Jimmy Wei Hwa Tan, Surg, MD
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1 Jimmy Wei Hwa Tan, Surg, MD Director, Department of Surgery Chief, Department of Cardiovascular Surgery Tainan An-Nan Municipal Hospital, China Medical University, Taiwan
2 Disclosure I have the following potential conflicts of interest to report: No Conflict of Interest
3 Prevalence of ESRD
4 Prevalence of Hemodialysis
5 Causes of Hospitalization for new ERSD patient
6 Fistula Initiative DOQI Guidelines National Kidney Foundation sponsored Dialysis Outcomes Quality Initiative, 1997 <10% long-term (>90day) catheter usage >40% functioning AVF/dialysis unit >50% AVF of new access procedures
7 Bart Dolmatch from Dallas, Tx Professor of Radiology 30-60% of AVF remain immature after 3 months in US after AVF first initiative Aggressive preop mapping lead to more AVF creation but increased immaturation In Netherland, 10% primary AVF failure was found in surgeon with high surgical volume( >5 AVF per year), 40% in those inexperience
8 Pathophysiology
9 Sites of Stenosis or Immaturity
10 Juxtaanastomosis Stenosis 38%-64% stenosis at anstomosis or downstream 2-5cm outflow vein For forearm AVF Primary Patency : 41%-60% Assisted Primary Patency : 61%-96% Residual stenosis >50% after the first endovascular procedure impaired long term outcome, 26% surgical revision at 36 M Julie Mortamais:J Vasc Interv Radiol 2013; 24:
11 Alexander Yevlin :Clin J Am Soc Nephrol 4: , 2009 Stents for Access Stenosis
12 Role of Stent Graft (Viabahn) in AV Access Salvage stenting of VGJ which persisted recoil to balloon angioplasty with PTA > two times in three months Salvage stenting of venous outflow tract including superficial or deep vein Salvage stenting of cephalic arch Salvage stenting of central vein including subclavian v and innominate v. Primary stenting of pseudoaneurysm over AGJ or inflow artery
13 DCB for AVF : Clinical Evidence Author Katsanos Kitrou Patan Swinnen Study device IN.PACT IN.PACT IN.PACT IN.PACT Design Prospective RCT Prospective RCT Prospective Single Arm Prospective Single Arm Single/multicenter single center single center single center single center # patients Type of anastomosis AVF (14) and AVG (26) AVF AVF Lesion location Mid-arm Mid-arm Fore-arm JAS AVF ISR Fore-arm (54%) Mid-arm (46%) % of RC anastomosis 5% 2.5% 100% 100% Primary EP Primary Patency TLR free survival Primary Patency Freedom from TLR Results 6-month Target Lesion Primary Patency 70% (DCB) vs 25% (PTA) p< month Primary Patency 30% (DCB) vs. 10% (PTA) p<0.05 Median Survival 308 (DCB) vs. 161 (PTA) p< months patency: 81.8% 24-months patency : 57.8% ( SP 94.7%) Freedom from TLR: 69% (DCB) vs 19% (PTAhistorical cohort)
14 12 and 24 months TL PP D. Patene: J Vasc Access 2014
15 Case with JAS 80 y/o woman with ESRD and HTN Left arm brachiocephalic AVF done else where for 5 months Repeated AVF stenosis and occlusion First PTA done on 2015/7/31 Reocclusion on 2015/10/27
16 Plain Balloon Angioplasty 2015/7
17 Plain balloon Plus DCB ( InPact Admiral)Angioplasty
18 Plain balloon Plus DCB ( InPact Admiral)Angioplasty
19 Dont Forget to check Outflow
20 5M Echo Follow-up (PSVR <1:2)
21 60 y/o Woman, ESRD and DM JAS with radial a stenosis
22 JAS and inflow stenosis
23 Restenosis within 3M Post PTA with Plain Balloon
24 Post PTA with DCB ( InPact Admiral 6x150mm)
25 Preliminary Observation From M : F = 3:7 Failing AVF with juxtaanstomosis stenosis(8) or cephalic arch(2) were targeted Mean lesion length : 8.2 ±3.6cm Mean DCB Balloon diameter: 6.2±0.8mm Target lesion PP : 6M 100% Dialysis circuit PP: 6M 80% Dialysis circuit survival : 6M 100%
26 Conclusions From single center prospective RCT, DCB seems to provide better 6, 12 months target lesion primary patency compared to plain balloon angioplasty in treating AV access stenosis, especially in JAS and ISR At stenotic site such as JAS and cephalic arch, DCB seems to provide better PP compared to plain balloon in our limited experience
27 Tainan, Taiwan Thank You! neugine@gmail.com
28 Jimmy Wei Hwa Tan, Surg, MD Director, Department of Surgery Chief, Department of Cardiovascular Surgery Tainan An-Nan Municipal Hospital, China Medical University, Taiwan
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