Appendix 2 Drug Information
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1 Appendix 2 Drug Information Chemical Name: baclofen (bak-loe-fen) Brand Name: Lioresal (U.S. and Canada) Description: Baclofen acts on the central nervous system to relieve spasms, cramping, and tightness of muscles caused by spasticity in multiple sclerosis. It is usually administered orally in pill form. An intrathecal delivery system is available for those individuals with significant spasticity who cannot tolerate a sufficiently high dose of the oral form of the medication. The intrathecal system delivers the medication via a surgically implanted pump directly into the fluid surrounding the spinal cord. Chemical Name: ciprofloxacin (sip-roe-flox-a-sin) Brand Name: Cipro (U.S. and Canada) Description: Ciprofloxacin is one of a group of antibiotics (fluoroquinolones) used to kill bacterial infections in many parts of the body. It is used in multiple sclerosis primarily to treat urinary tract infections. Cipro administered with tizanidine (used for spasticity) results in higher concentrations of tizanidine in the blood, which could lead to clinically significant adverse events such as increased sedation. Chemical Name: darifenacin (dar-i-fen-a-sin) Brand Name: Enablex (U.S. and Canada) Description: Darifenacin is an extended-release antispasmodic/ antimuscarinic medication that works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination. Urinary Dysfunction and MS 19
2 Chemical Name: desmopressin (des-moe-press-in) acetate Brand Name: DDAVP Nasal Spray (U.S. and Canada) Description: Desmopressin acetate is a hormone used as a nasal spray. The hormone works on the kidneys to control frequent urination. Chemical Name: imipramine (im-ip-ra-meen) Brand Name: Tofranil (U.S. and Canada) Description: Imipramine is a tricyclic antidepressant used to treat mental depression. Its primary use in multiple sclerosis is to treat bladder symptoms, including urinary frequency and incontinence. Imipramine is also prescribed occasionally for the management of neurologic pain in MS. Chemical Name: oxybutynin (ox-i-byoo-ti-nin) Brand Name: Ditropan (U.S. and Canada) Generic Available: Yes (U.S.) Description: Oxybutynin is an antispasmodic/anticholinergic that helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Chemical Name: oxybutynin (ox-i-byoo-ti-nin) chloride extended release Brand Name: Ditropan XL (U.S. and Canada) Description: This form of oxybutynin is an extended-release antispasmodic/anticholinergic that is formulated to help decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. 20
3 Chemical Name: oxybutynin (ox-i-byoo-ti-nin)-transdermal Brand Name: Oxytrol (U.S. and Canada) Description: This form of oxybutynin, which is delivered via a skin patch, is an antispasmodic/anticholinergic medication that helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Chemical Name: prazosin (pra-zoe-sin) Brand Name: Minipress (U.S. and Canada) Description: Prazosin belongs to the general class of medicines called anti-hypertensives, which are used to treat high blood pressure. It is used in MS help promote the flow of urine through the sphincter. Chemical Name: propantheline (pro-pan-the-leen) bromide Brand Name: Pro-Banthine (U.S. and Canada) Generic Available: Yes (U.S.) Description: Propantheline is one of a group of antispasmodic/anticholinergic medications used to relieve cramps or spasms of the stomach, intestines, and bladder. Propantheline is used in the management of neurogenic bladder symptoms to control urination. Chemical Name: solifenacin succinate (sol-i-fen-ah-sin SUC-sin-ate) Brand Name: Vesicare (U.S.) Description: Solifenacin succinate is an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, and/or urge incontinence. In MS, overactive bladder is seen in failure to store and combined failure to store/failure to empty types of dysfunction. Urinary Dysfunction and MS 21
4 Chemical Name: tamsulosin (tam-soo-loh-sin) Brand Name: Flomax (U.S.) Description: Tamsulosin is generally used to treat the signs and symptoms of benign enlargement of the prostate. It helps to relax the muscles in the prostate and bladder, and is used in MS to promote the flow of urine. Chemical Name: terazosin (ter-ay-zoe-sin) Brand Name: Hytrin (U.S. and Canada) Description: Terazosin belongs to the general class of medicines called anti-hypertensives, which are used to treat high blood pressure. It also helps relax the muscles of the prostate and the bladder. In MS, it is used to help promote the flow of urine through the sphincter. Chemical Name: tizanidine (tye-zan-i-deen) hydrochloride Brand Name: Zanaflex (U.S. and Canada) Description: Tizanidine is used in multiple sclerosis to treat the increased muscle tone associated with spasticity. While it does not provide a cure for the problems, it is designed to relieve the spasms, cramping, and tightness of muscles. Chemical Name: tolterodine (tole-tare-oh-deen) Brand Name: Detrol (U.S.) Description: Tolterodine is an antimuscarinic that is used to treat bladder spasms causing urinary frequency, urgency, or urge incontinence. 22
5 Chemical Name: tolterodine (tole-tare-oh-deen) tartrate Brand Name: Detrol LA (U.S. and Canada) Description: Detrol LA (long acting) is an antimuscarinic agent used to treat overactive bladder with symptoms of urgency, frequency, and/or urge incontinence. This problem occurs in failure to store and combined failure to store/failure to empty types of dysfunction. It differs from Detrol in that Detrol LA can usually be taken as a single daily dose. Chemical Name: trospium chloride (trose-pee-um chloride) Brand Name: Sanctura (U.S.) Description: Trospium is an antispasmodic/anticholinergic medication that works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination. For more detailed information on these medications including common and rare side effects, call your local Society office or log on to the Society s Web site at <nationalmssociety.org> and go to Treatments and then to the Medications Used in MS section. Cipro is a registered trademark of Bayer. DDAVP is a registered trademark of Aventis Pharmaceuticals. Detrol, Detrol LA and Minipress are registered trademarks of Pfizer, Inc. Ditropan and Ditropan XL are registered trademarks of ALZA Corporation. Enablex and Tofranil are registered trademarks of Novartis. Flomax is a registered trademark of Boehringer Ingelheim Int l. Hytrin is a registered trademark of Abbott Labs. Lioresal is a registered trademark of Ciba Geigy. Oxytrol is a registered trademark of Watson Pharmaceuticals. Sanctura is a registered trademark of Esprit Pharma. Vesicare is a registered trademark of Astellas Pharmaceuticals. Zanaflex is a registered trademark of Elan Pharmaceuticals. Urinary Dysfunction and MS 23
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