C ( Hepatitis C virus ) ( Membranoproliferative glomerulonephritis ) ( Membranous nephropathy ) ( Focal segmental glomerulosclerosis )

Size: px
Start display at page:

Download "C ( Hepatitis C virus ) ( Membranoproliferative glomerulonephritis ) ( Membranous nephropathy ) ( Focal segmental glomerulosclerosis )"

Transcription

1 ( extrahepatic manifestations ) ( membranoproliferative glomerulonephritis ) ( membranous nephropathy ) ( focal segmental glomerulosclerosis ) ( immunosuppressive therapy ) ( plasma-exchange ) ( Hepatitis virus ) ( Membranoproliferative glomerulonephritis ) ( Membranous nephropathy ) ( Focal segmental glomerulosclerosis ) ( membranoproliferative glomerulonephritis ) 3 ( membranous glomerulonephritis ) 36%-40% 80%~100% B ( extrahepatic manifesta- 30%~45% 1 tions ) porphyria cutanea tarda ( SLE ) ( sicca syndrome ) 90% B 2 4% 4-6 B % 7 B 1993 Johnson RJ ;

2 Johnson RJ % ( cryoglobulinemia ) 4 ( idiopathic ) RNA 9.5kb E1 E2 P7 NS2 NS3 NS4AB NS5AB RNA RNA ( negative strand RNA ) RNA 13,14 ( complement ) rheumatoid factor ( immune complex ) ( purpura ) ( arthralgia ) ( neuropathy ) ( weakness ) ( nephrotic syndrome ) 8 ( mesangial ) ( toll-like receptor 3, TLR3 ) 15 porphyria cutanea tarda ( membranous nephropathy ) 2.7% rheumatoid factor 10 ( focal segmental glomerulosclerosis, FSGS ) HIV Sabry A 24% 6, 8 Stehman-Breen ( hypocomplementemia ) cryoglobulinemia rheumatoid factor GFR 16 Okada K ( indirect immunofluorescence ) ( HV core protein ) 17 7,18 hepatitis virus RNA hepatitis virus RNA 19 IgA nephropathy fibrillary glomerulonephritis immunotactoid glomerulopathy 8 ( Symptomatic therapy )

3 ( angiotensin converting enzyme inhibitors, AEI ) ( HV anti-viral therapy ) 1994 Misiani R ( Interferon alfa-2a ) 21 Johnson RJ ( Intron-A ) g/day g/day HV RNA 22 H u SL 23 0 mg 400 mg 600 mg Protein/reatinine ( immunosuppressive therapy) ( plasma-exchange ) yclophosphamide B-lymphocyte cryoglobulins ( steroid pulse therapy ) cryoglobulinemia cryoglobulin yclophosphamide ( remission ) 27 ALT 5X ( bilirubin 2g/dL ) ( pegylated -interferon ) ( conventional -INF ) 3 MU 3 ( pegylated -INF ) 1.5 g/kg/week mg/d ( mmol ) 24 67% ( erythropoietin ) flu-like syndrome 10 g/dl 750/mm 3 80,000/mm 3 8 g/dl 500/mm 3 25,000/mm B 15 B 9.8% % B D- (Anti-D monoclonal antibody therapy Rituximab) B-lymphocyte, 30 NS3-4A protease inhibitors ( BILN 61 ) NS5B polymerase inhibitors 31, 32

4 262 1.Brady HR, O'Meara YM, Brenner BM. Glomerular disease. In: Kasper DL, Braunwald E, Fauci AS, et al, eds Harrison's Principles of Internal Medicine. 16th ed. New York: McGraw- Hill; 05; Hsu H, Lin GH, hang MH, hen H. Association of hepatitis B surface (HBs) antigenemia and membranous nephropathy in children in Taiwan. lin Nephrol 1983; : Johnson RJ, Gretch DR, Yamabe H, et al. Membranoproliferative glomerulonephritis associated with hepatitis virus infection. N Engl J Med 1993; 328: acoub P, Renou, Rosenthal E, et al. Extrahepatic manifestations associated with hepatitis virus infection. A prospective multicenter study of 321 patients. Medicine 00; 79: Ali A, Zein NN. Hepatitis infection: a systemic disease with extrahepatic manifestations. leve lin J Med 05; 72: Sterling RK, Bralow S. Extrahepatic manifestations of hepatitis virus. urr Gastroenterol Rep 06; 8: Sabry A, E-Agroudy A, Sheashaa H, et al. HV associated glomerulopathy in Egyptian patients: clinicopathological analysis. Virology 05; 334: Meyers M, Seeff LB, Stehman-Breen O, et al. Hepatitis and renal disease: an update. Am J Kidney Dis 03; 42: Arase Y, Ikeda K, Murashima N, et al. Glomerulonephritis in autopsy cases with hepatitis virus infection. Intern Med 1998; 37: Stehman-Breen, Alpers E, ouser WG, et al. Hepatitis virus associated membranous glomerulonephritis. lin Nephrol 1995; 44: di Belgiojoso GB, Ferrario F, Landriani N. Virus-related glomerular diseases: histological and clinical aspects. J Nephrol 02; 15: Stehman-Breen, Alpers E, Fleet WP, et al. Focal segmental glomerular sclerosis among patients infected with hepatitis virus. Nephron 1999; 81: ABDE 06; 33: B 06; 33: Wornle M, Schmid H, Banas B, et al. Novel role of toll-like receptor 3 in hepatitis -associated glomerulonephritis. Am J Pathol 06; 168: Tsui JI, Vittinghoff E, Shlipak MG, O'Hare AM. Relationship between hepatitis and chronic kidney disease: results from the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol 06; 17: Okada K, Takishita Y, Shimomura H, et al. Detection of hepatitis virus core protein in the glomeruli of patients with membranous glomerulonephritis. lin Nephrol 1996; 45: Sabry AA, Sobh MA, Irving WL, et al. A comprehensive study of the association between hepatitis virus and glomerulopathy. Nephrol Dial Transplant 02; 17: Yamabe H, Nakamura N, Nakamura M, et al. Hepatitis virusassociated glomerulonephritis without hepatitis virus in the blood. Am J Kidney Dis 05; 46: e65-9..kamar N, Rostaing L, Alric L. Treatment of hepatitis -virusrelated glomerulonephritis. Kidney Int 06; 69: Misiani R, Bellavita P, Fenili D, et al. Interferon alfa-2a therapy in cryoglobulinemia associated with hepatitis virus. N Engl J Med 1994; 330: Johnson RJ, Gretch DR, ouser WG, et al. Hepatitis virus-associated glomerulonephritis. Effect of alpha-interferon therapy. Kidney Int 1994; 46: Hu SL, Jaber BL. monotherapy for hepatitis virusassociated membranous nephropathy. lin Nephrol 05; 63: Sherman M, ohen L, ooper MA, et al. linical recommendations for the use of recombinant human erythropoietin in patients with hepatitis virus being treated with ribavirin. an J Gastroenterol. 06; : Strader DB, Wright T, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis. Hepatology 04; 39: Sulkowski M. Management of the hematologic complications of hepatitis therapy. lin Liver Dis 05; 9: Kurihara I, Saito T, Nakayama K, et al. A case of hepatitis virus associated membranous glomerulonephritis ameliorated by corticosteroid therapy. Nippon Jinzo Gakkai Shi 1998; 40: Ni YH, hang MH, Huang LM, et al. Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination. Ann Intern Med 01; 135: Houghton M, Abrignani S. Prospects for a vaccine against the hepatitis virus. Nature 05; 436: Roccatello D, Baldovino S, Rossi D, et al. Long-term effects of anti-d monoclonal antibody treatment of cryoglobulinaemic glomerulonephritis. Nephrol Dial Transplant 04; 19: De Francesco R, Migliaccio G. hallenges and successes in developing new therapies for hepatitis. Nature 05; 43: Pawlotsky J. Therapy of hepatitis : from empiricism to eradication. Hepatology 06; 43: S7-.

5 263 Hepatitis Virus--Related Nephropathy hen-wang hang, heng-hsin hu, Wen-Hsiung hang, and Yi-hou hen 1 Division of Gastroenterology, 1 Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan The hepatitis virus general encroaches upon the liver and causing the liver pathological change. Liver cirrhosis and even hepatocelluar carcinoma can be seen in patient with HV infection. Except of liver, HV can involve other organ and causing many extrahepatic manifestations, nephropathy is one of the most important extrahepatic manifestations that maybe neglected. Most of the HV-related nephropathy is membranoproliferative glomerulonephritis, and membranous nephropathy, focal segmental glomerulosclerosis are also reported previously. Except of symptoms control, anti-hv therapy, immunosuppressive therapy and plasma-exchange can be used for treatment of HV related nephropathy. ( J Intern Med Taiwan 06; 17: )

considered for patients with cryoglobulinemic kidney diseases. (Weak)

considered for patients with cryoglobulinemic kidney diseases. (Weak) http://www.kidney-international.org & 2008 DIGO Guideline 5: Diagnosis and management of kidney diseases associated with HCV infection idney International (2008) 73 (Suppl 109), S69 S77; doi:10.1038/ki.2008.88

More information

Tubulointerstitial nephritis associated with hepatitis C virus infection

Tubulointerstitial nephritis associated with hepatitis C virus infection CASE REPORT Advance Access publication 25 March 2009 Tubulointerstitial nephritis associated with hepatitis C virus infection Ana Oliveira, Raquel Cabral, Susana Sampaio, Manuela Bustorff, Manuel Pestana

More information

Therapy With Interferon-α Plus Ribavirin for Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus

Therapy With Interferon-α Plus Ribavirin for Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus BJID ; 7 (October) 5 Therapy With Interferon-α Plus Ribavirin for Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus Edmundo P.A. Lopes, Lucila M. Valente, Divisions of Gastroenterology

More information

Effect of combination therapy (ribavirin and interferon) in HCV-related glomerulopathy

Effect of combination therapy (ribavirin and interferon) in HCV-related glomerulopathy Nephrol Dial Transplant (2002) 17: 1924 1930 Original Article Effect of combination therapy (ribavirin and interferon) in HCV-related glomerulopathy Alaa A. Sabry 1, Mohamed A. Sobh 1, Hussein A. Sheaashaa

More information

HCV Treat now! Robert G Gish MD. Professor Consultant Stanford University

HCV Treat now! Robert G Gish MD. Professor Consultant Stanford University HCV Treat now! Robert G Gish MD Professor Consultant Stanford University Steering committee and Executive Board NVHR National Viral Hepatitis Roundtable Founding Member CEVHAP Singapore Viral Hepatitis

More information

Intron A Hepatitis C. Intron A (interferon alfa-2b) Description

Intron A Hepatitis C. Intron A (interferon alfa-2b) Description Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.01.05 Subject: Intron A Hepatitis C Page: 1 of 5 Last Review Date: November 30, 2018 Intron A Hepatitis

More information

Journal of Nephropathology

Journal of Nephropathology www.nephropathol.com DOI:10.12860/JNP.2013.36 J Nephropathology. 2013; 2(4): 217-233 Journal of Nephropathology Hepatitis C virus infection in nephrology patients Lionel Rostaing 1,2,3,*, Jacques Izopet

More information

Glomerular Pathology- 1 Nephrotic Syndrome. Dr. Nisreen Abu Shahin

Glomerular Pathology- 1 Nephrotic Syndrome. Dr. Nisreen Abu Shahin Glomerular Pathology- 1 Nephrotic Syndrome Dr. Nisreen Abu Shahin The Nephrotic Syndrome a clinical complex resulting from glomerular disease & includes the following: (1) massive proteinuria (3.5 gm /day

More information

Prior Authorization Guideline

Prior Authorization Guideline Prior Authorization Guideline Guideline Name Olysio (simeprevir) Formulary UnitedHealthcare Community & State Formulary Note Approval Date 2/19/2014 Revision Date 7/9/2014 1. Indications Drug Name: Olysio

More information

Indications for treatment in chronic HCV infection

Indications for treatment in chronic HCV infection MODULE VI Vol. 9 Suppl.1, 2010: S49-S53 S49 Indications for treatment in chronic HCV infection Milagros Dávalos Moscol* * Jefa Unidad de Hígado. Hospital Nacional Edgardo Rebagliati Martins. EsSalud. ABSTRACT

More information

Prior Authorization Guideline

Prior Authorization Guideline Prior Authorization Guideline Guideline Name Sovaldi (sofosbuvir) Formulary UnitedHealthcare Community & State Formulary Note Approval Date 2/19/2014 Revision Date 7/8/2014 1. Indications Drug Name: Sovaldi

More information

Intron A (interferon alfa-2b) with ribavirin, (Copegus, Moderiba, Rebetol, Ribapak, Ribasphere, RibaTab, ribavirin tablets/capsules - all strengths)

Intron A (interferon alfa-2b) with ribavirin, (Copegus, Moderiba, Rebetol, Ribapak, Ribasphere, RibaTab, ribavirin tablets/capsules - all strengths) Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 Subject: Intron A Ribavirin Page: 1 of 5 Last Review Date: November 30, 2018 Intron A Ribavirin Description

More information

Pegasys Ribavirin

Pegasys Ribavirin Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.01.08 Subsection: Anti-infective Agents Original Policy Date: January 1, 2006 Subject: Pegasys Ribavirin

More information

Special Challenges and Co-Morbidities

Special Challenges and Co-Morbidities Special Challenges and Co-Morbidities Renal Disease/ Hypertension/ Diabetes in African-Americans M. Keith Rawlings, MD Medical Director Peabody Health Center AIDS Arms, Inc Dallas, TX Chair, Internal Medicine

More information

Glomerular diseases with organized deposits

Glomerular diseases with organized deposits Glomerular diseases with organized deposits Banu Sis, MD, FRCPC University of Alberta, Edmonton, AB, Canada Ulusal Patoloji Kongresi, Manavgat, Antalya 8/11/2012 What is an organized deposit? A number

More information

C1q nephropathy the Diverse Disease

C1q nephropathy the Diverse Disease C1q nephropathy the Diverse Disease Danica Galešić Ljubanović School of Medicine, University of Zagreb Dubrava University Hospital Zagreb, Croatia Definition Dominant or codominant ( 2+), mesangial staining

More information

Case Report Successful Antiviral Triple Therapy in a Longstanding Refractory Hepatitis C Virus Infection with an Acute Kidney Injury

Case Report Successful Antiviral Triple Therapy in a Longstanding Refractory Hepatitis C Virus Infection with an Acute Kidney Injury Case Reports in Nephrology, Article ID 308729, 4 pages http://dx.doi.org/10.1155/2014/308729 Case Report Successful Antiviral Triple Therapy in a Longstanding Refractory Hepatitis C Virus Infection with

More information

FIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS

FIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS FIBRILLARY GLOMERULONEPHRITIS DIAGNOSTIC CRITERIA, PITFALLS, AND DIFFERENTIAL DIAGNOSIS Guillermo A. Herrera MD Louisiana State University, Shreveport Fibrils in bundles 10-20 nm d Diabetic fibrillosis

More information

Hepatitis C Management and Treatment

Hepatitis C Management and Treatment Hepatitis C Management and Treatment Kaya Süer Near East University Faculty of Medicine Infectious Diseases and Clinical Microbiology 1 Discovery of Hepatitis C Key facts Hepatitis C: the virus can cause

More information

Assessing the patient with a new diagnosis of Hepatitis C LAUREN MYERS MMSC, PA-C OREGON HEALTH & SCIENCE UNIVERSITY

Assessing the patient with a new diagnosis of Hepatitis C LAUREN MYERS MMSC, PA-C OREGON HEALTH & SCIENCE UNIVERSITY Assessing the patient with a new diagnosis of Hepatitis C LAUREN MYERS MMSC, PA-C OREGON HEALTH & SCIENCE UNIVERSITY Disclosures Nothing to Disclose Assessing the patient with a new diagnosis of Hepatitis

More information

Intron A (interferon alfa-2b) with ribavirin, (Moderiba, Rebetol, Ribasphere, RibaTab, ribavirin tablets/capsules - all strengths)

Intron A (interferon alfa-2b) with ribavirin, (Moderiba, Rebetol, Ribasphere, RibaTab, ribavirin tablets/capsules - all strengths) Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.01.06 Subject: Intron A Ribavirin Page: 1 of 6 Last Review Date: March 18, 2016 Intron A Ribavirin Description

More information

Monoclonal Gammopathies and the Kidney. Tibor Nádasdy, MD The Ohio State University, Columbus, OH

Monoclonal Gammopathies and the Kidney. Tibor Nádasdy, MD The Ohio State University, Columbus, OH Monoclonal Gammopathies and the Kidney Tibor Nádasdy, MD The Ohio State University, Columbus, OH Monoclonal gammopathy of renal significance (MGRS) Biopsies at OSU (n=475) between 2007 and 2016 AL or AH

More information

Secondary IgA Nephropathy & HSP

Secondary IgA Nephropathy & HSP Secondary IgA Nephropathy & HSP Anjali Gupta, MD 1/11/11 AKI sec to Hematuria? 65 cases of ARF after an episode of macroscopic hematuria have been reported in the literature in patients with GN. The main

More information

This is an AbbVie sponsored educational webinar which is being presented

This is an AbbVie sponsored educational webinar which is being presented Presented by Joseph Lim, MD April 5 th, 2017 AbbVie disclosures This is an AbbVie sponsored educational webinar which is being presented by Joseph Lim, MD, on behalf of AbbVie The purpose of the medical

More information

RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT. J. H. Helderman,MD,FACP,FAST

RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT. J. H. Helderman,MD,FACP,FAST RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT J. H. Helderman,MD,FACP,FAST Vanderbilt University Medical Center Professor of Medicine, Pathology and Immunology Medical Director, Vanderbilt Transplant

More information

Treatment of Hepatitis C and Renal Disease

Treatment of Hepatitis C and Renal Disease Treatment of Hepatitis C and Renal Disease David E. Bernstein, MD, FACG Vice Chair of Medicine for Clinical Trials Chief, Division of Hepatology and Director, Sandra Atlas Bass Center for Liver Diseases

More information

SECONDARY GLOMERULONEPHRITIDES

SECONDARY GLOMERULONEPHRITIDES SECONDARY GLOMERULONEPHRITIDES This review of the secondary glomerulonephritides outlines presentation clues to assist the primary healthcare worker in making the diagnosis. Glomerulonephritis (GN) due

More information

Current Standard of Care for Naïve HCV Patients (SVR)

Current Standard of Care for Naïve HCV Patients (SVR) Hepatitis C: Non-responders Nikunj Shah, MD Associate Professor of medicine University of Illinois Medical center 1 Current Standard of Care for Naïve HCV Patients (SVR) 1 8 8 6 53 45 4 6 52 46 4 2 2 Peg

More information

Epidemiological survey of oral lichen planus among HCV-infected inhabitants in a town in Hiroshima Prefecture in Japan from 2000 to 2003

Epidemiological survey of oral lichen planus among HCV-infected inhabitants in a town in Hiroshima Prefecture in Japan from 2000 to 2003 ONCOLOGY REPORTS 18: 1177-1181, 2007 Epidemiological survey of oral lichen planus among HCV-infected inhabitants in a town in Hiroshima Prefecture in Japan from 2000 to 2003 YUMIKO NAGAO 1, YOSHINARI MYOKEN

More information

Hepatitis C in Dr. Michael Bays D.O.

Hepatitis C in Dr. Michael Bays D.O. Hepatitis C in 2015 Dr. Michael Bays D.O. HCV Virology Member of the Flavivirus family (Yellow Fever, Dengue) Hepacivirus genus Enveloped, positive, singlestranded RNA virus 9.6 Kb genome encodes a single

More information

Disclosures. Viral Nephritides Including HIV and Hepatitis. Objectives HIV 7/20/2015. Advisory board

Disclosures. Viral Nephritides Including HIV and Hepatitis. Objectives HIV 7/20/2015. Advisory board Disclosures Viral Nephritides Including HIV and Hepatitis Advisory board Merck Jai Radhakrishnan, MD, MS Professor of Medicine at Columbia University Medical Center Objectives Epidemiology, pathogenesis,

More information

Case report Telaprevir in a patient with chronic hepatitis C and cryoglobulinemic glomerulonephritis

Case report Telaprevir in a patient with chronic hepatitis C and cryoglobulinemic glomerulonephritis Antiviral Therapy 04; 9:57 5 (doi:.85/imp684) Case report Telaprevir in a patient with chronic hepatitis C and cryoglobulinemic glomerulonephritis Stella De Nicola, Alessio Aghemo *, Maria Rosaria Campise,

More information

Steroid Resistant Nephrotic Syndrome. Sanjeev Gulati, Debashish Sengupta, Raj K. Sharma, Ajay Sharma, Ramesh K. Gupta*, Uttam Singh** and Amit Gupta

Steroid Resistant Nephrotic Syndrome. Sanjeev Gulati, Debashish Sengupta, Raj K. Sharma, Ajay Sharma, Ramesh K. Gupta*, Uttam Singh** and Amit Gupta Steroid Resistant Nephrotic Syndrome Sanjeev Gulati, Debashish Sengupta, Raj K. Sharma, Ajay Sharma, Ramesh K. Gupta*, Uttam Singh** and Amit Gupta From the Departments of Nephrology, Pathology* and Biostatistics**,

More information

Dense deposit disease with steroid pulse therapy

Dense deposit disease with steroid pulse therapy Case Report Dense deposit disease with steroid pulse therapy Jun Odaka, Takahiro Kanai, Takane Ito, Takashi Saito, Jun Aoyagi, and Mariko Y Momoi Abstract Treatment of dense deposit disease DDD has not

More information

Infergen Monotherapy. Infergen (interferon alfacon-1) Description

Infergen Monotherapy. Infergen (interferon alfacon-1) Description Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.03.03 Subject: Infergen Monotherapy Page: 1 of 7 Last Review Date: March 13, 2014 Infergen Monotherapy

More information

Clinical Outcomes of Renal Transplantation in Hepatitis C Virus Positive Recipients

Clinical Outcomes of Renal Transplantation in Hepatitis C Virus Positive Recipients Original Research Article Clinical Outcomes of Renal Transplantation in Hepatitis C Virus Positive Recipients Surendran Sujit 1*, N. Gopalakrishnan 2 1 Assistant Professor, 2 Professor and Head Department

More information

Hepatitis C Virus Infection, Mixed Cryoglobulinemia, and Kidney Disease

Hepatitis C Virus Infection, Mixed Cryoglobulinemia, and Kidney Disease In Practice Hepatitis C Virus Infection, Mixed Cryoglobulinemia, and Kidney Disease Fabrizio Fabrizi, MD, 1 Emmanuelle Plaisier, MD, 2 David Saadoun, MD, 3 Paul Martin, MD, 4 Piergiorgio Messa, MD, 1 and

More information

Renal Pathology 1: Glomerulus. With many thanks to Elizabeth Angus PhD for EM photographs

Renal Pathology 1: Glomerulus. With many thanks to Elizabeth Angus PhD for EM photographs Renal Pathology 1: Glomerulus With many thanks to Elizabeth Angus PhD for EM photographs Anatomy of the Kidney http://www.yalemedicalgroup.org/stw/page.asp?pageid=stw028980 The Nephron http://www.beltina.org/health-dictionary/nephron-function-kidney-definition.html

More information

Pegasys Pegintron Ribavirin

Pegasys Pegintron Ribavirin Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.01.47 Subsection: Anti-infective nts Original Policy Date: January 1, 2019 Subject: Pegasys Pegintron

More information

The CARI Guidelines Caring for Australasians with Renal Impairment

The CARI Guidelines Caring for Australasians with Renal Impairment Specific management of IgA nephropathy: role of triple therapy and cytotoxic therapy Date written: July 2005 Final submission: September 2005 Author: Merlin Thomas GUIDELINES a. Triple therapy with cyclophosphamide,

More information

PATTERNS OF RENAL INJURY

PATTERNS OF RENAL INJURY PATTERNS OF RENAL INJURY Normal glomerulus podocyte Glomerular capillaries electron micrograph THE CLINICAL SYNDROMES 1. The Nephrotic Syndrome 2. The Acute Nephritic Syndrome 3. Rapidly Progressive Glomerulonephritis

More information

Is prioritization the best way to treat hepatitis C? Vicente Soriano Infectious Diseases Unit La Paz University Hospital Madrid, Spain

Is prioritization the best way to treat hepatitis C? Vicente Soriano Infectious Diseases Unit La Paz University Hospital Madrid, Spain Is prioritization the best way to treat hepatitis C? Vicente Soriano Infectious Diseases Unit La Paz University Hospital Madrid, Spain Disclosures Advisory boards and speaker s bureau for: Gilead, Merck,

More information

Department of Internal Medicine, Pordenone General Hospital, Italy; 2

Department of Internal Medicine, Pordenone General Hospital, Italy; 2 Le Infezioni in Medicina, n. 4, 337-341, Caso clinico Case reports Recombinant Human Erythropoietin (RHuEpo) and Granular Colony Stimulating Factor (G-CSF) in hepatitis C virus (HCV) related to mixed cryoglobulinaemia

More information

Proteinuria After Kidney Transplantation Its Relation to Hepatitis C Virus and Graft Outcome

Proteinuria After Kidney Transplantation Its Relation to Hepatitis C Virus and Graft Outcome transplantation Proteinuria After Kidney Transplantation Its Relation to Hepatitis C Virus and Graft Outcome Alaa Sabry, 1 Rashad Hassan, 1 Ihab Mahmoud, 1 Magdy Hamed, 2 Mohamed Sobh 1 Original Paper

More information

Dr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust

Dr Ian Roberts Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust Dr Ian Roberts Oxford Oxford Pathology Course 2010 for FRCPath Present the basic diagnostic features of the commonest conditions causing proteinuria & haematuria Highlight diagnostic pitfalls Nephrotic

More information

Hepatits C Criteria Direct Acting Antiviral Medications

Hepatits C Criteria Direct Acting Antiviral Medications Hepatits C Criteria Direct Acting Antiviral Medications Harvoni-Formulary PA required 1. Is the patient being treated for a funded condition by the Oregon Health Plan? 2. Does the member have a diagnosis

More information

Chronic Active Hepatitis B with HBV- Associated Nephropathy: Close Resemblance to Lupus Nephritis

Chronic Active Hepatitis B with HBV- Associated Nephropathy: Close Resemblance to Lupus Nephritis Chronic Active Hepatitis B with HBV- Associated Nephropathy: Close Resemblance to Lupus Nephritis Amitesh Aggarwal a, Mukul P. Agarwal a, Surendra Rajpal a, Vineeta V. Batra b, Ankit Kumar Sahu a a Department

More information

Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome

Use of mycophenolate mofetil in steroid-dependent and -resistant nephrotic syndrome Pediatr Nephrol (2003) 18:833 837 DOI 10.1007/s00467-003-1175-4 BRIEF REPORT Gina-Marie Barletta William E. Smoyer Timothy E. Bunchman Joseph T. Flynn David B. Kershaw Use of mycophenolate mofetil in steroid-dependent

More information

Case Presentation Turki Al-Hussain, MD

Case Presentation Turki Al-Hussain, MD Case Presentation Turki Al-Hussain, MD Director, Renal Pathology Chapter Saudi Society of Nephrology & Transplantation Consultant Nephropathologist & Urological Pathologist Department of Pathology & Laboratory

More information

Navigating The Prior Authorization Approval Process. Kristin Webb, RPCA University at Buffalo

Navigating The Prior Authorization Approval Process. Kristin Webb, RPCA University at Buffalo Navigating The Prior Authorization Approval Process Kristin Webb, RPCA University at Buffalo Disclosures DISCLOSURES Commercial Entity Relevance Role K. Webb Abbvie Merck, AbbVie, Tobira, Gilead Honorarium

More information

Navigating The Prior Authorization Approval Process

Navigating The Prior Authorization Approval Process Navigating The Prior Authorization Approval Process Kristin Webb, RPCA University at Buffalo Disclosures DISCLOSURES Commercial Entity Relevance Role K. Webb Abbvie Merck, AbbVie, Tobira, Gilead Honorarium

More information

Treatment Aspects of Primary Nephrotic Syndrome in Adults

Treatment Aspects of Primary Nephrotic Syndrome in Adults & Treatment Aspects of Primary Nephrotic Syndrome in Adults Senija Rašić*¹, Snježana Unčanin¹, Jasminka Džemidžić¹, Kenana Aganović¹, Amira Srna¹, Ismar Rašić² 1. Institute for Nephrology, Clinical Centre

More information

Hepatitis C Virus Clinical Criteria Update September 18, For: New York State Medicaid

Hepatitis C Virus Clinical Criteria Update September 18, For: New York State Medicaid Hepatitis C Virus Clinical Criteria Update September 18, 2014 For: New York State Medicaid 1 Purpose Characterize the place in therapy for the agents utilized for management of chronic hepatitis C (CHC)

More information

NON-HEPATIC COMPLICATIONS OF HCV. Kenneth E. Sherman, MD, PhD Gould Professor of Medicine University of Cincinnati College of Medicine

NON-HEPATIC COMPLICATIONS OF HCV. Kenneth E. Sherman, MD, PhD Gould Professor of Medicine University of Cincinnati College of Medicine NON-HEPATIC COMPLICATIONS OF HCV Kenneth E. Sherman, MD, PhD Gould Professor of Medicine University of Cincinnati College of Medicine DISCLOSURES RESEARCH GRANTS/CONTRACTS (to Institution) AbbVie Gilead

More information

The CARI Guidelines Caring for Australasians with Renal Impairment. Idiopathic membranous nephropathy: use of other therapies GUIDELINES

The CARI Guidelines Caring for Australasians with Renal Impairment. Idiopathic membranous nephropathy: use of other therapies GUIDELINES Idiopathic membranous nephropathy: use of other therapies Date written: July 2005 Final submission: September 2005 Author: Merlin Thomas GUIDELINES No recommendations possible based on Level I or II evidence

More information

Infergen (interferon alfacon-1) with Ribavirin (Copegus, Rebetol, RibaPak, Ribasphere, RibaTab, ribavirin tablets/capsules - all strengths)

Infergen (interferon alfacon-1) with Ribavirin (Copegus, Rebetol, RibaPak, Ribasphere, RibaTab, ribavirin tablets/capsules - all strengths) Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.03.04 Subject: Infergen with Ribavirin Page: 1 of 8 Last Review Date: March 13, 2014 Infergen with Ribavirin

More information

Professor Patrice Cacoub

Professor Patrice Cacoub Five Nations Conference on HIV and Hepatitis in partnership with Professor Patrice Cacoub La Pitié-Salpêtrière Hospital, Paris, France HCV and its Extra Hepatic Manifestations: From Immune- to Inflammatory-Related

More information

CHAPTER 2. Primary Glomerulonephritis

CHAPTER 2. Primary Glomerulonephritis 2nd Report of the PRIMARY GLOMERULONEPHRITIS CHAPTER 2 Primary Glomerulonephritis Sunita Bavanandan Lee Han Wei Lim Soo Kun 21 PRIMARY GLOMERULONEPHRITIS 2nd Report of the 2.1 Introduction This chapter

More information

Case Presentation Turki Al-Hussain, MD

Case Presentation Turki Al-Hussain, MD Case Presentation Turki Al-Hussain, MD Director, Renal Pathology Chapter Saudi Society of Nephrology & Transplantation Consultant Nephropathologist & Urological Pathologist Department of Pathology & Laboratory

More information

Hepatitis C in Disclosures

Hepatitis C in Disclosures Hepatitis C in 2018 Sandeep Mukherjee, MD CHI Health and Creighton University Medical Center Division of Gastroenterology Grant support: Abbvie Disclosures Speaker: Abbvie, Gilead, Merck Section editor

More information

KDOQI US Commentary on the KDIGO Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in CKD

KDOQI US Commentary on the KDIGO Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in CKD VOL 52, NO 5, NOVEMBER 2008 KDOQI COMMENTARY KDOQI US Commentary on the KDIGO Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in CKD Craig E. Gordon,

More information

RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT

RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT HISTOPATHOLOGIC DISORDERS AFFECTING THE ALLOGRAFT OTHER THAN REJECTION RECURRENT DISEASE DE NOVO DISEASE TRANSPLANT GLOMERULOPATHY Glomerular Non-glomerular

More information

6/2/2015. Interactive Case-Based Presentations and Audience Discussion

6/2/2015. Interactive Case-Based Presentations and Audience Discussion 6/2/215 Interactive Case-Based Presentations and Audience Discussion Andrew Aronsohn, MD Assistant Professor of Medicine University of Chicago Medical Center Chicago, Illinois Formatted:5-6-215 Washington,

More information

Elevated Serum Creatinine, a simplified approach

Elevated Serum Creatinine, a simplified approach Elevated Serum Creatinine, a simplified approach Primary Care Update Creighton University School of Medicine. April 27 th, 2018 Disclosure Slide I have no disclosures and have no conflicts with this presentation.

More information

Hepatitis C virus (HCV) causes chronic systemic infection,

Hepatitis C virus (HCV) causes chronic systemic infection, Hepatitis C Virus and Its Renal Manifestations: A Review and Update Nyan Latt, MD, Nada Alachkar, MD, and Ahmet Gurakar, MD Dr. Latt is a Resident Physician in the Internal Medicine Department at Greater

More information

BOTH HEPATITIS C and chronic renal disease

BOTH HEPATITIS C and chronic renal disease REVIEWS Hepatitis C and Renal Disease: An Update Catherine M. Meyers, MD, Leonard B. Seeff, MD, Catherine O. Stehman-Breen, MD, MS, and Jay H. Hoofnagle, MD Hepatitis C is both a cause and a complication

More information

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency

Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency Hepatitis C Virus Infection and the Prevalence of Renal Insufficiency Lorien S. Dalrymple,* Thomas Koepsell, Joshua Sampson, Tin Louie, Jason A. Dominitz,* ** Bessie Young, and Bryan Kestenbaum *Health

More information

Hépatite E & transplantation d organes Pr Nassim KAMAR

Hépatite E & transplantation d organes Pr Nassim KAMAR Hépatite E & transplantation d organes Pr Nassim KAMAR Service de Néphrologie, Dialyse et Transplantation d Organes CHU Rangueil- Toulouse Genotype 3 HEV infection is an emerging disease in developing

More information

Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy

Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy CASE REPORT Complete Remission of Nephrotic Syndrome of Hepatitis B Virus-associated Membranous Glomerulopathy After Lamivudine Monotherapy Tang-Wei Chuang, 1 Chao-Hung Hung, 1 * Shun-Chen Huang, 2 Chuan-Mo

More information

Hepatitis C Direct-Acting Antivirals

Hepatitis C Direct-Acting Antivirals Hepatitis C Direct-Acting Antivirals Goals: Approve use of cost-effective treatments supported by the medical evidence. Provide consistent patient evaluations across all hepatitis C treatments. Ensure

More information

Research Article Hepatitis B Virus-Related Glomerulonephritis: Not a Predominant Cause of Proteinuria in Korean Patients with Chronic Hepatitis B

Research Article Hepatitis B Virus-Related Glomerulonephritis: Not a Predominant Cause of Proteinuria in Korean Patients with Chronic Hepatitis B Gastroenterology Research and Practice Volume 2015, Article ID 126532, 6 pages http://dx.doi.org/10.1155/2015/126532 Research Article Hepatitis B Virus-Related Glomerulonephritis: Not a Predominant Cause

More information

IgA Nephropathy - «Maladie de Berger»

IgA Nephropathy - «Maladie de Berger» IgA Nephropathy - «Maladie de Berger» B. Vogt, Division de Néphrologie/Consultation d Hypertension CHUV, Lausanne 2011 Montreux CME SGN-SSN IgA Nephropathy 1. Introduction 2. Etiology and Pathogenesis

More information

Alpha-interferon therapy for chronic hepatitis C may induce acute allograft rejection in kidney transplant patients with failed allografts

Alpha-interferon therapy for chronic hepatitis C may induce acute allograft rejection in kidney transplant patients with failed allografts Nephrol Dial Transplant (2008) 23: 1043 1047 doi: 10.1093/ndt/gfm678 Advance Access publication 3 October 2007 Original Article Alpha-interferon therapy for chronic hepatitis C may induce acute allograft

More information

Hepatitis C Virus. https://www.labcorp.com/wps/wcm/connect/labcorp+content/labcorp/education+and+re...

Hepatitis C Virus. https://www.labcorp.com/wps/wcm/connect/labcorp+content/labcorp/education+and+re... Page 1 of 16 Hepatitis C Virus Data reflected in this report are based solely on the collection of samples submitted to LabCorp for testing. Refer to the limitations section of this report for additional

More information

Xi Yang, Ri-Bao Wei, Ping Li, Yue Yang, Ting-Yu Su, Yu-Wei Gao, Qing-Ping Li, Xue-Guang Zhang, Xiang-Mei Chen

Xi Yang, Ri-Bao Wei, Ping Li, Yue Yang, Ting-Yu Su, Yu-Wei Gao, Qing-Ping Li, Xue-Guang Zhang, Xiang-Mei Chen Int J Clin Exp Pathol 2016;9(9):9401-9407 www.ijcep.com /ISSN:1936-2625/IJCEP0028098 Original Article Correlation between serum hepatitis B virus DNA replication level and clinicopathology in 235 patients

More information

2018 UnitedHealthcare Services, Inc.

2018 UnitedHealthcare Services, Inc. UnitedHealthcare Pharmacy Clinical Pharmacy Programs Program Number 2018 P 1127-9 Program Prior Authorization/Notification Medication Sovaldi (sofosbuvir) P&T Approval Date 2/2014, 4/2014, 5/2014, 8/2014,

More information

Arvind R. Murali, MD Assistant Professor of Medicine Gastroenterology & Hepatology Organ Transplant Center UIHC, Carver College of Medicine

Arvind R. Murali, MD Assistant Professor of Medicine Gastroenterology & Hepatology Organ Transplant Center UIHC, Carver College of Medicine Arvind R. Murali, MD Assistant Professor of Medicine Gastroenterology & Hepatology Organ Transplant Center UIHC, Carver College of Medicine No financial disclosures No conflicts of interest No affiliations

More information

Overview of glomerular diseases

Overview of glomerular diseases Overview of glomerular diseases *Endothelial cells are fenestrated each fenestra: 70-100nm in diameter Contractile, capable of proliferation, makes ECM & releases mediators *Glomerular basement membrane

More information

Renal failure in HCV cirrhosis

Renal failure in HCV cirrhosis IM BOARD REVIEW CHITRA DEEPAK PUNJABI, MD Department of Medicine, Albert Einstein Medical Center, YU KUANG LAI, MD Department of Medicine, Albert Einstein Medical Center, MANJULA BALASUBRAMANIAN, MD Chief,

More information

Glomerular pathology in systemic disease

Glomerular pathology in systemic disease Glomerular pathology in systemic disease Lecture outline Lupus nephritis Diabetic nephropathy Glomerulonephritis Associated with Bacterial Endocarditis and Other Systemic Infections Henoch-Schonlein Purpura

More information

Antiviral agents in HCV

Antiviral agents in HCV Antiviral agents in HCV : Upcoming Therapeutic Options Su Jong Yu, M.D., Ph.D. Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine Estimated 170 Million

More information

All Hands on Deck: Taking on Hepatitis C in Tennessee

All Hands on Deck: Taking on Hepatitis C in Tennessee All Hands on Deck: Taking on Hepatitis C in Tennessee Cody A. Chastain, MD Assistant Professor of Medicine Viral Hepatitis Program Division of Infectious Diseases Vanderbilt University Medical Center Cody.a.Chastain@Vanderbilt.edu

More information

SASKATCHEWAN FORMULARY BULLETIN Update to the 62nd Edition of the Saskatchewan Formulary

SASKATCHEWAN FORMULARY BULLETIN Update to the 62nd Edition of the Saskatchewan Formulary April 1, 2017 Bulletin #165 ISSN 1923-0761 SASKATCHEWAN FORMULARY BULLETIN Update to the 62nd Edition of the Saskatchewan Formulary Related Information for Prescribers: Only prescribers who have completed

More information

Supplementary materials: Predictors of response to pegylated interferon in chronic hepatitis B: a

Supplementary materials: Predictors of response to pegylated interferon in chronic hepatitis B: a Supplementary materials: Predictors of response to pegylated interferon in chronic hepatitis B: a real-world hospital-based analysis Yin-Chen Wang 1, Sien-Sing Yang 2*, Chien-Wei Su 1, Yuan-Jen Wang 3,

More information

HEPATITIS C UPDATES. Sanaa S. Said 10 th April, 2014

HEPATITIS C UPDATES. Sanaa S. Said 10 th April, 2014 HEPATITIS C UPDATES Sanaa S. Said 10 th April, 2014 CONTENTS Introduction Epidemiology Transmission and Natural history Kenyan guidelines What is new? References INTRODUCTION Hepacivirus genus, Flaviviridae

More information

Antiviral therapy guidelines for the general population

Antiviral therapy guidelines for the general population Discussion 10 Chapter 10 Hepatitis C a worldwide problem More than 170 million people worldwide suffer from chronic hepatitis C. Its prevalence is 2% in industrialized countries. 1 Approximately 20% of

More information

HCV-related cryoglobulinemic glomerulonephritis: implications of antiviral and immunosuppressive therapies

HCV-related cryoglobulinemic glomerulonephritis: implications of antiviral and immunosuppressive therapies ACTA BIOMED 2007; 78: 51-59 Mattioli 1885 C A S E R E P O R T HCV-related cryoglobulinemic glomerulonephritis: implications of antiviral and immunosuppressive therapies Giovanni Garini, Landino Allegri,

More information

Resistant Nephrotic Syndrome: Review of Trials Using ACTH and a Case Series of Six Patients Treated with ACTHar

Resistant Nephrotic Syndrome: Review of Trials Using ACTH and a Case Series of Six Patients Treated with ACTHar British Journal of Medicine & Medical Research 5(11): 1453-1457, 2015, Article no.bjmmr.2015.164 ISSN: 2231-0614 SCIENCEDOMAIN international www.sciencedomain.org Resistant Nephrotic Syndrome: Review of

More information

Hepatitis C and Chronic Kidney Disease: Overview of Evaluation and Management

Hepatitis C and Chronic Kidney Disease: Overview of Evaluation and Management Hepatitis C and Chronic Kidney Disease: Overview of Evaluation and Management Hepatitis C Hepatitis C virus infection (HCV) is associated with increased risk of liver fibrosis or cirrhosis and development

More information

DISEASE LEVEL MEDICAL EVIDENCE PROTOCOL

DISEASE LEVEL MEDICAL EVIDENCE PROTOCOL DISEASE LEVEL MEDICAL EVIDENCE PROTOCOL 1. This Protocol sets out the medical evidence that must be delivered to the Administrator for proof of Disease Level. It is subject to such further and other Protocols

More information

Diabetes, Obesity and Heavy Proteinuria

Diabetes, Obesity and Heavy Proteinuria Diabetes, Obesity and Heavy Proteinuria Clinical Case 41 yo Black woman with heavy proteinuria History 2014: noted to have proteinuria on routine lab testing (1.1g/g). 1+ edema. Blood pressure has been

More information

CHAPTER 4. Paediatric Renal Biopsies

CHAPTER 4. Paediatric Renal Biopsies 2nd Report of the Malaysian Registry of Renal Biopsy 2008 PAEDIATRIC RENAL BIOPSIES CHAPTER 4 Paediatric Renal Biopsies Lee Ming Lee Lim Yam Ngo Lynster Liaw Susan Pee Wan Jazilah Wan Ismail Yap Yok Chin

More information

Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab

Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab TRANSPLANTATION Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab Khadijeh Makhdoomi, 1,2 Saeed Abkhiz, 1,2 Farahnaz Noroozinia, 1,3

More information

Commonly Asked Questions About Chronic Hepatitis C

Commonly Asked Questions About Chronic Hepatitis C Commonly Asked Questions About Chronic Hepatitis C From the American College of Gastroenterology 1. How common is the hepatitis C virus? The hepatitis C virus is the most common cause of chronic viral

More information

Biopsy-Proven Childhood Glomerulonephritis in Johor

Biopsy-Proven Childhood Glomerulonephritis in Johor ORIGINAL ARTICLE Biopsy-Proven Childhood Glomerulonephritis in Johor J J Khoo, MPath*, S Pee, MRCP**, B Thevarajah, MRCP***, Y C Yap, MRCP**, C K Chin, MRCP**** 'Department of Pathology, "Department of

More information

Treatment of Chronic Hepatitis C in HIV infection

Treatment of Chronic Hepatitis C in HIV infection Treatment of Chronic Hepatitis C in HIV infection June 25, 211 Andrew Talal, MD, MPH Associate Professor of Medicine Associate Medical Director Center for the Study of Hepatitis C Weill Cornell Medical

More information

Nephrotic Syndrome NS

Nephrotic Syndrome NS Nephrotic Syndrome NS By : Dr. Iman.M. Mudawi Pediatric Nephrology Unit Gaafar Ibn Auf Hospital Definitions: In children NS is applied to any condition with a triad of: Heavy proteinuria (UACR ratio >200

More information

Immunoglobulin M Nephropathy in Adults A Clinicopathological Study

Immunoglobulin M Nephropathy in Adults A Clinicopathological Study Kidney Diseases Immunoglobulin M Nephropathy in Adults A Clinicopathological Study Muhammed Mubarak, 1 Rubina Naqvi, 2 Javed I Kazi, 1 Shaheera Shakeel 1 Original Paper 1 Histopathology Department, Sindh

More information

THIS ACTIVITY HAS EXPIRED. CME CREDIT IS NO LONGER AVAILABLE

THIS ACTIVITY HAS EXPIRED. CME CREDIT IS NO LONGER AVAILABLE THIS ACTIVITY HAS EXPIRED. CME CREDIT IS NO LONGER AVAILABLE The following content is provided for informational purposes only. Diagnosing and Managing Hepatitis C Sandy Van Sant MPH, APN Hepatitis C virus

More information

C3 GLOMERULOPATHIES. Budapest Nephrology School Zoltan Laszik

C3 GLOMERULOPATHIES. Budapest Nephrology School Zoltan Laszik C3 GLOMERULOPATHIES Budapest Nephrology School 8.30.2018. Zoltan Laszik 1 Learning Objectives Familiarize with the pathogenetic mechanisms of glomerular diseases Learn the pathologic landscape and clinical

More information