Future Perspectives of Micromesh Stents Antonio Micari MD Director Cardiovascular Units GVM Care and Research (Palermo, Italy)
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1 Future Perspectives of Micromesh Stents Antonio Micari MD Director Cardiovascular Units GVM Care and Research (Palermo, Italy)
2 Potential conflicts of interest Antonio Micari MD I have the following potential conflicts of interest to report. Consulting; Study Honoraria; Travel Expenses; Trials Involvement: Medtronic Covidien
3 CAS: the Challenge Lesions in the Carotid arteries are often anatomically and morphologically very challenging Stroke prevention by plaque coverage with a dedicated stent is mandatory. Vulnerable Plaque
4 Near Past: Carotid Stent Performances Precise NexStent Xact Stent Carotid Wallstent RX Acculink ProtégéRX Cristallo Ideale
5 Ideal stenting High scaffolding Ideal High conformability
6 Open vs closed cell design Open cell Closed cell
7 Variable scaffolding: hybrid stent Open cell Ø1.94 Closed cell Ø1.02 Open cell Ø2.00
8 Lesion specific stenting A: Braided mesh B: Laser cut tube, closed cell design C: Segmented crown, open cell desiign B A D D: Hybrid Stent C
9 Lesion specific stenting: Definition the solution How to put in practice Lesion specific stenting: Tailored procedure which consists in matching stent biomechanical characteristics to carotid lesion features Main goal: sustained anti-embolic protection
10 Evaluation of stent influence on outcomes: the role of confounding variables Neurological events Operator skill 5 Team experience Aortic arch New 4 Anatomical limitations Engagement Embolic complexity Procedure Events time Plaque EPD Stent Post-procedural Plaque Stent 1 Neuro / Imaging evaluations Procedure // Baseline 24 h 30 days
11 Analysis on 377 consecutive patients A. Cremonesi, F Castriota et al. EuroIntervention, December 2005
12 Self-evidence: poor stent scaffolding Unstable soft carotid plaque Filling defect?
13 CAS - IVUS Guided Stent protrusion disappeared after stenting in stent. Stent protrusion Courtesy Norihiko Shinozaki PRECISE mm PRECISE mm
14 Severe Left Internal Carotid Artery stenosis LEFT
15 Severe Left Internal Carotid Artery stenosis Proximal Protection\closed cell stent
16 Good angiographic result: OCT evaluation Distal not complete wall apposition
17 OCT evaluation: significant plaque prolapse LEFT Proximal not complete wall apposition Prolapse of plaque\*dissection
18 The CAS New Waves Double layer Micromesh Stent Smallest stent cell size
19 Terumo Carotid Stent Roadsaver Stent Platform Design Construction Double layer, micromesh Braided mesh Material Stent Delivery System Nitinol Guide wire compatibility 0.014" (0.36mm) Introducer sheath compatibility 5Fr. (I.D.> 0.074") Delivery system construction Rapid Exchange (RX), RX segment length 25cm 21
20 Primary Attributes Chronic Embolic Protection Double layer micromesh design Smallest stent cell size - preventing emboli release Lesion specific scaffolding Extremely high plaque coverage Superior in-vessel flexibility Excellent wall apposition 22
21 Micromesh Stent A: Micromesh Stent High scaffolding Ideal A High conformability
22 Terumo Carotid Stent Roadsaver 25
23 Terumo Carotid Stent Roadsaver 26
24 Terumo Carotid Stent Roadsaver 27
25 Terumo Carotid Stent Roadsaver
26 29
27
28 Carotid plaque EV treatment Practical considerations Technical self-evidence and scientific data suggest carotid stent design impacts CAS outcomes, especially in symptomatic patients (unstable plaque) Stents may exert intrinsic anti-embolic properties Stent scaffolding and conformability may contribute to improve procedural results, as well as to solve the problem of post-procedural events
29 CAS Personal conclusions The ideal stent does not exists at the moment! The individual treatment strategy remains by now the only logical answer for treating standard as well as complex carotid lesions and anatomies (different stents for different anatomies ) New generation of stent (micromesh) combining high scaffolding and conformability properties will give new rush to CAS
30 Thank You for your attention
31 Future Perspectives of Micromesh Stents Antonio Micari MD Director Cardiovascular Units GVM Care and Research (Palermo, Italy)
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