Liposomal Targeting of Glucocorticoids to Inhibit Tumor Angiogenesis

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2 ACKNOWLEDGMENTS Living in The Netherlands for two and a half years was one of the most challenging periods of my professional and private life. The opportunity of working in the Department of Pharmaceutics as well as the chance of meeting exceptional people, both good colleagues and friends, equally helped me to the finalize the present thesis. Therefore, I would like to acknowledge all who supported and helped me during my stay in Utrecht. First of all, I wish to express my sincere gratitude to my promotor, Professor Dr Gert Storm for giving me the opportunity to work at the Utrecht University. Dear Professor Storm, (as I used to address you in my thousand s) you are an excellent scientist and great writer. I truly enjoyed our meetings also when we argued on so many things and I hope you have never been disappointed in me. Thank you for the chance to learn from you. I am very grateful to my co-promotor, Dr Raymond Schiffelers for his patient and instructive guidance. Dear Raymond, you are a good person and your optimism and wise advice helped me to get over all my frustrations during my PhD. An important part of the research work would not have been possible without the financial support of the Galenos network in the Pharmaceutical Sciences. The Galenos network is greatly acknowledged for the fellowship awarded me in 2005 and I would like to thank Renate Wobken and Karin Schuller for their friendly help with bureaucratic procedures. I have a special acknowledge for the head of the Department of Pharmaceutics, Professor Dr Wim Hennink. Dear Professor Hennink, you are the glue that sticks together more than 60 people in a big family. I enjoyed your sense of humor and I always appreciated your clever advice on my career. I wish to express my thanks to two great ladies, Barbara and Lidija, and to Dr Herre Talsma who assisted and solved all my paperworks and administrative problems during my PhD. 207

3 Special thanks to Mies for his help with the HPLC, Louis for his assistance in liposome preparation. Heartly thanks to all my colleagues and friends at the Department of Pharmaceutics for their aid and support and especially for the great social life I have never experienced before. I enjoyed our borrels, dinners, birthdays, bowling evenings, ladies dinner.. Thank you for making me feel so great, thank you for being my colleagues. Special thanks to my labmates and colleagues: Joris, Holger, Birgit, Inge, Melody, Sarianne, Marcel, Ellen, Ethlinn, Cor, Marjan, Enrico, Cristianne, Adrienne, Emmy, Roy, Francisco, Amir, and Markus for creating such a cheerful, relaxing, and cooperative environment. I will miss you all a lot. Special appreciation goes to Marcel for his support and encouragement, especially in my first year of my PhD. Besides great colleagues, I got friends here. I will start in the order in which I met them. My dear Sabrina, we had a wonderful time together. I enjoyed our conversations, dinners, trips in The Netherlands and in USA. Do not forget to visit me in Romania and to put all unimportant things in your small box. Good luck with finishing your thesis. In my first year in Utrecht, I met three wonderful ladies, Silvina, Verena and Selcan. Thank you for the great time we spent together. My dear Maryam, we knew each other better only for one year and a half but I think you are my sister I have never had it. Deep thanks for your friendship, patience, kindness, and mature way of thinking. Besides my work, I had my private life in Utrecht and I met wonderful people and hopefully, friends for the whole life. I wish to thank my friends Vera, Ebru and Rodrigo. I am very grateful for everything we did together: dinners, barbeques, trips, bowling and Saturdays-with-a-lot-of-fun-in-Albert-Heijn. I am very grateful to a very special person, my dear Vera. Vera, you are the meaning of friendship for me. Thank you for meeting you, for not judging me, for listening to me, for sharing our happiness and sadness, as well. 208

4 Also, I would like to express my gratitude to my Professors in Cluj-Napoca, Sorin Leucuta, Ioan Petrescu and Nicolae Dragos for their support during my stay abroad. I am deeply indebted to my former supervisor from Romania, Professor Sorin Leucuta for agreeing and understanding how important a PhD obtained abroad is for my career. To all my friends and colleagues in Romania, Marcela Achim (iti sunt recunoscatoare pentru ca m-ai ajutat ori de cate ori am avut nevoie), Delia, Codruta, Mihaela, Feli, Carmen, Alin, Nicu, Bogdan, Alina, va multumesc din suflet. Stiu ca sunteti acolo pentru mine si ma pot baza pe voi. Doamna Dorina, va multumesc pentru ca v am intalnit. Cred ca Dumnezeu a vrut sa ne cunoastem, si probabil de aceea imi amintesc doar clipele placute cand am lucrat impreuna cu dumneavoastra la Terapia. To all my friends from abroad, Simona, Monica, Corina, Malina, Felicia, Alina va multumesc pentru momentele petrecute impreuna si apoi -urile si lungile discutii pe messenger in care ne-am impartasit bucuriile si suferintele. Dragele mele suflete pereche, Simo, Delia si Moni, va iubesc si va simt intotdeauna cu mine. Finally, I wish to express my gratefulness to my husband and to my family. My dear Horia, thank you for your patience, for being always there for me, for your love, for your sacrifice, for supporting and trusting me and for believing in me and in our relationship. I am also grateful to my parents-in-law for their permanent encouragement and support. I would have never been who I am if I had not had such a wonderful family. Therefore, my last words of this thesis are dedicated to them. I will start with my father, who unfortunately is not among us anymore. My dear father, you always believed in me. You were always so proud of me and now I am so sad you will not be with me at my defense. I am sure, from high above, you will be there to watch me and then to tell everybody: asta e copila mea (this is my daughter). 209

5 Draga mea mamica, as fi vrut sa fi aici cu mine si sa ma incurajezi si sa imi spui asa cum mi-ai zis intotdeauna cand am inceput un nou drum in viata: Cu Dumnezeu inainte, Manuela! Dragii mei parinti, va multumesc pentru tot ce ati facut pentru mine, pentru toate sacrificiile si sper ca nu v-am dezamagit niciodata. Va iubesc! 210

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