1 Organ that controls 6 vital functions of the body

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2 1 Organ that controls 6 vital functions of the body Removes poisonous substances Helps in digestion Stores Energy Purifies Blood Manufactures new proteins Processes Food

3 Liver functions continued...

4 Liver functions continued...

5 Did you Know...??? The Liver is the Largest internal Organ & Largest gland in the human body. The human Liver weighs approximately lbs. Alcohol abuse is the most common cause of liver disease in India.

6 Common Diseases of Liver HEPATITIS: Inflamation of Liver caused due to Viral Infections. Its of three types. CIRRHOSIS: Fibrosis of Liver tissues characterized by loss of Liver Function.

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8 Launching Dabur Hepano Everyday care for Liver For everyday Liver Health

9 DABUR HEPANO PRODUCT Enriched with Herbs like Bhumiamlaki, Guduchi, Nimba, Haritaki, Kalmegh etc. KEY DIFFERENTIATOR Pre Clinical studies have shown significant Hepato protective Action. Reduces SGOT, SGPT and Serum bilirubin levels to normal PACKAGING PRICING 200 ml Pack with Monocarton 30 Units in one Case. Pack comes with QR code. MRP : Rs.85/-.

10 DABUR HEPANO BRAND DETAILS

11 DABUR HEPANO COMPOSITION Bhumiamalaki Baheda Guduchi Amla Kalmegh Harad Kutki Pippali Nimba

12 Bhumyamlaki (Phyllanthus niruri) Parts used: Whole plant Properties: Taste inducer (Rocana), useful in Amlapitta (Hyperacidity), Pandu (Anaemia), Hepatosplenomegaly and Jaundice. Scientific studies: Hepatoprotective acitivity on nimesulide- induced oxidative stress in vivo etc

13 Guduchi (Tinospora cordifolia) Parts used: Stem Properties: Strength promoting (Balya), Digestion promoter (Dipana), Rejuvenator (Rasayana), Blood purifier (Raktasodhaka), useful in Jaundice (Kamala)and Anaemia (Pandu) Scientific studies: Hepatoprotective acitivity by modulation of kupffer cell activity by in liver damage, in CCl4 intoxicated mature albino rats etc

14 Neem (Azadirachta indica) Parts used: Bark Properties: Neem is used for tastelessness conditions. It is having anti-parasitic, anti-inflammatory, antiulcer and hepato-protective effects. Scientific studies: Hepatoprotective acitivity paracetamol-induced hepatic damage in albino rats, against diethylnitrosamine (NDEA) induced hepatotoxicity in mice etc

15 Kalmegh (Andrographis paniculata) Parts used: Whole plant Properties: Digestion promoter properties and is used in Ajirna (dyspepsia), Jvara (fever), Kandu (itching), Kamala (jaundice) and Yakrtvikara (disorders of liver.. Scientific studies: Hepatoprotective acitivity in acute hepatitis induced by galactosamine & paracetamol intoxication in rats, against against carbon tetrachloride-induced liver damage etc

16 Haritaki (Terminalia chebula) Parts used: Pericarp Properties: Rejuvenator, Antioxidant, Laxative. It is used as appetizer and is used in tastelessness conditions, jaundice, hepato-splenomegaly, Anaemia etc.

17 Amla (Emblica officinalis) Parts used: Fruit Properties: Mild purgative, agni deepak (Digestion promoter), Skin diseases, inflammation, It is a potent Rasayana (Rejuvenating agent) and Bulk promoting (Brmhaniya) Scientific studies: Amla possess hepatoprotective, antioxidant, cholesterol lowering property

18 Vibhitaki (Terminalia belerica) Parts used: Pericarp Properties: Laxative, diuretic and cardio tonic treatments. Scientific studies: Amla possess hepato-protective, antioxidant property

19 Kutki (Picrorhiza kurroa) Parts used: Roots and Rhizomes Properties: Digestion promoter properties and is used in Jaundice and tastelessness conditions. Scientific studies: Hepatoprotective action against subacute liver damages induced by carbon tetrachloride etc

20 Pre-Clinical Efficacy Study Study drug: Hepano Pre clinical efficacy study conducted at Jamia Hamdard, Hamdard University, New Delhi (Third party independent centre). Model used D-galactosamine induced Hepatotoxicity Paracetamol induced Hepatotoxicity New Livfit and Liv 52 were used as reference standards used in the study.

21 Pre-Clinical Efficacy Study.contd HEPATOPROTECTIVE ACTIVITY OF HEPANO Paracetamol caused hepatotoxicity in the toxicant group, elevated levels of SGOT, SGPT, serum bilirubin, ALP as well as increased lipid peroxidation and significantly reduced level of serum albumin and tissue glutathione compared to toxicant. Liv 52 and New Livfit significantly improved these parameters Hepano at 120 mg/kg and 240 mg/kg also showed significant improvement in comparison to toxicant.

22 Pre-Clinical Safety Study Study drug and duration: : Hepano was administered orally once daily for 28 consecutive days. Results No mortality and clinical signs of toxicities were observed in all the treated group animals and control group animals throughout the study period. Hematological investigation & blood biochemistry parameters were found to be within the normal range both in treated and control groups. Gross pathological examination of all the animals did not reveal any abnormality and the mean values of absolute & relative organ weights were comparable to their respective vehicle control. Histo-pathological examination did not reveal any test item related changes. The no observed adverse effect level (NOAEL) of HEPANO when administered orally once daily for a period of 28 days in both the sexes of Wistar rats was found to be 1000mg/kg body weight.

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