Sodium Nitrite for Out-of-Hospital Cardiac Arrest MICHAEL SAYRE, MD MEDICAL DIRECTOR, SEATTLE FIRE DEPARTMENT
|
|
- Roger Floyd
- 5 years ago
- Views:
Transcription
1 Sodium Nitrite for Out-of-Hospital Cardiac Arrest MICHAEL SAYRE, MD MEDICAL DIRECTOR, SEATTLE FIRE DEPARTMENT
2 Disclosures EMS Medicine Fellowship Director, University of Washington Physio-Control provides a significant grant to par@ally fund the fellow s salary and benefits. I receive travel reimbursement from the fund. We will discuss a poten@al indica@on, not approved by FDA, for an approved drug.
3 Half of OHCA pacents admieed to hospital following restoracon of pulses die of brain injury. The Hot Dog Study
4 Time Electrical Defibrillation
5 Time Hemodynamic CPR +? Epinephrine
6 Time Metabolic?
7 It s all about the mitochrondia.
8 Known protective effects of nitric oxide Vascular smooth muscle relaxation and vasodilation Inhibits leukocyte adhesion Suppression of Smooth muscle proliferation Inhibits platelet aggregation EC
9 QuesCon Will increasing nitric oxide (NO) levels in improve neurologic outcome following from cardiac arrest?
10 Possible approaches Inhaled nitric oxide gas Drugs that directly increase nitric oxide Nitroglycerin, Sodium nitroprusside Drugs that indirectly increase nitric oxide s effect Sildenafil
11
12 Sodium nitroprusside is not affordable
13 Can a different FDA approved drug serve as a source for nitric oxide?
14 Nitrite Nitrate NO NO 2 - NO 3 -
15 Oxy-Hb NO 3 - NO NO 2 - De-Oxy-Hb NO
16
17 The bad Nitrite as a food preserva@ve. FDA regulates it. Nitrosamines produced during acidic/high heat
18 Beet Juice: mg nitrite
19 What happens to nitrite levels during cardiac arrest? Nitrite Levels Inflammatory Arrest ROSC Time
20 Nitrite Levels Add nitrite to restore Blood levels Arrest ROSC Time
21 Mouse cardiac arrest model
22 SNOCAT Study Hypothesis Infusion of sodium nitrite during (before ROSC) will improve neurologic outcome and survival arer cardiac arrest.
23 SNOCAT: Sodium nitrite out of hospital cardiac arrest trial Phase 1 (dose finding and safety trial) n=100, expect 40 to survive to ED admission Open label, start dose of 25 mg. Achieve plasma level of 10 um?
24 Eligibility Out-of-hospital cardiac arrest (VF, non-vf) Unconscious/not following commands IV access/io Not in the three P s: Pregnant, Pediatric, Prisoners
25 Safety Data Being Collected Re-arrest Use of vasopressors: norepinephrine or epinephrine infusions Blood Draws for NO 2 levels at ED or in field For Harborview Medical Center only addi@onal draws at 20, 40, 60, 80, 100, 120 points
26 Endpoints Plasma level of nitrite at hospital, ED arrival Safety: re-arrest, use of pressors N=100 (expect 40 to be admi_ed to ED)
27 SNOCAT: Sodium nitrite out of hospital cardiac arrest trial Phase 2 (safety and efficacy) n=1000, expect 400 to survive to ED Randomized/blinded Primary endpoint: Survival to ED (safety endpoint) Secondary endpoint: Survival to discharge
28 SNOCAT InvesCgators Francis Kim Peter Kudenchuk Graham Nichol Michele Olsuea Michael Sayre Sue Scruggs Chuck Maynard Susanne May
29 Safety Low risk for hypotension No risk for methemoglobin Restores nitrite level to baseline Given post-arrest at doses up to 9 mg, no significant effects Effect during resuscita@on unknown?
30 The good Increases NO levels in blood (blood pressure lowering effects) May protect blood vessels Found in supplements (increase endurance)
31
32 Ischemia/reperfusion X X X Superoxide Nitric oxide Hydrogen sulfide Carbon monoxide
33 NO CO H 2 S Toxic Gas? Exhaust, air pollution Air pollution Sewers, swamps Produced by cells Nitric oxide synthase (NOS) nitrite Made from hemoglobin Synthesized from L-cysteine Vascular effects Vasodilates Vasodilates Vasodilates Anti-inflammatory effects Yes Yes Yes Mitochondrial Decrease Decrease Decrease
34 Membrane permeability Coagulation activation x Ischemia Reperfusion Injury Inflammatory Response x Ca 2+, glutamate x NO Brain cell injury/death
35 NO-ischemia role of nitric oxide in ischemia reperfusion (liver,heart, brain) overexpression studies Drug (NO-donor) (different structures)
36 NO produccon is reduced during ischemia Nitric oxide by NOS requires oxygen (not suitable for ischemia) Nitric oxide requires cofactors (limited during ischemia)
37 Dezfulian, C. et al. Cardiovasc Res : ; doi: /j.cardiores The NO-nitrite-nitrate pool
38
39
40 IV nitrite in acute ST elevacon MI 229 pts randomized (70 um, 5 mg over 5 minutes) or placebo before coronary interven@on Mean nitrite level at randomiza@on (.70 um) Nitrite (1.42 um) vs. placebo (.18 um) 5 min arer comple@on of infusion Siddiqu N, European Heart Journal 2014
41 Siddiqi N et al. Eur Heart J 2014;35: The Author Published by Oxford University Press on behalf of the European Society of Cardiology.
42 Clinical-nitrites Peripheral arterial disease (oral doses mg)-2014 CHF (17.5 mg)-2015 Organ for transplant Cardiac arrest (post) (1-14 mg)
43
44
45
46 Coagulation activation Membrane permeability Ischemia Reperfusion Injury Inflammatory Response Ca 2+ glutamate Brain cell injury/death
47
48 Ischemia/reperfusion Superoxide
49 Ischemia/reperfusion X X X Superoxide
The ARREST Trial: Amiodarone for Resuscitation After Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation
The ARREST Trial: Amiodarone for Resuscitation After Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation Introduction The ARREST (Amiodarone in out-of-hospital Resuscitation of REfractory Sustained
More informationEpinephrine Cardiovascular Emergencies Symposium 2018
Epinephrine Cardiovascular Emergencies Symposium 218 Corey M. Slovis, M.D. Vanderbilt University Medical Center Metro Nashville Fire Department Nashville International Airport Nashville, TN High Quality
More informationPROBLEM: Shock refractory VF/pVT BACKGROUND: Both in 2015 CoSTR. Amiodarone favoured.
Question Should AMIODARONE vs LIDOCAINE be used for adults with shock refractory VF/pVT PROBLEM: Shock refractory VF/pVT BACKGROUND: Both in 2015 CoSTR. Amiodarone favoured. OPTION: AMIODARONE plus standard
More informationPCTH 400. Endothelial dysfunction and cardiovascular diseases. Blood vessel LAST LECTURE. Endothelium. High blood pressure
PCTH 400 LAST LECTURE Endothelial dysfunction and cardiovascular diseases. Classic Vascular pharmacology -chronic -systemic Local Vascular pharmacology -acute -targeted High blood pressure Blood pressure
More informationEMT. Chapter 14 Review
EMT Chapter 14 Review Review 1. All of the following are common signs and symptoms of cardiac ischemia, EXCEPT: A. headache. B. chest pressure. C. shortness of breath. D. anxiety or restlessness. Review
More informationOut-of-hospital Cardiac Arrest. Franz R. Eberli MD, FESC, FAHA Cardiology Triemli Hospital Zurich, Switzerland
Out-of-hospital Cardiac Arrest Franz R. Eberli MD, FESC, FAHA Cardiology Triemli Hospital Zurich, Switzerland Conflict of Interest I have no conflict of interest to disclose regarding this presentation.
More informationDisclosures. Pediatrician Financial: none Volunteer :
Brain Resuscitation Neurocritical Care Monitoring & Therapies CCCF November 2, 2016 Anne-Marie Guerguerian Critical Care Medicine, The Hospital for Sick Children University of Toronto Disclosures Pediatrician
More informationWhat is the op3mal electrical therapy for refractory ventricular fibrilla3on?
Jon Jui MD, MPH What is the op3mal electrical therapy for refractory ventricular fibrilla3on? Strategies High performance + vasopressors CPR Effect Op:mize coronary blood flow An:-arrhythmics Defibrilla:on
More informationNew Therapeutic Hypothermia Techniques
New Therapeutic Hypothermia Techniques Joseph P. Ornato, MD, FACP, FACC, FACEP Professor & Chairman, Emergency Medicine Virginia Commonwealth University Health System Richmond, VA Medical Director Richmond
More informationIn-hospital Care of the Post-Cardiac Arrest Patient. David A. Pearson, MD, FACEP, FAAEM Associate Program Director Department of Emergency Medicine
In-hospital Care of the Post-Cardiac Arrest Patient David A. Pearson, MD, FACEP, FAAEM Associate Program Director Department of Emergency Medicine Disclosures I have no financial interest, arrangement,
More informationPost-Arrest Care: Beyond Hypothermia
Post-Arrest Care: Beyond Hypothermia Damon Scales MD PhD Department of Critical Care Medicine Sunnybrook Health Sciences Centre University of Toronto Disclosures CIHR Physicians Services Incorporated Main
More informationSCVMC RESPIRATORY CARE PROCEDURE
Page 1 of 7 New: 12/08 R: 4/11 R NC: 7/11, 7/12 B7180-63 Definitions: Inhaled nitric oxide (i) is a medical gas with selective pulmonary vasodilator properties. Vaso-reactivity is the evidence of acute
More informationVasopressori ed Antiaritmici
Vasopressori ed Antiaritmici cosa e quando? Claudio Sandroni Istituto Anestesiologia e Rianimazione UCSC ILCOR ALS Task Force - ERC ALS Working Group Deputy Chair, ESICM TEM Section COI Co-author, ERC
More informationEmergency Cardiac Care Guidelines 2015
Emergency Cardiac Care Guidelines 2015 VACEP 2016 William Brady, MD University of Virginia Guidelines 2015 Basic Life Support & Advanced Cardiac Life Support Acute Coronary Syndrome Pediatric Advanced
More informationPost Cardiac Arrest Care 2015 American Heart Association Guideline Update for CPR and Emergency Cardiovascular Care
Post Cardiac Arrest Care 2015 American Heart Association Guideline Update for CPR and Emergency Cardiovascular Care รศ.ดร.พญ.ต นหยง พ พานเมฆาภรณ ภาคว ชาว ส ญญ ว ทยา คณะแพทยศาสตร มหาว ทยาล ยเช ยงใหม System
More informationUpdate on Sudden Cardiac Death and Resuscitation
Update on Sudden Cardiac Death and Resuscitation Ashish R. Panchal, MD, PhD Medical Director Center for Emergency Medical Services Assistant Professor Clinical Department of Emergency Medicine The Ohio
More informationIN HOSPITAL CARDIAC ARREST AND SEPSIS
IN HOSPITAL CARDIAC ARREST AND SEPSIS MARGARET DISSELKAMP, MD OVERVIEW Background Epidemiology of in hospital cardiac arrest (IHCA) Use a case scenario to introduce new guidelines Review surviving sepsis
More informationManagement of Cardiac Arrest Based on : 2010 American Heart Association Guidelines
Management of Cardiac Arrest Based on : 2010 American Heart Association Guidelines www.circ.ahajournals.org Elham Pishbin. M.D Assistant Professor of Emergency Medicine MUMS C H E S Advanced Life Support
More informationINDUCED HYPOTHERMIA A Hot Topic. R. Darrell Nelson, MD, FACEP Emergency Medicine Wake Forest University Health Sciences
INDUCED HYPOTHERMIA A Hot Topic R. Darrell Nelson, MD, FACEP Emergency Medicine Wake Forest University Health Sciences Conflicts of Interest Sadly, we have no financial or industrial conflicts of interest
More informationIs the Statistical Deck Stacked in Observational Resuscitation Studies?
Is the Statistical Deck Stacked in Observational Resuscitation Studies? Michael Levy MD, FAEMS, FACEP, FACP Medical Director Anchorage Fire Department Medical Director State of Alaska Emergency Programs
More informationStayin Alive: Pediatric Advanced Life Support (PALS) Updated Guidelines
Stayin Alive: Pediatric Advanced Life Support (PALS) Updated Guidelines Margaret Oates, PharmD, BCPPS Pediatric Critical Care Specialist GSHP Summer Meeting July 16, 2016 Disclosures I have nothing to
More informationState of the art lecture: 21st Century Post resuscitation management
State of the art lecture: 21st Century Post resuscitation management ACCA Masterclass 2017 Prof Alain CARIOU Intensive Care Unit - Cochin Hospital (APHP) Paris Descartes University INSERM U970 - France
More informationPUZZLE. EARLY IMPACT ALS Jamie Syrett, MD Director of Prehospital Care Rochester General Health System PUZZLE THINKING OUTSIDE THE BOX! EARLY IMPACT?
PUZZLE EARLY IMPACT ALS Jamie Syrett, MD Director of Prehospital Care Rochester General Health System PUZZLE THINKING OUTSIDE THE BOX! EARLY IMPACT? IV ACCESS? What things do we do that make a difference?
More informationIntravenous Infusions
Intravenous Infusions 1) An IV insulin infusion can be used for patients: a) with out of control diabetes b) with DKA (Diabetic Ketoacidosis) c) after a heart attack 2) Hyperglycemia is an adaptive response
More informationNitric Resource Manual
Nitric Resource Manual OBJECTIVES Describe the biologic basis for inhaled nitric oxide therapy Describe the indications for inhaled nitric oxide therapy Describe the potential hazards, side effects and
More informationUpdate on Sudden Cardiac Death and Resuscitation
Update on Sudden Cardiac Death and Resuscitation Ashish R. Panchal, MD, PhD Medical Director Center for Emergency Medical Services Assistant Professor Clinical Department of Emergency Medicine The Ohio
More information5 Key EMS Articles for 2012
5 Key EMS Articles for 2012 Corey M. Slovis, M.D. Vanderbilt University Medical Center Metro Nashville Fire Department Nashville International Airport Nashville, TN 5 Key Topics Cardiac Arrest Trauma
More informationObjectives. Trends in Resuscitation POST-CARDIAC ARREST CARE: WHAT S THE EVIDENCE?
POST-CARDIAC ARREST CARE: WHAT S THE EVIDENCE? Nicole Kupchik RN, MN, CCNS, CCRN, PCCN, CMC Objectives Discuss the 2015 AHA Guideline Updates for Post- Arrest Care Discuss oxygenation & hemodynamic taregts
More informationPOST-CARDIAC ARREST CARE: WHAT HAPPENS AFTER ROSC MATTERS! Emergency Nurses Association
POST-CARDIAC ARREST CARE: WHAT HAPPENS AFTER ROSC MATTERS! Emergency Nurses Association - 2016 Nicole Kupchik MN, RN, CCNS, CCRN, PCCN, CMC Objectives Discuss the 2015 AHA Guideline Updates for Post- Arrest
More informationWhat works in sepsis. Topics. EGDT: Severe Sepsis/ Shock. Sepsis
What works in sepsis Eric Schmidt, MD Denver Health Medical Center University of Colorado School of Medicine Topics Understanding and implemen@ng early goal directed therapy (EGDT) Ac@vated Protein C should
More informationPost-Resuscitation Care. Prof. Wilhelm Behringer Center of Emergency Medicine University of Jena
Post-Resuscitation Care Prof. Wilhelm Behringer Center of Emergency Medicine University of Jena Conflict of interest Emcools Shareholder and founder, honoraria Zoll: honoraria Bard: honoraria, nephew works
More informationACLS Review. Pulse Oximetry to be between 94 99% to avoid hyperoxia (high oxygen tension can lead to tissue death
ACLS Review BLS CPR BLS CPR changed in 2010. The primary change is from the ABC format to CAB. After establishing unresponsiveness and calling for a code, check for a pulse less than 10 seconds then begin
More informationGETTING TO THE HEART OF THE MATTER. Ritu Sahni, MD, MPH Lake Oswego Fire Department Washington County EMS Clackamas County EMS
GETTING TO THE HEART OF THE MATTER Ritu Sahni, MD, MPH Lake Oswego Fire Department Washington County EMS Clackamas County EMS TAKE HOME POINTS CPR is the most important thing Train like we fight Measure
More informationEvidence for Lidocaine and Amiodarone in Cardiac Arrest Due to VF/Pulseless VT
Evidence for Lidocaine and Amiodarone in Cardiac Arrest Due to VF/Pulseless VT Introduction Evidence supporting the use of lidocaine and amiodarone for advanced cardiac life support was considered by international
More informationHypothermia: The Science and Recommendations (In-hospital and Out)
Hypothermia: The Science and Recommendations (In-hospital and Out) L. Kristin Newby, MD, MHS Professor of Medicine Duke University Medical Center Chair, Council on Clinical Cardiology, AHA President, Society
More informationJUST SAY NO TO DRUGS?
JUST SAY NO TO DRUGS? THE EVIDENCE BEHIND MEDICATIONS USED IN CARDIAC RESUSCITATION NTI 2014 CLASS CODE 148 Nicole Kupchik RN, MN, CCNS, CCRN, PCCN Objectives 1. Discuss the historical evidence supporting
More informationRuminations about the Past, Present, and Future
Ruminations about the Past, Present, and Future Raymond L. Fowler, MD, FACEP, DABEMS Professor and Chief Division of Emergency Medical Services Department of Emergency Medicine UT Southwestern Medical
More informationROC ALPS. Amiodarone, Lidocaine, or Placebo Study
ROC ALPS Amiodarone, Lidocaine, or Placebo Study Learning Objectives Understand the rationale for antiarrhythmic use in out-of-hospital cardiac arrest Understand how to carry out the ROC ALPS study protocol
More informationAfter resuscitation from cardiac arrest, brain injury is a
Pilot Randomized Clinical Trial of Prehospital Induction of Mild Hypothermia in Out-of-Hospital Cardiac Arrest Patients With a Rapid Infusion of 4 C Normal Saline Francis Kim, MD; Michele Olsufka, RN;
More informationInhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction
Inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction 4th Annual Pulmonary Hypertension Drug Discovery and Development Symposium July -, 7 Berlin,
More informationPrehospital Post Arrest Care AHA Strive to Revive 2017 November 3, 2017
Prehospital Post Arrest Care AHA Strive to Revive 2017 November 3, 2017 Jon Rittenberger, MD, MS Department of University of Pittsburgh Employers: Disclosures - Rittenberger University of Pittsburgh UPMC
More informationSamphant Ponvilawan Bumrungrad International
Samphant Ponvilawan Bumrungrad International Definitions Artificial circulation using VA ECMO as an alternative to ventilation and external cardiac massage Indications Out-of-Hospital Cardiac Arrest (OHCA)
More informationLesson learnt from big trials. Sung Phil Chung, MD Gangnam Severance Hospital, Yonsei Univ.
Lesson learnt from big trials Sung Phil Chung, MD Gangnam Severance Hospital, Yonsei Univ. Trend of cardiac arrest research 1400 1200 1000 800 600 400 200 0 2008 2009 2010 2011 2012 2013 2014 2015 2016
More informationACLS AND MORE. Ryan Clark D.O. Medical Education Fellow University of Massachusetts Medical School Baystate Medical Center
ACLS AND MORE Ryan Clark D.O. Medical Education Fellow University of Massachusetts Medical School Baystate Medical Center FOCUS 1. The death of the pulse check 2. PEA and why you can stop memorizing the
More informationEvidence-Based. Management of Severe Sepsis. What is the BP Target?
Evidence-Based Management of Severe Sepsis Michael A. Gropper, MD, PhD Professor and Vice Chair of Anesthesia Director, Critical Care Medicine Chair, Quality Improvment University of California San Francisco
More informationCase: 65 year old post-cardiac arrest patient with myoclonus
Case: 65 year old post-cardiac arrest patient with myoclonus David B. Seder MD, FCCP, FCCM, FNCS Associate Professor of Medicine Tufts University School of Medicine Interim Department Chief and Director
More informationAngina Pectoris Dr. Shariq Syed
Angina Pectoris Dr. Syed 1 What is Angina Pectoris (AP)? Commonly known as angina is chest pain often due to ischemia of the heart muscle, Because of obstruction or spasm of the coronary arteries 2 What
More informationDIAGNOSIS AND MANAGEMENT OF ACUTE HEART FAILURE
DIAGNOSIS AND MANAGEMENT OF ACUTE HEART FAILURE Mefri Yanni, MD Bagian Kardiologi dan Kedokteran Vaskular RS.DR.M.Djamil Padang The 3rd Symcard Padang, Mei 2013 Outline Diagnosis Diagnosis Treatment options
More informationControversies in ACLS Drugs: What, When, Why
Controversies in ACLS Drugs: What, When, Why Michael W. Donnino, MD Emergency Medicine and Critical Care Director of the Center for Resuscitation Science Beth Israel Deaconess Medical Center mdonnino@bidmc.harvard.edu
More information7/18/2018. Cerebral Vasospasm: Current and Emerging Therapies. Disclosures. Objectives
Cerebral : Current and Emerging Therapies Chad W. Washington MS, MD, MPHS Assistant Professor Department of Neurosurgery Disclosures None Objectives Brief Overview How we got here Review of Trials Meta-analysis
More informationDisclosures. Extra-Corporeal Membrane Oxygenation During Cardio- Pulmonary Resuscitation ECPR April 22, 2016 ECG. Case. Case. Case Summary 4/22/2016
Extra-Corporeal Membrane Oxygenation During Cardio- Pulmonary Resuscitation ECPR April 22, 2016 Nothing to disclose. Disclosures Ivan J Chavez MD Case ECG History 60 y/o male No prior history of CAD In
More informationEmergency Medical Training Services Emergency Medical Technician Basic Program Outlines Outline Topic: CARDIAC EMERGENCIES Revised: 11/2013
DEFINITIONS: Emergency Medical Training Services Emergency Medical Technician Basic Program Outlines Outline Topic: CARDIAC EMERGENCIES Revised: 11/2013 Chain of survival (adult) - early activation, early
More informationVanderbiltEM.com. Prehospital STEMIs. EMS Today 2018 Research That Should Be On Your Radar Screen 3/1/2018
EMS Today 2018 Research That Should Be On Your Radar Screen Corey M. Slovis, M.D. Vanderbilt University Medical Center Metro Nashville Fire Department Nashville International Airport Nashville, TN VanderbiltEM.com
More informationManagement of Post Cardiac Arrest Syndrome
Management of Post Cardiac Arrest Syndrome Wilhelm Behringer Associated Professor of Emergency Medicine Medical University of Vienna, Austria Patients % What happens after ROSC? 35 30 25 20 15 10 5 ROSC
More informationACLS Prep. Preparation is key to a successful ACLS experience. Please complete the ACLS Pretest and Please complete this ACLS Prep.
November, 2013 ACLS Prep Preparation is key to a successful ACLS experience. Please complete the ACLS Pretest and Please complete this ACLS Prep. ACLS Prep Preparation is key to a successful ACLS experience.
More informationSUMMARY OF MAJOR CHANGES 2010 AHA GUIDELINES FOR CPR & ECC
SUMMARY OF MAJOR CHANGES 2010 AHA GUIDELINES FOR CPR & ECC The following is a summary of the key issues and changes in the AHA 2010 Guidelines for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiac
More informationACLS/ACS Updates 2015
ACLS/ACS Updates 2015 Advanced Cardiovascular Life Support by: Fareed Al Nozha, JBIM, ABIM, FKFSH&RC(Cardiology) Consultant Cardiologist Faculty, National CPR Committee, ACLS Program Head, SHA Dr Abdulhalim
More informationIntraaortic Balloon Counterpulsation- Supportive Data for a Role in Cardiogenic Shock ( Be Still My Friend )
Intraaortic Balloon Counterpulsation- Supportive Data for a Role in Cardiogenic Shock ( Be Still My Friend ) Stephen G. Ellis, MD Section Head, Interventional Cardiology Professor of Medicine Cleveland
More informationECLS: A new frontier for refractory V.Fib and pulseless VT
ECLS: A new frontier for refractory V.Fib and pulseless VT Ernest L. Mazzaferri, Jr. MD, FACC September 15, 2017 Cardiovascular Emergencies: An exploration into the expansion of time-critical diagnosis
More informationMost Important EMS Articles EAGLES 2017
Most Important EMS Articles EAGLES 2017 Corey M. Slovis, M.D. Vanderbilt University Medical Center Metro Nashville Fire Department Nashville International Airport Nashville, TN Overview Best antiarrhythmic
More informationProf Gavin Perkins Co-Chair ILCOR
Epidemiology of out of hospital cardiac arrest how to improve survival Prof Gavin Perkins Co-Chair ILCOR Chair, Community Resuscitation Committee, Resuscitation Council (UK) Conflict of interest Commercial
More informationRACE CARS: Hospital Response. David A. Pearson, MD Department of Emergency Medicine Carolinas Medical Center February 23, 2012
L MODULE 9 RACE CARS: Hospital Response David A. Pearson, MD Department of Emergency Medicine Carolinas Medical Center February 23, 2012 2 Objectives: Post-cardiac arrest syndrome Therapeutic hypothermia
More informationMost Important EMS Articles EAGLES 2017
Most Important EMS Articles EAGLES 2017 Corey M. Slovis, M.D. Vanderbilt University Medical Center Metro Nashville Fire Department Nashville International Airport Nashville, TN Overview Best antiarrhythmic
More informationDisclosures. Overview. Cardiopulmonary Arrest: Quality Measures 5/29/2014. In-Hospital Cardiac Arrest: Measuring Effectiveness and Improving Outcomes
Disclosures In-Hospital Cardiac Arrest: Measuring Effectiveness and Improving Outcomes Research support from UCOP CHQI award J. Matthew Aldrich, MD Anesthesia & Critical Care UCSF Overview Epidemiology
More informationUniversity of Washington. From the SelectedWorks of Kent M Koprowicz
University of Washington From the SelectedWorks of Kent M Koprowicz 2007 Site variation in EMS Treatment, Transport and Survival in relation to Restoration of Spontaneous Circulation (ROSC) for Adult Out-of-Hospital
More informationEmergency Cardiovascular Care: EMT-Intermediate Treatment Algorithms. Introduction to the Algorithms
Emergency Cardiovascular Care: EMT-Intermediate Treatment Algorithms Introduction to the Algorithms Cardiac Arrest Algorithms Prehospital Medication Profiles Perspective regarding the EMT- Intermediate
More informationScience Behind Resuscitation. Vic Parwani, MD ED Medical Director CarolinaEast Health System August 6 th, 2013
Science Behind Resuscitation Vic Parwani, MD ED Medical Director CarolinaEast Health System August 6 th, 2013 Conflict of Interest No Financial or Industrial Conflicts Slides: Drs. Nelson, Cole and Larabee
More informationThe Evidence Base. Stephan A. Mayer, MD. Columbia University New York, NY
Hypothermic for Cardiac Arrest The Evidence Base Stephan A. Mayer, MD Director, Neuro-ICU Columbia University New York, NY Disclosures Columbia University Clinical Trials Pilot Award Radiant Medical, Inc.
More informationThe Need for Basic & Translational Research in Cardiac Arrest Customized Treatment. Robert A. Berg IOM August 2014
The Need for Basic & Translational Research in Cardiac Arrest Customized Treatment Robert A. Berg IOM August 2014 Present State of Translational Large Animal CPR Research in the USA Dismal Few labs (~10)
More informationPulmonary Vasodilator Treatments in the ICU Setting
Pulmonary Vasodilator Treatments in the ICU Setting Lara Shekerdemian Circulation 1979 Ann Thorac Surg 27 Anesth Analg 211 1 Factors in the ICU Management of Pulmonary Hypertension After Cardiopulmonary
More informationCardio Pulmonary Cerebral Resuscitation
Cardio Pulmonary Cerebral Resuscitation Brain Under Pressure October 3, 2017 Canadian Critical Care Forum Anne-Marie Guerguerian Critical Care Medicine, The Hospital for Sick Children University of Toronto
More informationCarbon Monoxide, Cyanide, and Hydrogen Sulfide Antidote Treatment Clinical Questions
Carbon Monoxide, Cyanide, and Hydrogen Sulfide Antidote Treatment Clinical Questions Tammi H. Schaeffer, DO, FACEP, FACMT, FAACT Associate Professor, Emergency Medicine, Tufts Univ. School of Medicine,
More informationWhat works? What doesn t? What s new? Terry M. Foster, RN
What works? What doesn t? What s new? Terry M. Foster, RN 2016 Changes Updated every 5 years Last update was 2010 All recommendations have been heavily researched with studies involving large number of
More informationNothing to Disclose. Severe Pulmonary Hypertension
Severe Ronald Pearl, MD, PhD Professor and Chair Department of Anesthesiology Stanford University Rpearl@stanford.edu Nothing to Disclose 65 year old female Elective knee surgery NYHA Class 3 Aortic stenosis
More informationSimulation 15: 51 Year-Old Woman Undergoing Resuscitation
Simulation 15: 51 Year-Old Woman Undergoing Resuscitation Flow Chart Flow Chart Opening Scenario Section 1 Type: DM Arrive after 5-6 min in-progress resuscitation 51 YO female; no pulse or BP, just received
More informationThe 2015 BLS & ACLS Guideline Updates What Does the Future Hold?
The 2015 BLS & ACLS Guideline Updates What Does the Future Hold? Greater Kansas City Chapter Of AACN 2016 Visions Critical Care Conference Nicole Kupchik RN, MN, CCNS, CCRN, PCCN, CMC Independent CNS/Staff
More informationH 2 S: Synthesis and functions
H 2 S: Synthesis and functions 1 Signaling gas molecules: O 2, NO and CO Then, H 2 S - Fourth singling gas molecule after O 2, NO and CO 2 Nothing Rotten About Hydrogen Sulfide s Medical Promise Science
More informationObjectives: This presentation will help you to:
emergency Drugs Objectives: This presentation will help you to: Five rights for medication administration Recognize different cardiac arrhythmias and determine the common drugs used for each one List the
More informationChapter 19 Detection of ROSC in Patients with Cardiac Arrest During Chest Compression Using NIRS: A Pilot Study
Chapter 19 Detection of ROSC in Patients with Cardiac Arrest During Chest Compression Using NIRS: A Pilot Study Tsukasa Yagi, Ken Nagao, Tsuyoshi Kawamorita, Taketomo Soga, Mitsuru Ishii, Nobutaka Chiba,
More informationCHILL OUT! Induced Hypothermia: Challenges & Successes in the
CHILL OUT! Induced Hypothermia: Challenges & Successes in the ICU Colleen Bell RN, BS, CCRN, Donna Brault RN, BSN, CCRN, Cathy Patnode RN, BSN, CCRN Champlain Valley Physician Hospital November 2012 Objectives
More informationVictorian Ambulance Cardiac Arrest Registry (VACAR)
Victorian Ambulance Cardiac Arrest Registry (VACAR) Dr Karen Smith (PhD) VACAR Chair Manager Research and Evaluation Ambulance Victoria Smith K, Bray J, Barnes V, Lodder M, Cameron P, Bernard S and Currell
More informationPost-Cardiac Arrest Syndrome. MICU Lecture Series
Post-Cardiac Arrest Syndrome MICU Lecture Series Case 58 y/o female collapses at home, family attempts CPR, EMS arrives and notes VF, defibrillation x 3 with return of spontaneous circulation, brought
More informationTherapeutic hypothermia
INDUCED HYPOTHERMIA Dr. Attilla Kiss M.D. Acting Medical Director Emergency Services EMS Medical Director St. John Medical Center OBJECTIVES Define and explain Induced Hypothermia Discuss both pre-hospital
More informationBut unfortunately, the first sign of cardiovascular disease is often the last. Chest-Compression-Only Resuscitation Gordon A.
THE UNIVERSITY OF ARIZONA Sarver Heart Center 1 THE UNIVERSITY OF ARIZONA Sarver Heart Center 2 But unfortunately, the first sign of cardiovascular disease is often the last 3 4 1 5 6 7 8 2 Risk of Cardiac
More informationIpotermia terapeutica controversie e TTM 2 Trial Iole Brunetti
Ipotermia terapeutica controversie e TTM 2 Trial Iole Brunetti U.O.C Anestesia e Terapia Intensiva Policlinico San Martino - GENOVA Natural Course of Neurological Recovery Following Cardiac Arrest Cardiac
More informationAmino acids. Dr. Mamoun Ahram Summer semester,
Amino acids Dr. Mamoun Ahram Summer semester, 2017-2018 Resources This lecture Campbell and Farrell s Biochemistry, Chapters 3 (pp.66-76) General structure (Chiral carbon) The amino acids that occur in
More informationHow to maintain optimal perfusion during Cardiopulmonary By-pass. Herdono Poernomo, MD
How to maintain optimal perfusion during Cardiopulmonary By-pass Herdono Poernomo, MD Cardiopulmonary By-pass Target Physiologic condition as a healthy person Everything is in Normal Limit How to maintain
More informationStructure and organization of blood vessels
The cardiovascular system Structure of the heart The cardiac cycle Structure and organization of blood vessels What is the cardiovascular system? The heart is a double pump heart arteries arterioles veins
More informationino in neonates with cardiac disorders
ino in neonates with cardiac disorders Duncan Macrae Paediatric Critical Care Terminology PAP Pulmonary artery pressure PVR Pulmonary vascular resistance PHT Pulmonary hypertension - PAP > 25, PVR >3,
More informationTHE EVIDENCED BASED 2015 CPR GUIDELINES
SAUDI HEART ASSOCIATION NATIONAL CPR COMMITTEE THE EVIDENCED BASED 2015 CPR GUIDELINES Page 1 Chapter 7 ACS CHAPTER DIAGNOSTIC INTERVENTIONS IN ACS Prehospital ECG ILCOR Treatment Recommendation: We recommend
More informationPresented by Dr Nishat Siddiqi on behalf of:
The effects of intravenous sodium nitrite in acute ST elevation myocardial infarction: a randomised controlled trial Presented by Dr Nishat Siddiqi on behalf of: Ischaemia-reperfusion-injury Can account
More information2015 Interim Training Materials
2015 Interim Training Materials ACLS Manual and ACLS EP Manual Comparison Chart Assessment sequence Manual, Part 2: The Systematic Approach, and Part BLS Changes The HCP should check for response while
More informationWith My Heart, Can or Should I Take Erectile Dysfunction Drugs?
With My Heart, Can or Should I Take Erectile Dysfunction Drugs? Timothy R. Malinowski MD, FACC UMG Carolina Cardiology Consultants Greenville Health System Definition of Erectile Dysfunction 1992 NIH Consensus
More informationManagement of Acute Shock and Right Ventricular Failure
Management of Acute Shock and Right Ventricular Failure Nader Moazami, MD Department of Thoracic and Cardiovascular Surgery and Biomedical Engineering, Cleveland Clinic NONE Disclosures CARDIOGENIC SHOCK
More informationECG Changes in Patients Treated with Mild Hypothermia after Cardio-pulmonary Resuscitation for Out-of-hospital Cardiac Arrest
ECG Changes in Patients Treated with Mild Hypothermia after Cardio-pulmonary Resuscitation for Out-of-hospital Cardiac Arrest R. Schneider, S. Zimmermann, W.G. Daniel, S. Achenbach Department of Internal
More informationStudent Contribution THE USE OF VASOPRESSIN IN THE TREATMENT OF CARDIAC ARREST A CASE STUDY. Aaron Turner, SA Ambulance Service
ISSN 1447-4999 Student Contribution THE USE OF VASOPRESSIN IN THE TREATMENT OF CARDIAC ARREST A CASE STUDY Aaron Turner, SA Ambulance Service INTRODUCTION Despite widespread use, current methods of treatment
More informationSooner to the Ballooner: Going Straight to the Cath Lab with Refractory VF/VT
Sooner to the Ballooner: Going Straight to the Cath Lab with Refractory VF/VT Marc Conterato, MD, FACEP Office of the Medical Director NMAS and the HC EMS Council/Minnesota Resuscitation Consortium DISCLOSURE
More information201 0 Miracle on Ice Conference Minneapolis Heart Institute at Abbott Northwestern Hospital
Miracle on Ice 2010 :Therapeutic Hypothermia for Cardiac Arrest Patients Sept 9 10, 2010 Allina Commons Midtown Exchange Minneapolis, Minnesota Course Directors: Barbara Tate Unger RN, BS,FAACVPR,FAHA
More informationHeart Disease. Signs and Symptoms
Heart Disease The term "heart disease" refers to several types of heart conditions. The most common type is coronary artery disease, which can cause heart attack, angina, heart failure, and arrhythmias.
More informationSpecial circulations, Coronary, Pulmonary. Faisal I. Mohammed, MD,PhD
Special circulations, Coronary, Pulmonary Faisal I. Mohammed, MD,PhD 1 Objectives Describe the control of blood flow to different circulations (Skeletal muscles, pulmonary and coronary) Point out special
More information