Variation of organ at risk dose due to daily rectal filling during prostate intensitymodulated
|
|
|
- Camron Conley
- 5 years ago
- Views:
Transcription
1 Variation of organ at risk dose due to daily rectal filling during prostate intensitymodulated radiotherapy Leonel A. Kahn B.S., Arthur Y. Hung, M.D., Barbara Agrimson, B.S., C.M.D., Sanja Ognjenovic, Tulsee S. Doshi, Halkene M. Gemechu, Catherine M. Kato, Lu Z. Meng, Ph.D., Anna O. Simeonova, M.D., James A. Tanyi, Ph.D Department of Radiation Medicine Oregon Health & Science University The authors have no disclosures
2 Study Aims Characterize the values of and evaluate for daily trends in the rectal volume, rectal anterior-posterior translation, and volume of the rectum receiving 45 Gy, 65 Gy and 70 Gy (V 40 /V 65 /V 70 ) during IMRT of the prostate Assess for correlation between the interfraction motion parameters and the dosimetric data
3 Methods Retrospective review of 16 patients undergoing IMRT of the prostate Enemas prior to simulation & no bowel preparation prior to daily treatment Outer walls of the rectum were contoured on all on-treatment CBCT series for each patient Determined daily rectal volume changes, displacement of the anterior rectal wall at three levels, and rectal V 45, V 60, V 70 Pearson s coefficients were used to determine trends in dosevolume histogram (DVH) values vs. fraction number, translation change, and volume change
4 Anterior-posterior positional change of anterior wall of the rectum Patient Number Displacement [cm] Superior level Isocenter level Inferior level (0.34, 1.64) 0.45 (0.19, 0.88) 0.21 (0.29, 1.65) (0.82, 4.17) 0.46 (0.44, 2.04) (0.44, 1.59) (0.45, 2.17) 0.19 (0.18, 0.81) (0.31, 1.56) (0.44, 1.97) 0.31 (0.18, 0.72) 0.27 (0.3, 1.31) (0.6, 2.94) 0.04 (0.25, 1.26) (0.41, 1.65) (0.68, 2.59) 0.34 (0.24, 1.01) 0.49 (0.4, 1.45) (0.45, 2.01) 0.63 (0.29, 1.42) (0.55, 4.11) (0.62, 2.64) 0.29 (0.35, 1.73) (0.31, 1.52) (0.84, 2.96) 0.32 (0.27, 1.12) 0.05 (0.35, 1.35) (0.41, 1.82) 0.71 (0.35, 2.12) (0.43, 2.29) (0.97, 3.97) (0.56, 2.2) (0.37, 1.85) (0.3, 1.31) 0.58 (0.41, 2.09) 0.23 (0.33, 1.34) (0.56, 2.61) 0.42 (0.27, 1.46) (0.96, 2.98) (0.89, 3.56) 0.25 (0.26, 1.33) 0.37 (0.33, 1.39) (1.03, 3.64) 0.29 (0.24, 1.06) (0.2, 0.74) (0.76, 2.78) 0.27 (0.26, 0.92) (0.29, 1.35)
5 Anterior-posterior positional change of anterior wall of the rectum Largest translation means and ranges at the superior level Patient Number Displacement [cm] Superior level Isocenter level Inferior level (0.34, 1.64) 0.45 (0.19, 0.88) 0.21 (0.29, 1.65) (0.82, 4.17) 0.46 (0.44, 2.04) (0.44, 1.59) (0.45, 2.17) 0.19 (0.18, 0.81) (0.31, 1.56) (0.44, 1.97) 0.31 (0.18, 0.72) 0.27 (0.3, 1.31) (0.6, 2.94) 0.04 (0.25, 1.26) (0.41, 1.65) (0.68, 2.59) 0.34 (0.24, 1.01) 0.49 (0.4, 1.45) (0.45, 2.01) 0.63 (0.29, 1.42) (0.55, 4.11) (0.62, 2.64) 0.29 (0.35, 1.73) (0.31, 1.52) (0.84, 2.96) 0.32 (0.27, 1.12) 0.05 (0.35, 1.35) (0.41, 1.82) 0.71 (0.35, 2.12) (0.43, 2.29) (0.97, 3.97) (0.56, 2.2) (0.37, 1.85) (0.3, 1.31) 0.58 (0.41, 2.09) 0.23 (0.33, 1.34) (0.56, 2.61) 0.42 (0.27, 1.46) (0.96, 2.98) (0.89, 3.56) 0.25 (0.26, 1.33) 0.37 (0.33, 1.39) (1.03, 3.64) 0.29 (0.24, 1.06) (0.2, 0.74) (0.76, 2.78) 0.27 (0.26, 0.92) (0.29, 1.35)
6 Anterior-posterior positional change of anterior wall of the rectum No significant correlation between translational motion and fraction number for any patient at any rectal level Patient Number Displacement [cm] Superior level Isocenter level Inferior level (0.34, 1.64) 0.45 (0.19, 0.88) 0.21 (0.29, 1.65) (0.82, 4.17) 0.46 (0.44, 2.04) (0.44, 1.59) (0.45, 2.17) 0.19 (0.18, 0.81) (0.31, 1.56) (0.44, 1.97) 0.31 (0.18, 0.72) 0.27 (0.3, 1.31) (0.6, 2.94) 0.04 (0.25, 1.26) (0.41, 1.65) (0.68, 2.59) 0.34 (0.24, 1.01) 0.49 (0.4, 1.45) (0.45, 2.01) 0.63 (0.29, 1.42) (0.55, 4.11) (0.62, 2.64) 0.29 (0.35, 1.73) (0.31, 1.52) (0.84, 2.96) 0.32 (0.27, 1.12) 0.05 (0.35, 1.35) (0.41, 1.82) 0.71 (0.35, 2.12) (0.43, 2.29) (0.97, 3.97) (0.56, 2.2) (0.37, 1.85) (0.3, 1.31) 0.58 (0.41, 2.09) 0.23 (0.33, 1.34) (0.56, 2.61) 0.42 (0.27, 1.46) (0.96, 2.98) (0.89, 3.56) 0.25 (0.26, 1.33) 0.37 (0.33, 1.39) (1.03, 3.64) 0.29 (0.24, 1.06) (0.2, 0.74) (0.76, 2.78) 0.27 (0.26, 0.92) (0.29, 1.35)
7 Rectal volume change and rectal V 40, V 65 and V 70 for individual patients Patient Number Volume changes [cm 3 ] Rectal V 40 [cm 3 ] Rectal V 65 [cm 3 ] Rectal V 70 [cm 3 ] (5.89, 30.1) (3.44, 19.55) 4.19 (2.06, 11.52) 3.2 (1.77, 9.93) (16.71, (10.71, (25.29, 99.3) 9.96 (9.41, 39.52) 71.74) 45.28) (5.98, 27.1) 8.92 (3.1, 11.32) 4.49 (2.15, 8.71) 3.63 (1.9, 7.91) (6.9, 28.9) 8.62 (4.05, 15.26) 2.55 (1.8, 7.54) 1.76 (1.41, 6.08) (12.37, 74.2) (5.71, 32.11) 4.28 (3.05, 16.08) 3.09 (2.55, 13.39) (12.42, 53.4) 6.68 (4.21, 14.93) 2.77 (2.15, 8.28) 2.15 (1.78, 6.99) (9.2, 40.3) 9.98 (5.78, 22.7) 4.53 (3.63, 15.41) 3.51 (3.12, 13.71) (8.99, 44.5) 12.6 (4.56, 20.53) 5.7 (2.55, 11.99) 4.57 (2.12, 10.02) (13.41, 55.6) (8.91, 37.94) 7.87 (6.83, 29.09) 6.73 (6.3, 26.82) (4.47, 17.7) (3.84, 23.22) 8.21 (3.11, 19.51) 7.14 (2.92, 18.41) (10.42, (19.85, 68.6) 5.4 (6.32, 23.82) 4.25 (5.38, 20.75) 36.82) (4.87, 18.3) (3.12, 13.44) 8.56 (2.51, 11.69) 7.31 (2.37, 10.94) (20.96, 86.6) (8.15, 29.37) 9.37 (4.85, 18.55) 7.98 (4.06, 15.54) (12.65, 51) (7.29, 32.09) 8.36 (5.15, 23.69) 6.38 (3.62, 17.26) (11.29, 47) (7.2, 28.95) 4.34 (4.71, 20.34) 2.92 (3.87, 16.99) (2.99, 12.26) 4.13 (2.99, 12.26) 1.19 (1.17, 5.03) 0.49 (0.42, 1.73)
8 Rectal volume change and rectal V 40, V 65 and V 70 for individual patients All patients had a mean volume change of at least 30 cc (except patient 16) Patient Number Volume changes [cm 3 ] Rectal V 40 [cm 3 ] Rectal V 65 [cm 3 ] Rectal V 70 [cm 3 ] (5.89, 30.1) (3.44, 19.55) 4.19 (2.06, 11.52) 3.2 (1.77, 9.93) (16.71, (10.71, (25.29, 99.3) 9.96 (9.41, 39.52) 71.74) 45.28) (5.98, 27.1) 8.92 (3.1, 11.32) 4.49 (2.15, 8.71) 3.63 (1.9, 7.91) (6.9, 28.9) 8.62 (4.05, 15.26) 2.55 (1.8, 7.54) 1.76 (1.41, 6.08) (12.37, 74.2) (5.71, 32.11) 4.28 (3.05, 16.08) 3.09 (2.55, 13.39) (12.42, 53.4) 6.68 (4.21, 14.93) 2.77 (2.15, 8.28) 2.15 (1.78, 6.99) (9.2, 40.3) 9.98 (5.78, 22.7) 4.53 (3.63, 15.41) 3.51 (3.12, 13.71) (8.99, 44.5) 12.6 (4.56, 20.53) 5.7 (2.55, 11.99) 4.57 (2.12, 10.02) (13.41, 55.6) (8.91, 37.94) 7.87 (6.83, 29.09) 6.73 (6.3, 26.82) (4.47, 17.7) (3.84, 23.22) 8.21 (3.11, 19.51) 7.14 (2.92, 18.41) (10.42, (19.85, 68.6) 5.4 (6.32, 23.82) 4.25 (5.38, 20.75) 36.82) (4.87, 18.3) (3.12, 13.44) 8.56 (2.51, 11.69) 7.31 (2.37, 10.94) (20.96, 86.6) (8.15, 29.37) 9.37 (4.85, 18.55) 7.98 (4.06, 15.54) (12.65, 51) (7.29, 32.09) 8.36 (5.15, 23.69) 6.38 (3.62, 17.26) (11.29, 47) (7.2, 28.95) 4.34 (4.71, 20.34) 2.92 (3.87, 16.99) (2.99, 12.26) 4.13 (2.99, 12.26) 1.19 (1.17, 5.03) 0.49 (0.42, 1.73)
9 Rectal volume change and rectal V 40, V 65 and V 70 for individual patients No significant correlation between volume change and the fraction number was noted for any patient Patient Number Volume changes [cm 3 ] Rectal V 40 [cm 3 ] Rectal V 65 [cm 3 ] Rectal V 70 [cm 3 ] (5.89, 30.1) (3.44, 19.55) 4.19 (2.06, 11.52) 3.2 (1.77, 9.93) (16.71, (10.71, (25.29, 99.3) 9.96 (9.41, 39.52) 71.74) 45.28) (5.98, 27.1) 8.92 (3.1, 11.32) 4.49 (2.15, 8.71) 3.63 (1.9, 7.91) (6.9, 28.9) 8.62 (4.05, 15.26) 2.55 (1.8, 7.54) 1.76 (1.41, 6.08) (12.37, 74.2) (5.71, 32.11) 4.28 (3.05, 16.08) 3.09 (2.55, 13.39) (12.42, 53.4) 6.68 (4.21, 14.93) 2.77 (2.15, 8.28) 2.15 (1.78, 6.99) (9.2, 40.3) 9.98 (5.78, 22.7) 4.53 (3.63, 15.41) 3.51 (3.12, 13.71) (8.99, 44.5) 12.6 (4.56, 20.53) 5.7 (2.55, 11.99) 4.57 (2.12, 10.02) (13.41, 55.6) (8.91, 37.94) 7.87 (6.83, 29.09) 6.73 (6.3, 26.82) (4.47, 17.7) (3.84, 23.22) 8.21 (3.11, 19.51) 7.14 (2.92, 18.41) (10.42, (19.85, 68.6) 5.4 (6.32, 23.82) 4.25 (5.38, 20.75) 36.82) (4.87, 18.3) (3.12, 13.44) 8.56 (2.51, 11.69) 7.31 (2.37, 10.94) (20.96, 86.6) (8.15, 29.37) 9.37 (4.85, 18.55) 7.98 (4.06, 15.54) (12.65, 51) (7.29, 32.09) 8.36 (5.15, 23.69) 6.38 (3.62, 17.26) (11.29, 47) (7.2, 28.95) 4.34 (4.71, 20.34) 2.92 (3.87, 16.99) (2.99, 12.26) 4.13 (2.99, 12.26) 1.19 (1.17, 5.03) 0.49 (0.42, 1.73)
10 Rectal volume change and rectal V 40, V 65 and V 70 for individual patients All patients had mean V 70 <17%, a mean V 65 <25%, and a mean V 40 <35% (ie: less than than the rectal tolerance limits) Patient Number Volume changes [cm 3 ] Rectal V 40 [cm 3 ] Rectal V 65 [cm 3 ] Rectal V 70 [cm 3 ] (5.89, 30.1) (3.44, 19.55) 4.19 (2.06, 11.52) 3.2 (1.77, 9.93) (16.71, (10.71, (25.29, 99.3) 9.96 (9.41, 39.52) 71.74) 45.28) (5.98, 27.1) 8.92 (3.1, 11.32) 4.49 (2.15, 8.71) 3.63 (1.9, 7.91) (6.9, 28.9) 8.62 (4.05, 15.26) 2.55 (1.8, 7.54) 1.76 (1.41, 6.08) (12.37, 74.2) (5.71, 32.11) 4.28 (3.05, 16.08) 3.09 (2.55, 13.39) (12.42, 53.4) 6.68 (4.21, 14.93) 2.77 (2.15, 8.28) 2.15 (1.78, 6.99) (9.2, 40.3) 9.98 (5.78, 22.7) 4.53 (3.63, 15.41) 3.51 (3.12, 13.71) (8.99, 44.5) 12.6 (4.56, 20.53) 5.7 (2.55, 11.99) 4.57 (2.12, 10.02) (13.41, 55.6) (8.91, 37.94) 7.87 (6.83, 29.09) 6.73 (6.3, 26.82) (4.47, 17.7) (3.84, 23.22) 8.21 (3.11, 19.51) 7.14 (2.92, 18.41) (10.42, (19.85, 68.6) 5.4 (6.32, 23.82) 4.25 (5.38, 20.75) 36.82) (4.87, 18.3) (3.12, 13.44) 8.56 (2.51, 11.69) 7.31 (2.37, 10.94) (20.96, 86.6) (8.15, 29.37) 9.37 (4.85, 18.55) 7.98 (4.06, 15.54) (12.65, 51) (7.29, 32.09) 8.36 (5.15, 23.69) 6.38 (3.62, 17.26) (11.29, 47) (7.2, 28.95) 4.34 (4.71, 20.34) 2.92 (3.87, 16.99) (2.99, 12.26) 4.13 (2.99, 12.26) 1.19 (1.17, 5.03) 0.49 (0.42, 1.73)
11 Rectal volume change and rectal V 40, V 65 and V 70 for individual patients In 14/16 patients, 97.8% of the fractions delivered met the rectal tolerance criteria at each dose level Patient Number Volume changes [cm 3 ] Rectal V 40 [cm 3 ] Rectal V 65 [cm 3 ] Rectal V 70 [cm 3 ] (5.89, 30.1) (3.44, 19.55) 4.19 (2.06, 11.52) 3.2 (1.77, 9.93) (16.71, (10.71, (25.29, 99.3) 9.96 (9.41, 39.52) 71.74) 45.28) (5.98, 27.1) 8.92 (3.1, 11.32) 4.49 (2.15, 8.71) 3.63 (1.9, 7.91) (6.9, 28.9) 8.62 (4.05, 15.26) 2.55 (1.8, 7.54) 1.76 (1.41, 6.08) (12.37, 74.2) (5.71, 32.11) 4.28 (3.05, 16.08) 3.09 (2.55, 13.39) (12.42, 53.4) 6.68 (4.21, 14.93) 2.77 (2.15, 8.28) 2.15 (1.78, 6.99) (9.2, 40.3) 9.98 (5.78, 22.7) 4.53 (3.63, 15.41) 3.51 (3.12, 13.71) (8.99, 44.5) 12.6 (4.56, 20.53) 5.7 (2.55, 11.99) 4.57 (2.12, 10.02) (13.41, 55.6) (8.91, 37.94) 7.87 (6.83, 29.09) 6.73 (6.3, 26.82) (4.47, 17.7) (3.84, 23.22) 8.21 (3.11, 19.51) 7.14 (2.92, 18.41) (10.42, (19.85, 68.6) 5.4 (6.32, 23.82) 4.25 (5.38, 20.75) 36.82) (4.87, 18.3) (3.12, 13.44) 8.56 (2.51, 11.69) 7.31 (2.37, 10.94) (20.96, 86.6) (8.15, 29.37) 9.37 (4.85, 18.55) 7.98 (4.06, 15.54) (12.65, 51) (7.29, 32.09) 8.36 (5.15, 23.69) 6.38 (3.62, 17.26) (11.29, 47) (7.2, 28.95) 4.34 (4.71, 20.34) 2.92 (3.87, 16.99) (2.99, 12.26) 4.13 (2.99, 12.26) 1.19 (1.17, 5.03) 0.49 (0.42, 1.73)
12 Rectal volume change and rectal V 40, V 65 and V 70 for individual patients No significant correlation between the fraction number and the rectal V 40, V 65, and V 70 values, respectively, were noted for any patient Patient Number Volume changes [cm 3 ] Rectal V 40 [cm 3 ] Rectal V 65 [cm 3 ] Rectal V 70 [cm 3 ] (5.89, 30.1) (3.44, 19.55) 4.19 (2.06, 11.52) 3.2 (1.77, 9.93) (16.71, (10.71, (25.29, 99.3) 9.96 (9.41, 39.52) 71.74) 45.28) (5.98, 27.1) 8.92 (3.1, 11.32) 4.49 (2.15, 8.71) 3.63 (1.9, 7.91) (6.9, 28.9) 8.62 (4.05, 15.26) 2.55 (1.8, 7.54) 1.76 (1.41, 6.08) (12.37, 74.2) (5.71, 32.11) 4.28 (3.05, 16.08) 3.09 (2.55, 13.39) (12.42, 53.4) 6.68 (4.21, 14.93) 2.77 (2.15, 8.28) 2.15 (1.78, 6.99) (9.2, 40.3) 9.98 (5.78, 22.7) 4.53 (3.63, 15.41) 3.51 (3.12, 13.71) (8.99, 44.5) 12.6 (4.56, 20.53) 5.7 (2.55, 11.99) 4.57 (2.12, 10.02) (13.41, 55.6) (8.91, 37.94) 7.87 (6.83, 29.09) 6.73 (6.3, 26.82) (4.47, 17.7) (3.84, 23.22) 8.21 (3.11, 19.51) 7.14 (2.92, 18.41) (10.42, (19.85, 68.6) 5.4 (6.32, 23.82) 4.25 (5.38, 20.75) 36.82) (4.87, 18.3) (3.12, 13.44) 8.56 (2.51, 11.69) 7.31 (2.37, 10.94) (20.96, 86.6) (8.15, 29.37) 9.37 (4.85, 18.55) 7.98 (4.06, 15.54) (12.65, 51) (7.29, 32.09) 8.36 (5.15, 23.69) 6.38 (3.62, 17.26) (11.29, 47) (7.2, 28.95) 4.34 (4.71, 20.34) 2.92 (3.87, 16.99) (2.99, 12.26) 4.13 (2.99, 12.26) 1.19 (1.17, 5.03) 0.49 (0.42, 1.73)
13 Correlation of rectal translation (superior and isocenter levels) with rectal V 40, V 65 and V 70 for individual patients Patient Number Translation/V 40 Translation/V 65 Translation/V 70 1 ** ** 2 * * * 3 ** ** 4 5 * 6 ** ** 7 *,** *,** ** 8 9 * * * 10 ** ** ** 11 * * * ** ** ** (*) positive superior displacement correlation; (**) positive isocenter displacement correlation
14 Correlation of rectal translation (superior and isocenter levels) with rectal V 40, V 65 and V 70 for individual patients Patient Number Translation/V 40 Translation/V 65 Translation/V 70 1 ** ** 2 * * * Significant correlations between the superior rectal translations and the V 40, V 65, and/or V 70 present in a minority of patients 3 ** ** 4 5 * 6 ** ** 7 *,** *,** ** 8 9 * * * 10 ** ** ** 11 * * * ** ** ** (*) positive superior displacement correlation; (**) positive isocenter displacement correlation
15 Correlation of rectal translation (superior and isocenter levels) with rectal V 40, V 65 and V 70 for individual patients Patient Number Translation/V 40 Translation/V 65 Translation/V 70 1 ** ** Compared to superior translations, positive correlations between the isocenter-level rectal translations and the V 40, V 65, and/or V 70 were seen in a slightly greater number, yet still a minority, of patients 2 * * * 3 ** ** 4 5 * 6 ** ** 7 *,** *,** ** 8 9 * * * 10 ** ** ** 11 * * * ** ** ** (*) positive superior displacement correlation; (**) positive isocenter displacement correlation
16 Correlation of rectal translation (superior and isocenter levels) with rectal V 40, V 65 and V 70 for individual patients Patient Number Translation/V 40 Translation/V 65 Translation/V 70 1 ** ** 2 * * * 3 ** ** 4 No significant correlations were seen between the inferior rectal translations and the V 40, V 65, or V 70 in any patient 5 * 6 ** ** 7 *,** *,** ** 8 9 * * * 10 ** ** ** 11 * * * ** ** ** (*) positive superior displacement correlation; (**) positive isocenter displacement correlation
17 Correlations of rectal volume changes and rectal V 40, V 65 and V 70 values for individual patients Patient Number Volume change/v 40 Volume change/v 65 Volume change/v 70 1 * * * 2 * * * 3 * * * 4 * * * 5 * * * 6 * * * 7 * * * 8 * * 9 * * * * * * * * * 14 * * 15 * * * 16 * (*) Indicates positive correlation
18 Correlations of rectal volume changes and rectal V 40, V 65 and V 70 values for individual patients Patient Number Volume change/v 40 Volume change/v 65 Volume change/v 70 1 * * * 2 * * * Significant positive correlations between rectal volume changes and V 40, V 65, and/or V 70 in the majority (87.5%) of patients 3 * * * 4 * * * 5 * * * 6 * * * 7 * * * 8 * * 9 * * * * * * * * * 14 * * 15 * * * 16 * (*) Indicates positive correlation
19 Correlations of rectal volume changes and rectal V 40, V 65 and V 70 values for individual patients Patient Number Volume change/v 40 Volume change/v 65 Volume change/v 70 1 * * * 2 * * * 3 * * * 4 * * * 11/16 patients had a positive correlation between volume changes and all three dose-volume levels 5 * * * 6 * * * 7 * * * 8 * * 9 * * * * * * * * * 14 * * 15 * * * 16 * (*) Indicates positive correlation
20 How to Ensure Adequate Rectal DVH Throughout Treatment Course? No correlation between treatment fraction number and rectal V 40, V 65, or V 70 values Underscores random nature of variation in the rectal DVH values Not practical to create population-based algorithm, applicable to all patients, to ensure reproducible daily rectal DVH parameters
21 Method to Ensure Adequate Rectal DVH Over Treatment Course? IGRT for the purpose of online dosimetric evaluation of rectal doses with subsequent implementation of multi-adaptive planning (MAP) may be the solution Dynamically adjusting apertures on a daily basis MAP Method 1 Creation of a series of plans that represent possible relationships between the prostate and rectum prior to treatment, with selection of an appropriate plan on a daily basis MAP Method 2 Accommodate independent prostate and rectal motion
22 Is Further Intervention Required to Ensure Appropriate Rectal DVHs? Interfraction variation in rectal DVHs likely to be reduced with MAP However: potential benefit must be interpreted in a clinically relevant manner Goal of MAP: ensure maintenance of rectal DVH under specified tolerance values Frequency with which the tolerance limits are met could argue for or against the need for MAP
23 Is Further Intervention Required to Ensure Appropriate Rectal DVHs? 97.8% remained within the specified dose-volume limits on a daily basis Argue against need for MAP for the purpose of improving rectal DVH
24 Is Further Intervention Required to Ensure Appropriate Rectal DVHs? Volumetric Changes MAP not needed for all patients Significant correlation between rectal volume changes and V 40, V 65, and/or V 70 in the majority of patients Volume not predictable over the course of treatment, necessitating individualized approach to managing volumeinduced DVH change May benefit from MAP
25 Is Further Intervention Required to Ensure Appropriate Rectal DVHs? Volumetric Changes However: subset of patients may benefit Significant correlation between rectal volume changes and V 40, V 65, and/or V 70 in the majority of patients Volume not predictable over the course of treatment, necessitating individualized approach to managing volumeinduced DVH change May benefit from MAP
26 Is Further Intervention Required to Ensure Appropriate Rectal DVHs? Vast majority of patients continued to meet the rectal dosevolume tolerance criteria despite the presence of interfraction volume changes Volumetric Changes Significant correlation between rectal volume changes and V 40, V 65, and/or V 70 in the majority of patients Volume not predictable over the course of treatment, necessitating individualized approach to managing volumeinduced DVH change May benefit from MAP
27 Conclusion Documented that nearly all patients met rectal tolerance criteria at all dose-volume levels at least 97.8% of the time MAP post-interfraction prostate motion correction not needed in the majority of cases for the purpose of improving daily rectal DVH compliance
28 Limitations Retrospective Use of CBCTs Number of patients Present study and the current literature fail to evaluate the correlation of acute and late rectal toxicity compared to the interfraction DVH variation
29 Variation of organ at risk dose due to daily rectal filling during prostate intensity-modulated radiotherapy Project funding Rubinstein Research Scholarship 2012 Tartar Trust Fund OHSU School of Medicine Dean s Fund Ted R. Lilley Cancer Continuing Umbrella of Research Experience Program
30 Variation of organ at risk dose due to daily rectal filling during prostate intensity-modulated radiotherapy Collaboration investigators James Tanyi, PhD Arthur Hung, MD Charles Thomas, MD Barbara Agrimson, CMD Departmental Affiliation OHSU Department of Radiation Medicine Knight Cancer Institute
31 Questions?
Regional Variation of Interfraction Tumor Breathing Motion in Lung Stereotactic Body Radiation Therapy (SBRT)
Regional Variation of Interfraction Tumor Breathing Motion in Lung Stereotactic Body Radiation Therapy (SBRT) Katelyn M. Atkins, Ph.D. Department of Radiation Medicine KNIGHT CANCER INSTITUTE Oregon Health
ART for Cervical Cancer: Dosimetry and Technical Aspects
ART for Cervical Cancer: Dosimetry and Technical Aspects D.A. Jaffray, Ph.D. Radiation Therapy Physics Princess Margaret Cancer Centre/Techna/Ontario Cancer Institute Professor Departments of Radiation
Dosimetric Analysis of 3DCRT or IMRT with Vaginal-cuff Brachytherapy (VCB) for Gynaecological Cancer
Dosimetric Analysis of 3DCRT or IMRT with Vaginal-cuff Brachytherapy (VCB) for Gynaecological Cancer Tan Chek Wee 15 06 2016 National University Cancer Institute, Singapore Clinical Care Education Research
Medical Marijuana Use in Patients with History of SCCHN Treated with Radiotherapy
HEALTH SERVICES RESEARCH Assessment the Impact of Real-time Tumor Tracking & Reduced Planning Target Volume Margins on Quality-of-Life in Prostate Cancer Patients Treatment with Intensity Modulated Radiotherapy
CBCT of the patient in the treatment position has gained wider applications for setup verification during radiotherapy.
Gülcihan CÖDEL Introduction The aim of this study is to evaluate the changes in bladder doses during the volumetric modulated arc therapy (VMAT) treatment of prostate cancer patients using weekly cone
Hampton University Proton Therapy Institute
Hampton University Proton Therapy Institute Brief introduction to proton therapy technology, its advances and Hampton University Proton Therapy Institute Vahagn Nazaryan, Ph.D. Executive Director, HUPTI
A TREATMENT PLANNING STUDY COMPARING VMAT WITH 3D CONFORMAL RADIOTHERAPY FOR PROSTATE CANCER USING PINNACLE PLANNING SYSTEM *
Romanian Reports in Physics, Vol. 66, No. 2, P. 394 400, 2014 A TREATMENT PLANNING STUDY COMPARING VMAT WITH 3D CONFORMAL RADIOTHERAPY FOR PROSTATE CANCER USING PINNACLE PLANNING SYSTEM * D. ADAM 1,2,
Vaginal Sparing with Volumetric Modulated Arc Therapy (VMAT) for Rectal Cancer. Scott Boulet BSc, RT(T)
Vaginal Sparing with Volumetric Modulated Arc Therapy (VMAT) for Rectal Cancer Scott Boulet BSc, RT(T) Outline Background Objectives Design Results Discussion Conclusion Acknowledgements Questions Background
IMRT for Prostate Cancer
IMRT for Cancer All patients are simulated in the supine position. Reproducibility is achieved using a custom alpha cradle cast that extends from the mid-back to mid-thigh. The feet are positioned in a
Role of Belly Board Device in the Age of Intensity Modulated Radiotherapy for Pelvic Irradiation
Role of Belly Board Device in the Age of Intensity Modulated Radiotherapy for Pelvic Irradiation 2017 AAMD 42 nd Annual Meeting Neil C. Estabrook, MD 6 / 14 / 2017 7/5/2017 1 Conflicts of Interest None
Evaluation of Monaco treatment planning system for hypofractionated stereotactic volumetric arc radiotherapy of multiple brain metastases
Evaluation of Monaco treatment planning system for hypofractionated stereotactic volumetric arc radiotherapy of multiple brain metastases CASE STUDY Institution: Odette Cancer Centre Location: Sunnybrook
Measurement of Dose to Critical Structures Surrounding the Prostate from. Intensity-Modulated Radiation Therapy (IMRT) and Three Dimensional
Measurement of Dose to Critical Structures Surrounding the Prostate from Intensity-Modulated Radiation Therapy (IMRT) and Three Dimensional Conformal Radiation Therapy (3D-CRT); A Comparative Study Erik
Sanja Ognjenovic A PROJECT. submitted to. Oregon State University. University Honors College
Volumetric-modulated arc radiotherapy for pancreatic malignancies: Dosimetric comparison with helical TomoTherapy By Sanja Ognjenovic A PROJECT submitted to Oregon State University University Honors College
IGRT Protocol Design and Informed Margins. Conflict of Interest. Outline 7/7/2017. DJ Vile, PhD. I have no conflict of interest to disclose
IGRT Protocol Design and Informed Margins DJ Vile, PhD Conflict of Interest I have no conflict of interest to disclose Outline Overview and definitions Quantification of motion Influences on margin selection
Potential systematic uncertainties in IGRT when FBCT reference images are used for pancreatic tumors
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 16, NUMBER 3, 2015 Potential systematic uncertainties in IGRT when FBCT reference images are used for pancreatic tumors Ahmad Amoush, May Abdel-Wahab,
A Dosimetric Comparison of Whole-Lung Treatment Techniques. in the Pediatric Population
A Dosimetric Comparison of Whole-Lung Treatment Techniques in the Pediatric Population Corresponding Author: Christina L. Bosarge, B.S., R.T. (R) (T) Indiana University School of Medicine Department of
Volumetric-based image guidance is superior to marker-based alignments for stereotactic body radiotherapy of prostate cancer
Received: 23 July 2017 Revised: 15 December 2017 Accepted: 3 January 2018 DOI: 10.1002/acm2.12280 RADIATION ONCOLOGY PHYSICS Volumetric-based image guidance is superior to marker-based alignments for stereotactic
IGRT Solution for the Living Patient and the Dynamic Treatment Problem
IGRT Solution for the Living Patient and the Dynamic Treatment Problem Lei Dong, Ph.D. Associate Professor Dept. of Radiation Physics University of Texas M. D. Anderson Cancer Center Houston, Texas Learning
Feasibility of the partial-single arc technique in RapidArc planning for prostate cancer treatment
Chinese Journal of Cancer Original Article Feasibility of the partial-single arc technique in RapidArc planning for prostate cancer treatment Suresh Rana 1 and ChihYao Cheng 2 Abstract The volumetric modulated
Margin Reduction in Prostate. Radiotherapy. Richard Oates, A/Prof Michal Schneider Monash Prof Tomas Kron Peter Mac Dr Michael Lim Joon Peter Mac
Margin Reduction in Prostate Richard Oates, Radiotherapy Click to edit Master PhD Candidate subtitle style A/Prof Michal Schneider Monash Prof Tomas Kron Peter Mac Dr Michael Lim Joon Peter Mac Presentation
Josh Howard CMD Upendra Parvathaneni MBBS, FRANZCR
Anatomic and Dosimetric Correlation in the Treatment of Advanced Larynx Cancer- When is the Brachial Plexus at Risk? Josh Howard CMD Upendra Parvathaneni MBBS, FRANZCR AAMD 39th Annual Meeting - Seattle
New Technologies for the Radiotherapy of Prostate Cancer
Prostate Cancer Meyer JL (ed): IMRT, IGRT, SBRT Advances in the Treatment Planning and Delivery of Radiotherapy. Front Radiat Ther Oncol. Basel, Karger, 27, vol. 4, pp 315 337 New Technologies for the
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 17, NUMBER 6, 2016
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 17, NUMBER 6, 2016 Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT-guided prostate IMRT: analysis based on daily
Department of Radiotherapy & Nuclear Medicine, National Cancer Institute, Cairo University, Cairo, Egypt.
Original article Res. Oncol. Vol. 12, No. 1, Jun. 2016:10-14 Dosimetric comparison of 3D conformal conventional radiotherapy versus intensity-modulated radiation therapy both in conventional and high dose
A Comparison of IMRT and VMAT Technique for the Treatment of Rectal Cancer
A Comparison of IMRT and VMAT Technique for the Treatment of Rectal Cancer Tony Kin Ming Lam Radiation Planner Dr Patricia Lindsay, Radiation Physicist Dr John Kim, Radiation Oncologist Dr Kim Ann Ung,
The Accuracy of 3-D Inhomogeneity Photon Algorithms in Commercial Treatment Planning Systems using a Heterogeneous Lung Phantom
The Accuracy of 3-D Inhomogeneity Photon Algorithms in Commercial Treatment Planning Systems using a Heterogeneous Lung Phantom Gary Fisher, B.S. David Followill, Ph.D. Geoffrey Ibbott, Ph.D. This investigation
Neoplasie prostatiche Radioterapia: le nuove strategie
Neoplasie prostatiche Radioterapia: le nuove strategie Dr. PL Losardo U.O.C di Radioterapia Azienda Ospedaliero-Universitaria di Parma Parma, 19.5.2015 VS Very Low risk Low risk Intermediate risk High
Statistical Analysis and Volumetric Dose for Organ at Risk of Prostate Cancer
The African Review of Physics (2013) 8:0063 477 Statistical Analysis and Volumetric Dose for Organ at Risk of Prostate Cancer F. Assaoui¹,*, A. Bazine² and T. Kebdani³ ¹ Medical Physics Unit, Radiotherapy
IROC Liver Phantom. Guidelines for Planning and Irradiating the IROC Liver Phantom. Revised July 2015
IROC Liver Phantom Guidelines for Planning and Irradiating the IROC Liver Phantom. Revised July 2015 The study groups are requests that each institution keep the phantom for no more than 2 weeks. During
Application of asi-kvcbct for Volume Assessment and Dose Estimation: An Offline Adaptive Study for Prostate Radiotherapy
DOI:10.31557/APJCP.2019.20.1.229 Volume and Dose Assessment on Adapted CT RESEARCH ARTICLE Editorial Process: Submission:08/10/2018 Acceptance:01/05/2019 Application of asi-kvcbct for Volume Assessment
Helical Tomotherapy Experience. TomoTherapy Whole Brain Head & Neck Prostate Lung Summary. HI-ART TomoTherapy System. HI-ART TomoTherapy System
The Challenges Associated with Differential Dose Delivery using IMRT Chester Ramsey, Ph.D. Director of Medical Physics Thompson Cancer Center Knoxville, Tennessee, U.S.A Collaborators Chester Ramsey, Ph.D.
Impact of Contouring Variability on Dose- Volume Metrics used in Treatment Plan Optimization of Prostate IMRT
Open Access Original Article DOI: 10.7759/cureus.144 Impact of Contouring Variability on Dose- Volume Metrics used in Treatment Plan Optimization of Prostate IMRT Arvand Barghi, Carol Johnson 2, Andrew
Jean Pouliot, PhD Professor and Vice Chair, Department of Radiation Oncology, Director of Physics Division
IMRT / Tomo / VMAT / Cyberknife / HDR Brachytherapy: Jean Pouliot, PhD Professor and Vice Chair, Department of Radiation Oncology, Director of Physics Division Should Choices be Based on Dosimetric and
Pitfalls in SBRT Treatment Planning for a Moving Target
Pitfalls in SBRT Treatment Planning for a Moving Target Cynthia F. Chuang, Ph.D. Department of Radiation Oncology University of California-San Francisco I have no conflicts of interests to disclose In
OPTIMIZATION OF COLLIMATOR PARAMETERS TO REDUCE RECTAL DOSE IN INTENSITY-MODULATED PROSTATE TREATMENT PLANNING
Medical Dosimetry, Vol. 30, No. 4, pp. 205-212, 2005 Copyright 2005 American Association of Medical Dosimetrists Printed in the USA. All rights reserved 0958-3947/05/$ see front matter doi:10.1016/j.meddos.2005.06.002
BLADDER RADIOTHERAPY PLANNING DOCUMENT
A 2X2 FACTORIAL RANDOMISED PHASE III STUDY COMPARING STANDARD VERSUS REDUCED VOLUME RADIOTHERAPY WITH AND WITHOUT SYNCHRONOUS CHEMOTHERAPY IN MUSCLE INVASIVE BLADDER CANCER (ISRCTN 68324339) BLADDER RADIOTHERAPY
VAGINAL MOTION AND BLADDER AND RECTAL VOLUMES DURING PELVIC INTENSITY-MODULATED RADIATION THERAPY AFTER HYSTERECTOMY
doi:10.1016/j.ijrobp.2010.08.024 Int. J. Radiation Oncology Biol. Phys., Vol. 82, No. 1, pp. 256 262, 2012 Copyright Ó 2012 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/$ - see front
Leila E. A. Nichol Royal Surrey County Hospital
2 nd UK and Ireland Dosimetry Check User Meeting Symposium Clatterbridge Cancer Centre, 24 th October 2012 Leila E. A. Nichol Royal Surrey County Hospital Leila.Nichol@nhs.net *My experience with Dosimetry
SUPERIORITY OF A REAL TIME PLANNING TECHNIQUE OVER IMAGE GUIDED RADIATION THERAPY FOR THE TREATMENT OF PRIMARY PROSTATE CANCERS
SUPERIORITY OF A REAL TIME PLANNING TECHNIQUE OVER IMAGE GUIDED RADIATION THERAPY FOR THE TREATMENT OF PRIMARY PROSTATE CANCERS Authors: Scott Merrick James Wong MD, Mona Karim MD, Yana Goldberg MD DISCLOSURE
MRI Applications in Radiation Oncology:
MRI Applications in Radiation Oncology: Physician s Perspective Jeff Olsen, MD Department of Radiation Oncology Washington University, St. Louis, MO Disclosures Washington University has research and service
A PRACTICAL METHOD TO ACHIEVE PROSTATE GLAND IMMOBILIZATION AND TARGET VERIFICATION FOR DAILY TREATMENT
PII S0360-3016(01)02663-3 Int. J. Radiation Oncology Biol. Phys., Vol. 51, No. 5, pp. 1431 1436, 2001 Copyright 2001 Elsevier Science Inc. Printed in the USA. All rights reserved 0360-3016/01/$ see front
SBRT and hypofractionated RT for HCC patients with varying degrees of hepatic impairment
SBRT and hypofractionated RT for HCC patients with varying degrees of hepatic impairment Nima Nabavizadeh, MD Assistant Professor Division Leader Hematologic Malignancies Co-division Leader Gastrointestinal
Intensity Modulated Radiation Therapy for Squamous Cell Carcinoma of the Penis
1 Louise Francis September Case Study September 23, 2011 Intensity Modulated Radiation Therapy for Squamous Cell Carcinoma of the Penis History of Present Illness: JM is a 56 year-old African American
Prostate volumetric-modulated arc therapy: dosimetry and radiobiological model variation between the single-arc and double-arc technique
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 14, NUMBER 3, 2013 Prostate volumetric-modulated arc therapy: dosimetry and radiobiological model variation between the single-arc and double-arc technique
Clinical Implementation of a New Ultrasound Guidance System. Vikren Sarkar Bill Salter Martin Szegedi
Clinical Implementation of a New Ultrasound Guidance System Vikren Sarkar Bill Salter Martin Szegedi Disclosure The University of Utah has research agreements with Elekta Agenda Historical Review Trans-Abdominal
Linac or Non-Linac Demystifying And Decoding The Physics Of SBRT/SABR
Linac or Non-Linac Demystifying And Decoding The Physics Of SBRT/SABR PhD, FAAPM, FACR, FASTRO Department of Radiation Oncology Indiana University School of Medicine Indianapolis, IN, USA Indra J. Das,
An image-guided radiotherapy decision support framework incorporating a Bayesian network and visualization tool
An image-guided radiotherapy decision support framework incorporating a Bayesian network and visualization tool Catriona Hargrave a) Radiation Oncology, Princess Alexandra Hospital Raymond Terrace, Queensland
The Effects of DIBH on Liver Dose during Right-Breast Treatments: A Case Study Abstract: Introduction: Case Description: Conclusion: Introduction
1 The Effects of DIBH on Liver Dose during Right-Breast Treatments: A Case Study Megan E. Sullivan, B.S., R.T.(T)., Patrick A. Melby, B.S. Ashley Hunzeker, M.S., CMD, Nishele Lenards, M.S., CMD, R.T. (R)(T),
Radiotherapy Outcomes
in partnership with Outcomes Models with Machine Learning Sarah Gulliford PhD Division of Radiotherapy & Imaging sarahg@icr.ac.uk AAPM 31 st July 2017 Making the discoveries that defeat cancer Radiotherapy
IMRT/IGRT Patient Treatment: A Community Hospital Experience. Charles M. Able, Assistant Professor
IMRT/IGRT Patient Treatment: A Community Hospital Experience Charles M. Able, Assistant Professor Disclosures I have no research support or financial interest to disclose. Learning Objectives 1. Review
1 : : Medical Physics, Città della Salute e della Scienza, Torino, Italy
Fusella M. 1, Badellino S. 2, Boschetti A. 1, Cadoni F. 1, Giglioli F. R. 1, Guarneri A. 3, Fiandra C. 2, Filippi A. 2, Ricardi U. 2, Ragona R. 2 1 : : Medical Physics, Città della Salute e della Scienza,
Insights into Thymic Epithelial Tumors: Radiation Therapy
Insights into Thymic Epithelial Tumors: Radiation Therapy Charles R. Thomas, MD Professor and Chairman, Department of Radiation Medicine Professor, Department of Medicine, Division of Hematology/Medical
From position verification and correction to adaptive RT Adaptive RT and dose accumulation
From position verification and correction to adaptive RT Adaptive RT and dose accumulation Hans de Boer Move away from Single pre-treatment scan Single treatment plan Treatment corrections by couch shifts
8/1/2017. Clinical Indications and Applications of Realtime MRI-Guided Radiotherapy
Clinical Indications and Applications of Realtime MRI-Guided Radiotherapy Michael F Bassetti MD PhD Assistant Professor, Department of Human Oncology University of Wisconsin, Madison. Carbone Cancer Center
Quality ID #156 (NQF 0382): Oncology: Radiation Dose Limits to Normal Tissues National Quality Strategy Domain: Patient Safety
Quality ID #156 (NQF 0382): Oncology: Radiation Dose Limits to Normal Tissues National Quality Strategy Domain: Patient Safety 2018 OPTIONS FOR INDIVIDUAL MEASURES: CLAIMS ONLY MEASURE TYPE: Process DESCRIPTION:
UNIVERSITY OF WISCONSIN-LA CROSSE Graduate Studies
UNIVERSITY OF WISCONSIN-LA CROSSE Graduate Studies A SINGLE INSTITUTION S EXPERIENCE IN DEVELOPING A PURPOSEFUL AND EFFICIENT OFF-LINE TECHNIQUE FOR ADAPTIVE RADIOTHERAPY IN A CLINICAL ENVIRONMENT A Research
Evaluation of Whole-Field and Split-Field Intensity Modulation Radiation Therapy (IMRT) Techniques in Head and Neck Cancer
1 Charles Poole April Case Study April 30, 2012 Evaluation of Whole-Field and Split-Field Intensity Modulation Radiation Therapy (IMRT) Techniques in Head and Neck Cancer Abstract: Introduction: This study
Advanced Technology Consortium (ATC) Credentialing Procedures for 3D Conformal Therapy Protocols 3D CRT Benchmark*
Advanced Technology Consortium (ATC) Credentialing Procedures for 3D Conformal Therapy Protocols 3D CRT Benchmark* Purpose: To evaluate an institution s 3D treatment planning process and the institution
Intensity modulated radiotherapy (IMRT) for treatment of post-operative high grade glioma in the right parietal region of brain
1 Carol Boyd March Case Study March 11, 2013 Intensity modulated radiotherapy (IMRT) for treatment of post-operative high grade glioma in the right parietal region of brain History of Present Illness:
Knowledge-Based IMRT Treatment Planning for Prostate Cancer: Experience with 101. Cases from Duke Clinic. Deon Martina Dick
Knowledge-Based IMRT Treatment Planning for Prostate Cancer: Experience with 101 Cases from Duke Clinic by Deon Martina Dick Department of Medical Physics Duke University Date: Approved: Joseph Lo, Chair
Clinical Implications of High Definition Multileaf Collimator (HDMLC) Dosimetric Leaf Gap (DLG) Variations
Original Article PROGRESS in MEDICAL PHYSICS 27(3), Sept. 2016 http://dx.doi.org/10.14316/pmp.2016.27.3.111 pissn 2508-4445, eissn 2508-4453 Clinical Implications of High Definition Multileaf Collimator
Measure #156 (NQF 0382): Oncology: Radiation Dose Limits to Normal Tissues National Quality Strategy Domain: Patient Safety
Measure #156 (NQF 0382): Oncology: Radiation Dose Limits to Normal Tissues National Quality Strategy Domain: Patient Safety 2016 PQRS OPTIONS FOR INDIVIDUAL MEASURES: CLAIMS, REGISTRY DESCRIPTION: Percentage
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 16, NUMBER 6, 2015
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 16, NUMBER 6, 2015 Determination of optimal PTV margin for patients receiving CBCT-guided prostate IMRT: comparative analysis based on CBCT dose calculation
8/2/2012. Transitioning from 3D IMRT to 4D IMRT and the Role of Image Guidance. Part II: Thoracic. Peter Balter, Ph.D.
8/2/2012 Transitioning from 3D IMRT to 4D IMRT and the Role of Image Guidance Part II: Thoracic Peter Balter, Ph.D. Disclosure Dr. Balter is Physics PI on a trial comparing Cyberknife based SBRT with surgery,
Independent Dose Verification for IMRT Using Monte Carlo. C-M M Charlie Ma, Ph.D. Department of Radiation Oncology FCCC, Philadelphia, PA 19111, USA
Independent Dose Verification for IMRT Using Monte Carlo C-M M Charlie Ma, Ph.D. Department of Radiation Oncology FCCC, Philadelphia, PA 19111, USA Outline Why Monte Carlo for IMRT QA? Experimental verification
7/16/2009. Cost-benefit, QALYs and the Value of a Statistical Life
7/16/29 Cost-benefit, QALYs and the Value of a Statistical Life Alan McKenzie, Bristol The benefits of many developments in radiotherapy may be obvious for instance, replacing hand planning by computer
What do we Know About Adaptive Radiotherapy? Lei Dong, Ph.D. Scripps Proton Therapy Center San Diego, California
What do we Know About Adaptive Radiotherapy? Lei Dong, Ph.D. Scripps Proton Therapy Center San Diego, California AAMD Region II Meeting Houston, Texas September 13-14, 2012 Learning Objectives To gain
SBRT I: Overview of Simulation, Planning, and Delivery
Disclosure SBRT I: Overview of Simulation, Planning, and Delivery I have received research funding from NIH, the Golfers Against Cancer (GAC) foundation, and Philips Health System. Jing Cai, PhD Duke University
Impact of internal variations on the dose distribution during the course of radiotherapy of prostatectomy patients
SAHLGRENSKA ACADEMY Impact of internal variations on the dose distribution during the course of radiotherapy of prostatectomy patients Tommy Andreasson Thesis: 30 hp Program: Medical Physicist Programme
Technique For Plan Quality and Efficiency Using VMAT Radiosurgery For Patients with Multiple Brain Metastases
Technique For Plan Quality and Efficiency Using VMAT Radiosurgery For Patients with Multiple Brain Metastases Kimberly Dempsey, BS, CMD, RT(T) Heather Smith, MS, CMD, RT(R)(T) The University of Alabama
Particle (proton) Therapy Randomized trials vs. Prospective registry. Andrew K. Lee, MD, MPH Associate Professor Department of Radiation Oncology
Particle (proton) Therapy Randomized trials vs. Prospective registry Andrew K. Lee, MD, MPH Associate Professor Department of Radiation Oncology Should we do randomized trials? Are randomized trials needed
THE TRANSITION FROM 2D TO 3D AND TO IMRT - RATIONALE AND CRITICAL ELEMENTS
THE TRANSITION FROM 2D TO 3D AND TO IMRT - RATIONALE AND CRITICAL ELEMENTS ICTP SCHOOL ON MEDICAL PHYSICS FOR RADIATION THERAPY DOSIMETRY AND TREATMENT PLANNING FOR BASIC AND ADVANCED APPLICATIONS March
Research Article Implant R100 Predicts Rectal Bleeding in Prostate Cancer Patients Treated with IG-IMRT to 45 Gy and Pd-103 Implant
Radiotherapy, Article ID 130652, 6 pages http://dx.doi.org/10.1155/2014/130652 Research Article Implant R100 Predicts Rectal Bleeding in Prostate Cancer Patients Treated with IG-IMRT to 45 Gy and Pd-103
Radiation Therapy: From Fallacy to Science
27 th Annual Management of Colon and Rectal Diseases 2.23.2019 Radiation Therapy: From Fallacy to Science Hadi Zahra, MD, DABR Radiation Oncologist CHI Health Henry Lynch Cancer Center Assistant Clinical
Comparison of high and low energy treatment plans by evaluating the dose on the surrounding normal structures in conventional radiotherapy
Turkish Journal of Cancer Volume 37, No. 2, 2007 59 Comparison of high and low energy treatment plans by evaluating the dose on the surrounding normal structures in conventional radiotherapy MUHAMMAD BASIM
8/3/2016. Outline. Site Specific IGRT Considerations for Clinical Imaging Protocols. Krishni Wijesooriya, PhD University of Virginia
Site Specific IGRT Considerations for Clinical Imaging Protocols Krishni Wijesooriya, PhD University of Virginia Outline Image registration accuracies for different modalities What imaging modality best
Ranking radiotherapy treatment plans: physical or biological objectives?
Ranking radiotherapy treatment plans: physical or biological objectives? Martin Ebert Department of Radiation Oncology, Sir Charles Gairdner Hospital, Western Australia, Australia Background. The ranking
Utilization of cone-beam CT for offline evaluation of target volume coverage during prostate image-guided radiotherapy based on bony anatomy alignment
reports of practical oncology and radiotherapy 1 7 (2 0 1 2) 134 140 Available online at www.sciencedirect.com journal homepage: http://www.elsevier.com/locate/rpor Original research article Utilization
Can we deliver the dose distribution we plan in HDR-Brachytherapy of Prostate Cancer?
Can we deliver the dose distribution we plan in HDR-Brachytherapy of Prostate Cancer? Dimos Baltas Dept. of Medical Physics & Engineering, Strahlenklinik, Klinikum Offenbach GmbH 63069 Offenbach, Germany
IMRT Planning Basics AAMD Student Webinar
IMRT Planning Basics AAMD Student Webinar March 12, 2014 Karen Chin Snyder, MS Senior Associate Physicist Department of Radiation Oncology Disclosures The presenter has received speaker honoraria from
Dosimetric Effects of Using Generalized Equivalent Uniform Dose (geud) in Plan Optimization
Dosimetric Effects of Using Generalized Equivalent Uniform Dose (geud) in Plan Optimization Ontida Apinorasethkul, MS, CMD AAMD Indianapolis June 14, 2017 Disclaimer This presentation is not sponsored
The Non-Gaussian Nature of Prostate Motion Based on Real-Time Intrafraction Tracking
The Non-Gaussian Nature of Prostate Motion Based on Real-Time Intrafraction Tracking Yuting Lin, University of California, Irvine Tian Liu, Emory University Wells Yang, Georgia Institute of Technology
IMRT - the physician s eye-view. Cinzia Iotti Department of Radiation Oncology S.Maria Nuova Hospital Reggio Emilia
IMRT - the physician s eye-view Cinzia Iotti Department of Radiation Oncology S.Maria Nuova Hospital Reggio Emilia The goals of cancer therapy Local control Survival Functional status Quality of life Causes
Uncertainties and Quality Assurance of Localization and Treatment in Lung SBRT Jing Cai, PhD Duke University Medical Center
Uncertainties and Quality Assurance of Localization and Treatment in Lung SBRT Jing Cai, PhD Duke University Medical Center 2013 AAPM 55 th Annual Meeting, Educational Course, Therapy Track, MOC SAM Program
7/10/2015. Acknowledgments. Institution-specific TG-142? AAPM:Task Group-142. Failure-Mode & Effects Analysis
Acknowledgments Thanks to Saiful Huq for an illuminating conversation about the application of TG-100 Jennifer O Daniel, Ph.D. & Fang-Fang Yin, Ph.D. Duke University Medical Center Annual AAPM Meeting,
UvA-DARE (Digital Academic Repository) Towards image-guided radiotherapy of prostate cancer Smitsmans, M.H.P. Link to publication
UvA-DARE (Digital Academic Repository) Towards image-guided radiotherapy of prostate cancer Smitsmans, M.H.P. Link to publication Citation for published version (APA): Smitsmans, M. H. P. (2010). Towards
TRANS-TASMAN RADIATION ONCOLOGY GROUP INC. Quality Assurance. Treatment Planning Benchmark
TRANS-TASMAN RADIATION ONCOLOGY GROUP INC. Quality Assurance Treatment Planning Benchmark PORTEC-3/ TROG 08.04 Randomised Phase III Trial Comparing Concurrent Chemoradiation and Adjuvant Chemotherapy with
Tomohisa FURUYA*, Satoru SUGIMOTO, Chie KUROKAWA, Shuichi OZAWA, Kumiko KARASAWA and Keisuke SASAI
Journal of Radiation Research, 2013, 54, 157 165 doi: 10.1093/jrr/rrs064 Advance Access Publication 1 August 2012 The dosimetric impact of respiratory breast movement and daily setup error on tangential
DELIVERED PATIENT DOSE
SOFTWARE DELIVERED PATIENT DOSE The only software that provides a true picture of patient and dose at each stage of treatment. Adaptivo patient dosimetry software does something other patient dosimetry
Rectal Volume Analysis in Prostate Radiation Therapy: Volumetric or Orthogonal Image Guided Radiation Therapy
Rectal Volume Analysis in Prostate Radiation Therapy: Volumetric or Orthogonal Image Guided Radiation Therapy L. Huynh, A. Do, J. Frantzis, P. Fenton Epworth Radiation Oncology, Melbourne Epworth HealthCare
Determining optimal planning target volume and image guidance policy for post-prostatectomy intensity modulated radiotherapy
Bell et al. Radiation Oncology (2015) 10:151 DOI 10.1186/s13014-015-0467-8 RESEARCH Open Access Determining optimal planning target volume and image guidance policy for post-prostatectomy intensity modulated
Chapters from Clinical Oncology
Chapters from Clinical Oncology Lecture notes University of Szeged Faculty of Medicine Department of Oncotherapy 2012. 1 RADIOTHERAPY Technical aspects Dr. Elemér Szil Introduction There are three possibilities
Proton Therapy for Prostate Cancer. Andrew K. Lee, MD, MPH Director Proton Therapy Center
Proton Therapy for Prostate Cancer Andrew K. Lee, MD, MPH Director Proton Therapy Center Disclosures No relevant financial disclosures This presentation will not discuss off-label or investigational treatments
Stereotactic MR-guided adaptive radiation therapy (SMART) for locally advanced pancreatic tumors
Stereotactic MR-guided adaptive radiation therapy (SMART) for locally advanced pancreatic tumors Anna Bruynzeel, Radiation Oncologist VU University Medical Center, Amsterdam, The Netherlands Current standard
ISSN: X (Print) X (Online) Journal homepage:
Acta Oncologica ISSN: 0284-186X (Print) 1651-226X (Online) Journal homepage: https://www.tandfonline.com/loi/ionc20 Bag and loop small bowel contouring strategies differentially estimate small bowel dose
Intrafractional prostate motion during external beam radiotherapy monitored by a real-time target localization system
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, VOLUME 16, NUMBER 2, 2015 Intrafractional prostate motion during external beam radiotherapy monitored by a real-time target localization system Xu Tong, 1 Xiaoming
Can we deliver the dose distribution we plan in HDR-Brachytherapy of Prostate Cancer?
Can we deliver the dose distribution we plan in HDR-Brachytherapy of Prostate Cancer? Dimos Baltas 1,3, Natasa Milickovic 1, Nikolaos Zamboglou 2 1 Dept. of Medical Physics & Engineering, 2 Strahlenklinik,
Dosimetric Comparison of Intensity-Modulated Radiotherapy versus 3D Conformal Radiotherapy in Patients with Head and Neck Cancer
Dosimetric Comparison of Intensity-Modulated Radiotherapy versus 3D Conformal Radiotherapy in Patients with Head and Neck Cancer 1- Doaa M. AL Zayat. Ph.D of medical physics, Ayadi-Al Mostakbl Oncology
Innovative RT SBRT. The variables with REQ in superscript are required.
The variables with REQ in superscript are required. The variables with a are single-select variables; only one answer can be selected. The variables with a are multi-select variables; multiple answers
Outline. Contour quality control. Dosimetric impact of contouring errors and variability in Intensity Modulated Radiation Therapy (IMRT)
Dosimetric impact of contouring errors and variability in Intensity Modulated Radiation Therapy (IMRT) James Kavanaugh, MS DABR Department of Radiation Oncology Division of Medical Physics Outline Importance