The Tromsø study. Biobank conference March Sameline Grimsgaard Professor Head Tromsø Study

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1 The Tromsø study Biobank conference March 2018 a Sameline Grimsgaard Professor Head Tromsø Study

2 The Tromsø study research laboratory inhabitants Photo: Hanne Knudsen/

3 The Tromsø study from 1974 Background 1970-ties cardiovascular disease (CVD) epidemic in Norway and Western countries put a substantial burden on North Norway Aim Study causes of CVD Risk factor surveillance Prevent disease Gradually expanded To cover widespread diseases as diabetes, cancer, lung -, musculoskeletal -, kidney - and eye diseases, chronic pain, osteoporosis, mental health, dental health and many others

4 The Tromsø Study 44 years Questionnaire: education, work, physical and mental health, disease, symptoms, diet, physical activity, use of medication and health care services Biological specimens: Blood, urine, saliva, stool Measurements: Height, weight, blood pressure, heart rate, waist-hip ratio Clinical examinations: Ultrasound examination of the heart, carotid artery, aorta, electrocardiogram, bone mass, muscle strength, lung function, pain sensitivity, retinal photography, dental health Year Fit futures Participants, n Year Tromsø 1 Tromsø 2 Tromsø 3 Tromsø 4 Tromsø 5 Tromsø 6 Tromsø 7 Participants, n Age, yrs yrs yrs yrs yrs yrs yrs 40+ Participation %

5 «I am thinking about the future of my children and grandchildren. As participant, I invest in health for future generations». Inger Johanne (60) has participated six times

6 Biobank Blood samples Serum and plasma - Most participants in Tromsø Stored at 70º C - > serum/plasma samples in biobank DNA - > ; stored in national CONOR biobank

7 Follow-up data on disease Mortality: total and cause-specific (Death Registry) Cancer: incidence and mortality (Cancer Registry) Tromsø Study Disease Registries Cardiovascular disease - Myocardial infarction - Atrial fibrillation - Stroke - Venous thromboembolism Diabetes Bone fractures

8 Scientific production and data access > 120 PhD s >100 ongoing research projects >60 ongoing PhD-projects All researchers can apply for data access See variable presentation:

9 The Tromsø 7 survey March 2015 November 2016 All Tromsø municipality inhabitants > 40 yrs were invited, participated (65 %) 1. Questionnaires (digital and paper) 2. Biological samples (blood, urine, stools, saliva) 3. Measurements and clinical examinations electrocardiogram, echocardiography, carotid ultrasound, pain sensitivity, retinal photography, cognitive function, body composition, bone density, dental examination, physical activity, lung function

10 Tromsø 7 Extensive data collection in > 50 projects Cardiovascular diseases Cancer Diabetes Environmental pollutants Microbial resistance (AMR) Risk factors for disease Physical activity Diet Use of medications Mental health Drug abuse Dental health Eye health Cognitive function - dementia Osteoporosis and fractures Chronic pain Sleep problems Use of health care services

11 Research focus Lasting lifestyle changes Recruit study participants Randomize Can Regular excercise in groups Dietary advice Fitness trackers and smartphones Intervention Endpoint Control Endpoint Increase physical activity and create lasting lifestyle changes among individuals who are at risk for cardiovascular disease? Does boiled coffee increase blood cholesterol? Do omega-3 fatty acids reduce blood pressure and blood lipids? Can vit. B protect against myocardial infarction? Can vit. D protect against overweight, depression and diabetes? Can lifstyle interventions change diet and physical activity? Year Tromsø 1 Tromsø 2 Tromsø 3 Tromsø 4 Tromsø 5 Tromsø 6 Tromsø 7 Participants, n Age, yrs Participation %

12 The Tromsø study - rich opportunities Rich source of epidemiological and clinical data Repeated measurements Source of comparable data Broad local, national and international research collaboration Excellence in medical research Improved public health - reduced incidence of cardiovascular disease, public health surveillance Improved patient care More than half of PhD candidates are clinicians from the university hospital

13 Thank you