Stroke School for Internists Part 1

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1 Stroke School for Internists Part 1 November 4, 2017 Dr. Albert Jin Dr. Gurpreet Jaswal

2 Disclosures I receive a stipend for my role as Medical Director of the Stroke Network of SEO I have no commercial disclosures or conflicts of interest

3 Three Main Objectives 1. Obtain a history and examination in five minutes in the ED 2. Identify the stroke syndrome 3. Read a plain noncontrast CT scan of the head and recognize thrombus, infarction, hemorrhage

4 1. Stroke History and Exam

5 The history (~ 3minutes) is focused on enabling a thrombolysis decision The exam (~ 2 minutes) has two main aims: Confirm the clinical suspicion of stroke Clarify the stroke syndrome and localization

6 Within 5 minutes there is usually enough information to diagnose stroke This sets up imaging as the decision point for thrombolysis

7 Last known well Last seen normal, or last known well is the time of onset Time of onset is not necessarily when the patient was found Time of onset is not necessarily when there was an abrupt change if the patient changed from having a mild deficit to a severe deficit When was the last time today that Mr. Jones was seen to be walking and talking normally?

8 What are the symptoms? Weakness in face, arm or leg Speech: Is it aphasia, or something else? Sensory and Vision: Do they notice bilateral stimulation? Ataxia: Felt dizzy, Had to hold on to wall

9 Chronology How quickly did symptoms reach maximal severity? Symptom onset is often described as sudden But symptoms often worsen after sudden onset Sudden onset right face and arm numbness becomes Sudden onset right face numbness which got worse over the next 30 minutes and spread to the right arm

10 Did things get worse after you first noticed problems? How long did it take to get to the very worst?

11 Medications, Comorbidities, Independence Anticoagulants and when taken? Other meds? Allergies? Medical conditions, recent stroke/tia, recent trauma or surgery? Are they independent at baseline? If not independent, can they walk, converse, cognitive impairment?

12 Examination in 3 minutes NIH Stroke Scale Consciousness Gaze, Visual Fields, Face Arm & leg: weak, clumsy, numb Language Dysarthria Inattention Start at head Move to arms and legs Back up to the head

13 Let s practice the NIHSS Please pair off and we ll go through the examination technique together

14 NIHSS

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19 2. Stroke Syndromes

20 Objectives Recognize clinical features of anterior circulation stroke involving: Middle cerebral artery Anterior cerebral artery Recognize features of posterior circulation stroke involving: Posterior cerebral artery (occipital lobe, thalamus, medial temporal lobe) Brainstem (midbrain, pons, medulla) Cerebellum Recognize four common lacunar stroke syndromes Pure motor stroke Pure sensory stroke Sensorimotor stroke Ataxic hemiparesis Clumsy hand-dysarthria

21 Anterior Circulation Stroke MCA and/or ACA Occlusion of the ICA can result in ischemia in both MCA and ACA territory simultaneously

22 Middle cerebral artery About two-thirds of all ischemic stroke occurs in the middle cerebral artery territory MCA stroke can involve the frontal, temporal, and parietal lobes MCA stroke can also involve the basal ganglia through the lenticulostriate arteries

23 The MCA covers a large territory shown in blue on this CT scan image taken at the basal ganglionic level

24 MCA covers a large portion of the hemisphere

25 MCA stroke syndromes Left hemisphere (ie, dominant) Right hemiparesis Right-sided sensory loss Right homonymous hemianopia Dysarthria Aphasia Right hemisphere (ie, nondominant) Left hemiparesis Left-sided sensory loss Left homonymous hemianopia Dysarthria Neglect of the left side of environment

26 Anterior cerebral artery

27 ACA covers the medial portion of the brain

28 ACA stroke syndrome Contralateral leg paresis > arm paresis Or, bilateral leg weakness if both ACAs are involved Abulia, disinhibition, executive dysfunction In some cases, akinetic mutism if bilateral caudate head infarction

29 Posterior Circulation This includes: Vertebral arteries Posterior and anterior inferior cerebellar artery Basilar artery posterior inferior cerebellar artery

30 Left PCA infarction on CT Medial temporal lobe infarct Medial occipital lobe infarct This is a thrombus in the left PCA

31 PCA stroke syndromes The most common syndromes involve the occipital lobe, the medial temporal lobe or the thalamus Occipital lobe: Contralateral homonymous hemianopia Cortical blindness (bilateral lesions) Medial temporal lobe: Deficits in long-term and short-term memory Behaviour alteration (agitation, anger, paranoia)

32 PCA stroke syndromes, cont d Thalamic infarct Contralateral sensory loss Aphasia (if dominant side involvement) Executive dysfunction Decreased level of consciousness Memory impairment

33 Brainstem stroke syndromes Some of the clinical features seen are: Crossed sensory findings (e.g. ipsilateral face and contralateral body numbness) Crossed motor findings (ipsilateral face, contralateral body) Gaze-evoked nystagmus

34 Other findings in brainstem stroke Ataxia and vertigo, limb dysmetria Diplopia and eye movement abnormalities Dysarthria, dysphagia Tongue deviation Deafness (very rare) Locked-in syndrome (can t move any limb, can t speak, can sometimes blink

35 Ipsilateral 3 rd nerve palsy Midbrain stroke Contralateral hemiparesis of the arm and leg, sometimes with hemiplegia of the face Contralateral hemiataxia

36 Ipsilateral signs: Horner s syndrome 6 th or 7 th nerve palsy (diplopia, whole side of face is weak) Hearing loss (rare) Loss of pain and temperature sense Contralateral signs: Weakness in leg and arm Loss of sensation in arm and leg Nystagmus, nausea Pontine stroke

37 Medullary stroke Ipsilateral signs: Tongue weakness Sensory loss in face Horner s syndrome Ataxia Palate weakness (dysphagia) Contralateral signs: Weakness, sensory loss in arm and leg Nausea, nystagmus, dysphagia, dysarthria Medullary infarct on diffusion-weighted imaging

38 Cerebellar stroke Ataxia, vertigo, nausea, vomiting, dysarthria Often headache and nystagmus Can also have rapid deterioration in level of consciousness

39 Cerebellar infarction Infarction causes edema resulting in mass effect, herniation and compression of the fourth ventricle This can lead to rapid deterioration in level of consciousness Surgical decompression is often necessary in these circumstances

40 Lacunar stroke syndromes Pure motor stroke usually arises from infarction in the posterior limb of the internal capsule; course is often stuttering over hours to days: Pure sensory stroke usually arises from thalamic infarction

41 Lacunar stroke syndromes Sensorimotor stroke can arise from infarcts at the junction between the thalamus and the internal capsule As the name implies, the symptoms consist of weakness and sensory loss with no visual field deficit, aphasia, neglect or other symptoms

42 Lacunar stroke syndromes Ataxic hemiparesis often arises from infarction in the corona radiata Ataxia is unilateral and is in excess of the mild weakness found on exam

43 Lacunar stroke syndromes Clumsy hand-dysarthria is caused by infarction in the pons, but can also occur in corona radiata and the internal capsule Contralateral facial weakness with dysarthria and dysphagia occurs with contralateral hand weakness/ataxia, and sometimes weakness in the arm or leg

44 Summary MCA stroke: hemiparesis, sensory loss, hemianopia, and either aphasia or neglect ACA stroke: leg weakness and executive dysfunction PCA stroke: hemianopia, pure sensory infarct (thalamus), memory impairment, decreased level of consciousness Brainstem strokes: crossed sensory or motor findings, nystagmus, ataxia, dysarthria, diplopia, vertigo, Horner s syndrome Cerebellar strokes: ataxia, nystagmus, vertigo, nausea, headache and rapid deterioration in consciousness Lacunar strokes: pure motor, pure sensory, sensorimotor, ataxic hemiparesis, clumsy hand-dysarthria

45 3. How to read a CT scan

46 We will learn the following: Recognize basic anatomical structures on a plain CT head Recognize acute thrombus in the MCA Recognize acute ischemic stroke Recognize acute intracranial hemorrhage

47 Reading a plain CT head Know the following levels on an axial CT: Medulla, Cerebellum, and Vertebral Arteries Pons, and Basilar Artery Midbrain, and Proximal Middle Cerebral Arteries Basal ganglia and Insula Corona radiata Centrum semiovale

48 Medulla Reading a plain CT head It helps to know where you are in the brain when scrolling through a plain CT head: Medulla and Cerebellum Pons Midbrain Basal ganglia Corona radiata Centrum semiovale Cerebellum Left vertebral artery

49 Pons Basilar artery

50 Midbrain Middle cerebral artery

51 Basal ganglia: Caudate and Lentiform Nuclei Insula Thalamus

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53 Corona radiata

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55 Centrum semiovale Central sulcus

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57 Recognize acute thrombus As you review the following slides, recall that the Midbrain level is where you see the proximal MCA (and distal ICA)

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63 Detecting early cerebral ischemia on CT scan Loss of grey-white differentiation You may have to adjust the brightness and contrast (the window width and window level ) Loss of sulci Use the same system every time you look at a CT for possible acute stroke For example, the Alberta Stroke Program Early CT Score (ASPECTS)

64 Alberta Stroke Program Early CT Score M1 M4 C I L IC M2 M5 M3 M6 C = caudate, L = lentiform, I = insula, IC = internal capsule M1, M2, M3 = anterior, lateral, posterior MCA territory; M4 to M6 are above the lentiform nuclei

65 Right hemiparesis and aphasia: Where is the infarct?

66 Can you see the infarct using ASPECTS? I M2 M5

67 Case 77 year old female with left hemiparesis, left homonymous hemianopia, left side sensory loss

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103 Intracranial Hemorrhage

104 Subarachnoid hemorrhage, acute

105 Lobar hemorrhage, acute

106 Intraventricular hemorrhage, acute

107 Epidural hemorrhage, acute

108 Subdural hematoma, acute

109 Subdural hematoma, chronic

110 Subdural hemorrhage, acute on chronic

111 End of Part 1 of Stroke School

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