Pulmonary-Vascular Disease. Howard J. Sachs, MD.
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1 Pulmonary-Vascular Disease Howard J. Sachs, MD
2 Dyspnea Cardiac Pulmonary CAD Pump Failure Chest Wall Airways Valve Disease Pericardial Disease Alveoli Interstitium Rhythm Disturbance Vascular Pleural Space
3 Pulmonary Vascular Disorders Part I: General Principles Differential Diagnoses Basic Physiology/Diagnostics Part II (The Disorders): Primary Pulmonary Hypertension Thromboembolic Disease
4 Pulmonary HTN Pulmonary Artery > 25 mmhg (normal ~ 12) COPD/ILD Chronic Hypoxia Vasoconstrictive Obliterative PPH Obstructive Hyperkinetic LEFT right Shunt Passive 2 nd to LV Failure
5 What do all the causes share in common? Elevated Pressures Clinical Stigmata Edema >25 JVD S2
6 Pulmonary Artery 8/0 < 5 25/10 25/5
7 >25 Pulmonary Artery PPH: Media Hypertrophy COPD/ILD: Hypoxic Vasoconstriction
8 2/6 systolic murmur at LLSB TR >25 Pulmonary Artery PPH: Medial Hypertrophy COPD/ILD: Hypoxic Vasoconstriction
9 Obstructive Thrombus >25
10 >25 Passive Congestion Heart Failure
11 >25 Passive Congestion Heart Failure Also referred to as pulmonary venous HTN
12 Hyperkinetic Left Right Shunt >25 130/9 VSD
13 Hyperkinetic Left Right Shunt >25 RV: Low Pressure LV: High Pressure
14 What do all the causes share in common? Elevated Pressures Causes: >25 1. Primary Pulmonary HTN 2. Thromboembolism 3. Hypoxic Vasoconstriction 4. Congestive Heart Failure 5. Left Shunt (VSD)
15 What do all the causes share in common? Clinical Stigmata (Cor Pulmonale) Edema Pulm Artery Pressure JVD S2
16 What do all the causes share in common? Left Upper Sternal Border S2 Pulm Artery Pressure JVD S2: A2 + P2 S2 S1 P2: loud, accentuated
17 What do all the causes share in common? Left Upper Sternal Border S2 Pulm Artery Pressure S2: A2 + P2 P2: loud, accentuated The Language of Pulmonary HTN
18 Causes: 1. Primary Pulmonary HTN 2. Thromboembolism 3. Hypoxic Vasoconstriction 4. Congestive Heart Failure 5. Left Shunt (VSD) What will the pulmonary exam reveal?
19 Causes: 1. *Primary Pulmonary HTN normal breath sounds 2. *Thromboembolism normal breath sounds 3. Hypoxic Vasoconstriction stigmata of COPD, ILD 4. Congestive Heart Failure rales 5. Left Shunt (VSD); murmur (mid LSB, maneuvers) * Primary Pulmonary-Vascular diseases reveal normal breath sounds. If the patient is noted with rales (plus edema, JVD and/or S3), they are telling you the patient has CHF.
20 Diagnostic Testing: Diffusing Capacity (DLCO) Pulmonary Capillary DLCO: Alveolar Gas Exchange
21 Diagnostic Testing: Diffusing Capacity (DCLO) Pulmonary Capillary DLCO: Alveolar Gas Exchange
22 Diagnostic Testing: Pulmonary Capillary Wedge Pressure PCWP Wedged in Pulmonary Capillary Measures Left Atrial Pressures Normal value means no left sided failure
23 Diagnostic Testing: Pulmonary Capillary Wedge Pressure Language: PCWP Patient day 3 post-mi. Acute onset of symptoms (SOB, hypotension). PE: lungs clear; no murmur. Wedged EKG tachycardia. in Pulmonary Troponin negative. The PCWP is normal. What Capillary happened? LV Failure LV Failure Measures Left Atrial MI extension MI Pressures Papillary Ruptured Muscle Papillary Rupture Muscle Pulmonary Embolism Normal value means no left sided failure
24 Pulmonary Vascular Disorders Part I: General Principles Differential Diagnoses Basic Physiology/Diagnostics Part II (The Disorders): Primary Pulmonary Hypertension Thromboembolic Disease
25 Pulmonary-Vascular Disease Howard J. Sachs, MD
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