Ventricular Tachycardia Substrate. For the ablationist. Stanley Tung, MD FRCPC Arrhythmia Service/St Paul Hospital University of British Columbia

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1 Ventricular Tachycardia Substrate For the ablationist Stanley Tung, MD FRCPC Arrhythmia Service/St Paul Hospital University of British Columbia

2 Two Attitudes of Ventricular Tachycardia Ablation 1 2C:\Documents and Settings\Stanley Tung\My Documents\Bear Monday.mp4

3 Ventricular Tachycardia Substrate Mechanism of Ventricular Tachycardia (VT) Principals of scar related substrate (ischemic and non-ischemic) Disease specific VT substrate: Infiltrative Cardiomyopathy: ARVD/C, Sarcoidosis Post Valvular Surgery Cardiomyopathy Repaired Adult Congenital Heart Disease

4 Three Mechanisms of VT Re-entry

5 Three Mechanisms of VT Triggered Activity Automaticity

6 Magnetic Resonance Based Anatomical Analysis of Scar-Related Ventricular Tachycardia Implications for Catheter Ablation Ashikaga et al.

7 Magnetic Resonance Based Anatomical Analysis of Scar-Related Ventricular Tachycardia Implications for Catheter Ablation Ash

8 Magnetic Resonance Based Anatomical Analysis of Scar-Related Ventricular Tachycardia Implications for Catheter Ablation Ash

9 Josephson ME, Waxman HL, Am J Cardiol. 1982; 50:11 22.

10 Normal myocardium > mV Low Voltage region mV Scar <0.5mV Francis E. Marchlinski, MD; David J. Callans, MD; Circulation. 2000;101: )

11 Francis E. Marchlinski, MD; David J. Callans, MD; Circulation. 2000;101: )

12 CAFCAA 2008 Relationship Between Successful Ablation Sites and the Scar Border Zone Defined by Substrate Mapping for Ventricular Tachycardia Post-Myocardial Infarction VERMA et al

13 CAFCAA 2008 Relationship Between Successful Ablation Sites and the Scar Border Zone Defined by Substrate Mapping for Ventricular Tachycardia Post-Myocardial Infarction VERMA et al

14 CAFCAA 2008 Relationship Between Successful Ablation Sites and the Scar Border Zone Defined by Substrate Mapping for Ventricular Tachycardia Post-Myocardial Infarction VERMA et al

15 CAFCAA 2008 Relationship Between Successful Ablation Sites and the Scar Border Zone Defined by Substrate Mapping for Ventricular Tachycardia Post-Myocardial Infarction VERMA et al

16 Christian de Chillou, MD, PhD; Dominique Lacroix, MD; Circulation. 2002;105: )

17 Characteristics of Isthmus: Average length 31mm 7mm Average width 16mm 8mm (R 6-24mm) Isolated potentials IP often long delay during SR, and pre-systolic during VT S-QRS=E-QRS < 70% VTCL SR pacing often >40ms, but more specific if >80ms. Morphology adds no extra value

18 Frank Bogun, MD,* Subramaniam Krishnan, MD, J Am Coll Cardiol 2005;46:667 74)

19 Frank Bogun, MD,* Subramaniam Krishnan, MD, J Am Coll Cardiol 2005;46:667 74)

20 Frank Bogun, MD,* Subramaniam Krishnan, MD, J Am Coll Cardiol 2005;46:667 74)

21 Christian de Chillou, MD, PhD; Dominique Lacroix, MD; Circulation. 2002;105: )

22

23

24 CAFCAA 2008Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Nonischemic Cardiomyopathy Nazarian et al.

25 CAFCAA 2008Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Nonischemic Cardiomyopathy Nazarian et al.

26 Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Nonischemic Cardiomyopathy Nazarian et al.

27 19 patients, 20% of the endocardium bipolar EGM<1.8mV Characterization of Endocardial Electrophysiological Substrate in Patients With Nonischemic Cardiomyopathy and Monomorphic Ventricular Tachycardia Henry H. Hsia et al.

28 Characterization of Endocardial Electrophysiological Substrate in Patients With Nonischemic Cardiomyopathy and Monomorphic Ventricular Tachycardia Henry H. Hsia et al.

29 5% Ischemic cardiomyopathy 20-40% Non-ischemic cardiomyopathy Baseline IVCD and HV prolongation (>75ms) Stable HV during VT and HV interval >/= SR

30

31 Epicardial substrate More common in non-ischemic cardiomyopathy and in inferior MI Antonio Berruezo, MD; Lluis Mont, MD; Circulation. 2004;109: )

32 Victor Bazan, MD, Edward P. Gerstenfeld, MD, Heart Rhythm 2007;4:

33 Inferior, basal and apical, epicardial: Initial Q s II,III,aVF Anterior, apical, epicardial: Q wave in lead I Anterior, basal, epicaridal: Q wave in lead I, absent of initial Q s II,III,aVF Victor Bazan, MD, Edward P. Gerstenfeld, MD, Heart Rhythm 2007;4:

34 William G. Stevenson, MD; Kyoko Soejima, MD Circulation. 2007;115: )

35 William G. Stevenson, MD; Kyoko Soejima, MD Circulation. 2007;115: )

36 ARVC/D VT Substrate Around TA and outflow tract usually re-entry RV apex could be re-entry or automaticity KAZUHIRO SATOMI, M.D., PH.D., TAKASHI KURITA, M.D., PH.D., J Cardiovasc Electrophysiol, Vol. 17, pp , May 2006)

37 ARVC/D VT Substrate Atul Verma, MD; Fethi Kilicaslan, MD; Circulation. 2005;111:

38 ARVC/D VT Substrate Atul Verma, MD; Fethi Kilicaslan, MD; Circulation. 2005;111:

39 ARVC/D VT Substrate Atul Verma, MD; Fethi Kilicaslan, MD; Circulation. 2005;111:

40 ARVC/D VT Substrate Atul Verma, MD; Fethi Kilicaslan, MD; Circulation. 2005;111:

41 Post Corrective Valve Surgery VT Substrate 20 patients with 17 patients inducible, 42 VT induced. All reentry Robert E. Eckart, DO; Tomasz W. Hruczkowski, MD; Circulation. 2007;116: )

42 Post Corrective Valve Surgery VT Substrate 41/42 VT was successfully ablated Robert E. Eckart, DO; Tomasz W. Hruczkowski, MD; Circulation. 2007;116: )

43 Post Corrective CHD Surgery VT Substrate Late recurrent of VT post TOF, VSD, or RVOT patch repair 12% SCD rate was 9% over 35 years of follow up All VTs were reentrant Katja Zeppenfeld, MD; Martin J. Schalij, MD; Circulation. 2007;116: )

44 Post Corrective CHD Surgery VT Substrate Katja Zeppenfeld, MD; Martin J. Schalij, MD; Circulation. 2007;116: )

45 Post Corrective CHD Surgery VT Substrate Katja Zeppenfeld, MD; Martin J. Schalij, MD; Circulation. 2007;116: )

46 Conclusions Scar resulting in reentry is the most common cause of VT Isthmus mostly present along scar border zone Isthmus length and width are variable Characteristic of the isthmus can often identify during substrate mapping Isolate potential is crucial in targeting isthmus site for successful ablation

47 Conclusions cont d Ischemic scar closely locates to previous infarct territory Non-ischemic scar often locates around valvular apparatus without following coronary perfusion landmarks BB reentrant VT is far more common with non-ischemic VTs

48 Conclusions cont d Epicardial VT substrate is more common with inferior MI and nonischemic cardiomyopathy ARVC/D often with scar around TA, RVOT, and RVA with VT mostly due to reentry Ablation often successful with ablation line connecting the scar border to the vulvular annulus

49 Conclusions cont d Reentrant VT Post valvular surgery is not infrequently presents late after surgery Critical isthmus leading to VT exit often around the valvular apparatus with successful ablation along the region

50 Conclusions cont d Post repair surgery for congenital heart disease is not infrequently presents late with reentrant VT Most experience are with repair of TOF, VSD and RVOT patch Critical isthmus often borders by the valve annulus with either the ventriculotomy scar, or with the patch. Ablation is highly successful with ablation lines connecting either the scar of the patch to the annulus

51 CAFCAA 2008 S.A.

52 CAFCAA 2008 S.A.

53 CAFCAA 2008 S.A.

54 CAFCAA 2008 S.A.

55 CAFCAA 2008

56

57 CAFCAA 2008 Magnetic Resonance Based Anatomical Analysis of Scar-Related Ventricular Tachycardia Implications for Catheter Ablation Ashi

58 Three Mechanisms of Tachycardia Re-entry

59 Ischemic VT Substrate CAFCAA 2008 Magnetic Resonance Based Anatomical Analysis of Scar-Related Ventricular Tachycardia Implications for Catheter Ablation Ash

60 Ischemic VT Substrate CAFCAA 2008 Magnetic Resonance Based Anatomical Analysis of Scar-Related Ventricular Tachycardia Implications for Catheter Ablation Ash

61

62

63 Disease Specific VT Substrate Normal Structure Heart: Outflow Tract VTs: Right, Left Great Vessels VTs: Pulmonary, Aortic Cusp LV Fascicular VT Mitral Annulus VT Polymorphic VT/VF: Long QT Syndrome Brugada Syndrome

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