Key words : herpes zoster, skin reaction, systemic lunus erythematosus (SLE)
|
|
- Claribel Greene
- 5 years ago
- Views:
Transcription
1 Key words : herpes zoster, skin reaction, systemic lunus erythematosus (SLE)
2 Fig. 1 Cumulative percent of cases with herpes zoster in relation to systemic lupus eryth- (SLE). Patients with SLE who had ematosus herpes zoster (9 cases) before diaymosis of SLE were omitted. Fig. 2 Dose of prednisolone (mg/day) when a patient with systemic lupus erythematosus had herpes zoster. Horizontal bars represent means Table 1 Crude incidence of herpes zoster in patients with systemic lupus erythematosus (SLE) No. of patients 119 No. of patients with zoster 56(47%) twice or more 11 before diagnosis of SLE 9 after diagnosis of SLE 50(42%) Person-Years observed* 918 Rate per 100 Person-Years 5.45 * The number of years observed is after diagnosis of SLE. (SD).
3 Table 2 Renal disorder and herpes zoster in patients with systemic lupus erythematosus Table 3 Complement fixation (CF) antibodies to varicella zoster virus in patients with systemic lupus erythematosus subjects (SLE) and in normal *not significant. * *Persistent proteinuria greater than 0.5g/day or cellular cast positive. *Antibody determined by complement fixation was considered positive when the titer was 1/4 or higher Fig. 3 Antibody titers to varicella zoster virus (VZV) determined by the neutralization test in patients with systemic lupus erythematosus (SLE) and in normal subjects. Horizontal bars represent means (SD). The titers in patients with SLE and a history of herpes zoster are significantly higher (p < 0. 01) than those in another groups. Table 4 Skin test reactions to varicella zoster virus (VZV) antigen in patients with systemic lupus erythematosus (SLE) and in normal subjects *Skin reactions to VZV antigen was considered positive when a diameter of erythema was 5mm or more
4 Table 5 Comparison of the characteristics of SLE patients based on the skin reactions *Skin reactions to varicella zoster virus antigen **Cumn1Pment fiyatinn greater than 0.5g/day or cellular cast positive. Table 6 Effect of prednisolone on skin reactions to varicella zoster virus *Patients with systemic lupus erythematosus who had not received steroid therapy
5 4) Nagafuchi, S., Iwahashi, T., Higa, K., Kusaba, T., Dan, K. & Mori, R.: Delayed type hypersensitivity (DTH) skin reaction to varicella- zoster virus antigen in patients with systemic lupus erythematosus (SLE). Fukuoka Acta Medica, 79 : , ) Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N. & Winchester, R.J. : The 1982 revised criteria for the classification of sys- lupus erythematosus. Arthritis temic Rheum., 25 : , ) Kamiya, H., Ihara, T., Hattori, A., Iwasa, T., Sakurai, M., Izawa, T., Yamada, A. & Takaha-
6 shi, M.: Diagnostic skin reactions with varicella virus antigen and clinical application of the test. J. Infect. Dis., 136 : 784 \788, ) Asano, Y., Shiraki, K., Takahashi, M., Nagai, H., Ozaki, T. & Yazaki, T.: Soluble skin test antigen of varicella-zoster virus prepared from the fluid of infected cultures. J. Infect. Dis., 143 : 684 \692, ) Ginzler, E., Diamond, H., Kaplan, D., Weiner, M., Schlesinger, M. & Seleznick, M.: Computer analysis of factors influencing frequency of infection in systemic lupus erythematosus. Arthritis Rheum., 21 : 37 \44, ) Gold, E. & Godek, G.: Complement fixation studies with a varicella-zoster antigen. J. Immunol., 95 : 692 \695, ) Blaese, R.M., Grayson, J. & Steinberg, A.D. : Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus. Am. J. Med., 69 : 345 \350, ) Stites, D.P.: Clinical laboratory methods of detection of cellular immune function. In Basic and Clinical immunology. (Stites, D.P., Stobo, J.D., Fundenberg, H.H., Wells, J.V. eds), p. 366 Lange Medical Publications, Drawer L. Los, Altos, ) Fauci, A.S., Dale, D.C. & Balow, J.E. : Glucocorticosteroid therapy : Mechanism of action and clinical considerations. Ann. Intern. Med., 84 : 304 \315, ) Rinehart, J.J., Wuest, D. & Ackerman, G.A. : Corticosteroid alteration of human monocyte to macrophage differentiation. J. Immunol., 129 : 1436 \1440, ) Smolen, J.S., Chused, T.M., Leiserson, W.M., Reeves, J.P., Alling, D. & Steinberg, A.D. : Heterogeneity of immunoregulatory T-cell subsets in systemic lupus erythematosus. Correlation with clinical features. Am. J. Med., 72 : ) Horwitz, D.A.: Lymphocytes and immune regulation in systemic lupus erythematosus. In Dubois' lupus erythematosus. (Walance, D.J. & Dubois, E.L. ed.), p. 194 \210, Lea and Febiger, Philadelphia, ) Bakke, A.C., Kirkland, P.A., Kitridou, R.C., Quismorio, F.P. Jr., Rea, T., Ehresmann, G.R. & Horwitz, D.A.: T lymphocyte subsets in systemic lupus erythematosus. Correlations with corticosteroid therapy and disease activity. Arthritis Rheum., 26 : 745 \750, Herpes Zoster in Connective Tissue Diseases: I. Association with Systemic Lupus Erythematosus and Its Immunological Abnormalities Yasuo YAMAUCHI, Kohei NAGASAWA, Yoshifumi TADA, Hiroshi TSUKAMOTO, Shigeru YOSHIZAWA, Takehito MAYUMI, Yoshiyuki NIHO & Tomohiro KUSABA The First Department of Internal Medicine, Faculty of Medicine, Kyushu University We determined the incidence of herpes zoster (HZ) in 119 patients with systemic lupus erythematosus (SLE). HZ occurred in 56 patients (47%), and 9 patients had had HZ even before SLE developed. After diagnosis of SLE, an incidence of zoster was high, 5.45 cases per 100 person-years. It was found that the susceptibility to HZ was not related to the presence of renal disorder or maximum dose of corticosteroids. The patients with SLE who had had HZ showed significantly higher antibody titers than those without a history of HZ and normal subjects as assayed by both complement fixation technique and neutralization test. On the other had, only 17 of 55 patients (31%) with SLE showed positive skin reactions to varicella zoster virus (VZV) antigen, whereas all 15 normal subjects had positive reactions. In the patients who were receiving less than 10 mg/day of prednisolone, 11 of 17 (65%) had positive skin reactions to VZV antigen, whereas only 4 of 31 (13%) patients who were receiving 10 mg/day or more prednisolone showed positive reactions. It was of interest that in 7 patients with SLE who had not received corticosteroids, only 2 (29%) patients showed positive skin reactions to VZV antigen. These results suggest that high incidence of HZ in patients with SLE is probably due to an impaired cellular immunity because of both underlying disease and corticosteroid treatment.
If We Diagnose Herpes Zoster, Should We Search for Any Underlying Malignancy?
International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531 (Print & Online) http://gssrr.org/index.php?journal=journalofbasicandapplied ---------------------------------------------------------------------------------------------------------------------------
More informationKey words: systemic lupus erythematosus (SLE), monocyte, priming effect, polymorphnuclear neutrophils-chemiluminescence corticosteroid
Key words: systemic lupus erythematosus (SLE), monocyte, priming effect, polymorphnuclear neutrophils-chemiluminescence corticosteroid (PMN-CL), Table 1 Patient profiles PSL: prednisolone,*: duration of
More informationUniversity of Groningen
University of Groningen Longitudinal analysis of varicella-zoster virus-specific antibodies in systemic lupus erythematosus Rondaan, Christien; van Leer, C C; van Assen, S; Bootsma, Hendrika; de Leeuw,
More informationRelation between soluble interleukin 2 receptor and
Annals of the Rheumatic Diseases 1989; 48: 803-809 Relation between soluble interleukin 2 receptor and clinical findings in patients with systemic lupus erythematosus YOSHIAKI TOKANO,1 ATSUKO MURASHIMA,'
More informationJournal of Epidemiology 1993 by Japan Epidemiological Association Vol. 3, No. 1 June
Journal of Epidemiology 1993 by Japan Epidemiological Association Vol. 3, No. 1 June ORIGINAL CONTRIBUTION Follow Up Study on the Changes in the Clinical Features and Prognosis of Japanese Patients with
More informationEfficacy and Safety of Belimumab in the treatment of Systemic Lupus Erythematosus: a Prospective Multicenter Study.
1. Title Efficacy and Safety of Belimumab in the treatment of Systemic Lupus Erythematosus: a Prospective Multicenter Study. 2. Background Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune and
More informationObservations on the occurrence of exacerbations in clinical course of systemic lupus erythematosus
112 ORIGINAL Observations on the occurrence of exacerbations in clinical course of systemic lupus erythematosus Reiko Tomioka 1, Kenji Tani 2,KeikoSato 1, Chiyuki Suzuka 1, Yuko Toyoda 1, Jun Kishi 1,
More informationExperimental Infection and Immune Response of Guinea Pigs with Varicella-Zoster Virus
INFECTION AND IMMUNITY, Aug. 1982, p. 407-412 0019-9567/82/080407-06$02.00/0 Vol. 37, No. 2 Experimental Infection and Immune Response of Guinea Pigs with Varicella-Zoster Virus YOSHINO MATSUNAGA, KOICHI
More informationCLINICAL FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS
55 CLINICAL FEATURES OF SYSTEMIC LUPUS ERYTHEMATOSUS Differences Related to Race and Age of Onset STANLEY P. BALLOU, MUHAMMAD A. KHAN, and IRVING KUSHNER ' We compared the frequency of clinical features
More informationHow the Innate Immune System Profiles Pathogens
How the Innate Immune System Profiles Pathogens Receptors on macrophages, neutrophils, dendritic cells for bacteria and viruses Broad specificity - Two main groups of bacteria: gram positive, gram-negative
More informationMAJOR ARTICLE. Downloaded from by guest on 10 November 2018
MAJOR ARTICLE Measurement of Varicella-Zoster Virus (VZV) Specific Cell-Mediated Immunity: Comparison between VZV Skin Test and Interferon- Enzyme-Linked Immunospot Assay Kay Sadaoka, 1,a Shigefumi Okamoto,
More informationEpstein-Barr Virus Antibody Levels in Systemic Lupus Erythematosus
Epstein-Barr Virus Antibody Levels in Systemic Lupus Erythematosus Paul E. Phillips and Yashar Hirshaut Mean Epstein-Barr virus antibody was not significantly elevated in sera from 50 patients with systemic
More informationand rheumatism arthritis THE 1982 REVISED CRITERIA FOR THE CLASSIFICATION OF SYSTEMIC LUPUS ERYTHEMATOSUS SPECIAL ARTICLE
arthritis and rheumatism * Official Journal of the American Rheumatism Association Section of the Arthritis Foundation SPECIAL ARTICLE THE 1982 REVISED CRITERIA F THE CLASSIFICATION OF SYSTEMIC LUPUS ERYTHEMATOSUS
More informationThe Lymphatic System and Body Defenses
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College The Lymphatic System and Body Defenses 12PART B Adaptive Defense System: Third Line of Defense Immune
More informationCirculating 20S Proteasome Levels in Patients with Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
CLINICAL AND VACCINE IMMUNOLOGY, Sept. 2008, p. 1489 1493 Vol. 15, No. 9 1556-6811/08/$08.00 0 doi:10.1128/cvi.00187-08 Copyright 2008, American Society for Microbiology. All Rights Reserved. Circulating
More informationUnderstanding Autoimmune Diseases: Evolving Issues. Alvina D. Chu, M.D. April 23, 2009
Understanding Autoimmune Diseases: Evolving Issues Alvina D. Chu, M.D. April 23, 2009 Objectives Define the key pathogenic characteristics of: Type I diabetes mellitus Multiple sclerosis Rheumatoid arthritis
More informationSystemic lupus erythematosus in a male patient
IOP Conference Series: Earth and Environmental Science PAPER OPEN ACCESS Systemic lupus erythematosus in a male patient To cite this article: H Sibarani and Z Zubir 2018 IOP Conf. Ser.: Earth Environ.
More informationCLINICAL GUIDELINES. Summary of Literature and Recommendations Concerning Immunization and Steroid Injections Thomas J. Gilbert M.D., M.P.P.
CLINICAL GUIDELINES Summary of Literature and Recommendations Concerning Immunization and Steroid Injections Thomas J. Gilbert M.D., M.P.P. 11/2/15 Several practices routinely delay steroid injections
More informationIntravenous cyclophosphamide combined with steroids in pediatric onset severe lupus nephritis
Int Urol Nephrol (2013) 45:1301 1308 DOI 10.1007/s11255-012-0331-9 NEPHROLOGY - ORIGINAL PAPER Intravenous cyclophosphamide combined with steroids in pediatric onset severe lupus nephritis Prayong Vachvanichsanong
More informationanti-dna and disease activity in systemic lupus
Annals of the Rheumatic Diseases, 1977, 36, 44-49 Relation of titred peripheral pattern ANA to anti-dna and disease activity in systemic lupus erythematosus RAYMOND JAY WEITZMAN* AND SARA ELLEN WALKER
More informationLONG-TERM OUTCOME OF PATIENTS WITH LUPUS NEPHRITIS: A SINGLE CENTER EXPERIENCE
& LONG-TERM OUTCOME OF PATIENTS WITH LUPUS NEPHRITIS: A SINGLE CENTER EXPERIENCE Senija Rašić 1 *, Amira Srna 1, Snežana Unčanin 1, Jasminka Džemidžić 1, Damir Rebić 1, Alma Muslimović 1, Maida Rakanović-Todić
More informationSystemic Lupus. Case records for patients who attended the SLE clinic at Universiti Kebangsaan Malaysia between October
Mortoli in M Eryth ematosus alolysians wiwk 6\VWHPLF /XSXV Systemic Lupus N I J Paton, MRCP', I Cheong, FRCP", N C T Kong, FRACP", M Segasothy, FRCP", 'Department of Infectious Diseases, St. George's Hospital,
More informationRecent advances in autoimmunity
Recent advances in autoimmunity Randall S. Krakauer, M.D. John D. Clough, M.D. Department of Rheumatic and Immunologic Diseases David Ilfeld, M.D.* Although autoimmunity in terms of immune reaction of
More informationLong-Term Followup of Patients Treated With Total Lymphoid Irradiation for Lupus Nephritis
ARTHRITIS & RHEUMATISM Vol. 46, No. 4, April 2002, pp 1014 1018 DOI 10.1002/art.10216 2002, American College of Rheumatology Long-Term Followup of Patients Treated With Total Lymphoid Irradiation for Lupus
More informationGender Differences in the Clinical and Serological Features of Systemic Lupus Erythematosus in Malaysian Patients
o ORIGINAL ARTICLE Gender Differences in the Clinical and Serological Features of Systemic Lupus Erythematosus in Malaysian Patients M R Azizah, MBBCh*, S S Ainol, MMed**, N C T Kong, MRCP***, Y Normaznah,
More informationAdditional file 2: Details of cohort studies and randomised trials
Reference Randomised trials Ye et al. 2001 Abstract 274 R=1 WD=0 Design, numbers, treatments, duration Randomised open comparison of: (45 patients) 1.5 g for 3, 1 g for 3, then 0.5 to 0.75 g IV cyclophosphamide
More informationONE of the following:
Medical Coverage Policy Belimumab (Benlysta) EFFECTIVE DATE: 01 01 2012 POLICY LAST UPDATED: 11 21 2017 OVERVIEW Belimumab (Benlysta ) is indicated for the treatment of adult patients with active, autoantibody-positive,
More informationOriginal Article Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous
Int J Clin Exp Med 2015;8(9):16658-16663 www.ijcem.com /ISSN:1940-5901/IJCEM0011022 Original Article Role of IL-1β, IL-6, IL-8 and IFN-γ in pathogenesis of central nervous system neuropsychiatric systemic
More informationAlida R Harahap & Farida Oesman Department of Clinical Pathology Faculty of Medicine, University of Indonesia
Alida R Harahap & Farida Oesman Department of Clinical Pathology Faculty of Medicine, University of Indonesia Foreign molecules = antigens Immune response Immune system non-specific specific cellular humoral
More informationLupus and Your Kidneys. Michael P. Madaio, MD Professor of Medicine Chairman of Medicine Medical College of Georgia Augusta, Georgia
Lupus and Your Kidneys Michael P. Madaio, MD Professor of Medicine Chairman of Medicine Medical College of Georgia Augusta, Georgia Kidney Inflammation and Abnormal Function as a Result of Lupus (Lupus
More informationREPEATED B CELL DEPLETION IN TREATMENT OF REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS
ARD Online First, published on November 3, 2005 as 10.1136/ard.2005.044487 REPEATED B CELL DEPLETION IN TREATMENT OF REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS Concise report Kristine P. Ng 1 Maria J. Leandro
More informationAutoimmune Diseases. Betsy Kirchner CNP The Cleveland Clinic
Autoimmune Diseases Betsy Kirchner CNP The Cleveland Clinic Disclosures (financial) No relevant disclosures Learning Objectives Explain the pathophysiology of autoimmune disease Discuss safe administration
More informationAssociation of anti-mcv autoantibodies with SLE (Systemic Lupus Erythematosus) overlapping with various syndromes
International Journal of Medicine and Medical Sciences Vol. () pp. 21-214, June 211 Available online http://www.academicjournals.org/ijmms ISSN 2-972 211 Academic Journals Full Length Research Paper Association
More informationBachelor of Chinese Medicine ( ) AUTOIMMUNE DISEASES
Bachelor of Chinese Medicine (2002 2003) BCM II Dr. EYT Chan February 6, 2003 9:30 am 1:00 pm Rm 134 UPB AUTOIMMUNE DISEASES 1. Introduction Diseases may be the consequence of an aberrant immune response,
More informationLes 2 articles qui peuvent changer votre pratique sur: Vaccination et biothérapies
Les 2 articles qui peuvent changer votre pratique sur: Vaccination et biothérapies VZV Epidemiology and Pathogenesis 98% adults Respiratory spread 1,000,000/year and increasing CMI continuously boosted
More informationBlood and Immune system Acquired Immunity
Blood and Immune system Acquired Immunity Immunity Acquired (Adaptive) Immunity Defensive mechanisms include : 1) Innate immunity (Natural or Non specific) 2) Acquired immunity (Adaptive or Specific) Cell-mediated
More informationUPDATES ON PEDIATRIC SLE
UPDATES ON PEDIATRIC SLE BY ANGELA MIGOWA, PEDIATRIC RHEUMATOLOGIST/SENIOR INSTRUCTOR AKUHN MBCHB-UON, MMED-AKUHN,PEDIATRIC RHEUMATOLOGY- MCGILL UNIVERSITY HEALTH CENTRE ROSA PARKS OBJECTIVES RECOGNIZE
More informationActa Medica Okayama OCTOBER Decreased plasma postheparin lipolytic activity in systemic lupus erythematosus
Acta Medica Okayama Volume 31, Issue 5 1977 Article 4 OCTOBER 1977 Decreased plasma postheparin lipolytic activity in systemic lupus erythematosus Koichi Kawanishi Hidenori Ueda Masayuki Nagase Tadashi
More information40% varicella-zoster virus VZV. 15 gene 62 WHO. gene TEL FAX
59 2 pp.249-256 29 2. 1974 Lancet 3 1 9% 4% varicella-zoster virus VZV VZV 1974 1 WHO 26 8 16 47-1192 1-98 TEL 562-93-9251 FAX 562-95-2216 E-mail yasano@fujita-hu.ac.jp VZV 34 11 37 12 WI-38 3 MRC-5 2
More informationApproach to Glomerular Diseases: Clinical Presentation Nephrotic Syndrome Nephritis
GLOMERULONEPHRITIDES Vivette D Agati Jai Radhakrishnan Approach to Glomerular Diseases: Clinical Presentation Nephrotic Syndrome Nephritis Heavy Proteinuria Renal failure Low serum Albumin Hypertension
More informationApoptosis of lymphocytes in SLE: the level, correlation with dosage prednisolone and lymphocyte phenotypes
Apoptosis of lymphocytes in SLE: the level, correlation with dosage prednisolone and lymphocyte phenotypes ABDELMAROUF MOHIELDEIN 1, NATALIA BELUSHKINA 2, ULIANA PETROVA 3. 1,2 Department of Biochemistry,
More informationIt is crucial that practitioners refer to this updated chapter when administering the shingles vaccine.
In October Public Health England published a revised Green Book chapter for shingles and also health care professional FAQs. These revisions include changes to the contraindications and precautions sections.
More informationDISCLOSURE. Relevant relationships with commercial entities none. Potential for conflicts of interest within this presentation none
AUTOIMMUNITY DISCLOSURE Relevant relationships with commercial entities none Potential for conflicts of interest within this presentation none Steps taken to review and mitigate potential bias N/A MODULE
More informationProgress in varicella vaccine research
40 1, 1, 1, 2 1., 230032; 2., 10032 : - ( VZV) VZV 1995,, Oka,,, VZV : - ; Oka ; Progress in varicella vaccine research GAN Lin 1, WANG Ming-Li 1, Jason Chen 1, 2 1. Department of Microbiology, Anhui Medical
More informationARTHRITIS RHEUMATISM
ARTHRITIS & RHEUMATISM OFFICIAL JOUKNXL OF THE AMERICAN RHEUM&%TISM ASSOCIATION SECTION OF?'HE ;IRTHRITIS FOUNDATION 209 INCREASED TOXOPLASMA ANTIBODIES IN IDIOPATHIC INFLAMMATORY MUSCLE DISEASE A Case-Controlled
More informationCitation Journal Of Clinical Pathology, 1996, v. 49 n. 8, p
Title Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: A prospective study Author(s) Chan, EYT; Lau, CS; Zola, H
More informationMLAB 1235 Immunology/Serology Course Objectives and Course Ooutlinee Fall 2003
MLAB 1235 Immunology/Serology Course Objectives and Course Ooutlinee Fall 2003 1. Nature of the Immune System I. Historical Concepts 1. Define immunology and immunity. 2. Describe the process and purpose
More informationAcyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus
Antiviral Chemistry & Chemotherapy 1:251 257 Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus ZhiHong Li 1,, Hitoshi Sato 1, Yoshiko
More informationElevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab
(2016) 25, 346 354 http://lup.sagepub.com PAPER Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab DA Roth 1, A Thompson 2, Y Tang 2*, AE
More informationApplication of genetic signatures to clinical care of lupus
Application of genetic signatures to clinical care of lupus Dr Durga Prasanna Misra MD, MRCP(UK), DM Assistant Professor Department of Clinical Immunology, JIPMER, Puducherry. LAYOUT Genetics of lupus
More informationClinical Features and Outcome of Systemic Lupus Erythematosus
SHORT COMMUNICATION Clinical Features and Outcome of Systemic Lupus Erythematosus INDIRA AGARWAL, T SATHISH KUMAR, KALA RANJINI, CHELLAM KIRUBAKARAN AND *DEBASHISH DANDA From the Departments of Child Health
More informationLate onset systemic lupus erythematosus in southern Chinese. Citation Annals Of The Rheumatic Diseases, 1998, v. 57 n. 7, p.
Title Late onset systemic lupus erythematosus in southern Chinese Author(s) Ho, CTK; Mok, CC; Lau, CS; Wong, RWS Citation Annals Of The Rheumatic Diseases, 1998, v. 57 n. 7, p. 437-440 Issued Date 1998
More informationRole of BAFF in B cell Biology and Autoimmunity
Role of BAFF in B cell Biology and Autoimmunity B cell development in health and disease: B-lymphocytes or B cells, and the antibodies they produce, are crucial mediators of humoral immunity, providing
More informationPrognostic value of anti-dsdna in SLE
Annals of the Rheumatic Diseases, 1982, 41, 388-395 Prognostic value of anti-dsdna in SLE A. J. G. SWAAK,1 J. GROENWOLD,2 L. A. AARDEN,2 L. W. STATIUS VAN EPS,3 AND T. E. W. FELTKAMP2 From the 'Jan van
More informationInfluence of Corticosteroids on Lymphocyte Recirculation
216 Summary Lymphology 11 (1978) 216-221 Influence of Corticosteroids on Lymphocyte Recirculation P.M. Lundin, L.A. Hedman Department of Pathology, University of Gothenburg, Sahlgren's Hospital, S-413
More informationdifferent serological and histological manifestations and a high incidence of D-penicillamine side effects. Materials
Annals of the Rheu)natic Diseases, 1985, 44, 215-219 Anti-Ro(SSA) positive rheumatoid arthritis (RA): a clinicoserological group of patients with high incidence of D-penicillamine side effects HARALAMPOS
More informationDEFECTIVE CD2 PATHWAY T CELL ACTIVATION IN SYSTEMIC LUPUS ERYTHEMATOSUS
56 1 DEFECTIVE CD2 PATHWAY T CELL ACTIVATION IN SYSTEMIC LUPUS ERYTHEMATOSUS DAVID A. FOX, JO ANN MILLARD, JONATHAN TREISMAN, WENDY ZELDES, ALICE BERGMAN, JOEL DEPPER, ROBERT DUNNE, and W. JOSEPH McCUNE
More informationMechanisms of Autontibodies
Mechanisms of Autontibodies Production in Rheumatic Diseases Eisa Salehi PhD Tehran University of Medical Sciences Immunology Department Introduction Rheumatic diseases: Cause inflammation, swelling, and
More informationParallel session IVB. Chair: Hans Wildiers
Parallel session IVB Biology of ageing and cancer Chair: Hans Wildiers IMMUNOSENESCENCE AND AGEING Tamas Fulop M.D., PhD Research Center on Aging, Division of Geriatrics, University of Sherbrooke, Sherbrooke,
More information. Autoimmune disease. Dr. Baha,Hamdi.AL-Amiedi Ph.D.Microbiology
. Autoimmune disease Dr. Baha,Hamdi.AL-Amiedi Ph.D.Microbiology, Paul Ehrich The term coined by the German immunologist paul Ehrich ( 1854-1915) To describe the bodys innate aversion to immunological
More informationANTIBODIES TO Sm AND RNP
848 ANTIBODIES TO Sm AND RNP Prognosticators of Disease Involvement ELLEN FIELD MUNVES and PETER H. SCHUR The charts of 190 consecutive patients found to have antibodies to Sm, ribonuclebprotein (RNP),
More informationCommittee Approval Date: May 9, 2014 Next Review Date: May 2015
Medication Policy Manual Policy No: dru248 Topic: Benlysta, belimumab Date of Origin: May 13, 2011 Committee Approval Date: May 9, 2014 Next Review Date: May 2015 Effective Date: June 1, 2014 IMPORTANT
More informationTherapy for patients with life-threatening systemic
Methylprednisolone and Cyclophosphamide, Alone or in Combination, in Patients with Lupus Nephritis A Randomized, Controlled Trial Mark F. Gourley, MD; Howard A. Austin III, MD; Dorothy Scott, MD; Cheryl
More informationSystemic lupus erythematosus in 50 year olds
Postgrad Med J (1992) 68, 440-444 The Fellowship of Postgraduate Medicine, 1992 Systemic lupus erythematosus in 50 year olds I. Domenech, 0. Aydintug, R. Cervera, M. Khamashta, A. Jedryka-Goral, J.L. Vianna
More informationEffect of mycophenolate mofetil on the white blood cell count and the frequency of infection in systemic lupus erythematosus.
Thomas Jefferson University Jefferson Digital Commons Department of Medicine Faculty Papers Department of Medicine 10-22-2015 Effect of mycophenolate mofetil on the white blood cell count and the frequency
More informationSerum Soluble Interleukin-2 Receptor Alpha in Systemic Lupus Erythematosus
Kidney Diseases Serum Soluble Interleukin-2 Receptor Alpha in Systemic Lupus Erythematosus Eid M El-Shafey, 1 Gamal F El-Nagar, 2 Aml S El-Bendary, 2 Alaa A Sabry, 3 Abdel-Ghani A Selim 4 Original Paper
More informationDevelopment of Classification and Response Criteria for Rheumatic Diseases
Arthritis & Rheumatism (Arthritis Care & Research) Vol. 55, No. 3, June 15, 2006, pp 348 352 DOI 10.1002/art.22003 2006, American College of Rheumatology EDITORIAL Development of Classification and Response
More informationSeroepidemiology of Herpes Simplex Virus Type 1 in Yanji, Jilin, China
Seroepidemiology of Herpes Simplex Virus Type 1 in Yanji, Jilin, China Microbiol. Immunol. Vol. 34 (6), 551-555, 1990 Yu-Yu LI,1 Yasufumi HIDAKA,*,1 Yoichiro KINO,2 and Ryoichi MORI1 1 Department of Virology,
More informationComparison of Performance of ELISA with Indirect Immunofluoresence for the Testing of Antinuclear Antibodies
International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 12 (2016) pp. 423-427 Journal homepage: http://www.ijcmas.com Original Research Article http://dx.doi.org/10.20546/ijcmas.2016.512.046
More informationSerum Vascular Endothelial Growth Factor (VEGF) as a Biomarker for Disease Activity in Lupus Nephritis
Original Article Serum Vascular Endothelial Growth Factor (VEGF) as a Biomarker for Disease Activity in Lupus Nephritis Wan Syamimee Wan Ghazali 1, Rahimah Iberahim 1, Noor Suryani Mohd Ashari 2 Submitted:
More informationLack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population
Lack of association of IL-2RA and IL-2RB polymorphisms with rheumatoid arthritis in a Han Chinese population J. Zhu 1 *, F. He 2 *, D.D. Zhang 2 *, J.Y. Yang 2, J. Cheng 1, R. Wu 1, B. Gong 2, X.Q. Liu
More informationKey words Corticosteroid, systemic lupus erythematosus, osteonecrosis, MRI, long-term follow-up.
Development of new osteonecrosis in systemic lupus erythematosus patients in association with long-term corticosteroid therapy after disease recurrence J. Nakamura 1, 2, S. Ohtori 2, M. Sakamoto 3, A.
More informationSystemic Lupus Erythematosus
Josef S. Smolen Christoph C. Zielinski Systemic Lupus Erythematosus Clinical and Experimental Aspects Foreword by G. Geyer With 60 Figures and 44 Tables Springer-Verlag Berlin Heidelberg New York London
More informationNeuropsychiatric Systemic Lupus Erythematosus (NPSLE) Case presentations and topic discussion The Rheumatology Unit UMMC experience
Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) Case presentations and topic discussion The Rheumatology Unit UMMC experience References Sanna G, Bertolaccini ML. Neuropsychiatric manifestations
More informationOriginal Article The expression of EBV-encoded LMP1 in young patients with lupus nephritis
Int J Clin Exp Med 2015;8(4):6073-6078 www.ijcem.com /ISSN:1940-5901/IJCEM0005602 Original Article The expression of EBV-encoded LMP1 in young patients with lupus nephritis Yan Ding 1,2*, Xiaojie He 3*,
More informationHendrika Bootsma, Peter E Spronk, Evert J Ter Borg, Elsje J Hummel, Greetje de Boer, Pieter C Limburg, Cees G M Kallenberg
Annals of the Rheumatic Diseases 1997;56:661 666 661 The predictive value of fluctuations in IgM and IgG class anti-dsdna antibodies for relapses in systemic lupus erythematosus. A prospective long term
More informationCSTAR CASE STUDIES: BLOCK F Type 3 Hypersensitivity Reaction
CSTAR CASE STUDIES: BLOCK F Type 3 Hypersensitivity Reaction Setting: ER Mr. Smith I ve just felt so weak for so long, and I ve lost so much weight, and now I m having trouble breathing it s affecting
More information4. SYSTEMIC REACTIONS
HUMAN HERPES VIR US-6 25 3.3 Further Reading Krueger GRF, Koch B, Ramon A, Ablashi DV, Salahuddm SZ, Josephs SF, Streicher HZ, Gallo RC, Habermann U. Antibody prevalence to HBLV (human herpesvirus-6, HHV-6)
More informationImmunosuppressants. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia
Immunosuppressants Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Immunosuppressive Agents Very useful in minimizing the occurrence of exaggerated or inappropriate
More informationLUPUS CAN DO EVERYTHING, BUT NOT EVERYTHING IS LUPUS LUPUS 101 SLE SUBSETS AUTOIMMUNE DISEASE 11/4/2013 HOWARD HAUPTMAN, MD IDIOPATHIC DISCOID LUPUS
LUPUS 101 LUPUS CAN DO EVERYTHING, BUT NOT EVERYTHING IS LUPUS HOWARD HAUPTMAN, MD IDIOPATHIC DISCOID LUPUS SLE SUBSETS SUBACUTE CUTANEOUS LUPUS DRUG INDUCED LUPUS NEONATAL LUPUS LATE ONSET LUPUS ANTI-PHOSPHOLIPID
More informationNew biomarkers for ANCA-associated Vasculitis? Juliana Bordignon Draibe
New biomarkers for ANCA-associated Vasculitis? Juliana Bordignon Draibe Summary Introduction Antibodies: ANCAs, Anti-LAMP-2, Anti-moesin B and T lymphocytes Markers of vascular activation: complement,
More informationASSESSMENT OF LYMPHOCYTE SUBGROUPS IN CHRONIC BRUCELLOSIS BEFORE AND AFTER IMMUNOTHERAPY
ASSESSMENT OF LYMPHOCYTE SUBGROUPS IN CHRONIC BRUCELLOSIS BEFORE AND AFTER IMMUNOTHERAPY D. Tahamzadeh 1, A. Massoud *1, G. Samar 2 and B. Nikbin 1 1) Department of Immunology, School of Medicine, Tehran
More informationUnit title: The Immune Response System
Unit title: The Immune Response System Unit code: M/601/0228 QCF level: 5 Credit value: 15 Aim This unit develops an understanding of the function and manipulation of the immune system and its abnormalities.
More informationHelminth worm, Schistosomiasis Trypanosomes, sleeping sickness Pneumocystis carinii. Ringworm fungus HIV Influenza
Helminth worm, Schistosomiasis Trypanosomes, sleeping sickness Pneumocystis carinii Ringworm fungus HIV Influenza Candida Staph aureus Mycobacterium tuberculosis Listeria Salmonella Streptococcus Levels
More informationThird line of Defense
Chapter 15 Specific Immunity and Immunization Topics -3 rd of Defense - B cells - T cells - Specific Immunities Third line of Defense Specific immunity is a complex interaction of immune cells (leukocytes)
More informationAll animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity
1 2 3 4 5 6 7 8 9 The Immune System All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity Figure 43.2 In innate immunity, recognition and
More informationIntensive immunosuppression versus prednisolone in the treatment of connective tissue diseases
Annsials of the Rheumatic Diseases, 198, 41, 557-56 Intensive immunosuppression versus prednisolone in the treatment of connective tissue diseases P. HOLLINGWORTH, A. DE VERE TYNDALL, B. M. ANSELL, T.
More informationPhysiology Unit 3. ADAPTIVE IMMUNITY The Specific Immune Response
Physiology Unit 3 ADAPTIVE IMMUNITY The Specific Immune Response In Physiology Today The Adaptive Arm of the Immune System Specific Immune Response Internal defense against a specific pathogen Acquired
More informationReview B cell targeted therapies Edward Keystone
Available online http://arthritis-research.com/contents/7/s3/s13 Review B cell targeted therapies Edward Keystone Department of Medicine, University of Toronto, Ontario, Canada Corresponding author: Edward
More informationInfection of Human T Lymphocytes with Varicella-Zoster Virus: an Analysis with Viral Mutants and Clinical Isolates
JOURNAL OF VIROLOGY, Feb. 2000, p. 1864 1870 Vol. 74, No. 4 0022-538X/00/$04.00 0 Copyright 2000, American Society for Microbiology. All Rights Reserved. Infection of Human T Lymphocytes with Varicella-Zoster
More informationFemale Systemic Lupus Erythematosus in Miyagi Prefecture, Japan : A Case-Control Study of Dietary and Reproductive Factors
Tohoku J. Exp. Med., 1993, 169, 245-252 Female Systemic Lupus Erythematosus in Miyagi Prefecture, Japan : A Case-Control Study of Dietary and Reproductive Factors YUKO MINAMI, TAKESHI SASAKI*, SHOKO KOMATSU,
More informationEnvironmental Influence in Autoimmune Diseases. Mark Gourley, MD
Environmental Influence in Autoimmune Diseases Mark Gourley, MD Newsweek January, 2003 Current Knowledge of Environment and Myositis Environment Genes Autoimmunity What Is an Environmental Exposure?
More informationIntroduction. Key-Words: - SLE, apoptosis, lymphocyte phenotypes, prednisolone, dsdna autoantibodies, flow cytometry.
Apoptosis of lymphocytes in SLE: the level, correlation with dosage prednisolone and lymphocyte phenotypes ABDELMAROUF MOHIELDEIN 1, NATALIA BELUSHKINA 2, ULIANA PETROVA 3. Abstract: - Introduction SLE
More informationTest Definition: FMCPS Meningoencephalitis Comprehensive Panel (Serum)
Reporting Title: Meningoencephalitis Comp Panel, S Performing Location: Focus Diagnostics, Specimen Requirements: Draw blood in a plain, red-top tube(s). (Serum gel tube is acceptable.) Spin down and send
More informationA Study of Lupus Nephritis
A Study of Lupus Nephritis Pages with reference to book, From 167 To 170 Manohar Lal S. Dawani, Muzamil H. Osmani, Masood A. Shaikh, S. Ali Jaffar Naqvi ( Department of Nephrourology, Jinnab Postgraduate
More informationAssociation of the Charlson Comorbidity Index With Mortality in Systemic Lupus Erythematosus
Arthritis Care & Research Vol. 63, No. 9, September 2011, pp 1233 1237 DOI 10.1002/acr.20506 2011, American College of Rheumatology ORIGINAL ARTICLE Association of the Charlson Comorbidity Index With Mortality
More informationPersistence of Immunity to Live Attenuated Varicella Vaccine in Healthy Adults
MAJOR ARTICLE Persistence of Immunity to Live Attenuated Varicella Vaccine in Healthy Adults Krow Ampofo, 1 Lisa Saiman, 1,2 Philip LaRussa, 1 Sharon Steinberg, 1 Paula Annunziato, 1 and Anne Gershon 1
More informationLupus Erythematosus - Can Anti-SS-A Antibody Predict the Next Event?
Original Article Thrombocytopenia Subsequently Develops Systemic Lupus Erythematosus - Can Anti-SS-A Antibody Predict the Next Event? Masanori ADACHI*, Seiji MlTA, Mitsuo OBANA, Yasuo MATSUOKA,Keiichi
More informationEditing file. Color code: Important in red Extra in blue. Autoimmune Diseases
Editing file Color code: Important in red Extra in blue Autoimmune Diseases Objectives To know that the inflammatory processes in autoimmune diseases are mediated by hypersensitivity reactions (type II,
More information