J. Mike Overton, Ph.D., Course Director (850) Click here to return to the syllabus

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1 Clinical Physiology BMS 6511 J. Mike Overton, Ph.D., Course Director (850) Course Calendar Click here to return to the syllabus Date Instructor Activity Topic & Context Major Concepts Week 1 1/5 Overton Lecture Hemodynamics I Organization of the vasculature Components of vascular tree Determinants and distribution of Blood flow (Cardiac output, Pressure and Resistance) 1/5 1/6 Overton Lecture Hemodynamics II Characteristics of Blood flow (velocity; laminar vs turbulent) Compliance Blood pressure across vascular tree 1/7 Overton Lecture Cardiac Electrophysiology SA nodal potential Ventricular myocyte potential Conduction of cardiac action potential Autonomic modulation of heart rate Week 2 1/10 Overton Lecture ECG Components of standard ECG ECG lead configurations Arrhythmias 1/11 1/11 1/12 Overton Lecture Cardiac Cycle and Cardiac Volumes Phases of cardiac cycle Heart sounds

2 Stroke volume and cardiac output 1/12 1/13 Overton and Facilitators Small-Group Small groups: Essential Cardiovascular calculations 1/14 Overton Lecture Cardiac dynamics Cardiac EC coupling Determinants of SV Cardiac work Cardiac hypertrophy Week 3 1/17 Holiday 1/18 1/18 1/19 Overton Lecture Regulation of arterial pressure I Autonomic tone High Pressure Baroreflex Low Pressure Baroreflex Chemoreflexes 1/19 1/20 Overton and facilitators Small-Group Myocardial Infarction: LV failure 1/21 Overton Lecture Regulation of arterial pressure I Cardiac and vascular function curves Renin-Angiotensin Aldosterone system Vasopressin, Endothelin Week 4 1/24 Overton Lecture Microcirculation Capillary structure and function Hydrostatic and oncotic pressures Edema and lymphatics Endothelial function 1/25

3 1/25 1/26 Overton Small-Group To be announced and facilitators 1/26 1/27 Overton Small-Group Special circulations Autoregulation and hyperemia Neural and hormonal control of blood flow Regional circulations 1/27 1/28 Overton Lecture Integrative responses: Exercise and Temperature regulation Week 5 1/31 Overton Lecture Integrative responses: Orthostasis and Hemorrhage Central command Dynamic and resistance exercise responses Responses to heat and cold Response to standing Vasovagal syncope Hemorrhage and shock Orthostatic Intolerance 2/1 2/1 2/2 Olsen Lecture Introduction to Respiration Overview of system 2/2 2/3 Review for Exam 1 2/4 Examination 1 Week 6 2/7 Olsen Lecture Structure and function of respiration 2/8

4 2/8 2/9 Olsen Lecture Lung mechanics and muscles 2/9 2/10 Olsen Lecture Gas Exchange 2/11 Olsen Lecture Ventilation-Perfusion relationships Week 7 2/14 Olsen Lecture Control and integration of respiration 2/15 2/15 2/16 Olsen Lecture Pulmonary Function Testing 2/16 2/17 Olsen and Small Group Lung mechanics facilitators 2/18 Olsen Lecture Review and catch up 2/21 Olsen and facilitators 2/22 2/22 Small-Group Week 8 Gas Transport 2/23 Lecture Renal Introduction Introduction: filtration, tubular function,absorption, secretion, excretion, functional anatomy 2/23 2/24 Small-Group Hypertension/

5 Diabetes Insipidus 2/25 Lecture GFR and RBF cardiac output, autoregulation, GFR (diffusion, barriers), afferent, efferent arterioles, Bowmans capsule, nephron, inulin. RBF, PAH, clearance, tubular glomerular feedback, renin angiotensin system, alsosterone Week 9 2/28 Lecture Proximal Tubule transport, active, passive, cotransport, counter transport, Tm, reabsorption: glucose, Na, K, Cl, Ca, H 3/1 3/2 Lecture Tubular Function absorption, secretion, loop of Henle 3/2 3/3 Review Review for Exam 2 3/4 Examination Examination 2 2 3/7 Spring Break 3/7-3/11 Week 10 3/14 Lecture ECF Regulation & Fluid Volume 3/15 ADH, Renin, Angiotensin, Aldosterone, Loop of Henle (ascending limb), distal tubule, collecting duct, counter current multiplier system (osmolarity) for Na and NH3. 3/15 3/16 Lecture Acid/Base Renal and respiratory buffers and acid-base balance and imbalance, Henderson-Hasselbalch 3/16 3/17 Small-Group Acid/Base

6 3/18 Lecture Tubular Dysfunctiona dn Micturition Week 11 3/21 Trowers Lecture GI Introduction Regulatory Substances in GI tract Costanzo pp /22 Glomerular dysfunction, pre-renal, renal,post-renal, micturition Functional anatomy & innervation GI hormones (gastrin, CCK, secretin, GIP) Paracrines & Neurocrines, Peptic Ulcer Disease, Zollinger Ellison Syndrome) 3/22 3/23 Trowers Lecture Motility Part 1 & Part 2 Upper GI Tract Costanzo pp /23 3/24 Trowers Lecture GI Secretions Part 1 Costanzo pp /25 Trowers Lecture GI Secretions Part 2 Costanzo pp Week 12 3/28 Trowers Lecture Digestion & Absorption Costanzo pp /29 Slow waves, Chewing and Swallowing Esophageal Motility, Gastric Motility (receptive relaxation, mixing digestion, gastric emptying) GERD, Achalasia Segmentation Contractions, Peristaltic Contractions, Mass Movements, Defecation, Gastrocolic Reflex. Constipation, Diarrhea, Irritable Bowel Syndrome, Hirschsprung's Disease Salivary, Gastric, Pancreatic, Biliary (enterohepatic circulation of bile salts) Digestional Absorption of Carbohydrates, Proteins and Lipids, Lactose Intolerance, Malabsorption, Cystic Fibrosis, Deficiency of Bile Salts 3/30 Trowers Lecture Intestinal Fluid & Electrolyte Transport Costanzo pp Intestinal Absorption & Secretion, Diarrhea (osmotic, secretory), Decreased Surface Area for Absorption 3/30 3/31 Trowers Review for Open Session Review Review questions

7 Exam 3 4/1 Examination 3 for Exam Examination 3 Week 13 4/4 Olcese Lecture Endocrine Introduction 4/5 Costanzo pp Hypothalamic - Pituitary - target gland concepts 4/5 4/6 Olcese Lecture Hypothalamus- Pituitary: Thyroid Costanzo pp /6 4/7 Small-Group Thyroid and Adrenal Cases 4/8 Olcese Lecture Adrenal Glands Costanzo pp Week 14 4/11 Olcese Lecture Parathyroid: Calcium Homeostasis Costanzo pp /12 TSH, triiodothyronine, thyroxine, hyperthyroidism, hyperthyroidism ACTH, Cortisol(glucocorticoids),Aldosterone (mineralocorticoids), Cushing s, Addison s, hormone transport and release, receptors, binding, transduction, physiological effects. Adrenal medulla (catecholamines), Pheochromocytoma PTH, calcitonin, calcium, phosphate homeostasis, vitamin D3, GI and renal function, Skin, feedback loops 4/12 4/13 Olcese Lecture Diabetes Mellitus Costanzo pp /13 4/14 Small-Group Diabetes cases Insulin/Glucagon, release, feedback, alpha cells, beta cells, pancreas, isles of Langerhans, physiological function and dysfunction, Type 1 and Type 2, insulin dependent and insulin independent, receptors, transduction

8 4/15 Lecture Reproduction: Male Development and Function Week 15 4/18 Lecture Reproduction: Female Development and Function 4/19 functional anatomy, hormones, receptors, signal transduction, physiological effects: HPA axis Hormones, testes, sperm, puberty, fertilization functional anatomy, hormones, receptors, signal transduction, physiological effects: HPA axis Hormones, testes, ovarian cycle, puberty, fertilization, pregnancy, menopause 4/20 Lecture Pregnancy & Menopause 4/20 4/21 Exam Exam Review Review 4/22 Examination 4 Examination 4 4/25 NBME shelf examination 4/27 Week 16 NBME shelf examination