CELLULAR NEUROPHYSIOLOGY
|
|
- Virgil Alexander
- 5 years ago
- Views:
Transcription
1 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 5. SYNAPTIC TRANSMISSION II: GABAERGIC TRANSMISSION Video 5-1: GABA A receptor-mediated current and potential changes
2 GABAergic synaptic transmission 1 Constance Hammond
3 The inhibitory postsynaptic potential (IPSP) 2 whole-cell configuration current-clamp mode [Cl - ] i = 14 mm; [Cl - ] o = 146 mm E Cl = -59 mv V m (mv) In these experimental conditions, stimulation of the GABAergic presynaptic neuron causes a transient hyperpolarization of the postsynaptic membrane I (pa)
4 The inhibitory postsynaptic potential (IPSP) 3 whole-cell configuration current-clamp mode [Cl - ] i = 14 mm; [Cl - ] o = 146 mm E Cl = -59 mv Definition Benzodiazepines are psychoactive drugs used for instance in the treatment of anxiety (anxiolytic). V m (mv) I (pa)
5 The inhibitory postsynaptic potential (IPSP) 4 whole-cell configuration current-clamp mode [Cl - ] i = 14 mm; [Cl - ] o = 146 mm E Cl = -59 mv V m (mv) I (pa)
6 The inhibitory postsynaptic potential (IPSP) 5 What ion channel is involved? To which ion(s) is it permeable? How do benzodiazepines work?
7 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 5. SYNAPTIC TRANSMISSION II: GABAERGIC TRANSMISSION Video 5-2: GABA A receptors and unitary GABA A receptor-mediated current
8 GABA receptors 6 type A (GABA A ) - ionotropic type B (GABA B ) - metabotropic
9 GABA A receptor-channel 7 α, β or subunit 5 subunits
10 GABA A receptor-channel 8 α, β or subunit 2 GABA + R GABA 2 -R GABA 2 R*
11 Unitary GABA A receptor-mediated current 9 cell-attached configuration voltage-clamp mode [Cl - ] intrapipette = 146 mm V H outward current = positive charges flow outside the cell OR negative charges flow inside
12 Unitary GABA A current 10 cell-attached configuration voltage-clamp mode V H
13 Unitary GABA A current 11 cell-attached configuration voltage-clamp mode [Cl - ] i 14 mm [Cl - ] o = 146 mm
14 Unitary GABA A current 12 cell-attached configuration outside-out configuration [Cl - ] i 14 mm [Cl - ] o = 146 mm [Cl - ] i = 146 mm [Cl - ] o = 146 mm E Cl = 0 mv
15 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 5. SYNAPTIC TRANSMISSION II: GABAERGIC TRANSMISSION Video 5-3: The total GABA A receptor-mediated current
16 Total GABA A receptor-mediated current 13 whole-cell configuration voltage-clamp mode E Cl = 0 mv spontaneous currents glutamate channel blockers (10 µm CNQX + 40 µm APV) V rest = -70 mv Variable amplitude (1-30 pa), depending on the number of activated GABA A receptors
17 Total GABA A receptor-mediated current 14 Rising phase: rise time = ms summation of the unitary GABA A currents GABA release and binding receptorchannels open Decay phase: duration = hundreds of milliseconds GABA A receptor-channels close (GABA unbinding and re-uptake)
18 Take home message 15 GABA A receptor channels are made up of five subunits (a, b, ) Both a & b subunits delimit the receptor sites for GABA GABA A receptor channels are permeable to chloride ions (anions) The amplitude of the GABA A current is close to zero at resting membrane potential
19 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 5. SYNAPTIC TRANSMISSION II: GABAERGIC TRANSMISSION Video 5-4: GABA A receptor-channel and benzodiazepines
20 Unitary GABA A current and benzodiazepines 16 How do benzodiazepines work? Benzodiazepines are psychoactive drugs (anxiolytic and muscle relaxant). E.g.: diazepam
21 Unitary GABA A current and benzodiazepines 17 outside-out configuration voltage-clamp mode (V H = -75 mv) [Cl - ] i = [Cl - ] e ; E Cl = 0 mv I = Np o i GABA A channel opening frequency increases intensity of the total GABA A current increases
22 Benzodiazepine action on the GABA A channel 18
23 Take home message 19 Both a & subunits delimit the receptor site for benzodiazepines Benzodiazepines increase the total GABA A (chloride) current by increasing the probability of opening of the GABA A channel
24 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 5. SYNAPTIC TRANSMISSION II: GABAERGIC TRANSMISSION Video 5-5: GABA A receptor-mediated postsynaptic potential
25 GABA A postsynaptic potential 20 whole-cell configuration current-clamp mode spontaneous postsynaptic potentials 146 mm 14 mm V rest = -50 mv E Cl = -59 mv inibitory postsynaptic potential (IPSP)
26 GABA A postsynaptic potential 21 whole-cell configuration current-clamp mode spontaneous postsynaptic potentials truncated action potentials
27 Take home message 22 The GABA A current reverses at E Cl E Cl varies from neurons to neurons: therefore GABA sometimes hyperpolarizes sometimes depolarizes the postsynaptic membrane
28 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 5. SYNAPTIC TRANSMISSION II: GABAERGIC TRANSMISSION Video 5-6: Conclusion
29 Overview of GABAergic transmission 23 Type A receptor-channels (GABA A ): 5 subunits In general: 2 α subunits 2 β subunits 1 subunits 2 GABA receptor sites at the interface between α and β subunits 1 receptor site for benzodiazepines, allosteric agonists of the GABA A receptor Essentially permeable to chloride ions (Cl - ) Adult neurons: no or slightly hyperpolarizing current Immature neurons: high [Cl - ] i depolarizing current
30 Overview of GABAergic transmission 24 Presynaptic membrane: - Ca 2+ channel - anchoring proteins - synaptic vesicle fusion sites (GABA release) - GABA transporters (re-uptake) Postsynaptic membrane: - GABA A receptor-channels - GABA B receptors (not shown) Glial cell - GABA transporters (re-uptake) presynaptic element postsynaptic element
31 Overview of GABAergic transmission 25 (1) GABA binds to the GABA A receptor the channels open (2) GABA binds to transporters recapture in presynaptic terminals and glial cells (3) GABA spontaneously unbinds the channels close presynaptic element postsynaptic element
32 CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND Professor Constance Hammond Project manager Isabelle Virard Graphic designer Géraldine Fohr Movie director Marine Chabrolin Music Tetoma - Hicham Chahidi Translation Isabelle Virard et Atenao 2016
CELLULAR NEUROPHYSIOLOGY
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 4. SYNAPTIC TRANSMISSION II: GLUTAMATERGIC TRANSMISSION Video 4-1: Observations and glutamate receptor channels Synaptic transmission II 1 Constance Hammond Observation
More informationCELLULAR NEUROPHYSIOLOGY
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 6. SYNAPTIC INTEGRATION Video 6-1: Compound PSP, PSP propagation and summation Compound postsynaptic potential 2 whole-cell configuration current-clamp mode somatic
More informationCELLULAR NEUROPHYSIOLOGY
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND 2. THE SODIUM ACTION POTENTIAL Video 2-1: Observations and hypotheses Sodium action potential 1 Observations 2 Patch clamp recording whole-cell configuration
More informationChapter 5 subtitles GABAergic synaptic transmission
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND Chapter 5 subtitles GABAergic synaptic transmission INTRODUCTION (2:57) In this fifth chapter, you will learn how the binding of the GABA neurotransmitter to
More informationChapter 6 subtitles postsynaptic integration
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND Chapter 6 subtitles postsynaptic integration INTRODUCTION (1:56) This sixth and final chapter deals with the summation of presynaptic currents. Glutamate and
More informationChapter 3 subtitles Action potentials
CELLULAR NEUROPHYSIOLOGY CONSTANCE HAMMOND Chapter 3 subtitles Action potentials Introduction (3:15) This third chapter explains the calcium current triggered by the arrival of the action potential in
More informationNEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3 NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES Neurons communicate with other neurons or target cells at synapses. Chemical synapse: a very narrow
More informationQUIZ YOURSELF COLOSSAL NEURON ACTIVITY
QUIZ YOURSELF What are the factors that produce the resting potential? How is an action potential initiated and what is the subsequent flow of ions during the action potential? 1 COLOSSAL NEURON ACTIVITY
More informationCHAPTER 44: Neurons and Nervous Systems
CHAPTER 44: Neurons and Nervous Systems 1. What are the three different types of neurons and what are their functions? a. b. c. 2. Label and list the function of each part of the neuron. 3. How does the
More informationSynaptic Integration
Synaptic Integration 3 rd January, 2017 Touqeer Ahmed PhD Atta-ur-Rahman School of Applied Biosciences National University of Sciences and Technology Excitatory Synaptic Actions Excitatory Synaptic Action
More informationAction potential. Definition: an all-or-none change in voltage that propagates itself down the axon
Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Naturally
More informationProblem Set 3 - Answers. -70mV TBOA
Harvard-MIT Division of Health Sciences and Technology HST.131: Introduction to Neuroscience Course Director: Dr. David Corey HST 131/ Neuro 200 18 September 05 Explanation in text below graphs. Problem
More informationBIPN100 F15 Human Physiology 1 Lecture 3. Synaptic Transmission p. 1
BIPN100 F15 Human Physiology 1 Lecture 3. Synaptic Transmission p. 1 Terms you should know: synapse, neuromuscular junction (NMJ), pre-synaptic, post-synaptic, synaptic cleft, acetylcholine (ACh), acetylcholine
More informationLigand-Gated Ion Channels
Ligand-Gated Ion Channels The Other Machines That Make It Possible... Topics I Introduction & Electrochemical Gradients Passive Membrane Properties Action Potentials Voltage-Gated Ion Channels Topics II
More informationThe action potential travels down both branches because each branch is a typical axon with voltage dependent Na + and K+ channels.
BIO 360 - MIDTERM FALL 2018 This is an open book, open notes exam. PLEASE WRITE YOUR NAME ON EACH SHEET. Read each question carefully and answer as well as you can. Point values are shown at the beginning
More informationChapter 3 Neurotransmitter release
NEUROPHYSIOLOGIE CELLULAIRE CONSTANCE HAMMOND Chapter 3 Neurotransmitter release In chapter 3, we proose 3 videos: Observation Calcium Channel, Ca 2+ Unitary and Total Currents Ca 2+ and Neurotransmitter
More informationSynaptic Transmission
Synaptic Transmission Postsynaptic Mechanisms Synapses electrical and chemical Part I Neurotransmitters categories and life cycle Neurotransmitters examples and postsynaptic effects Pathology Part II Neurotransmitter
More informationWhat effect would an AChE inhibitor have at the neuromuscular junction?
CASE 4 A 32-year-old woman presents to her primary care physician s office with difficulty chewing food. She states that when she eats certain foods that require a significant amount of chewing (meat),
More informationBIPN140 Lecture 8: Synaptic Transmission II
BIPN140 Lecture 8: Synaptic Transmission II 1. Postsynaptic Receptors: Metabotropic & Ionotropic 2. Postsynaptic Responses (Postsynaptic Potentials, PSPs) 3. Neurotransmitters Su (FA16) Chemical Synapse:
More informationAction Potentials and Synaptic Transmission. BIO 219 Napa Valley College Dr. Adam Ross
Action Potentials and Synaptic Transmission BIO 219 Napa Valley College Dr. Adam Ross Review of action potentials Nodes of Ranvier Nucleus Dendrites Cell body In saltatory conduction, the nerve impulses
More informationPortions from Chapter 6 CHAPTER 7. The Nervous System: Neurons and Synapses. Chapter 7 Outline. and Supporting Cells
CHAPTER 7 The Nervous System: Neurons and Synapses Chapter 7 Outline Neurons and Supporting Cells Activity in Axons The Synapse Acetylcholine as a Neurotransmitter Monoamines as Neurotransmitters Other
More informationBIOLOGICAL PROCESSES
BIOLOGICAL PROCESSES CHAPTER 3 1 LEARNING GOALS Discuss how the nervous system communicates internally. Describe the structure and function of neurons Describe how the neuron transmits information Describe
More information5-Nervous system II: Physiology of Neurons
5-Nervous system II: Physiology of Neurons AXON ION GRADIENTS ACTION POTENTIAL (axon conduction) GRADED POTENTIAL (cell-cell communication at synapse) SYNAPSE STRUCTURE & FUNCTION NEURAL INTEGRATION CNS
More information9/28/2016. Neuron. Multipolar Neuron. Astrocytes Exchange Materials With Neurons. Glia or Glial Cells ( supporting cells of the nervous system)
Neuron Multipolar Neuron https://www.youtube.com/watch?v=lw-psbnu5xago to :38 Glia or Glial Cells ( supporting cells of the nervous system) 10X more numerous than neurons but one-tenth the size make up
More informationNotes are online at The Neuron
Notes are online at http://cogsci.ucsd.edu/~clovett/neuronotescogs17.pdf A. What is a neuron? The Neuron 1. A neuron is a type of cell that receives and transmits information in the Central Nervous System
More informationSession ID: 1001 June 14, 2012
It s Not Just Serotonin: Neurosignaling in Mental Illness Barbara J. Limandri, DNSc, APRN, BC Professor of Nursing Linfield College Learning Outcomes Distinguish between metabotropic and ionotropic neuroreceptors
More informationIt s Not Just Serotonin: Neurosignaling in Mental Illness
It s Not Just Serotonin: Neurosignaling in Mental Illness Barbara J. Limandri, DNSc, APRN, BC Professor of Nursing Linfield College Learning Outcomes Distinguish between metabotropic and ionotropic neuroreceptors
More informationCommunication within a Neuron
Neuronal Communication, Ph.D. Communication within a Neuron Measuring Electrical Potentials of Axons The Membrane Potential The Action Potential Conduction of the Action Potential 1 The withdrawal reflex
More informationCh. 45 Continues (Have You Read Ch. 45 yet?) u Central Nervous System Synapses - Synaptic functions of neurons - Information transmission via nerve
Ch. 45 Continues (Have You Read Ch. 45 yet?) u Central Nervous System Synapses - Synaptic functions of neurons - Information transmission via nerve impulses - Impulse may be blocked in its transmission
More informationNeurophysiology and Synaptic Transmission Modules
Neurophysiology and Synaptic Transmission Neurophysiology and Synaptic Transmission Modules Module Listing Please complete the following online neurophysiology modules during the first week of class: Module
More informationOverview of Neurons. Psychology 470. Introduction to Chemical Additions. Neurons2. Axons and Related Structures. Structures
Soma Collateral Overview of Neurons Psychology 470 Axon Hillock Teleodendria Introduction to Chemical Additions Steven E. Meier, Ph.D. Node of Ranvier Listen to the audio lecture while viewing these slides
More informationSynaptic Transmission: Ionic and Metabotropic
Synaptic Transmission: Ionic and Metabotropic D. Purves et al. Neuroscience (Sinauer Assoc.) Chapters 5, 6, 7. C. Koch. Biophysics of Computation (Oxford) Chapter 4. J.G. Nicholls et al. From Neuron to
More informationOutline. Neuron Structure. Week 4 - Nervous System. The Nervous System: Neurons and Synapses
Outline Week 4 - The Nervous System: Neurons and Synapses Neurons Neuron structures Types of neurons Electrical activity of neurons Depolarization, repolarization, hyperpolarization Synapses Release of
More informationPSY 215 Lecture 3 (1/19/2011) (Synapses & Neurotransmitters) Dr. Achtman PSY 215
Corrections: None needed. PSY 215 Lecture 3 Topic: Synapses & Neurotransmitters Chapters 2 & 3, pages 40-57 Lecture Notes: SYNAPSES & NEUROTRANSMITTERS, CHAPTER 3 Action Potential (above diagram found
More informationStructure of a Neuron:
Structure of a Neuron: At the dendrite the incoming signals arrive (incoming currents) At the soma current are finally integrated. At the axon hillock action potential are generated if the potential crosses
More informationCommunication Between
Communication Between Neurons Bởi: OpenStaxCollege The electrical changes taking place within a neuron, as described in the previous section, are similar to a light switch being turned on. A stimulus starts
More informationLESSON 3.3 WORKBOOK. Why does applying pressure relieve pain? Workbook. Postsynaptic potentials
Depolarize to decrease the resting membrane potential. Decreasing membrane potential means that the membrane potential is becoming more positive. Excitatory postsynaptic potentials (EPSP) graded postsynaptic
More informationSynapses and Neurotransmitters
Synapses and Neurotransmitters Action Potentials We have been talking about action potentials and how they allow an electrical impulse to travel from the dendrites to the end plates of a neuron. These
More informationSynaptic transmission
Outline Synaptic transmission Sompol Tapechum M.D., Ph.D. Department of Physiology Faculty of Medicine Siriraj Hospital, Bangkok, Thailand. sisth@mahidol.ac.th 2 Structure of synapse Modes of synaptic
More informationNeurons. Pyramidal neurons in mouse cerebral cortex expressing green fluorescent protein. The red staining indicates GABAergic interneurons.
Neurons Pyramidal neurons in mouse cerebral cortex expressing green fluorescent protein. The red staining indicates GABAergic interneurons. MBL, Woods Hole R Cheung MSc Bioelectronics: PGEE11106 1 Neuron
More informationNa + K + pump. The beauty of the Na + K + pump. Cotransport. The setup Cotransport the result. Found along the plasma membrane of all cells.
The beauty of the Na + K + pump Na + K + pump Found along the plasma membrane of all cells. Establishes gradients, controls osmotic effects, allows for cotransport Nerve cells have a Na + K + pump and
More informationSample Lab Report 1 from 1. Measuring and Manipulating Passive Membrane Properties
Sample Lab Report 1 from http://www.bio365l.net 1 Abstract Measuring and Manipulating Passive Membrane Properties Biological membranes exhibit the properties of capacitance and resistance, which allow
More informationQUIZ/TEST REVIEW NOTES SECTION 7 NEUROPHYSIOLOGY [THE SYNAPSE AND PHARMACOLOGY]
QUIZ/TEST REVIEW NOTES SECTION 7 NEUROPHYSIOLOGY [THE SYNAPSE AND PHARMACOLOGY] Learning Objectives: Explain how neurons communicate stimulus intensity Explain how action potentials are conducted along
More informationLESSON 3.3 WORKBOOK. Why does applying pressure relieve pain?
Postsynaptic potentials small changes in voltage (membrane potential) due to the binding of neurotransmitter. Receptor-gated ion channels ion channels that open or close in response to the binding of a
More informationElectrophysiology. General Neurophysiology. Action Potentials
5 Electrophysiology Cochlear implants should aim to reproduce the coding of sound in the auditory system as closely as possible, for best sound perception. The cochlear implant is in part the result of
More information1) Drop off in the Bi 150 box outside Baxter 331 or to the head TA (jcolas).
Bi/CNS/NB 150 Problem Set 3 Due: Tuesday, Oct. 27, at 4:30 pm Instructions: 1) Drop off in the Bi 150 box outside Baxter 331 or e-mail to the head TA (jcolas). 2) Submit with this cover page. 3) Use a
More informationMOLECULAR AND CELLULAR NEUROSCIENCE
MOLECULAR AND CELLULAR NEUROSCIENCE BMP-218 November 4, 2014 DIVISIONS OF THE NERVOUS SYSTEM The nervous system is composed of two primary divisions: 1. CNS - Central Nervous System (Brain + Spinal Cord)
More informationTA Review. Neuronal Synapses. Steve-Felix Belinga Neuronal synapse & Muscle
TA Review Steve-Felix Belinga sbelinga@wustl.edu Neuronal synapse & Muscle Neuronal Synapses 1 Things you should know beyond the obvious stuff 1. Differences between ionotropic and metabotropic receptors.
More informationElizabeth Biopsychology (PSY 302) The Synapses 08/29/2017. The Synapses
Elizabeth Biopsychology (PSY 302) The Synapses 08/29/2017 The Synapses Conduction of a Depolarization o In dendrites: passive propagation : There is attenuation of signal transmission -Further away they
More informationHuman Brain and Senses
Human Brain and Senses Outline for today Levels of analysis Basic structure of neurons How neurons communicate Basic structure of the nervous system Levels of analysis Organism Brain Cell Synapses Membrane
More informationSynapses and Neurotransmitters
Synapses and Neurotransmitters Communication Between Neurons Synapse: A specialized site of contact, and transmission of information between a neuron and an effector cell Anterior Motor Neuron Figure 45-5
More informationThe Nervous System. Nervous System Functions 1. gather sensory input 2. integration- process and interpret sensory input 3. cause motor output
The Nervous System Nervous System Functions 1. gather sensory input 2. integration- process and interpret sensory input 3. cause motor output The Nervous System 2 Parts of the Nervous System 1. central
More informationNEUROCHEMISTRY Brief Review
NEUROCHEMISTRY Brief Review UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY PBL MBBS YEAR V SEMINAR VJ Temple 1 Membrane potential Membrane potential:
More informationPrinciples of Anatomy and Physiology
Principles of Anatomy and Physiology 14 th Edition CHAPTER 12 Nervous Tissue Introduction The purpose of the chapter is to: 1. Understand how the nervous system helps to keep controlled conditions within
More information1) Drop off in the Bi 150 box outside Baxter 331 or to the head TA (jcolas).
Bi/CNS/NB 150 Problem Set 3 Due: Tuesday, Oct. 27, at 4:30 pm Instructions: 1) Drop off in the Bi 150 box outside Baxter 331 or e-mail to the head TA (jcolas). 2) Submit with this cover page. 3) Use a
More informationOutline. Animals: Nervous system. Neuron and connection of neurons. Key Concepts:
Animals: Nervous system Neuron and connection of neurons Outline 1. Key concepts 2. An Overview and Evolution 3. Human Nervous System 4. The Neurons 5. The Electrical Signals 6. Communication between Neurons
More informationIONOTROPIC RECEPTORS
BASICS OF NEUROBIOLOGY IONOTROPIC RECEPTORS ZSOLT LIPOSITS 1 NEURAL COMMUNICATION http://sciencecore.columbia.edu/s4.html 2 Post-synaptic mechanisms Receptors-signal transduction-messengers 3 TRANSMITTER
More information1. (1 pt) At the equilibrium potential of an ion, what two things are equal? Electrical potential (voltage) and chemical potential (concentration)
MIDERM REVIEW QUESIONS: IO 3411 (hese are questions from 3 of the previous years midterms) 1. (1 pt) t the equilibrium potential of an ion, what two things are equal? Electrical potential (voltage) and
More informationIntroduction to Neurobiology
Biology 240 General Zoology Introduction to Neurobiology Nervous System functions: communication of information via nerve signals integration and processing of information control of physiological and
More informationNeurons, Synapses and Signaling. Chapter 48
Neurons, Synapses and Signaling Chapter 48 Warm Up Exercise What types of cells can receive a nerve signal? Nervous Organization Neurons- nerve cells. Brain- organized into clusters of neurons, called
More informationBioscience in the 21st century
Bioscience in the 21st century Neurons, Synapses, and Signaling Dr. Michael Burger Outline: 1. Why neuroscience? 2. The neuron 3. Action potentials 4. Synapses 5. Organization of the nervous system 6.
More information9.98 Neuropharmacology January (IAP) 2009
MIT OpenCourseWare http://ocw.mit.edu 9.98 Neuropharmacology January (IAP) 2009 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. Neuropharmacology: The
More information9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. 9.01 Recitation (R02)
More informationBIOL Week 6. Nervous System. Transmission at Synapses
Collin County Community College BIOL 2401 Week 6 Nervous System 1 Transmission at Synapses Synapses are the site of communication between 2 or more neurons. It mediates the transfer of information and
More informationSynaptic plasticity. Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses.
Synaptic plasticity Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses. Repair/changes in the nervous system after damage. MRC Centre
More informationSTRUCTURAL ELEMENTS OF THE NERVOUS SYSTEM
STRUCTURAL ELEMENTS OF THE NERVOUS SYSTEM STRUCTURE AND MAINTENANCE OF NEURONS (a) (b) Dendrites Cell body Initial segment collateral terminals (a) Diagrammatic representation of a neuron. The break in
More informationSynaptic Communication. Steven McLoon Department of Neuroscience University of Minnesota
Synaptic Communication Steven McLoon Department of Neuroscience University of Minnesota 1 Course News The first exam is next week on Friday! Be sure to checkout the sample exam on the course website. 2
More informationTHE HISTORY OF NEUROSCIENCE
THE HISTORY OF NEUROSCIENCE BIOLOGICAL ASPECTS OF BEHAVIOR: THE NEURON & NEURAL COMMUNICATION NERVOUS SYSTEM Combined activity of the brain, spinal cord & other nerve fibers Acts as an information processing
More informationIon Channels (Part 2)
Ion Channels (Part 2) Graphics are used with permission of : adam.com (http://www.adam.com/) Benjamin/Cummings Publishing Co (http://www.awl.com/bc) -57- Quiz Question #2: Ion Channels This question asks
More informationAction potentials propagate down their axon
Action potentials propagate down their axon Larger diameter axons have less resistance to ion flow Speed of conduction is faster in large diameter axons Saltatory conduction in myelinated axons Large myelinated
More information浙江大学医学院基础医学整合课程 各论 III. The Nervous System. Dr. ZHANG Xiong Dept. of Physiology ZJU School of Medicine
The Nervous System Dr. ZHANG Xiong Dept. of Physiology ZJU School of Medicine xiongzhang@zju.edu.cn http://10.202.77.12/ 1 Part 1. Summary of the nervous system 2 The Nervous System Central Nervous System
More informationTHE HISTORY OF NEUROSCIENCE
1. Historically, how have neuroscientists determined the function of various brain regions? 2. Describe the impact of the Phineas Gage case on the field of neuroscience. 3. Explain neuron theory. THE HISTORY
More informationChapter 11: Nervous System and Nervous Tissue
Chapter 11: Nervous System and Nervous Tissue I. Functions and divisions of the nervous system A. Sensory input: monitor changes in internal and external environment B. Integrations: make decisions about
More informationChapter 45: Synapses Transmission of Nerve Impulses Between Neurons. Chad Smurthwaite & Jordan Shellmire
Chapter 45: Synapses Transmission of Nerve Impulses Between Neurons Chad Smurthwaite & Jordan Shellmire The Chemical Synapse The most common type of synapse used for signal transmission in the central
More informationPart 11: Mechanisms of Learning
Neurophysiology and Information: Theory of Brain Function Christopher Fiorillo BiS 527, Spring 2012 042 350 4326, fiorillo@kaist.ac.kr Part 11: Mechanisms of Learning Reading: Bear, Connors, and Paradiso,
More informationConcept 48.1 Neuron organization and structure reflect function in information transfer
Name Chapter 48: Neurons, Synapses, and Signaling Period Chapter 48: Neurons, Synapses, and Signaling Concept 48.1 Neuron organization and structure reflect function in information transfer 1. What is
More informationHow Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 https://nba.uth.tmc.edu/neuroscience/s1/chapter06.html https://nba.uth.tmc.edu/neuroscience/s1/chapter07.html Chris Cohan, Ph.D.
More informationAPs & Synapses. Review & outline. Thought experiment. Inside. Outside
Review & outline APs & Synapses Chapters 2 & 3 Cells of the nervous system The blood brain barrier Membrane potential (at rest = -70mV) Sodium potassium pump Concentration Electrical Action potentials
More informationDania Ahmad. Tamer Barakat + Dania Ahmad. Faisal I. Mohammed
16 Dania Ahmad Tamer Barakat + Dania Ahmad Faisal I. Mohammed Revision: What are the basic types of neurons? sensory (afferent), motor (efferent) and interneuron (equaled association neurons). We classified
More information3.E.2 Continued. This is the essential knowledge statement from the curriculum framework. Detect---process--- response
Nervous System: Part III What Happens at a Synapse? 3.E. Continued Animals have nervous systems that detect external and internal signals, transmit and integrate information, and produce responses. This
More informationBiopsychology. Neurons
Biopsychology What is Biopsychology? The study of the physiological, evolutionary, and developmental mechanisms of behavior and experience (Kalat) Primarily focused on brain activity especially as it relates
More informationWhat is Anatomy and Physiology?
Introduction BI 212 BI 213 BI 211 Ecosystems Organs / organ systems Cells Organelles Communities Tissues Molecules Populations Organisms Campbell et al. Figure 1.4 Introduction What is Anatomy and Physiology?
More informationNeurobiology: The nerve cell. Principle and task To use a nerve function model to study the following aspects of a nerve cell:
Principle and task To use a nerve function model to study the following aspects of a nerve cell: INTRACELLULAR POTENTIAL AND ACTION POTENTIAL Comparison between low and high threshold levels Comparison
More informationNeurons: Structure and communication
Neurons: Structure and communication http://faculty.washington.edu/chudler/gall1.html Common Components of a Neuron Dendrites Input, receives neurotransmitters Soma Processing, decision Axon Transmits
More informationNeuroscience 201A Problem Set #1, 27 September 2016
Neuroscience 201A Problem Set #1, 27 September 2016 1. The figure above was obtained from a paper on calcium channels expressed by dentate granule cells. The whole-cell Ca 2+ currents in (A) were measured
More informationIon Channels Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com)
Ion Channels Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction At synapses, ions move across cell membranes through
More informationChapter 4 Neuronal Physiology
Chapter 4 Neuronal Physiology V edit. Pg. 99-131 VI edit. Pg. 85-113 VII edit. Pg. 87-113 Input Zone Dendrites and Cell body Nucleus Trigger Zone Axon hillock Conducting Zone Axon (may be from 1mm to more
More informationSynaptic Transmission
Synaptic Transmission Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction Synaptic transmission involves the release
More informationCellular Neurobiology / BIPN 140
SECOND MIDTERM EXAMINATION Fall, 2015 GENERAL INSTRUCTIONS 1. Please write your name on ALL 6 pages. 2. Please answer each question IN THE SPACE ALLOTTED. 1) /10 pts 2) /10 pts 3) /15 pts 4) /15 pts 5)
More informationThe Nervous System. Dr. ZHANG Xiong Dept. of Physiology ZJU School of Medicine.
The Nervous System Dr. ZHANG Xiong Dept. of Physiology ZJU School of Medicine Http://10.10.10.151 Part 1. Summary of the nervous system The Nervous System Central Nervous System Brain + Spinal Cord Peripheral
More informationNervous System. 2. Receives information from the environment from CNS to organs and glands. 1. Relays messages, processes info, analyzes data
Nervous System 1. Relays messages, processes info, analyzes data 2. Receives information from the environment from CNS to organs and glands 3. Transmits impulses from CNS to muscles and glands 4. Transmits
More informationNeurons, Synapses, and Signaling
Neurons, Synapses, and Signaling The Neuron is the functional unit of the nervous system. Neurons are composed of a cell body, which contains the nucleus and organelles; Dendrites which are extensions
More informationBranches of the Nervous System
The Nervous System Branches of the Nervous System There are 2 main branches of the nervous system Central Nervous System Brain Spinal Cord Peripheral Nervous System All nerves leading to rest of body Anatomy
More informationCommunication Between Neurons *
OpenStax-CNX module: m46503 1 Communication Between Neurons * OpenStax This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of this section,
More informationNeurons! John A. White Dept. of Bioengineering
Neurons! John A. White Dept. of Bioengineering john.white@utah.edu What makes neurons different from cardiomyocytes? Morphological polarity Transport systems Shape and function of action potentials Neuronal
More information3) Most of the organelles in a neuron are located in the A) dendritic region. B) axon hillock. C) axon. D) cell body. E) axon terminals.
Chapter 48 Neurons, Synapses, and Signaling Multiple-Choice Questions 1) A simple nervous system A) must include chemical senses, mechanoreception, and vision. B) includes a minimum of 12 ganglia. C) has
More informationDepartment of medical physiology 1 st week
Department of medical physiology 1 st week Semester: summer Study program: Dental medicine Lecture: RNDr. Soňa Grešová, PhD. Department of medical physiology 1 st week 1. General neurophysiology 2. Central
More informationFunction of the Nervous System
Nervous System Function of the Nervous System Receive sensory information, interpret it, and send out appropriate commands to form a response Composed of neurons (functional unit of the nervous system)
More informationChapter 2: Cellular Mechanisms and Cognition
Chapter 2: Cellular Mechanisms and Cognition MULTIPLE CHOICE 1. Two principles about neurons were defined by Ramón y Cajal. The principle of connectional specificity states that, whereas the principle
More informationAnatomy of a Neuron. Copyright 2000 by BSCS and Videodiscovery, Inc. Permission granted for classroom use. Master 2.1
Anatomy of a Neuron Master 2.1 Neurons Interact With Other Neurons Through Synapses Master 2.2 How Do Neurons Communicate? 1 2 3 4 5 6 Master 2.3 Neurons Communicate by Neurotransmission Neurons communicate
More information