program Johns Hopkins Hospital Baltimore, Maryland USA The

More information

The Ketogenic and Atkins Diets Effect on Intractable Epilepsy: A Comparison

The Ketogenic and Atkins Diets Effect on Intractable Epilepsy: A Comparison original ARTICLE Ahad GHAZAVI MD 1 Seyed Hassan TONEKABONI MD 2, 3, Parvaneh KARIMZADEH MD 2, 3, Ahmad Ali NIKIBAKHSH MD 4, Ali KHAJEH MD 5, Afshin FAYYAZI MD 6 1. Neurophysiology Research Center, Department

More information

KETOGENIC DIET ISMAIL HALAHLEH, MSC. نقیب اخصاي یي التغذیة الفلسطینیین

KETOGENIC DIET ISMAIL HALAHLEH, MSC. نقیب اخصاي یي التغذیة الفلسطینیین KETOGENIC DIET ISMAIL HALAHLEH, MSC. نقیب اخصاي یي التغذیة الفلسطینیین INTRODUCTION WHAT IS KETOGENIC DIET???? KETOGENIC DIET The ketogenic diet (KD) is a diet that is high in fat, low in carbohydrate,

More information

Seizure Management Quality Care for Our Patients

Seizure Management Quality Care for Our Patients Seizure Management Quality Care for Our Patients Case 6 Jack Pellock, MD 8 year old female with refractory epilepsy Multiple handicaps, developmental delay Cerebral palsy spastic diplegia but ambulatory

More information

Prior Authorization Review Panel MCO Policy Submission

Prior Authorization Review Panel MCO Policy Submission Prior Authorization Review Panel MCO Policy Submission A separate copy of this form must accompany each policy submitted for review. Policies submitted without this form will not be considered for review.

More information

GLOBAL SYMPOSIUM ON DIETARY THERAPIES FOR EPILEPSY & OTHER NEUROLOGICAL DISORDERS

GLOBAL SYMPOSIUM ON DIETARY THERAPIES FOR EPILEPSY & OTHER NEUROLOGICAL DISORDERS GLOBAL SYMPOSIUM ON DIETARY THERAPIES FOR EPILEPSY & OTHER NEUROLOGICAL DISORDERS THE GRACE SUITE, LIVERPOOL HILTON HOTEL 7 TH 10 TH OCTOBER 2014 PROGRAMME FOR HEALTHCARE PROFESSIONALS Scientific Committee:

More information

Seizure. Use of dietary therapies amongst patients with GLUT1 deficiency syndrome

Seizure. Use of dietary therapies amongst patients with GLUT1 deficiency syndrome Seizure 35 (2016) 83 87 Contents lists available at ScienceDirect Seizure jou r nal h o mep age: w ww.els evier.co m/lo c ate/ys eiz Use of dietary therapies amongst patients with GLUT1 deficiency syndrome

More information

Review Article Efficacy of ketogenic diets in children with refractory epilepsy: a meta-analysis

Review Article Efficacy of ketogenic diets in children with refractory epilepsy: a meta-analysis Int J Clin Exp Med 2018;11(11):11396-11405 www.ijcem.com /ISSN:1940-5901/IJCEM0055358 Review Article Efficacy of ketogenic diets in children with refractory epilepsy: a meta-analysis Jinhong Zhang 1, Xueye

More information

A pilot trial with modified Atkins diet in adult patients with refractory epilepsy

A pilot trial with modified Atkins diet in adult patients with refractory epilepsy Clinical Neurology and Neurosurgery 110 (2008) 797 803 A pilot trial with modified Atkins diet in adult patients with refractory epilepsy Evelien Carrette a,, Kristl Vonck a, Veerle de Herdt a, Isabelle

More information

Complications of the Ketogenic Diet

Complications of the Ketogenic Diet Epilepsia, 39(7):744-748, 1998 Lippincott-Raven Publishers, Philadelphia 0 International League Against Epilepsy Complications of the Ketogenic Diet *f$karen Ballaban-Gil, *fc. Callahan, *fc. O'Dell, SM.

More information

Topics to be addressed. When medication isn t quite enough. Catamenial epilepsy. Catamenial epilepsy: ovulatory cycles 5/22/2009.

Topics to be addressed. When medication isn t quite enough. Catamenial epilepsy. Catamenial epilepsy: ovulatory cycles 5/22/2009. When medication isn t quite enough. Alternative and complementary treatment strategies in epilepsy Topics to be addressed Hormonal progesterone Diet Atkins, ketogenic Supplements Tina Shih, MD UCSF Epilepsy

More information

Clinical Aspects of the Ketogenic Diet

Clinical Aspects of the Ketogenic Diet Epilepsia, 48(1):31 42, 2007 Blackwell Publishing, Inc. C 2007 International League Against Epilepsy Critical Reviews Clinical Aspects of the Ketogenic Diet Adam L. Hartman and Eileen P. G. Vining The

More information

Karin Borges, PhD. October The urgent need for new metabolic (dietary) treatments of epilepsy

Karin Borges, PhD. October The urgent need for new metabolic (dietary) treatments of epilepsy Karin Borges, PhD October 2016 The urgent need for new metabolic (dietary) treatments of epilepsy Epilepsy is a common neurological disease that is characterized by recurrent seizures due to the spontaneous

More information

Ketogenic Diet Treatment - Malaysian Experience. Dr. Teik Beng Khoo Paediatric Institute Hospital Kuala Lumpur

Ketogenic Diet Treatment - Malaysian Experience. Dr. Teik Beng Khoo Paediatric Institute Hospital Kuala Lumpur Ketogenic Diet Treatment - Malaysian Experience Dr. Teik Beng Khoo Paediatric Institute Hospital Kuala Lumpur The Beginning Ketogenic diet (KD) treatment was first started among a small group of Malaysian

More information

LRI Children s Hospital

LRI Children s Hospital LRI Children s Hospital Management of Children on Ketogenic Diet for Epilepsy Staff relevant to: Health professionals caring for children with epilepsy being managed on a ketogenic diet. Team approval

More information

of epilepsy of epilepsy dietary treatment practical implementation elizabeth neal dietary treatment of epilepsy neal elizabeth neal

of epilepsy of epilepsy dietary treatment practical implementation elizabeth neal dietary treatment of epilepsy neal elizabeth neal practical implementation of ketogenic therapy edited by elizabeth neal Epilepsy is a common chronic neurological disorder characterised by recurrent unprovoked seizures, and affects 50 million people worldwide.

More information

Epilepsy s Big Fat Answer By John M. Freeman, M.D.

Epilepsy s Big Fat Answer By John M. Freeman, M.D. Epilepsy s Big Fat Answer By John M. Freeman, M.D. Editor s Note: Epilepsy and seizures affect nearly 3 million Americans of all ages. The incidence is greater in African-Americans and in socially disadvantaged

More information

Ketogenic Diet therapy in Myoclonic-Atonic Epilepsy (MAE)

Ketogenic Diet therapy in Myoclonic-Atonic Epilepsy (MAE) KD therapy in epilepsy syndromes Ketogenic Diet therapy in Myoclonic-Atonic Epilepsy (MAE) Hirokazu Oguni, MD Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan Epilepsy Center, TMG

More information

Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group

Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group SPECIAL REPORT Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group Eric H. Kossoff, ybeth A. Zupec-Kania, zper E. Amark,

More information

Review Article The Modified Atkins Diet in Refractory Epilepsy

Review Article The Modified Atkins Diet in Refractory Epilepsy Hindawi Publishing Corporation Epilepsy Research and Treatment Volume 2014, Article ID 404202, 6 pages http://dx.doi.org/10.1155/2014/404202 Review Article The Modified Atkins Diet in Refractory Epilepsy

More information

Ketogenic parenteral nutrition in 17 pediatric patients with epilepsy

Ketogenic parenteral nutrition in 17 pediatric patients with epilepsy FULL-LENGTH ORIGINAL RESEARCH Ketogenic parenteral nutrition in 17 pediatric patients with epilepsy *Anastasia Dressler, *Nadja Haiden, *Petra Trimmel-Schwahofer, Franz Benninger, *Sharon Samueli, *Gudrun

More information

Seizure remission in adults with long-standing intractable epilepsy: An extended follow-up

Seizure remission in adults with long-standing intractable epilepsy: An extended follow-up Epilepsy Research (2010) xxx, xxx xxx journal homepage: www.elsevier.com/locate/epilepsyres Seizure remission in adults with long-standing intractable epilepsy: An extended follow-up Hyunmi Choi a,, Gary

More information

SPECIAL REPORT SUMMARY. the Child Neurology Society. Epilepsia Open, 3(2): , 2018 doi: /epi

SPECIAL REPORT SUMMARY. the Child Neurology Society. Epilepsia Open, 3(2): , 2018 doi: /epi SPECIAL REPORT Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group 1 Eric H. Kossoff, 2 Beth A. Zupec-Kania,

More information

By Silas Aho. also used for treatment of epilepsy, a debilitating neurological disease. The success of this diet as an

By Silas Aho. also used for treatment of epilepsy, a debilitating neurological disease. The success of this diet as an 1 Ketosis on the Epileptic Brain By Silas Aho I m sure some of you reading this paper may remember a diet in the early 2000 s called the Atkins diet that was based on eating a diet high in fats/proteins

More information

THE KETOGENIC DIET IS A HIGHfat

THE KETOGENIC DIET IS A HIGHfat ORIGINAL CONTRIBUTION Effect of a High-Fat Ketogenic Diet on Plasma Levels of Lipids, Lipoproteins, and Apolipoproteins in Children Peter O. Kwiterovich, Jr, MD Eileen P. G. Vining, MD Paula Pyzik, BA

More information

Epilepsy. Seizures and Epilepsy. Buccal Midazolam vs. Rectal Diazepam for Serial Seizures. Epilepsy and Seizures 6/18/2008

Epilepsy. Seizures and Epilepsy. Buccal Midazolam vs. Rectal Diazepam for Serial Seizures. Epilepsy and Seizures 6/18/2008 Seizures and Epilepsy Paul Garcia, M.D. UCSF Epilepsy Epileptic seizure: the physical manifestation of aberrant firing of brain cells Epilepsy: the tendency to recurrent, unprovoked epileptic seizures

More information

FMZ-PET to assess the efficacy and the mechanism of ketogenic diet in patients with intractable epilepsy

FMZ-PET to assess the efficacy and the mechanism of ketogenic diet in patients with intractable epilepsy RESEARCH PAPER FMZ-PET to assess the efficacy and the mechanism of ketogenic diet in patients with intractable epilepsy Objective: A ketogenic diet (KD) is a strict dietary protocol that incorporates high-fat,

More information

The changing face of dietary therapy for epilepsy

The changing face of dietary therapy for epilepsy Eur J Pediatr (2016) 175:1267 1276 DOI 10.1007/s00431-016-2765-z REVIEW The changing face of dietary therapy for epilepsy Ludovica Pasca 1 & Valentina De Giorgis 1,2 & Joyce Ann Macasaet 3 & Claudia Trentani

More information

Modified Atkins diet is an effective treatment for children with Doose syndrome

Modified Atkins diet is an effective treatment for children with Doose syndrome FULL-LENGTH ORIGINAL RESEARCH Modified Atkins diet is an effective treatment for children with Doose syndrome *Adelheid Wiemer-Kruel, Edda Haberlandt, Hans Hartmann, Gabriele Wohlrab, and *Thomas Bast

More information

Ketogenic diet in epilepsy: an updated review

Ketogenic diet in epilepsy: an updated review Journal of Epileptology 2018 26 10.21307/jepil-2018-004 25 Paediatric Neurology Department Chorzów General Hospital, Poland Received June 4, 2018 Accepted for publication on-line August 27, 2018 Published

More information

Paediatric Epilepsy Update N o r e e n Te a h a n canp C o l e t t e H u r l e y C N S E p i l e p s y

Paediatric Epilepsy Update N o r e e n Te a h a n canp C o l e t t e H u r l e y C N S E p i l e p s y Paediatric Epilepsy Update 2018 N o r e e n Te a h a n canp C o l e t t e H u r l e y C N S E p i l e p s y Epilepsy Service CUH ~550 children New diagnosis-education, support, clinic follow up Epilepsy

More information

EPILEPSY. Elaine Wirrell

EPILEPSY. Elaine Wirrell EPILEPSY Elaine Wirrell Seizures are amongst the most common of neurological disorders in the pediatric age range. The incidence of new-onset epilepsy in children is approximately 40 per 100,000 per year

More information

- biochemical principles - practical applications

- biochemical principles - practical applications The ketogenic diet in pediatric neurology practice - biochemical principles - practical applications Some points from history 1921-1928: «The efficiency of fasting» and being free of seizures 1921-1970:

More information

The Ketogenic Diet: One Decade Later

The Ketogenic Diet: One Decade Later STATE-OF-THE-ART REVIEW ARTICLE The Ketogenic Diet: One Decade Later John M. Freeman, MD, Eric H. Kossoff, MD, Adam L. Hartman, MD John M. Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions,

More information

RESEARCH ARTICLE EPILEPSY IN CHILDREN WITH CEREBRAL PALSY

RESEARCH ARTICLE EPILEPSY IN CHILDREN WITH CEREBRAL PALSY RESEARCH ARTICLE EPILEPSY IN CHILDREN WITH CEREBRAL PALSY S.Pour Ahmadi MD, M.Jafarzadeh MD, M. Abbas MD, J.Akhondian MD. Assistant Professor of Pediatrics, Mashad University of Medical Sciences. Associate

More information

Disclosure. Learning Objectives

Disclosure. Learning Objectives Linda D. Leary, M.D. Associate Clinical Professor of Pediatrics & Neurology South Texas Comprehensive Epilepsy Center UT Health Science Center San Antonio Disclosure Linda D. Leary, M.D. discloses the

More information

Refractory Status Epilepticus in Children: What are the Options?

Refractory Status Epilepticus in Children: What are the Options? Refractory Status Epilepticus in Children: What are the Options? Weng Man Lam, PharmD, BCPS, BCPPS PICU Clinical Pharmacy Specialist Memorial Hermann Texas Medical Center November 11, 2017 Objectives 1.

More information

Pediatric Epilepsy Care in Milwaukee

Pediatric Epilepsy Care in Milwaukee Pediatric Epilepsy Care in Milwaukee Priya Monrad, MD Assistant Professor, Pediatric Neurology and Epilepsy Children s Hospital of Wisconsin Disclosures I have no relevant financial relationships to disclose.

More information

ORIGINAL ARTICLE. Prediction of Response to Treatment in Children with Epilepsy

ORIGINAL ARTICLE. Prediction of Response to Treatment in Children with Epilepsy ORIGINAL ARTICLE How to Cite This Article: Ghofrani M, Nasehi MM, Saket S, Mollamohammadi M, Taghdiri MM, Karimzadeh P, Tonekaboni SH, Javadzadeh M, Jafari N, Zavehzad A, Hasanvand Amouzadeh M, Beshrat

More information

Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study

Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study Neurology Asia 2006; 11 : 19 23 Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study Archana VERMA DM (Neurology) MD, Surendra MISRA DM (Neurology) FRCP (Edin) Department of

More information

Long-Term Efficacy and Safety of Zonisamide Monotherapy in Epilepsy Patients

Long-Term Efficacy and Safety of Zonisamide Monotherapy in Epilepsy Patients Journal of Clinical Neurology / Volume 3 / December, 2007 Original Articles Long-Term Efficacy and Safety of Zonisamide Monotherapy in Epilepsy Patients Sung-Pa Park, M.D., Sun-Young Kim, M.D., Yang-Ha

More information

A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome

A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome DEVELOPMENTAL MEDICINE & CHILD NEUROLOGY ORIGINAL ARTICLE A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome YASUSHI ITO HIROKAZU OGUNI SUSUMU ITO MIYAKO

More information

Approaches to Treatment of Epilepsy Syndromes Elizabeth A. Thiele, MD, PhD

Approaches to Treatment of Epilepsy Syndromes Elizabeth A. Thiele, MD, PhD Approaches to Treatment of Epilepsy Syndromes Elizabeth A. Thiele, MD, PhD Director, Pediatric Epilepsy Program Massachusetts General Hospital Professor of Neurology Harvard Medical School Approaches to

More information

The ketogenic diet for children with epilepsy

The ketogenic diet for children with epilepsy The ketogenic diet for children with epilepsy This leaflet has been given to you to help answer some of the questions you may have about the ketogenic diet as a treatment for epilepsy in children. If you

More information

Marleen Van Driessche Dietitian University Hospital Ghent, Belgium. The Ketogenic Diet

Marleen Van Driessche Dietitian University Hospital Ghent, Belgium. The Ketogenic Diet Marleen Van Driessche Dietitian University Hospital Ghent, Belgium The Ketogenic Diet The Ketogenic Diet, what is it? What is it? High En% of fat 70 90 En% Adequate protein intake 6 7 En% Low En% of carbohydrates

More information

Eastern Paediatric Epilepsy Network

Eastern Paediatric Epilepsy Network 1. Objective 2. Background 3. Vitamin D and epilepsy 4. Monitoring and optimizing bone health in healthy children 5. 6. Recommendations 1.) Objective: 1.1) To provide a rational basis for monitoring bone

More information

CONVULSIONS - AFEBRILE

CONVULSIONS - AFEBRILE Incidence All Children require Management Recurrence Risk Indications for starting therapy Starting Anticonvulsant medication Criteria for Referral to Paediatric Neurology Useful links References Appendix

More information

Downloaded from jssu.ssu.ac.ir at 0:37 IRST on Sunday February 17th 2019

Downloaded from jssu.ssu.ac.ir at 0:37 IRST on Sunday February 17th 2019 -2384 2 *. : 4 :. 2 / 4 3 6/. ( /) : 6 /4. 6. 00 92 6. 0 :. :. 0 :. International league Against Epilepsy (ILAE) First Unprovoked Seizure (FUS) 24 () (2) 20.. 2 3-4. (). : -* - 0 626024: 0 626024 : E-mial:

More information

KETOGENIC DIET FROM THE IMPLEMENTA- TION IN CLINICAL PRACTICE TO NOWADAYS

KETOGENIC DIET FROM THE IMPLEMENTA- TION IN CLINICAL PRACTICE TO NOWADAYS Journal of IMAB ISSN: 1312-773X https://www.journal-imab-bg.org https://doi.org/10.5272/jimab.2018241.1904 Journal of IMAB - Annual Proceeding (Scientific Papers). 2018 Jan-Mar;24(1) Review article KETOGENIC

More information

nothing is perfect Problems with triheptanoin and clinical trials

nothing is perfect Problems with triheptanoin and clinical trials nothing is perfect Problems with triheptanoin and clinical trials MILAN, Italy, 7th 8th ctober 2016 Joerg Klepper The State-and-Region Agreement asks for a declaration by Moderators, Speakers, Teachers

More information

The natural history of epilepsy in tuberous sclerosis complex

The natural history of epilepsy in tuberous sclerosis complex The natural history of epilepsy in tuberous sclerosis complex The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation Published

More information

Diverse Ketogenic Therapies; Classic, Modified Atkins, and Low Glycemic Index Diet Treatment

Diverse Ketogenic Therapies; Classic, Modified Atkins, and Low Glycemic Index Diet Treatment Diverse Ketogenic Therapies; Classic, Modified Atkins, and Low Glycemic Index Diet Treatment Kang, Hoon-Chul Pediatric Neurology, Severance Children s Hospital Pediatrics, Yonsei University College of

More information

Milk and Dairy for Cardiometabolic Health

Milk and Dairy for Cardiometabolic Health Milk and Dairy for Cardiometabolic Health Anne Mullen, BSc, PhD, FHEA, RD Director of Nutrition at The Dairy Council November 2016 Email: a.mullen@dairycouncil.org.uk Tel: 020 7025 0560 Web: www.milk.co.uk

More information

What do we know about prognosis and natural course of epilepsies?

What do we know about prognosis and natural course of epilepsies? What do we know about prognosis and natural course of epilepsies? Dr. Chusak Limotai, MD., M.Sc., CSCN (C) Chulalongkorn Comprehensive Epilepsy Center of Excellence (CCEC) The Thai Red Cross Society First

More information

Stop the Status: Improving Outcomes in Pediatric Epilepsy Syndromes. Michelle Welborn, PharmD ICE Alliance

Stop the Status: Improving Outcomes in Pediatric Epilepsy Syndromes. Michelle Welborn, PharmD ICE Alliance Stop the Status: Improving Outcomes in Pediatric Epilepsy Syndromes Michelle Welborn, PharmD ICE Alliance Overview Seizures and Epilepsy Syndromes Seizure Emergencies Febrile Seizures Critical Population

More information

Understanding Ketogenic Diet with Rodent Epilepsy Models. Do-Young Kim Barrow Neurological Institute Phoenix, Arizona, USA

Understanding Ketogenic Diet with Rodent Epilepsy Models. Do-Young Kim Barrow Neurological Institute Phoenix, Arizona, USA Understanding Ketogenic Diet with Rodent Epilepsy Models Do-Young Kim Barrow Neurological Institute Phoenix, Arizona, USA Causes of Epilepsy The most common causes of epilepsy include: Brain infection,

More information

Supporting your child s success on the ketogenic diet

Supporting your child s success on the ketogenic diet Eva, KetoCal user Supporting your child s success on the ketogenic diet KetoCal is a medical food for use under supervision A caregiver s guide to the ketogenic diet and the support & resources available

More information

Starving Away Stubborn Seizures: Food for Thought on the Ketogenic Diet for Refractory Epilepsy in Children

Starving Away Stubborn Seizures: Food for Thought on the Ketogenic Diet for Refractory Epilepsy in Children Starving Away Stubborn Seizures: Food for Thought on the Ketogenic Diet for Refractory Epilepsy in Children Learning Objectives Bernadette Espiritu, Pharm.D. PGY1 Pharmacy Resident Children s Hospital

More information

SETPEG GENETIC TESTING GUIDELINES Version 1.0, 5 th October 2017

SETPEG GENETIC TESTING GUIDELINES Version 1.0, 5 th October 2017 SETPEG GENETIC TESTING GUIDELINES Version 1.0, 5 th October 2017 1. The Epilepsy Genetic Diagnostic & Counselling Service at King s Health Partners Professor Deb Pal PhD MRCP (Consultant) deb.pal@nhs.net

More information

ACTH therapy for generalized seizures other than spasms

ACTH therapy for generalized seizures other than spasms Seizure (2006) 15, 469 475 www.elsevier.com/locate/yseiz ACTH therapy for generalized seizures other than spasms Akihisa Okumura a,b, *, Takeshi Tsuji b, Toru Kato b, Jun Natsume b, Tamiko Negoro b, Kazuyoshi

More information

2 nd Line Treatments for Dravet. Eric BJ Ségal, MD Northeast Regional Epilepsy Group

2 nd Line Treatments for Dravet. Eric BJ Ségal, MD Northeast Regional Epilepsy Group 2 nd Line Treatments for Dravet Eric BJ Ségal, MD Northeast Regional Epilepsy Group Disclosures Accepted honoraria from Greenwich Pharmaceuticals, Zogenix, Eisai, Lundbeck, Lineagen. Overview Evidence

More information

Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy

Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy REVIEW Neurobiochemical mechanisms of a ketogenic diet in refractory epilepsy Patricia Azevedo de Lima, I Leticia Pereira de Brito Sampaio, II Nágila Raquel Teixeira Damasceno III* I Universidade de São

More information

Factors associated with clinical remission in cats with diabetes mellitus Yu-Hsin Lien 1, Hui-Pi Huang 2

Factors associated with clinical remission in cats with diabetes mellitus Yu-Hsin Lien 1, Hui-Pi Huang 2 ACTA VET. BRNO 2012, 81: 421 425; doi:10.2754/avb201281040419 Factors associated with clinical remission in cats with diabetes mellitus Yu-Hsin Lien 1, Hui-Pi Huang 2 1 Azu Clinic for Animals, Taipei,

More information