Prevalence (%) Table S4 Prevalence of AF in women and men, age- specific Study name/country Study population Study period Age group
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1 Table S4 Prevalence of AF in and men, age- specific Study name/country Yunnan Province, China Random sample of government Guo (2015) 1 medical insurance plan Age 20 years Spain Gomez- Doblas (2014) 2 The Rotterdam Study, Netherlands Krijthe (2013) 3 China Li (2013) 4 Random sample of primary care physicians Age >40 years Invited residents of Rotterdam Age 55 years ICD- 9 codes and AF on ECG or Holter during hospitalization. AF 471,446 total diagnosed on outpatient visits or atrial flutter was excluded NS Single ECG or clinical history of nonpermanent AF 8,343 total (52.4% ) Total Prevalence on AF on a single ECG during at 1 January ,109 Random sample 2004 of residents in 10 regions 19,363 total Age 35 years > Total baseline and follow- up confirmed by two independent cardiologists Urban Rural Total Urban Rural Total Medical history or ECG evidence < *Total
2 Germany Wilke (2013) 5 Germany Schnabel (2012) 6 Recipients of 2008 < Presence of 2 outpatient ICD- 10 German statutory codes for AF health insurance 8,298,896 total funds > Total Random sample History of AF diagnosis by a of the residents physician and/or AF on ECGs of Mainz- Bingen 5,000 total Total confirmed by cardiologists Age years
3 Sweden Andersson (2012) 7 USA Prineas (2012) 8 Iceland Stefansdottir (2011) 9 Portugal Bonhorst (2010) 10 All residents of Northern Hälsingland Random sample of US residents Age 45 years All residents of Reykjavik Age years , ,150 Sample size NS Random sample 2009 of various regions Age 40 years 10,447 total (55% ) AF on ECG or Holter monitor confirmed by a general practitioner, an internist, or a cardiologist All White Black White Black AF on ECG confirmed by two < independent trained physician electrocardiographers ICD- 9 codes for AF for inpatient, outpatient, and emergency care settings *All AF on ECGs confirmed by two independent cardiologists All
4 Switzerland Schmutz (2010) 11 Sweden Smith (2010) 12 Northern Italy Bilato (2009) 13 Invited follow- up on previously randomly sampled population from Geneva Age 50 years Invited all residents of Malmo Age years Random sample of residents Age >65 years ,285 total ,323 Recruitment: Mean follow- up: 4 years AF on a single 6- lead ECG *All ICD- 8, ICD- 9, and ICD- 10 codes for AF in the Swedish Hospital Discharge Register and the Swedish Cause of Death Register All Single ECG confirmed by three independent cardiologists > *All Japan Inoue (2009) 14 Health examinations of community residents and employees Age 40 years ,138 total (53% ) AF on a single ECG at the time of exam Total
5 Japan Iguchi (2008) 15 China Zhou (2008) 16 Singapore Yap (2008) 17 Rotterdam Study, Netherlands Heeringa (2006) 18 All residents of Kurashiki city Age 40 years Cluster sampling from 14 cohorts from 13 provinces Invited all residents of Southeast region Age 55 years Invited residents of Rotterdam Age 55 years NS , All NS AF on a single ECG confirmed by two physicians; previous medical 29,079 total records documenting AF *All *0.63 *0.66 NS 55 *0.6 *2.6 AF on a single ECG at the time of exam 1,839 total AF on a single ECG during the examination or during hospitalization or outpatient visits All
6 Scotland Murphy (2007) 19 Korea Jeong (2005) 20 Japan Ohsawa (2005) primary care practices ,759 Residents of 2000 Gyeongsang- nam province 7,967 Age 40 years National survey Total: based on a 10,897 (1980) random sample 8,926 (1990) of the population 7,298 (2000) Age 30 years < Read codes for AF All AF on a single ECG during general health screening All ECG Mean prevalence over three surveys for 30 years
7 UK Lusignan (2004) 22 USA Go (2001) 23 4 th National Morbidity Survey, UK Caroll (2001) 24 Eight general practices Age 25 years Recipients of Kaiser Permanente of Northern California Age 20 years 60 general practices ,811 total million total ,493 total Read codes for AF *All < ICD- 9 codes from outpatient visits and hospital discharge, ECG database All Reads codes and ICD- 9 codes for AF All
8 UK Majeed (2001) 25 The Netherlands Langenberg (1996) 26 USA Furberg (1994) general practices 10 general practices Age 60 years Random sample of Medicare eligibility lists from four communities Age 65 years 1.4 million total Medical records All NS ECG for those with an irregular pulse total NS Both self- report (physician s diagnosis of this condition: Has a 2, doctor ever told you that you had All atrial fibrillation? If you are not sure, please answer Don t Know ) and ECG evidence or ECG evidence alone *Age- adjusted. AF, atrial fibrillation; ECG, electrocardiogram; ICD, international classification of diseases; NS, not specified.
9 References 1. Guo, Y. et al. Prevalence, incidence, and lifetime risk of atrial fibrillation in China: new insights into the global burden of atrial fibrillation. Chest 147, (2015). 2. Gomez- Doblas, J.J. et al. Prevalence of atrial fibrillation in Spain. OFRECE study results. Rev Esp Cardiol (Engl Ed) 67, (2014). 3. Krijthe, B.P. et al. Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to Eur Heart J 34, (2013). 4. Li, Y. et al. Prevalence of atrial fibrillation in China and its risk factors. Biomed Environ Sci 26, (2013). 5. Wilke, T. et al. Incidence and prevalence of atrial fibrillation: an analysis based on 8.3 million patients. Europace 15, (2013). 6. Schnabel, R.B., Wilde, S., Wild, P.S., Munzel, T. & Blankenberg, S. Atrial fibrillation: its prevalence and risk factor profile in the German general population. Dtsch Arztebl Int 109, (2012). 7. Andersson, P., Londahl, M., Abdon, N.J. & Terent, A. The prevalence of atrial fibrillation in a geographically well- defined population in northern Sweden: implications for anticoagulation prophylaxis. J Intern Med 272, (2012). 8. Prineas, R.J. et al. United States national prevalence of electrocardiographic abnormalities in black and white middle- age (45- to 64- Year) and older ( 65- Year) adults (from the Reasons for Geographic and Racial Differences in Stroke Study). Am J Cardiol 109, (2012). 9. Stefansdottir, H., Aspelund, T., Gudnason, V. & Arnar, D.O. Trends in the incidence and prevalence of atrial fibrillation in Iceland and future projections. Europace 13, (2011). 10. Bonhorst, D. et al. Prevalence of atrial fibrillation in the Portuguese population aged 40 and over: the FAMA study. Rev Port Cardiol 29, (2010). 11. Schmutz, M. et al. Low prevalence of atrial fibrillation in asymptomatic adults in Geneva, Switzerland. Europace 12, (2010). 12. Smith, J.G., Platonov, P.G., Hedblad, B., Engstrom, G. & Melander, O. Atrial fibrillation in the Malmo Diet and Cancer study: a study of occurrence, risk factors and diagnostic validity. Eur J Epidemiol 25, (2010). 13. Bilato, C. et al. Prevalence, functional impact, and mortality of atrial fibrillation in an older Italian population (from the Pro.V.A. study). Am J Cardiol 104, (2009). 14. Inoue, H. et al. Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination. Int J Cardiol 137, (2009). 15. Iguchi, Y. et al. Prevalence of atrial fibrillation in community- dwelling Japanese aged 40 years or older in Japan: analysis of 41,436 non- employee residents in Kurashiki- city. Circ J 72, (2008). 16. Zhou, Z. & Hu, D. An Epidemiological Study on the Prevalence of Atrial Fibrillation in the Chinese Population of Mainland China. J Epidemiol 18, (2008). 17. Yap, K.B., Ng, T.P. & Ong, H.Y. Low prevalence of atrial fibrillation in community- dwelling Chinese aged 55 years or older in Singapore: a population- based study. J Electrocardiol 41, 94-8 (2008). 18. Heeringa, J. et al. Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. Eur Heart J 27, (2006).
10 19. Murphy, N.F. et al. A national survey of the prevalence, incidence, primary care burden and treatment of atrial fibrillation in Scotland. Heart 93, (2007). 20. Jeong, J.H. Prevalence of and risk factors for atrial fibrillation in Korean adults older than 40 years. J Korean Med Sci 20, (2005). 21. Ohsawa, M. et al. Rapid increase in estimated number of persons with atrial fibrillation in Japan: an analysis from national surveys on cardiovascular diseases in 1980, 1990 and J Epidemiol 15, (2005). 22. de Lusignan, S. et al. Preventing stroke in people with atrial fibrillation: a cross- sectional study. J Public Health (Oxf) 27, (2005). 23. Go, A.S., Hylek, E.M., Phillips, K.A. & et al. Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: the anticoagulation and risk factors in atrial fibrillation (atria) study. JAMA 285, (2001). 24. Carroll, K. & Majeed, A. Comorbidity associated with atrial fibrillation: a general practice- based study. Br J Gen Pract 51, 884-6, (2001). 25. Majeed, A., Moser, K. & Carroll, K. Trends in the prevalence and management of atrial fibrillation in general practice in England and Wales, : analysis of data from the general practice research database. Heart 86, (2001). 26. Langenberg, M. et al. Atrial fibrillation in elderly patients: prevalence and comorbidity in general practice. BMJ 313, 1534 (1996). 27. Furberg, C.D. et al. Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). Am J Cardiol 74, (1994).
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