Are Heart Valve Referral Centers Feasible in Latin America?

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1 Are Heart Valve Referral Centers Feasible in Latin America? Vadim Kotowicz, MD Chief of Cardiovascular Surgery Department Italian Hospital of Buenos Aires

2 Disclosure Medtronic inc. Consultanting Johnson & Johnson Advisory Board Edwards Lifesciences Corp. Consultanting STS/EACTS Latin America Cardiovascular Surgery Conference 2018

3 Aortic Valve Stenosis Treatment - Evolution Homograft 1962 Animals Cases A. Cribier Animals Cases JC. Laborde Mechanical heart valve 1962 Transcatheter Porcine valve 1965 Pericardial tissue valve st.TAVI-TF in Argentina First TA Implant (Cribier-Edwards/Edwards- SAPIEN) Webb, Lichtenstein Nov 29, st.TAVI-TA in Argentina Surgery First Antegrade Implant Alain Cribier - Abril,2002 First CoreValve PERCUTANEOUS AVR Retrograde Oct 12, 2006 Serruys, DeJaegere, Laborde First CoreValve retrograde Case Laborde, Lal, Grube Julio, 2004

4 CONCLUSION What we learned in Cartagena

5 CONCLUSION What we learned: It is feasible to have a Heart Valve referral center 1- Built a Real TEAM - Heart Team 2- Training and Proctoring 3- Patient Selection and Rejection 4- Intensive Care Training 5- Preparation, planning and conductin the procedure 6- DATA Registry

6 WHY WE FIGHT EACH OTHER? It concerns me that the most aggressive doctors may not realize the risk in what they do, They look at images and X-rays, but I don t think they understand pathophysiology. Robert F. Tranbaugh, chief of cardiac surgery at Beth Israel. It s no trivial spat involving money and ego MONEY EGO

7 Heart - Team Surgeons Cardiologists Gerontologists Interventionals Cardiologists

8 Heart - Team Surgeons TEAM Cardiologists Indication Implantantation CARE Gerontologists Interventionals Cardiologists

9 Team - Work Post operative Risk Post Operative Recovery Gate Keeper- Cardiologists and Gerontologists

10 Team - Work Post operative Risk Post Operative Recovery Gate Keeper- Cardiologists and Gerontologists MITRAL VALVE MULTIPLE VALVES

11 Patients Distribution TAVR vs. SAVR Trials Low risk STS 4 Intermediate risk STS 4-10 High risk STS >10 Extremely High risk STS > 15

12 Symptomatic AS V>4m/s AVA<1cm 2 Gradiente >40mmhg 1/3 of Patients Cardiologics Evaluation Reject Treatment Medical Therapy Surgery Indication Cardiovascular Surgeons High Risk Euroscore >15% ó STS score >10 Heart Team indication Percutaneous Implantation NO percutaneous AVR VAB VAB TAVI-TA Other Access AV Implantation or Medical Therapy Agatiello C, Rojas Matas C, Bazzino O, Grinfeld L. Algorritmo adaptado para la seleccion de pacientes para Reemplazo valvular Aortico percutaneo. Febrero 2009

13 Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: risk assessment by Katz Index of activities of daily living EuroIntervention 2014;10: IINOPERABLE SURGERY CANDIDATE «Futility»

14 IINOPERABLE SURGERY CANDIDATE «Futility» CONVENTIONAL VALVE REPLACEMENT MINI INVASIVE SURGERY RAPID DEPLOYMENT VALVE REPLACEMENT

15 SURGERY CANDIDATE CONVENTIONAL VALVE REPLACEMENT RAPID DEPLOYMENT VALVE REPLACEMENT MINI INVASIVE SURGERY

16 SURGERY CANDIDATE CONVENTIONAL VALVE REPLACEMENT RAPID DEPLOYMENT VALVE REPLACEMENT MINI INVASIVE SURGERY

17 Why We fight each other? Prosthesis: u$d Total Cost/ Proc: u$d VS Surgery total cost/proc u$d

18 Why We fight each other? BECAUSE THE NUMBERS ARE RAISING!

19 Team - Work FORMAL REPORT MEDICAL INSURANCE OPTIMIZE RESOURSES

20 OPTIMIZE RESOURSES RAPID DEPLOYMENT TAVI ACCESSIBILITY CLINIC VALVE COST MINI INVASIVE SURGERY GERIATRICS ANATOMY SURGERY ACCESSIBILITY ACCESS Bioprosthesis TAVI COST

21 Team Trainning and Proctoring Interventionals Cardiologists SURGEONS CHARLES NICOLLE HOSPITAL ROUEN UNIVERSITY HERZZENTRUM LEIPZIG ROBERT-BOSCH-KRANKENHAUS

22 AVOID MISTAKES

23 Team Training and Proctoring Case Analysis Calcium PARAVALVULAR LEAK

24 Team Training and Proctoring Case Analysis AORTIC RING CORONARY OSTIUM Pre OP CT: Annulus-LCA: 11mm Post OP CT: LCA occluded

25 Team Trainning and Proctoring

26 Training surgicals Course Heart Valve Referral Center TEAM WORK SURGERY OPTIONS Team Trainning Proctoring REGIONAL DATA TECHNOLOGY UNIVERSITIES TAVR MINI INVASIVE SURGICAL TA - TF SURGERY RAPID DEPLOYMENT TRAINING CENTER INDUSTRY 3D TECH

27 ARGENTINA SURGERY DATA: Intermediate Risk n=877 MORTALITY 5,2%

28 Registry: Argentina TAVI 2300 patients 95%TAVI-TF 5% :TA, transubclavian, etc.- AGE: 80 ± 5 Euroscore >15 STS Score>10

29 Real World : ARGENTINA (n: 2300 TAVI) Para valvular Leak % % 0 Moderate Severe Industry Data Base

30 Real World : ARGENTINA (n: 2300 TAVI) 20 Pacemaker day Mortality % % MCD 0 MORTALIDAD Industry Data Base

31 N=155 Age (yr)-mean±sd 82.6+/-5.7 Male-total % 36% BMI (Kg/m 2 )-mean±sd 27.3+/-4.8 NYHA-No/total No.% I 12.7% II 52.0% III 32.7% IV 1.8% STS %-mean±sd 5.7+/-2.3 MSCT annulus area mm2 +/-SD /-84.0 Femoral access-no.total/ (%) 64.51% Transapical access-no.total/ (%) 35.49% MACCE (30-day) 10.32% MACCE (MI/Death/Stroke/Redo/dyalisis) 22.8% Pacemaker (30 day Post TAVR) 16.1% Paravalvular Leak mild/trivial 78,08% moderate 16,2 severe 5,8% 21,92%

32 CONCLUSION What we learned: It is feasible to have a Heart Valve referral center 1- Built a Real TEAM - Heart Team 2- Training and Proctoring 3- Patient selection and rejection 4- Intensive Care training 5- Preparation, planning and conductin the procedure 6- DATA Registry

33 THANK YOU Vadim Kotowicz, MD

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