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1 Index Note: Page numbers of article titles are in boldface type. A Acute ischemic stroke TOAST classification of, 270 Acute myocardial infarction (AMI) cardioembolic stroke following, noncardioembolic strokes following, 208 Aegis system in stroke prevention, 348 AF. See Atrial fibrillation (AF) Age prevention, 321 AHREs. See Atrial high-rate events (AHREs) AMI. See Acute myocardial infarction (AMI) Amplatzer cardiac plug in stroke prevention, Anticoagulation AF and stroke related to recent observations on, (See also Atrial fibrillation (AF), stroke and; Oral anticoagulation (OAC) therapy) in patients with heart failure AF, guidelines for, novel oral methods, 221 in sinus rhythm, periprocedural AF related catheter ablation and, Arteriovenous malformations (AVMs) pulmonary, (See also Pulmonary arteriovenous malformations (PAVMs)) ASDs. See Atrial septal defects (ASDs) Atrial fibrillation (AF) ablation for stroke risk associated with, (See also Catheter ablation, AF related) AHREs and, anticoagulation in patients with heart failure in, cognitive decline related to, described, discussion, introduction, 279 mechanisms underlying, brain morphometric changes, 283 changes in brain perfusion, hypercoagulable states and brain infarcts, Cardiol Clin 34 (2016) /16/$ see front matter Ó 2016 Elsevier Inc. All rights reserved. proinflammatory state, 282 in cryptogenic stroke cardiac monitoring for, (See also Cryptogenic stroke, AF in, cardiac monitoring for) described, 255, device-detected, (See also Atrial high-rate events (AHREs)) introduction, epidemiology of, following MI, introduction, , , 317 prevalence of, 299, 317 stroke and, 300 anticoagulation observations related to, (See also Oral anticoagulation (OAC) therapy) current clinical guidelines, from trials to real-world clinical practice, 323 epidemiology of, ischemic stroke subtypes, prevention of OAC with VKAs in, 317 treatment of stroke prevention in, Atrial high-rate events (AHREs) AF and, CIEDs with atrial lead in detection of, unanswered questions related to, 304 thromboembolism and, Atrial septal defects (ASDs) background of, cardioembolic strokes related to, background of, causes of, epidemiology of, 226 management of, closure in, medical, 229 presentation of, described, 225 incidence of, 225 presentation of, B Biventricular hearts paradoxical emboli related to, cardiology.theclinics.com

2 354 Index Brain infarctions hypercoagulable states and AF and cognitive decline related to, Brain morphometric changes AF and cognitive decline related to, 283 Brain perfusion changes AF and cognitive decline related to, C Cardiac implantable electronic devices (CIEDs) with atrial lead in AHREs detection (See Atrial fibrillation (AF); Atrial high-rate events (AHREs)) Cardiac monitoring for AF in cryptogenic stroke, (See also Cryptogenic stroke, AF in, cardiac monitoring for) Cardioembolic stroke(s) abnormalities associated with, 270 ASDs and, (See also Atrial septal defects (ASDs)) following MI, AF, introduction, left ventricular thrombus formation, imaging appearance of, Cardiomyopathy(ies) embolic stroke in, (See also Embolic stroke(s), in cardiomyopathy) Catheter ablation AF related cerebrovascular complications of, silent cerebral ischemia, stroke, 308 TIAs, 308 introduction, periprocedural anticoagulation in, stroke risk associated with, ablation energy source and, 312 ablation protocol and periprocedural cardioversion and, patient characteristics and, sheaths and catheters and, 312 Cerebral ischemia silent AF related ablation and, mechanisms of, Chronic kidney disease (CKD) prevention, CIEDs. See Cardiac implantable electronic devices (CIEDs) CKD. See Chronic kidney disease (CKD) Cognitive decline AF and, (See also Atrial fibrillation (AF), cognitive decline related to) Congenital malformations paradoxical emboli related to, (See also Paradoxical embolism, congenital malformations leading to) Coronary disease prevention, 322 Cryptogenic stroke AF in cardiac monitoring for, cost-effectiveness of, 295 future implications for, 295 holter monitoring, inpatient monitoring, 288 MCOT, 290 meta-analyses of monitoring techniques, observational studies of external monitors, observational studies of insertable cardiac monitors, outpatient event monitoring, randomized controlled trials comparing external monitoring strategies, randomized controlled trials of insertable cardiac monitors vs. external monitors, causes of, PFO and, management of, CRYSTAL AF, D Ductus venosus 249 E Embolic stroke(s) imaging modalities in, 273 management of emergency, in cardiomyopathy, anticoagulation in patients with heart failure in AF, anticoagulation in patients with heart failure in sinus rhythm, introduction, 215 novel oral anticoagulation in heart failure, 221 clinical presentation of, 270 radiological portrait of, introduction,

3 Index 355 Embolism(i) paradoxical congenital malformations leading to, (See also Paradoxical embolism, congenital malformations leading to) Ethnicity prevention, G Gender prevention, 320 H Heart(s) biventricular paradoxical emboli related to, univentricular paradoxical emboli related to, Heart failure in AF anticoagulation in patients with, anticoagulation in guidelines for, in sinus rhythm anticoagulation in patients with, stroke in Holter monitoring for AF in cryptogenic stroke, Hypercoagulable states brain infarcts and AF and cognitive decline related to, I Inferior vena cava draining to left atrium Ischemic stroke(s) TOAST classification of, 270 prevalence of, 317 epidemiology of AF related to, Isolated systemic venous abnormalities 249 L LARIAT procedure in stroke prevention, Left atrial appendage anatomy and physiology of, 330 function of, 330 Left atrial appendage closure in stroke prevention, introduction, surgical approach to, Aegis system in, 348 Amplatzer cardiac plug in, devices not yet tested in humans, endocardial suture closure in, 332 epicardial clip closure in, hybrid epicardial-endocardial approach, LARIAT procedure in, percutaneous approach, 333 PLAATO in, 339 stapler occlusion in, 332 trans-catheter patch in, WATCHMAN device implantation in, Wavecrest occluder device in, Left ventricular thrombus formation following MI, M MCOT. See Mobile cardiac outpatient telemetry (MCOT) Mobile cardiac outpatient telemetry (MCOT) for AF in cryptogenic stroke, 290 Myocardial infarction (MI) cardioembolic stroke following, noncardioembolic stroke following, 208 cardioembolic stroke following, (See also Cardioembolic stroke, following MI) N Noncardioembolic strokes following AMI, 208 O OAC therapy. See Oral anticoagulation (OAC) therapy Oral anticoagulation (OAC) therapy in AF related stroke prevention recent observations on, age, 321 CKD, coronary and peripheral vascular disease, 322 ethnicity, gender, 320 perioperative management,

4 356 Index Oral (continued) VKAs with in AF related stroke prevention, 317 Outpatient event monitoring for AF in cryptogenic stroke, P Paradoxical embolism congenital malformations leading to, biventricular hearts, introduction, isolated systemic venous abnormalities, univentricular hearts, Patent foramen ovale (PFO), cryptogenic stroke and, management of, introduction, 231 management of, medical therapy in, 233 ongoing studies in, 238 percutaneous therapy in, 234 randomized trials in evidence for, limitations of, surgical therapy in, recurrent stroke and, PAVMs. See Pulmonary arteriovenous malformations (PAVMs) Percutaneous left atrial appendage transcatheter occlusion (PLAATO) in stroke prevention, 339 Peripheral vascular disease prevention, 322 Persistent left superior vena cava PFO. See Patent foramen ovale (PFO) PLAATO. See Percutaneous left atrial appendage transcatheter occlusion (PLAATO) Proinflammatory state AF and cognitive decline related to, 282 Pulmonary arteriovenous malformations (PAVMs), clinical findings, described, 241 diagnosis of, incidence of, 241 introduction, 241 stroke risk related to, treatment of, R Recurrent stroke PFO and, Right superior vena cava draining to left atrium S Silent cerebral ischemia AF related ablation and, mechanisms of, Sinus rhythm heart failure in anticoagulation in patients with, Stroke(s) imaging modalities in, 273 AF and, 300 anticoagulation observations related to, (See also Atrial fibrillation (AF), stroke and; Oral anticoagulation (OAC) therapy) epidemiology of, (See also Atrial fibrillation (AF), stroke and) AF related ablation and, (See also Catheter ablation, AF related) ASDs and causes of, epidemiology of, 226 cardioembolic (See Cardioembolic stroke(s)) causes of, costs related to, 287 cryptogenic (See Cryptogenic stroke) disabilities related to, 287 embolic (See Embolic stroke(s)) epidemiology of, 257 in heart failure ischemic (See Ischemic stroke(s)) noncardioembolic following AMI, 208 PAVMs and, (See also Pulmonary arteriovenous malformations (PAVMs)) prevalence of, 269, 287 prevention of left atrial appendage closure in, (See also Left atrial appendage closure, in stroke prevention) recurrent PFO and, TOAST classification for, 270, 287 types of, T Thromboembolism AHREs and, TIAs. See Transient ischemic attacks (TIAs) TOAST classification, 287

5 Index 357 of ischemic stroke subtypes, 270 Trans-catheter patch in stroke prevention, Transcatheter therapy in PAVMs management, Transient ischemic attacks (TIAs) AF related ablation and, 308 U Univentricular hearts paradoxical emboli related to, V Vitamin K antagonists (VKAs) OAC therapy with in AF related stroke prevention, 317 VKAs. See Vitamin K antagonists (VKAs) W WATCHMAN device in stroke prevention, Wavecrest occluder device in stroke prevention,

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