Dr. Sarah N. Flaim Oxford University Computing Laboratory Wolfson Building Parks Road University of Oxford OX1 3QD

Transcription

1 Dr. Sarah N. Flaim Oxford University Computing Laboratory Wolfson Building Parks Road University of Oxford OX1 3QD Phone: (home) PERSONAL DETAILS Date of birth: 30 November 1979 Place of birth: Hamilton, New Zealand Nationality: New Zealand EDUCATION (work) University of California, San Diego, USA Ph.D. in Bioengineering 2006 Dissertation: Multiscale Computational Models of Transmural Heterogeneities and Ventricular Arrhythmogenesis supervised by Professor Andrew D. McCulloch GPA 4.0 University of California, San Diego, USA M.S. in Bioengineering 2003 By examination University of Auckland, New Zealand B.E. (Honours) in Engineering Science 2001 Honours Thesis: A New Approach to Solving the Inverse Problem of Electrocardiography supervised by Associate Professor Andrew J. Pullan AWARDS EPSRC Postdoctoral Fellowship in the Life Sciences American Heart Association Predoctoral Fellowship Joel Drillings Award for Excellence in Cardiovascular Research SIAM Student Travel Award (Dynamical Systems Conference) Fulbright Professional Enhancement Grant Gordon Research Conference Student Travel Award / / SIAM Student Travel Award (Annual Meeting) 2004 Page 1 of 5

2 Jacobs School of Engineering Research Review Poster and Library Award Top Achiever Doctoral Fellowship (NZ Government) 08/ /2005 Fulbright Graduate Fellowship 09/ /2002 Senior Scholarship (First in class, Engineering Science) Commonwealth Scholarship (not accepted) Rhodes Scholarship (Finalist) Federation of University Women Undergraduate Scholarship TEACHING EXPERIENCE 2000 University of California San Diego Teaching Assistant to Prof. Andrew McCulloch in Spring 2006 Computational Biomechanics Supervised practical labs, met with students upon request Senior Teaching Assistant to Prof. Shu Chien in Winter 2004 Introduction to Bioengineering Coordinated teams of teaching assistants, met with students upon request, graded all lab reports, and administered all grades Senior Teaching Assistant to Prof. Jeffrey Omens Spring 2003 in the Bioengineering Undergraduate Lab Class Coordinated teams of teaching assistants, supervised practical labs, led discussion sections, met with students upon request and graded all lab reports, including final exam papers Teaching Assistant to Profs. Robert Sah and Fall 2002 Bernhard Palsson in Tissue Engineering Collaborated on course and exam development, led discussion sections, taught specific lectures, and graded reports, including final exam papers Teaching Assistant to Prof. Jeffrey Omens in the Spring 2002 Bioengineering Undergraduate Lab Class Supervised practical labs, met with students upon request and graded all lab reports, including final exam papers COLLABORATIVE RESEARCH San Diego Supercomputer Center Dr Tim Kaiser Development of a generalized MPI interface for Python, MyMPI UCSD School of Medicine Dr Wilbur Lew Three month lab rotation investigating the cardiac effects of lipopolysaccharide using strain and pressure-volume analysis Page 2 of 5

3 WORK EXPERIENCE Bioengineering Institute, University of Auckland, New Zealand Research Assistantship 2001 Mathematical modeling of water and heat transfer in the lungs Bioengineering Technology, Ruakura, New Zealand Research Assistantship Researched, designed, constructed and tested a noninvasive handheld device for analysis of metabolites in the bloodstream National Institute of Water and Atmospheric Research, Hamilton, New Zealand Research Assistantship Developed computer program to predict stream temperatures using a finite difference numerical scheme RELEVANT SKILLS High Performance Computing Extensive experience with use of MPI in shared and distributed memory parallel processing for scientific applications Advanced programming ability in Python, FORTRAN, MATLAB, C Extensive experience with Linux, Unix and Windows Operating Systems Numerical Methods Proficient in finite element, boundary element and finite difference methods, numerical integration, nonlinear equations, numerical methods for ODEs Leadership Skills Bioengineering Graduate Student Society Steering Committee Member ( ) Laboratory Experience Skilled in biological wet lab measuring techniques, animal dissections, instrument calibration Workshop Skills Certificate of Workshop Practice, Auckland University of Technology (1998) Experienced in precision machining and welding PROFESSIONAL MEMBERSHIPS Biophysical Society (2004-present) PUBLICATIONS AND PRESENTATIONS Peer-Reviewed Journal Articles Flaim SN, Giles WR, McCulloch AD. Arrhythmogenic consequences Page 3 of 5

4 of Na + channel mutations in the transmurally heterogeneous mammalian left ventricle: An analysis of the I1l68V SCN5A mutation Heart Rhythm (in press) (2007) Flaim SN, Saucerman JJ, McCulloch AD. Arrhythmogenic consequences of asynchrony and heterogeneity in cardiac myocytes during β 1 -adrenergic stimulation (under revision) Flaim SN, Giles WR, McCulloch AD. Contributions of sustained I Na and I Kv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes Am J Physiol Heart Circ Physiol 291(6): H2617-H2629 (2006) Kerckhoffs RCP, Healy SN, Usyk TP, McCulloch AD. Computational methods for cardiac electromechanics P IEEE. 94: (2006) Healy SN, McCulloch AD. An ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytes Europace Suppl 2: (2005) Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue Circ Res 95(12): (2004) Selected Abstracts and Presentations Kerckhoffs RCP, Bordachar P, Healy SN, Omens JH, McCulloch AD. Myocardial mechanics during epicardial versus endocardial left ventricular pacing: simulations and experiments 5th World Congress of Biomechanics, München, Germany (2006) Kaiser T, Brieger L, Healy SN MyMPI - MPI Programming in Python International Conference on Parallel and Distributed Processing Techniques and Applications, Las Vegas, NV(2006) Healy SN, McCulloch AD Repolarization abnormalities due to remodeling of Na + -Ca 2+ exchange gradient in failing hearts Biophysical Society 50th Annual Meeting, Salt Lake City, UT (2006) Kerckhoffs RCP, Cole M, Sachse F, Healy SN, Neal M, Jones G, Johnson C, Bassingthwaighte J, McCulloch AD. From myocyte to torso: spatially and temporally multi-scale simulation of cardiac injury, Medicine Meets Virtual Reality, Long Beach, CA (2006) Kaiser T, Healy SN, Brieger L. Using MyMPI, a Generalized MPI Interface for Python. Cyberinfrastructure Seminar Series, San Diego, CA (2006) Kaiser T, Healy SN, Brieger L. Using a generalized MPI interface for Python, MyMPI. Scientific Python Meeting, Pasadena, CA (2005) Healy SN, McCulloch AD. Contributions of cellular and structural heterogeneity to rabbit ventricular arrhythmia. SIAM Meeting on Dynamical Systems, Snowbird, UT (2005) Healy SN, Mills RW, Gurji HA, Usyk T, McCulloch AD A 3D gating Page 4 of 5

5 law for stretch-activated currents in the rabbit left ventricle International Union of Physiological Sciences, San Diego, CA (2005) Healy SN, Saucerman JJ, McCulloch AD Increased arrhythmic risk during dynamic phosphorylation changes following β 1 -adrenergic stimulation Computational Physiology: from Genome to Physiome (IUPS Satellite Meeting), San Diego, CA (2005) Healy SN, Saucerman JJ, McCulloch AD Proarrhythmic effects of a KCNQ1 gene mutation in a 3D model of rabbit ventricular tissue with cellular heterogeneities Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Buellton, CA (2005) Healy SN, Mills RW, Gurji HA, Usyk T, McCulloch AD A 3D gating law for stretch-activated currents in the rabbit left ventricle Biophys J 88: 301a-301a Biophysical Society 49th Annual Meeting, Long Beach, CA (2005) Saucerman JJ, Healy SN, McCulloch AD Modeling the proarrhythmic effects of a KCNQ1 gene mutation Biophys J. 88: 474a-474a Biophysical Society 49th Annual Meeting, Long Beach, CA (2005) Healy SN, McCulloch AD. Computational methods for modeling structural and functional interactions in the heart. SIAM Annual Meeting, Portland, OR (2004) Healy SN, Belik ME, Michailova A, Puglisi JL, Bers DM, McCulloch AD. 3D simulation of action potential heterogeneity in rabbit ventricular tissue Biophys J. 86: 299a-299a, Biophysical Society 48 th Annual Meeting, Baltimore, MD (2004) Healy SN, Belik ME, Puglisi JL, Bers DM, McCulloch AD High performance computational modelling of transmural action potential heterogeneity in rabbit ventricular tissue Modelling Cellular Function Conference, Auckland, New Zealand (2003) LANGUAGES English native language German speak, read, and write with basic competence Page 5 of 5