EVOLUTION OF CARDIAC ELECTROPHYSIOLOGY
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1 EVOLUTION OF CARDIAC Mohamed El Guindy Cairo University
2 EVOLUTION OF CARDIAC 1960s His bundle recording (Scherlag, Damato) Programmed electrical stimulation (Durren, Wellens, Coumel) Transvenous permanent pacing (Chardack) 1970s Antiarrhythmic surgery for SVT and VT Anti-tachycardia pacing (Manz) 1980s Catheter ablation (Gonzales) Radiofrequency current Steerable ablation catheters Detailed mapping techniques ICD (Mirowski)
3 1990s EVOLUTION OF CARDIAC Catheter ablation of SVT, AF and scar-related VT Digital split-screen multichannel recorders Customization of mapping and ablation catheters and support sheaths Saline-irrigated RF and cryoablation Pulmonary vein ablation (Haissaguerre) 3-D electroanatomical mapping Image integration modalities Remote navigation systems
4 MODERN DEVELOPMENTS IN CARDIAC Atrial Fibrillation New anticoagulants: Dabigatran, Rivaroxaban, Apixiban (less ICH, no dietary restrictions, rapid action, no monitoring) Ablation of areas of high dominant frequencies and ganglionated plexi (vagal AF) Combined endocardial and epicardial approaches Cryoballoons, multipolar catheters, direct visual guidance, laser, basket catheters Ablation improves renal function and lower stroke and mortality rates
5 MODERN DEVELOPMENTS IN CARDIAC WPW High risk features in symptomatic patients: Short AP-RP, multiple, AVRT triggering AF, male sex Ventricular Tachycardia Epicardial routes for mapping and ablation
6 MODERN DEVELOPMENTS IN CARDIAC Translational Sciences AV nodal gene transfer to inhibit overexpression of G protein leading to heart rate control in AF Gene therapy to prevent AF with adenovirus containing KCNH2 G628S gene mutant that inhibits I Kr thus prolonging atrial RP Gene transfer to enhance connexin 40, 43 formation thus improving atrial conduction Gene manipulation to overexpress SERCA thereby reverse the effects of atrial stretching Biological pacemakers via gene transfer using dual HCN2/SkM1 constructs
7 MODERN DEVELOPMENTS IN CARDIAC Genetic Arrhythmia Syndromes Risk-stratification of LQT syndromes by identifying mutations affecting the transmembrane regions LQT1, LQT3 Genetic identification of concealed (normal QT) LQT syndromes (benign prognosis) ICD Entirely subcutaneous ICD (S-ICD) Pacemakers Still lacks ATP, delivers 85J shocks Rate drop DD pacing for +ve ATP test (10s SAB or AVB)
8 MODERN DEVELOPMENTS IN CARDIAC CRT Indices for favorable response: Prior hospitalization for heart failure..1 Female sex..2 Non-ischemic cardiomyopathy.2 QRS 150 ms.2 LBBB..2 EDV 125 ml/m2.2 LAV > 40 ml/m2.3 G1: 0-4 (no benefit) G2: 5-6 G3: 7-8 D4: 9-10
9 Stereotaxis Magnetic Navigation System
10 Intracardiac Echo
11 Novel Multipolar Electrode catheters
12 Novel Cryoablation Modalitites (Cryothermal Balloon Catheter)
13 High-intensity Focused Ultrasound (HIFU) Balloon Catheter
14 Laser Balloon
15 PRIORITIES FOR TRAINEES IN CARDIAC Basic principles underlying diagnostic EPS Study of narrow and wide-complex tachycardias EPS for features of common cardiac arrhythmias Standard techniques for ablation
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