Index. Note: Page numbers of article titles are in boldface type.

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1 Note: Page numbers of article titles are in boldface type. A Achalasia, barium esophagography for, Acid pocket, Acid-sensing ion, 20 Acupuncture, 128 Adiponectin, in obesity, 166 ADX10059 metabotropic glutamate receptor-5 antagonist, 126 ADZ2066 metabotropic glutamate receptor-5 antagonist, 126 Allison, Philip, as antireflux surgery pioneer, 135 Ambulatory reflux monitoring. See Reflux monitoring. American dilator, Antacids, 122 Antidepressants, 128 Antireflux barrier, augmentation of, Antireflux surgery, barium esophagography after, endoscopic, for elderly persons, future developments in, 143 historical review of, indications for, laparoscopic, manometry after, 80 manometry before, patient selection for, reflux monitoring after, 91 reflux monitoring before, 90 versus proton pump inhibitors, Antisecretory agents, Arbaclofen placarbil, 126 Asthma, in reflux asthma syndrome, 110, AZD1386 nociceptor blocker, 128 AZD8065 potassium-competitive acid blacker, 125 Azithromycin, B Baclofen, 126 for reflux cough syndrome, 112 Bariatric surgery, GERD and, Barium esophagography, after antireflux surgery, documentation of, 48 Gastroenterol Clin N Am 43 (2014) /14/$ see front matter ª 2014 Elsevier Inc. All rights reserved. gastro.theclinics.com

2 176 Barium (continued) examination elements of, feline esophagus finding in, 55 for Barrett esophagus, 59 for esophagitis, 59 outcome of, preoperative, reflux identification phase of, 54 right anterior oblique phase of, 51 54, 60 Schatzki ring in, 55 semiprone phase of, 51 54, 60 solid food ingestion phase of, 55 upright phase of, 49 51, 60 versus non-gerd conditions, Barrett esophagus, 154 barium esophagography for, 50, 59 endoscopy for, 43 44, gastric emptying in, 19 in hiatal hernia, 17 in obesity, incidence of, 3 4 Belsey fundoplication, 136 Bethanechol, for elderly persons, 156 Bicarbonate production, in elderly persons, 151 Bile acids, 21 22, Bilitec system, for reflux monitoring, Biopsy, endoscopic, 44 Bougie dilators, Bravo ph monitoring system, for reflux monitoring, C Capsule endoscopy, wireless, 41 Catheters, for reflux monitoring, Cellvizio device, 40 Central sensitization, Chest pain, noncardiac, reflux monitoring for, 91 Chicago classification, of motility, 81 Chromoendoscopy, 44 Cimetidine, , 156 Cisapride, 156 Citalopram, 128 Clopidogrel, 155 Clouse, Ray E., manometry advances by, 70 Collis gastroplasty, 62, 136 Confocal laser endomicroscopy, 40 41, 44 Cough, in reflux cough syndrome, D DeMeester fundoplication, 136, Dental erosion, in reflux dental erosion syndrome, 114

3 177 Deslansoprazole, 124, 155 Diet, 8 Dilation, esophageal, Distal contractile length, in manometry, Distal mucosal ring, 55 Domperidone, 127, 156 Donahue modification, of Nissen fundoplication, 136 Dor fundoplication, 136 Dronabinol, 126 Dx-pH Measurement System, 110 Dyspepsia, 33 Dysphagia barium esophagography for, in elderly persons, manometry for, E Economic impact, 4 8 Elderly persons, GERD in, aging changes and, clinical presentation of, complications of, 154 epidemiology of, , 152 treatment of, EndoCinch device, 141 Endoscopy, See also Esophagogastroduodenoscopy. advanced techniques for, 44 antireflux surgery with, for Barrett esophagus, for eosinophilic esophagitis, 44 for esophageal dilation, for GERD, indications for, types of, EndoStim LES Stimulation System, 143 Eosinophilic esophagitis, 44, 58 Esomeprazole, for reflux asthma syndrome, 113 for reflux cough syndrome, 111 for reflux dental erosion syndrome, 114 Esophagitis barium esophagography for, 50, 59 classification of, endoscopy for, eosinophilic, 44, 58 gastric emptying in, 19 in elderly persons, 154 in hiatal hernia, 17 in obesity, Esophagogastric junction abnormalities of, 16 19

4 178 Esophagogastric (continued ) function of, manometry of, Esophagogastric junction contractile integral, in manometry, 79 Esophagogastroduodenoscopy costs of, 5 6 description of, 40 for extraesophageal GERD, Esophagography, barium, Esophagus adenocarcinoma of, 154 incidence of, 3 obesity and, 166 aging changes in, clearance in, 19 dilation of, feline, 55 foreshortened, 57 hypomotility of, 81 length of, in manometry, 77 motility of. See Motility. nutcracker, 165 EsophyX device, Exercise, 9 Extraesophageal presentations, of GERD. See Gastroesophageal reflux disease (GERD), extraesophageal presentations of. F Famotidine, Feline esophagus, 55 *fgastroesophageal reflux disease (GERD), complications of, Fundoplication, See also specific techniques. barium esophagography after, manometry after, 80 reoperative, 136 transoral, 45 G Gabapentin, for reflux cough syndrome, 112 Gamma-aminobutyric acid agonists, 126 Gastric acid, neutralization of, Gastric acid pocket, Gastric emptying, delayed, 19 Gastroesophageal reflux disease (GERD) complications of, conditions associated with, 9 10 definition of, 41 diagnosis of, costs of, 5 6

5 179 economic impact of, 4 8 endoscopy for, epidemiology of, 1 14, , esophagography for, extraesophageal presentations of, diagnosis of, pathophysiology of, principles of, 106 reflux monitoring for, 91 treatment of, in elderly persons, manometry for. See Manometry. obesity and, 8 9, pathophysiology of, 15 25, , phenotypes of, reflux monitoring in, 32 33, refractory to proton pump inhibitors, risk factors for, 8 10 symptoms of assessment of, in elderly persons, treatment of costs of, 6 endoscopic, 45 in elderly persons, in obesity, medical, , surgical, 60 65, , Gastroplasty, Collis, 62 GERD. See Gastroesophageal reflux disease (GERD). GERD Symptom Assessment Scale, 29 H Heartburn, assessment of, conditions associated with, 33 definition of, perception of, 20 Helicobacter pylori infections, 9, 151 Hernia, hiatal. See Hiatal hernia. Hiatal hernia, 17 barium esophagography for, in elderly persons, 148 manometry of, obesity and, Histamine-2 receptor antagonists, , Hurst dilator, Hyperalgesia, Hypnotherapy, 128

6 180 I Impedance monitoring. See Reflux monitoring. Integrated relaxation pressure, in manometry, Itopride, 127 J Johrei therapy, 128 L Lansoprazole, 124 for reflux asthma syndrome, 113 for reflux postnasal drainage, 115 Laparoscopic antireflux surgery, for elderly persons, versus proton pump inhibitors, Laparoscopic bariatric surgery, GERD and, Laryngeal syndrome. See Gastroesophageal reflux disease (GERD), extraesophageal presentations of. Laryngitis, in reflux laryngitis syndrome, , Laryngoscopy, for extraesophageal GERD, Leptin, in obesity, 166 Lesogaberan, 126 LINX reflux management system, 143 Los Angeles classification, of GERD, Lower esophageal sphincter function of, 16 hypotension of, 73 in elderly persons, manometry of, 73 relaxation of, in achalasia, Lower esophageal sphincter pressure interval, in manometry, 79 Loxiglumide, 126 M Malabsorption from proton pump inhibitors, 155 surgeries for, GERD and, Maloney dilator, Manometry for motility measurement, 54 high-resolution, advances in, clinical applications of, pathophysiologic correlates of, preoperative, provocative maneuvers in, software tools for, 78 79

7 181 in obesity, 165 Manomety, in elderly persons, Medications, GERD due to, 151 Metabotropic glutamate receptor-5 antagonists, 126 Metoclopramide, 127, 156 Mobility, obesity and, 166 Montreal Definition and Classification of GERD, Mortality, in GERD, 2 Mosapride, 127 Motility. See also Peristalsis. in elderly persons, measurement of, 51 54, 57 barium esophagography for, 51 54, manometry for, Mucosal changes, Mucosal defense, drugs for, Multiple rapid swallow test, N NDO Surgical Plicator, 141 Nephritis, from proton pump inhibitors, 155 Nissen fundoplication barium esophagography after, history of, laparoscopic, modifications of, 136 Nizatidine, Nociceptors, blockade of, 128 Nocturnal GERD Symptom Severity and Impact Questionnaire, 29 Nutcracker esophagus, 165 O Obesity, GERD and, 8 9, bariatric surgery and, complications of, epidemiology of, pathophysiology of, positive pressure gradient in, 19 weight loss effects on, 167 Omeprazole, for elderly persons, 155 for proton pump inhibitor test, 36 Optical coherence tomography, P Pantoprazole, 124, 155 Pepsin, 21 22

8 182 Peripheral sensitization, 20 Peristalsis. See also Motility. absence of, in achalasia, barium visualization of, 57 ph monitoring. See Reflux monitoring. Positive pressure gradient, in obesity, 19 Postnasal drainage, in extraesophageal GERD, 115 Potassium-competitive acid blockers, 125 Pressure inversion point, in manometry, 73 Prokinetic agents, 18 19, 127, 156 Proton Pump Acid Suppression Symptom Test, 29 Proton pump inhibitor(s) adverse effects of, 155 during reflux testing, effectiveness of, 124 for elderly persons, for GERD, for reflux laryngitis syndrome, versus antireflux surgery, versus histamine-2 receptor antagonists, 123 Proton pump inhibitor test, Psychoneuroimmune interactions, Pulmonary fibrosis, in extraesophageal GERD, 114 Q Questionnaires, for symptom assessment, 29 32, 35 R Rabeprazole, 124 Radiofrequency therapy, 45 Ranitidine, , 127, 156 Rebamipide, 127 Reflex theory, Reflux barium esophagography for, 54, 61 perception of, 20 Reflux Disease Questionnaire, Reflux Finding Score, 108 Reflux monitoring, 32 33, duration of, for extraesophageal GERD, indications for, methods for, normal values for, 98 performance of, symptom association assessment in, test interpretation in, Reflux Questionnaire, 29 Reflux theory,

9 183 Regurgitation acid suppression effects on, 36 assessment of, 33 definition of, 27 perception of, 20 Relaxation training, 128 Rimonabant, 126 Roux-3n-Y gastric bypass, GERD and, S Savary-Gilliard dilator, Savary-Miller classification, of GERD, Schatzki ring, barium esophagography for, 55, 57 Sensation modulators, 128 Sensors, for reflux monitoring, Sensory neuropathic cough, Sensory perception, in elderly persons, 151 Sleep disorders, 10, 114 Sleeve gastrectomy, GERD and, Solid food swallow, in barium esophagography, 55, 61 Squamous epithelium, defense mechanisms of, Stress, Stress test, for esophagus, 83 Stretta system, 142 Swallow test, barium, T Tegaserod, Toupet fundoplication, 61, 136 Transient lower esophageal sphincter relaxations, 16, 18, 128 drugs acting on, in obesity, 165 manometric studies of, Transient receptor potential vanilloid subtype 1, 20 Transoral fundoplication, 45 U Upper esophageal sphincter dysfunction, in elderly persons, 151 V Visceral hypersensitivity, modulators of, 128 Vitamin deficiency, from proton pump inhibitors, 155 W Weight loss, GERD and, 167 Wireless capsule endoscopy, 41 Wireless sensors, for reflux monitoring, Work Productivity and Activity Impairment questionnaire, 7 8