Percutaneous transarterial aortic valve implantation: what do we know?
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- Marjorie Chandler
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1 European Heart Journal (2011) 32, doi: /eurheartj/ehq453 REVIEW Controversies in cardiovascular medicine Percutaneous transarterial aortic valve implantation: what do we know? John Webb 1 * and Alain Cribier 2 1 St. Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z1Y6; and 2 University Hospital Charles Nicolle, Rouen, France Received 12 October 2010; revised 8 November 2010; accepted 15 November 2010; online publish-ahead-of-print 4 December 2010 Transcatheter aortic valve implantation (TAVI) is assuming a major role in the routine management of patients with aortic stenosis. Surgical aortic valve replacement is generally accepted to prolong survival, on the basis of historical comparisons and long experience. However, recently percutaneous transarterial TAVI has assumed the position as the only therapy in any aortic stenosis patient group demonstrated to prolong survival in a randomized trial. Arguably, percutaneous TAVI is now the standard of care in symptomatic patients who are not candidates for conventional surgery. On the basis of almost 10 years of experience TAVI also appears to be a reasonable option for some operable, but high-risk patients. Nevertheless considerable work needs to be done before the indications for TAVI are expanded into lower risk groups. We review what is currently known about percutaneous transarterial implantation of the aortic valve Keywords Aortic valve Percutaneous Transcatheter Introduction Symptomatic aortic stenosis is associated with a dismal prognosis when managed conservatively. Surgical valve replacement is generally accepted to prolong survival on the basis of historical comparisons and long experience. 1,2 Multiple registries from multiple centres have shown that transcatheter aortic valve implantation (TAVI) can be accomplished in high-risk patients with outcomes that compare favourably with the outcomes of surgical valve replacement, as predicted by operative risk assessment tools. 3 8 Recently, percutaneous transarterial TAVI assumed the position as the only therapy in any aortic stenosis patient group demonstrated to prolong survival in a randomized trial. 9 An absolute 20% increase in survival at 1 year in patients determined to be too high risk for surgery is dramatic confirmation of this potential. As we approach 10 years of experience with TAVI, over cases and over 100 publications, a review of what we now know about percutaneous TAVI seems appropriate. As the bulk of the percutaneous experience to date has been with the Edwards SAPIEN and Medtronic CoreValve devices and with the femoral transarterial approach, this will be the focus of the discussion below. Current transcatheter valves There are currently two valves in widespread clinical use, as shown in Figure 1 and described in Table 1. The Edwards transcatheter heart valve (THV) (Edwards Lifesciences, USA) utilizes a balloon-expandable tubular frame (Figure 2). Earlier iterations, including the prototypic Cribier Edwards and the more widely used SAPIEN THV, required large diameter delivery systems. However, the current SAPIEN XT valve is mounted on a low profile NovaFlex delivery system. In contrast the CoreValve ReValving System (Medtronic Inc., Minneapolis, MN, USA) utilizes a self-expanding multi-staged frame. A unique feature is that this device is anchored not only within the aortic annulus, but also extends superiorly to anchor in the supracoronary aorta. Early versions of both the Edwards and CoreValve devices required large F delivery systems. For a period the CoreValve device offered the advantage of a lower profile delivery system. However, both devices are now available with comparable low profile F delivery systems; theoretically allowing application in the majority, but by no means all, patients with aortic stenosis. The CoreValve device is associated with less haemodynamic instability during deployment, more forgiving positioning and is potentially retrievable if positioned incorrectly. The risk of acute * Corresponding author. Tel: , Fax: , webb@providencehealth.bc.ca Published on behalf of the European Society of Cardiology. All rights reserved. & The Author For permissions please journals.permissions@oup.com.
2 Percutaneous aortic valve 141 Table 1 Comparison of the Edwards SAPIEN XT valve and Medtronic CoreValve prostheses Figure 1 Photographs of transcatheter aortic valves. (A) Balloon-expandable SAPIEN XT. (B) Self-expandable CoreValve. coronary obstruction by a displaced native valve leaflet may be lower. A relatively high rate of acute and delayed heart block may require prolonged electrocardiographic monitoring with temporary indwelling leads and more frequent pacemaker implantation. The late consequences of a CoreValve stent frame extending into the ascending aorta and over the coronary ostia are not known and the SAPIEN valves offer a more focal therapy. The SAPIEN valve is supported by a larger and longer body of publications and early randomized data demonstrating benefit over medical management in non-operative patients. Comparisons with regards to durability are largely speculative, although there is a surgical literature suggesting the superiority of bovine over porcine pericardial tissue valves. In the absence of comparative trials it difficult to definitely determine differences in the potential for clinical benefit. This review will focus, as much as possible, on the similarities between the two clinically available devices. Future valves A number of other valves are in early clinical evaluation. In general these incorporate features to reduce delivery catheter diameter, facilitate accurate positioning, reduce paravalvular leaks, or allow for retrieval Generally these next generation valves are selfexpanding rather than balloon-expandable, a feature which facilitates smaller diameter delivery systems and retrieval. Examples Edwards SAPIEN Medtronic XT CoreValve... Frame Cobalt chromium Nitinol Leaflets Bovine pericardial Porcine pericardial Expansion Balloon-expandable Self-expanding Balloon valvuloplasty Yes Yes required Retrievable No Prior to release Annular/valvar fixation Yes Yes Ascending No Yes aortastabilization Manufacturers diameter a 23, 26 mm 26, 29 mm Recommended annulus mm mm diameter Length mm mm Delivery system 18F&19F 18F diameter Sheath external diameter 7.3 mm 7.3 mm Minimum arterial 6mm 6mm diameter... Suitable for Aortic stenosis Yes Yes Aortic insufficiency If combined with Yes stenosis Pulmonaryposition Yes No Valve-in-valve All four valve Aortic only positions Transapical access Yes No Transaxillary access Yes, limited Yes experience... Longest reported 5 years 3 years follow-up Pacemaker 4 8% 15 40% CE mark approval Yes Yes Randomized trials PARTNER Results completed anticipated 2013 a SAPIEN XT 20 and 29 mm valves and CoreValve 23 mm valves anticipated. include the Lotus (Boston Scientific Inc., USA), Direct Flow (Direct Flow Medical Inc., USA), and HLT (Heart Leaflet Technologies Inc., USA) valves. Some utilize a secondary fixation point in the supra-coronary aorta such as the Accurate (Symetic Inc., CH) and St Jude (St Jude Medical Inc., USA) valves. Some incorporate features which facilitate positioning and anatomical orientation in relation to the native valve and coronaries such as the Engager (Medtronic Inc., USA) and the JenaClip (JenaValve Inc., Germany). Although these valves may incorporate desirable features little information is available on efficacy, procedural outcomes, and durability. It is possible that attempts to improve ease of implantation may lead to unexpected problems or compromise durability.
3 142 J. Webb and A. Cribier Figure 2 Percutaneous aortic valve implantation. Left. Aortic angiogram in a patient with severe aortic stenosis. Middle. A balloon-expandable Edwards SAPIEN valve is being expanded. Right. An aortogram after valve implantation confirms correct positioning, a patent left coronary artery and the absence of aortic regurgitation. Figure 3 Transaortic gradients in a patient with severe aortic stenosis before and after percutaneous aortic valve implantation. Valve function The haemodynamic performance of currently available THVs is comparable with surgical heart valves (Figure 3). 5,7,9,14 23 Mean systolic gradients are typically around 10 mmhg and effective orifice area is generally between 1.2 and 1.9 cm 2, depending on prosthesis size. Transcatheter heart valves appear associated with better haemodynamics than surgical bioprostheses, in part due to the absence of a bulky sewing ring. Paravalvular regurgitation, due to incomplete annular sealing, is common with current THVs. With current implant techniques, oversizing and increasingly accurate positioning paravalvular regurgitation is usually trivial or mild and sometimes moderate. Such leaks appear well tolerated, do not worsen with time, and clinical haemolysis has not been reported. Severe regurgitation may occur, but is relatively infrequent. Severe leaks are typically due to technical errors in terms of sizing or positioning. In such instances redilation or implantation of a second, overlapping valve-in-valve implant can be helpful. The majority of patients with aortic stenosis also have some degree of regurgitation at baseline. However, significant prosthetic transvalvular leaks are uncommon after TAVI. In current large series the general finding is that net aortic regurgitation (both valvular and paravalvular combined) is not increased and is often reduced, after TAVI. 5,9,17,19 Accelerated wear testing of currently available valves predicts durability in excess of 10 years. There are several reports of echocardiographic follow-up out to 1 and 2 years with both the SAPIEN
4 Percutaneous aortic valve 143 and CoreValve devices. 5,7,9,15 20 One published report documents late valve function in patients up to 5 years after implantation of the SAPIEN precursor valve. 24 The longest surviving patient, at 6.5 years in the original Cribier series, still has a normally functioning prosthesis. It is reassuring that structural THV failure has not been reported to date, although admittedly late follow-up remains limited and inadequate. Access Transvenous access was utilized to establish the feasibility of TAVI, but successful implantation was difficult to reproduce and this route is no longer utilized. Percutaneous implantation is currently performed utilizing retrograde access from the femoral artery. 25,26 Originally requiring open cutdown, arterial access this is now typically accomplished with percutaneous puncture and percutaneous suture closure (Figure 4). Alternatives include open surgical access to the retroperitioneal iliac artery, subclavian artery, ascending aorta, or left ventricular apex. All have been used very successfully to avoid problematic peripheral arterial or aortic disease. Greater proximity to the valve with these open central access techniques may, in some cases, facilitate improved catheter control during implantation. The transaxillary/subclavian route has found particular favour in conjunction with the CoreValve device, while the apical route is widely utilized with SAPIEN device. Disadvantages include the need for open surgical access and, in the case of the transapical procedure, concerns about thoracotomy and left ventricular injury. Although this review is focused on percutaneous TAVI, most of the following discussion is relevant to TAVI regardless of the route of access. Regardless of access route an optimal facility should be able to provide excellent fluoroscopic imaging, surgical sterility, and ready access to anaesthetic, echocardiographic, vascular, and cardiac surgical support (Figure 5). Moreover a multidisciplinary heart team combining interventionalists, surgeons, anaesthesia, and nursing is necessary for appropriate patient evaluation, selection, management, and optimal outcomes. Patient outcomes Procedural success rates (defined loosely here as implantation of a functional valve with the patient surviving the procedure) have increased steadily from 82% in the initial transvenous experience, 15 to over 95% in more recent series. 17,19 It appears that, when patients are appropriately selected, TAVI is a procedure that can be reproducibly and reliably performed. In a recent review 82 reports, representing 2356 patients receiving the Edwards Lifesciences and Medtronic THVs, were identified. 19 Survival at 30 days was 89%, similar for both valves. Similarly, survival continues to improve, with recent reports documenting 30-day survival rates of 93 95%. 3,5,9,22,27 To date the literature has largely consisted of registries, without the oversight expected from a prospective trial. To put this into perspective it is useful to look at outcomes in the recent PARTNER B trial (Figure 6). Patients were declined surgery due to prohibitive risk based on a rigorously monitored consensus amongst multiple senior surgeons from multiple centres. Despite early generation, large profile systems and minimal operator experience with TAVI before the trial, the low 30-day mortality of 6.4% amongst patients undergoing TAVI compares very favourably with the Society of Thoracic Surgeons (STS) surgical risk estimate of 11.6%. Moreover, the STS National Cardiac Database reports that, among patients undergoing surgical aortic valve replacement surgery in the USA, overall mortality was also 6.4%. 28 In this trial there was a dramatic 20% absolute improvement in survival at 1 year follow-up with percutaneous TAVI, with the survival curves continuing to diverge. Non-operative patients not receiving TAVI had a dismal survival of,50% at 1 year, with the survival curves Figure 4 Percutaneous access (left) and closure (right). The technique of preclosure involves percutaneous placement of sutures in the arterial wall prior to insertion of a large access sheath to facilitate haemostatic closure of the arteriotomy without a surgical cutdown.
5 144 J. Webb and A. Cribier Figure 5 A hybrid endovascular/surgical suite with excellent fluoroscopic imaging, a sterile environment and capabilities for general anaesthesia, cardiopulmonary support as well as cardiac and vascular surgery. continuing to diverge. Randomized comparisons of surgery and the SAPIEN valve in high risk, but operable, patients may be available in early Evaluations in lower risk operable patients with the CoreValve and SAPIEN XT devices can be anticipated to start enrolment shortly. Survival rates at 1 year ranging from 69 to 85% have been reported after TAVI. 5,9,17,19 This somewhat disappointing late survival is invariably the consequence of an array of comorbidities and very rarely due to the aortic valve. 5,9 Among the factors commonly tracked, logistic EuroSCORE, STS score, age, liver disease, severe mitral regurgitation, anaemia, prior stroke, pulmonary disease, and renal failure are predictors of late mortality following TAVI. 7 9 Improvement in functional class has been reported in most published series. Typically New York Heart Association class improves from class III to IV at baseline to I II after TAVI. 17,19 Functional benefit appears to be durable. 5,9,24 Still, the disappointing late survival in some very high-risk groups begs the question as to whether some elderly patients with comorbidities who may be able to tolerate this therapy may not derive significant benefit from it. This points to the need for multidisciplinary assessment of the complex, often frail and elderly patient currently being considered for this procedure. Patient evaluation Evaluation of the potential TAVI candidate is a complex process involving multidisciplinary review. The basics are similar to what is standard in the setting of surgical valve replacement. The standard TAVI work up includes transthoracic echocardiography to confirm aortic stenosis, assess other valvular lesions, left ventricular function and, notably, the diameter of the aortic annulus. Coronary angiography is performed to assess the need for revascularization. Invasive ascending and descending aortography and/ or computed tomographic angiography is needed for assessment of the dimensions and characteristics of the aortic root as well as the diameter, tortuosity, and calcification of the iliac and femoral arteries. The nuances of evaluation are largely dictated by the specific risks of TAVI, as discussed below. Figure 6 Patients with severe, symptomatic aortic stenosis not accepted for surgery were randomized to standard care or percutaneous aortic valve implantation in the PARTNER 1B study. At 1 year follow-up there was an absolute reduction in mortality of 20% and a 18.3% reduction in the combined endpoint of mortality or stroke. The number needed to treat (NNT) to prevent a death was five and to prevent a death or major stroke 5.5 patients had to be treated. The brain Stroke rates of 0 10% have been reported in association with TAVI. 3,9,17,19,22 To put this in perspective, the large post-marketing SOURCE self-reported registry reported a stroke rate of 2.4%, while the more rigorously monitored PARTNER B trial found a major stroke (permanent disability) rate of 5.0% (both with the older large profile SAPIEN delivery system). Despite this increased risk of stroke there was a dramatic 18.3% reduction in the combined risk of death or major stroke at 1 year (Figure 6). Procedural stroke is often due to embolization of the friable material found in the diseased aortic valve, as demonstrated by transcranial Doppler. New cerebral lesions, as assessed by diffusion-weighted magnetic resonance imaging, have been reported in 58 91% of patients undergoing TAVI. 23,24 Although these findings do not appear to correlate with clinical neurologic deficits. Experimental approaches to mitigation include catheters
6 Percutaneous aortic valve 145 designed to capture embolic material or deflect it away from the cerebral circulation. The risk of procedural stroke seems to be falling with smaller and less traumatic catheters, improved technique, and lower risk patients. However, not all strokes are atheroembolic. Possible factors include valve thrombosis, atrial fibrillation, and institution or discontinuation of anticoagulation. 22 In the absence of data the standard approach to prevention of valve thromboembolism has been long-term aspirin and 1 3 months of clopidogrel or, in the presence of additional risk factors such as atrial fibrillation, warfarin. The vasculature Vascular events have represented the most common complication associated with TAVI. 17,19,22,29 Vascular complications are often implicated, sometimes directly but often indirectly, in procedural mortality. Using the large diameter 22 and 24 F RetroFlex delivery system the recent SOURCE transarterial registry and the PARTNER B study reported vascular complication rates of 17.9 and 16.2% respectively. 3,9 Similarly CoreValve 18 F registries have reported complication rates of 2 17%. More recent experience suggests that vascular complication rates are falling and, that when vascular complications do occur, they are better managed and less likely to be associated with mortality. 3,9 Surgical access to the femoral artery is giving way to routine and reliable percutaneous access and percutaneous closure. It appears that with the availability of smaller delivery systems, such as the newer Core- Valve and NovaFlex SAPIEN XT catheter systems, better screening and expertise, that vascular complications, and the associated risk of morbidity and mortality, will continue to fall. The kidneys Previous studies have shown that acute renal injury post-tavi occurs in 12 28% of cases. 17,19,30 Limited clinical experience suggests that renal function may often improve in response to increased cardiac output following relief of aortic stenosis. The reported risk is lower with percutaneous than transapical procedures. Post-procedural renal impairment is generally mild and reversible and less common than in matched surgical patients. 30 The coronaries Placing the open cells of a THV over a coronary ostium appears to be generally well tolerated, at least acutely. However, coronary obstruction may rarely occur as a consequence of THV displacement of the native valve leaflet over the left main ostium. 25 Successful management may require temporary cardiopulmonary 25,31 35 support and percutaneous or surgical revascularization. Risk factors for left main occlusion include a low origin of the coronary ostium, a shallow sinus of Valsalva, a bulky native valve and design characteristics of the prosthesis. Concomitant coronary artery disease is common and negatively impacts both procedural outcomes and late survival following TAVI. 36 Clinical experience to date suggests that the majority of coronary disease in patients undergoing TAVI can be managed conservatively. When necessary percutaneous coronary intervention can be performed as a staged or single stage procedure. The conduction system Injury to the atrioventricular conduction system as it courses through the interventricular septum below the aortic valve may be associated with new left bundle or complete heart block. Surgical AVR is associated with a need for permanent pacing in 3 18%. Reportedly TAVI is associated with new pacemaker implantation in 3 36% of patients. 17,19 Comparisons are difficult, as current TAVI patients represent a particularly high-risk group and local practise varies widely in terms of the threshold for pacemaker implantation. Nevertheless the 9 36% rate of new pacemaker implantation with the CoreValve device is clearly higher than the 3 12% rate reported with the Edwards Lifesciences device, presumably as this device often extends further into the left ventricular outflow tract. 17,19 Additional risk factors for new heart block may include advanced age, pre-existing right bundle branch block or atrioventricular delay and oversizing. The heart Left ventricular function typically improves to a small degree shortly after TAVI and may continue to improve with time. Preliminary analyses suggest a reduction in left ventricular volumes and hypertrophy. 3,5,9,26,37 Mitral regurgitation is common in patients with aortic stenosis, increasing both surgical and TAVI procedural risk. As with isolated surgical aortic valve replacement, mitral regurgitation may improve and/or be better tolerated following TAVI. 38,39 This is more likely when regurgitation is functional, unassociated with structural abnormalities such as annular calcification, tethering, or left atrial enlargement. A therapeutic strategy of replacing the aortic valve alone may be desirable in many patients in whom the risk of double valve surgery might be prohibitive. Valve-in-valve Reoperation for degenerated surgical bioprostheses carries significant risk. Early reported experience with valve-in-valve implantation in aortic degenerated surgical bioprostheses with both the SAPIEN and CoreValve devices has been favourable (Figure 7). 40,41 Typically the surgical valve facilitates positioning, paravalvular sealing and shields the atrioventricular conduction system and left main ostium. However, some surgical valves are difficult to image, compromise coronary ostia, or are too small for a valve-in-valve implant. For instance, one widely used 21 mm surgical tissue valve has an internal diameter of 17 mm meaning that even the smallest currently available THV will be underexpanded resulting in moderate stenosis. Fortunately, early experience with damaged, incorrectly positioned or undersized THVs confirms that a second transcatheter valve can be implanted within the first with a good functional result. To some degree TAVI, like percutaneous coronary intervention, may be a repeatable therapeutic strategy.
7 146 J. Webb and A. Cribier Figure 7 Valve-in-valve implant. A SAPIEN valve was implanted inside a stenotic native aortic valve (top left). As a single stage procedure a second SAPIEN valve (white arrow) was implanted inside a severely regurgitant surgical bioprosthesis (black arrow) in the mitral position. The patient remains well at 2 year follow-up. Summary Surgical valve replacement remains standard therapy for symptomatic severe aortic stenosis due to a long and established track record. Arguably TAVI is becoming the standard of care for symptomatic patients who are not operative candidates. As outcomes improve and durability is documented TAVI is also becoming an option for selected patients who are eligible for surgery, but at high risk of morbidity. Where this line is drawn is a moving target and remains controversial. 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8 Percutaneous aortic valve 147 aortic valve implantation: Early results of the FRANCE (FRench Aortic National CoreValve and Edwards) registry. Eur Heart J Published online ahead of print 15 September 2010; doi: /eurheartj/ehq Bauer F, Lemercier M, Zajarias A, Tron C, Eltchaninoff H, Cribier A. Immediate and long-term echocardiographic findings after transcatheter aortic valve implantation for the treatment of aortic stenosis: the Cribier Edwards/Edwards Sapien valve experience. J Am Soc Echocardiogr 2010;23: Gurvitch R, Wood DA, Tay EL, Leipsic J, Ye J, Lichtenstein SV, Thompson CR, Carere RG, Wijesinghe N, Nietlispach F, Boone RH, Lauck S, Cheung A, Webb JG. Transcatheter aortic valve implantation. Durability of clinical and hemodynamic outcomes beyond 3 years in a large patient cohort. Circulation 2010;122: Webb JG, Chandavimol M, Thompson C, Ricci DR, Carere R, Munt B, Buller CE, Pasupati S, Lichtenstein S. Percutaneous aortic valve implantation retrograde from the femoral artery. Circulation 2006;113: Cribier A, Eltchaninoff H, Tron C, Bauer F, Gerber L. Percutaneous implantation of aortic valve prosthesis in patients with calcific aortic stenosis: technical advances, clinical results and future strategies. J Invasive Cardiol 2006;19:S88 S Petronio AS, De Carlo M, Bedogni F, Marzocchi A, Klugmann S, Maisano F, Ramondo A, Ussia GP, Ettori F, Poli A, Brambilla N, Saia F, De Marco F, Colombo A. Safety and efficacy of the subclavian approach for transcatheter aortic valve implantation with the corevalve revalving system. Circ Cardiovasc Interv 2010;3: Astor BC, Kaczmarek RG, Hefflin B, Daley WR. Mortality after aortic valve replacement: results from a nationally representative database. Ann Thorac Surg 2000; 70: Tchetche D, Dumonteil N, Sauguet A, Descoutures F, Luz A, Garcia O, Soula P, Gabiache Y, Fournial G, Marcheix B, Carrie D, Fajadet J. Thirty-day outcome and vascular complications after transarterial aortic valve implantation using both Edwards Sapien and medtronic corevalve bioprostheses in a mixed population. EuroIntervention 2010;5: Bagur R, Webb JG, Nietlispach F, Dumont E, De Larochellière R, Doyle D, Masson JB, Gutiérrez MJ, Clavel MA, Bertrand OF, Pibarot P, Rodés-Cabau J. Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement. Eur Heart J 2010;31: Kapadia SR, Svensson L, Tuzcu EM. Successful percutaneous management of left main trunk occlusion during percutaneous aortic valve replacement. Catheter Cardiovasc Interv 2009;73: Webb JG. Coronary obstruction and transcatheter valve implantation. Cathet Cardiovasc Interv 2009;73: Masson JB, Webb JG. Acute and early complications of transcatheter aortic valve implantation with the balloon-expandable Edwards system. In Serruys PW, Cribier A, Webb J, Laborde JC, Piazza N, de Jaegere P, eds. Percutaneous Implantation of the Aortic Valve Tips and Tricks to Avoid Failure. New York: Informa Masson JB, Kovac J, Schuler G, Ye J, Cheung A, Kapadia S, Tuzcu EM, Kodali S, Leon MB, Webb JG. Transcatheter aortic valve implantation: review of the nature, management and avoidance of procedural complications. JACC Cardiovasc Intervent 2009;2: Wood D, Tops LF, Mayo JR, Pasupati S, Schalij MJ, Humphries K, Lee M, Ali AA, Munt B, Thompson CR, Bax JR, Webb JG. Multislice computed tomography in transcatheter aortic valve replacement. Am J Cardiol 2007;103: Dewey TM, Brown DL, Herbert MA, Culica D, Smith CR, Leon MB, Svensson LG, Tuczu M, Webb JG, Cribier A, Mack MJ. The effect of concomitant coronary artery disease on procedural and late outcomes of transcatheter aortic valve implantation. Ann Thorac Surg 2010;89: Cribier A, Zajarais A. Percutaneous valve replacement: the future is here! Rev Esp Cardiol 2009;61: Tzikas A, Piazza N, van Dalen BM, Schultz C, Geleijnse ML, van Geuns RJ, Galema TW, Nuis RJ, Otten A, Gutierrez-Chico JL, Serruys PW, de Jaegere PP. Changes in mitral regurgitation after transcatheter aortic valve implantation. Catheter Cardiovasc Interv 2010;75: Webb JG, Pasupati SJ, Humphries K, Thompson C, Altwegg L, Moss R, Sinhal A, Carere RG, Munt B, Ricci D, Ye J, Cheung A, Lichtenstein SV. Percutaneous transarterial aortic valve replacement in selected high risk patients with aortic stenosis. Circulation 2007;116: Khawaja MZ, Haworth P, Ghuran A, Lee L, de Belder A, Hutchinson N, Trivedi U, Laborde JC, Hildick-Smith D. Transcatheter aortic valve implantation for stenosed and regurgitant aortic valve bioprostheses corevalve for failed bioprosthetic aortic valve replacements. J Am Coll Cardiol 2010;55: Webb JG, Wood DA, Ye J, Gurvitch R, Masson JB, Rodes-Cabau J, Osten M, Horlick E, Wendler O, Dumont E, Carere RG, Wijesinghe N, Nietlispach F, Johnson M, Thompson CR, Moss R, Leipsic J, Munt B, Lichtenstein SV, Cheung A. Transcatheter valve-in-valve implantation for failed bioprosthetic heart valves. Circulation 2010;121:
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