Appendix: Definition of variables in the studies included in the meta-analysis

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1 Appendix: Definition of variables in the studies included in the meta-analysis Belonging to the article: Bogers RP, BemelmansWJE, Hoogenveen RT, Boshuizen HC, Woodward M, Knekt P, van Dam RM, Hu FB, Visscher TLS, Menotti A, Thorpe RJ Jr, Jamrozik K, Calling S, Strand BH, Shipley MJ, for the BMI-CHD collaboration investigators. Overweight is associated with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including over 300,000 persons. Arch Int Med 1

2 Definition of variables in the studies included in the meta-analysis Ref. BMI BMI continuous normal or weight categories category Australian National Heart Foundation Risk Factor Prevalence Caerphilly cohort Dubbo study of Australian elderly Finnish Mobile Clinic Health Examination Survey Fletcher Challenge Italian Rural Areas Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Malmö Preventive Project (MPP) Melbourne Collaborative Cohort 1 2, Smoking Physical activity Blood pressure Cholesterol con + cat 20- not current / current yes, not con never, ex, current leisure-time physical activity diastolic con never, ex, current 2 categorical variables: walking (from daily to less frequently) and gardening (daily to less frequently) cat never, ex, current (pipe, cigar or 1-14 cigarettes/day), current (15+ cigarettes/day) yes, not 4 categories: SBP<140 and DBP<90, SBP or DBP 90-94, SBP or DBP 95-99, SBP200 or DBP100; + drugs (y/n) definitely hypertensive ((SBP 170 and DBP 100) or use of antihypertensive drugs); mild hypertension (SBP 160 and DBP 95); borderline hypertensive (not included in any of the three other categories); normotensive (SBP < 140 and DBP < 90) con + cat 20- not current / current yes, not sedentary, moderate, heavy cat 20- pack years continuous as duration of conditioning physical activity cat <25 never, ex, current Sedentary leisure time physical activity in 3 categories: no, yes, missing con + cat 20- not current / current yes, not 2

3 Definition of variables in the studies included in the meta-analysis (continued) Ref. BMI BMI continuous normal or weight categories category Multifactor Primary Prevention (MPPS) Göteborg NHANES I Epidemiologic Followup (NHEFS) Nijmegen Cohort Norwegian Counties Nurses Health PRIME study Rome Railroad Cohort Scottish Heart Health US Railroad cohort Ventimiglia di Sicilia Heart (VHS) Whitehall Zutphen Elderly , Smoking Physical activity Blood pressure Cholesterol cat never, ex, current leisure time physical activity: sedentary, moderately acitive, regular exercise cat cat never, ex, current regular exercise vs. otherwise and diastolic 20- yes (=current and quit < 1 y ago), no (=never or quit >1 y ago) moderate/vigorous, light cat 20- never, ex, current low, high con + cat never, ex, current (1-14,15-24, 25 cigs/d) 5 categories self-reported hypertension (y/n) elevated chol. (y/n) con never, ex, current no/low, intense sedentary, moderate, heavy con + cat 20- never, ex, current physical activity at work: inactive, average, active; leisure physical activity: inactive, average, active sedentary, moderate cat <27 never, ex, current physical activity at work and leisure time physical activity in 4 categories con + cat never, ex cig smk, current cig smk adj. for no. cigs/d, current pipe or cigar smk. leisure time activity: low, moderate, vigorous; travel activity: none, 1-9 mins, mins, 20 mins. and diastolic, LDL, HDL con + cat 20- never, ex, current minutes activity 3

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