ADVANTAGES AND DISADVANTAGES OF CATHETER MATERIALS TABLE 9 ADVANTAGES AND DISADVANTAGES OF CATHETER MATERIALS... 43

Transcription

1 CHAPTER ONE: INTRODUCTION... 1 STUDY GOALS AND OBJECTIVES... 1 REASONS FOR DOING THE STUDY... 1 SCOPE OF REPORT... 1 METHODOLOGY... 1 INTENDED AUDIENCE... 2 INFORMATION SOURCES... 2 ANALYST CREDENTIALS... 2 RELATED BCC REPORTS... 2 BCC ONLINE SERVICES... 3 DISCLAIMER... 3 CHAPTER TWO: SUMMARY... 4 SUMMARY TABLE: GLOBAL CATHETER MARKET, BY REGION, THROUGH 2016 ($ MILLIONS)... 5 SUMMARY FIGURE GLOBAL CATHETER MARKET, BY REGION, 2011 AND 2016 (%)... 5 SUMMARY FIGURE (CONTINUED)... 6 CHAPTER THREE: OVERVIEW OF GLOBAL CATHETER INDUSTRY... 7 CATHETER DEVELOPMENT... 7 CATHETER CONSTRUCTION... 7 CATHETER APPLICATIONS... 8 TYPES OF CATHETERS... 9 CARDIOVASCULAR CATHETERS... 9 Use of Cardiovascular Catheters... 9 Diagnostic Procedures and Cardiac Catheterization Therapeutic Procedures TABLE 1 INDICATIONS FOR CARDIAC CATHETERIZATION TABLE 2 TYPES OF CARDIAC CATHETERS Angiography Catheters Angiographic Catheter Features EP Catheters Cardiac Ablation Catheters PCI Catheters PCI and Stent Placement TABLE 3 PCI PROCEDURES Rapid Exchange Balloon Catheters Over the-wire PCI Catheters Guiding Catheter Possible Complications UROLOGICAL CATHETERS Development of the Foley Catheter Type of Urinary Catheterization... 16

2 Intermittent Catheterization Possible Complication of Intermittent Catheters Indwelling Catheterization Possible Complications from Indwelling Catheters Suprapubic Catheterization Possible Complications from Suprapubic Catheterization Male External Condom Catheterization Possible Complications From Urinary Catheter Use NEUROVASCULAR CATHETERS INTRAVENOUS (IV) CATHETERS Single-Lumen Catheters Multi-Lumen Catheter Specialty IV Catheters Peripheral Vein Catheter Central Venous Catheter (CVC) Tunneling Insertion Implantation Insertion Advantages to Central Venous Catheters Peripherally Inserted Central Catheters (PICCs) Advantages of PICC Lines Possible Complications due to IV Catheters TABLE 4 COMPLICATIONS DUE TO IV CATHETERS TABLE 4 (CONTINUED) SPECIALTY CATHETERS Thermodilution Catheters Suction Catheters Oximetry Catheters END-USER PREFERENCES SIZE OF CATHETER MATERIAL USED COATING LENGTH OF TIME CATHETER IS IN THE BODY INFECTION RATE COST CHAPTER FOUR: CATHETERS AND WORLD DEMOGRAPHICS CATHETER-ASSOCIATED INFECTIONS FROM SELECTED PROCEDURES TABLE 5 GLOBAL TRENDS IN CATHETER-ASSOCIATED INFECTIONS BY ESTIMATED NUMBER OF INFECTIONS PER PROCEDURE TYPE, (THOUSANDS) CORONARY PROCEDURES... 29

3 TABLE 6 SELECTED WORLDWIDE CORONARY PROCEDURES, 2007* (PER 100,000 POPULATIONS) WORLDWIDE ECONOMIC DEMOGRAPHICS TABLE 7 HEALTHCARE EXPENDITURE AS A PERCENTAGE OF GDP BY COUNTRY, * (%) WORLDWIDE POPULATION GROWTH CHAPTER FIVE: CATHETER MATERIALS TABLE 8 CHARACTERISTICS OF CATHETER MATERIALS KEY CHARACTERISTICS SURFACE CHARACTERISTICS CATHETER USE IN ADVANCED IMAGING MRA OCT RADIOPACITY IN CATHETERS Determining Appropriate Properties of Radiopaque Catheters Economics of Radiopacity COMPONENT MATERIALS LATEX Latex Allergic Reactions SILICONE Silicone Catheter Characteristics Disadvantage of Silicone Catheters Cost Considerations for Silicone Catheters POLYTETRAFLUOROETHYLENE (PTFE) Uses Cost Considerations POLYURETHANE (PU) Uses Cost Considerations POLYVINYL CHLORIDE (PVC) Uses Cost Considerations POLYETHYLENE Uses Cost Considerations CATHETER COATINGS SILICONE ELASTOMER HYDROPHILIC COATING ANTIMICROBIAL COATING Combating UTI Combining Hydrophilic and Antimicrobial Coatings Silver Coating... 42

4 ADVANTAGES AND DISADVANTAGES OF CATHETER MATERIALS TABLE 9 ADVANTAGES AND DISADVANTAGES OF CATHETER MATERIALS CHAPTER SIX: ANALYSIS OF THE GLOBAL CATHETER MARKET FACTORS INFLUENCING MARKET GROWTH FIGURE 1 FACTORS INFLUENCING THE MEDICAL DEVICE MARKET DEMOGRAPHIC TRENDS SURGICAL AND MEDICAL TRENDS PCI Versus CABG Combined Therapies Expansion of Microcatheter Use CATHETER REUSE PRODUCT DISTRIBUTION REIMBURSEMENT AND REGULATION TRENDS Global Financial Conditions Third-party Coverage and Reimbursement Global Cost Containment LEADING MANUFACTURERS TABLE 10 TOTAL REVENUES OF KEY CATHETER MANUFACTURERS, 2009 AND 2010 ($ MILLIONS) MERGERS/ACQUISITIONS IN THE CATHETER MARKET TABLE 11 MERGERS/ACQUISITIONS IN THE GLOBAL CATHETER MARKET KEY MARKET DRIVERS INCREASE IN PROCEDURES HAS LED TO INCREASED DEMAND FOR CATHETERS INCREASED DEMAND FOR DISPOSABLE CATHETERS DUE TO RISK OF INFECTION AND TRANSMITTABLE DISEASE NEW TECHNOLOGIES IN CATHETER DESIGN HAVE INCREASED CATHETER USE INCREASE IN MINIMALLY INVASIVE PROCEDURES REQUIRING CATHETERS HAS EXPANDED SALES ADVANCES IN IMAGING TECHNOLOGY HAVE LED TO NEW APPLICATIONS REQUIRING THE USE OF CATHETERS KEY MARKET RESTRAINTS PRICE EROSIONS DUE TO FIERCE COMPETITION ARE SHRINKING REVENUES... 52

5 LONGER APPROVAL TIMES ARE RESULTING IN DELAYED LAUNCHES OF NEW PRODUCTS REIMBURSEMENT ISSUES HAVE AFFECTED THE USE OF TECHNOLOGICALLY ADVANCED CATHETERS EXPERIENCED PHYSICIANS OFTEN ARE RELUCTANT TO ACCEPT NEW DEVICE TECHNOLOGIES GLOBAL CATHETER REVENUE ANALYSIS TABLE 12 PROJECTED GLOBAL CATHETER MARKET BY SEGMENT, THROUGH 2016 ($ MILLIONS) CARDIOVASCULAR CATHETERS KEY MARKET CHALLENGES Pharmacological Approaches Could Threaten Catheter Demand Lack of Clinical Data Is Hindering Acceptance of Newer Catheters by Physicians and Healthcare Purchasing Organizations KEY MARKET DRIVERS FOR THE CARDIOVASCULAR SEGMENT Increases in the Incidence of Cardiovascular Diseases is Driving the Number of Procedures Popularity of Angioplasty and Stent Placement over Bypass Surgery Is Leading to an Increase in the Use of Cardiac Catheters Angiography Is Driving the Increase in the Number of Diagnostic Procedures Interventional Cardiac Procedures Can Be More Effective than Pharmaceutical-based Therapies KEY MARKET RESTRAINTS IN THE CARDIOVASCULAR MARKET Constant Price Erosion Is Leading to Decreased Revenues Decrease in Restenosis is Affecting the Number of Stent Procedures Performed Catheter Usages Is Restrained due to Low Reimbursement Rates CATHETER USE IN CONJUNCTION WITH STENT PLACEMENT Exit of Cordis from Stent Market CARDIOVASCULAR CATHETER REVENUE ANALYSIS TABLE 13 PROJECTED GLOBAL MARKET FOR CARDIOVASCULAR CATHETERS BY TYPE, THROUGH 2016 ($ MILLIONS) Angiography EP Mapping Catheters Balloon Catheters Rapid-exchange Catheters... 61

6 Guiding Catheters MARKET SHARES BY COMPANY FIGURE 2 PROJECTED GLOBAL MARKET SHARE FOR ALL TYPES OF CARDIOVASCULAR CATHETERS, BY COMPANY, 2010 (%) UROLOGICAL SEGMENT Market Challenges Market Drivers Global Aging of the Population Catheters with Antimicrobial Coatings Are Increasing Confidence in the Use of Catheter Urological Catheter Market Revenues Intermittent Catheter Revenues Indwelling Catheter Revenues TABLE 14 PROJECTED GLOBAL MARKET FOR UROLOGICAL CATHETERS, BY TYPE, THROUGH 2016 ($ MILLIONS) FIGURE 3 PROJECTED GLOBAL MARKET SHARE FOR UROLOGICAL CATHETERS, BY COMPANY, 2010 (%) INTRAVENOUS TABLE 15 PROJECTED GLOBAL MARKET FOR INTRAVENOUS CATHETERS BY TYPE, THROUGH 2016 ($ MILLIONS) FIGURE 4 GLOBAL MARKET SHARE FOR IV CATHETERS, BY COMPANY, 2010 (%) NEUROVASCULAR SEGMENT Key Market Challenges Cost of Neurovascular Catheters Availability of Pharmacological Treatment Options Shortage of Qualified Professionals to Perform Surgeries Key Market Drivers Enhanced Diagnostic and Imaging Technologies Are Creating New Areas of Treatment Stenting and Aneurysm Treatments Are Increasing Microcatheter Use New Catheter Technologies Are Improving Procedures and Increasing Demand Expanding Market for Unmet Treatment Options Neurovascular Catheter Market Revenues TABLE 16 PROJECTED GLOBAL MARKET FOR NEUROVASCULAR CATHETERS, THROUGH 2016 ($ MILLIONS) Market Share by Company FIGURE 5 GLOBAL NEUROVASCULAR CATHETER MARKET SHARES BY COMPANY, 2011 (%) SPECIALTY CATHETER MARKET Types of Specialty Catheters... 73

7 Key Market Drivers Demand for Enhanced Monitoring Devices Is Contributing to Expanded Sales Effectiveness of Specialty Catheters Is Fueling Growth in Use Key Market Restraints Increased Cost of Specialty Catheters Inhibit Sales Introduction of Competing Technologies Use of Thrombolytic Drugs Specialty Catheter Market Revenue Analysis TABLE 17 PROJECTED GLOBAL SPECIALTY CATHETER MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) Specialty Catheter Market Analysis TABLE 18 GLOBAL SPECIALTY CATHETER MARKET SHARES, BY COMPANY AND TYPE OF CATHETER, 2010 (%) GLOBAL MARKET SHARE FORECAST BY TYPE OF CATHETER FIGURE 6 PERCENT OF MARKET SHARE BY TYPE OF CATHETER 2011 AND 2016 (%) FIGURE 6 (CONTINUED) CONSEQUENCES OF THE ONGOING GLOBAL ECONOMIC RECESSION PROJECTIONS FOR GLOBAL CATHETER MARKET BY REGION TABLE 19 PROJECTED GLOBAL CATHETER MARKET BY REGION, THROUGH 2016 ($ MILLIONS) MARKET REVENUE, BY REGION Reusable Catheter Use in World Market GEOGRAPHIC MARKET SHARE BY EMERGING TECHNOLOGIES BIOABSORBABLE STENTS BIFURCATED STENTS UROVALVE INC VOLCANO CORPORATION CHAPTER SEVEN: THE AMERICAS CATHETER MARKET GDP AND PERCENT SPENT ON HEALTHCARE IN THE AMERICAS TABLE 20 GDP AND EXPENDITURE ON HEALTHCARE AS A SHARE OF GDP IN THE AMERICAS, CATHETER MARKET IN THE AMERICAS TABLE 21 PROJECTED AMERICAS MARKET FOR CATHETERS BY COUNTRY, THROUGH 2016 ($ MILLIONS) REVENUE ANALYSIS FOR THE AMERICAS CATHETER MARKET, BY TYPE OF CATHETER TABLE 22 PROJECTED AMERICAS MARKET FOR CATHETERS BY TYPE, THROUGH 2016 ($ MILLIONS)... 84

8 THE CANADIAN MARKET THE MEXICAN MARKET THE LATIN AMERICAN MARKET THE SOUTH AMERICAN MARKET THE U.S. MARKET U.S. ECONOMIC CONDITIONS EFFECTS OF HEALTHCARE REFORM IN THE U.S REIMBURSEMENT Denial of Reimbursement in U.S U.S. REGULATIONS U.S. Regulations and Reprocessing CARDIOVASCULAR DISEASE TABLE 23 U.S. RATES OF CARDIOVASCULAR PROCEDURES, (THOUSANDS) TRENDS IN PROCEDURE USAGE COSTS OF HEART DISEASE IN THE U.S REVENUE ANALYSIS FOR CARDIOVASCULAR CATHETERS IN THE AMERICAS TABLE 24 PROJECTED AMERICAS MARKET FOR CARDIOVASCULAR CATHETERS, THROUGH 2016 ($ MILLIONS) AMERICAS MARKET TRENDS IN CARDIOVASCULAR CATHETERS URINARY CATHETERS TABLE 25 PROJECTED AMERICAS MARKET FOR URINARY CATHETERS, THROUGH 2016 ($ MILLIONS) AMERICAS MARKET TRENDS IN URINARY CATHETERS INTRAVENOUS CATHETERS TABLE 26 PROJECTED AMERICAS MARKET FOR INTRAVENOUS CATHETERS, THROUGH 2016 ($ MILLIONS) AMERICAS MARKET TRENDS FOR INTRAVENOUS CATHETERS NEUROVASCULAR TABLE 27 PROJECTED AMERICAS MARKET FOR NEUROVASCULAR CATHETERS, THROUGH 2016 ($ MILLIONS) AMERICAS MARKET TRENDS FOR NEUROVASCULAR CATHETERS SPECIALTY TABLE 28 PROJECTED AMERICAS MARKET FOR SPECIALTY CATHETERS, THROUGH 2016 ($ MILLIONS) AMERICAS MARKET TRENDS FOR SPECIALTY CATHETERS CHAPTER EIGHT: THE EUROPEAN, MIDDLE EAST, RUSSIAN, AND AFRICAN CATHETER MARKET WESTERN EUROPEAN HEALTHCARE SYSTEMS... 95

9 EASTERN EUROPEAN AND AFRICAN HEALTHCARE SYSTEMS MEDICAL TOURISM IN THE MIDDLE EAST RUSSIAN HEALTHCARE SYSTEMS HEALTHCARE IN RUSSIA TABLE 29 TOTAL EXPENDITURE ON HEALTHCARE AS A SHARE OF GDP IN SELECTED EMRA COUNTRIES, 2009 ($ MILLIONS/%) TABLE 30 PROJECTED EMRA MARKET FOR CATHETERS BY REGION, THROUGH 2016 ($ MILLIONS) TABLE 31 PROJECTED EMRA MARKET FOR CATHETERS BY TYPE, THROUGH 2016 ($ MILLIONS) GOVERNMENT REGULATIONS MARKET GROWTH IN EMRA COUNTRIES ECONOMIC CONDITIONS CARDIOVASCULAR MARKET TABLE 32 PROJECTED EMRA MARKET FOR CARDIOVASCULAR CATHETERS, THROUGH 2016 ($ MILLIONS) TRENDS IN THE EMRA CARDIOVASCULAR CATHETER MARKET UROLOGY CATHETER MARKET TABLE 33 PROJECTED EMRA MARKET FOR UROLOGICAL CATHETERS, THROUGH 2016 ($ MILLIONS) TRENDS IN THE EMRA UROLOGICAL CATHETER MARKET INTRAVENOUS CATHETER MARKET TABLE 34 PROJECTED EMRA MARKET FOR INTRAVENOUS CATHETERS, THROUGH 2016 ($ MILLIONS) TRENDS IN THE EMRA INTRAVENOUS CATHETER MARKET NEUROVASCULAR CATHETER MARKET TABLE 35 PROJECTED EMRA MARKET FOR NEUROVASCULAR CATHETERS, THROUGH 2016 ($ MILLIONS) TRENDS IN THE EMRA NEUROVASCULAR CATHETER MARKET SPECIALTY CATHETER MARKET TABLE 36 PROJECTED EMRA MARKET FOR SPECIALTY CATHETERS, THROUGH 2016 ($ MILLIONS) TRENDS IN THE EMRA SPECIALTY CATHETER MARKET CHAPTER NINE: THE ASIAN CATHETER MARKET REGIONAL ECONOMIC CONSIDERATIONS TABLE 37 PROJECTED ASIAN CATHETER MARKET, THROUGH 2016 ($ MILLIONS) GDP AND GROWTH RATES TABLE 38 GDP OF SELECTED ASIAN COUNTRIES, GDP GROWTH RATE, PERCENT OF GDP DEVOTED TO HEALTHCARE

10 REGULATIONS AND HEALTHCARE COVERAGE IN THE AUSTRALIAN MARKET Health Insurance in Australia REGULATIONS AND HEALTHCARE COVERAGE IN THE JAPANESE MARKET REGULATIONS AND HEALTHCARE COVERAGE IN THE INDIAN MARKET Medical Insurance in India Growth of the Indian Healthcare Industry REGULATIONS AND HEALTHCARE COVERAGE IN THE CHINESE MARKET Medical Device Regulations Chinese Healthcare Institutions Rural and Urban Healthcare Services ASIAN CATHETER MARKET BY TYPE OF PRODUCT TABLE 39 PROJECTED ASIAN CATHETER MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) CARDIOVASCULAR MARKET TABLE 40 PROJECTED ASIAN CARDIOVASCULAR CATHETER MARKET, THROUGH 2016 ($ MILLIONS) Trends in the Asian Cardiovascular Catheter Market UROLOGY CATHETER MARKET TABLE 41 PROJECTED ASIAN UROLOGY CATHETER MARKET, THROUGH 2016 ($ MILLIONS) Trends in the Asian Urological Catheter Market INTRAVENOUS CATHETER MARKET TABLE 42 PROJECTED ASIAN INTRAVENOUS CATHETER MARKET, THROUGH 2016 ($ MILLIONS) Trends in the Asian IV Catheter Market NEUROVASCULAR CATHETER MARKET TABLE 43 PROJECTED ASIAN NEUROVASCULAR CATHETER MARKET, THROUGH 2016 ($ MILLIONS) Trends in the Asian Neurological Catheter Market SPECIALTY CATHETER MARKET TABLE 44 PROJECTED ASIAN SPECIALTY CATHETER MARKET, THROUGH 2016 ($ MILLIONS) Trends in the Asian Specialty Catheter Market CHAPTER TEN: PATENT ANALYSIS GLOBAL CATHETER PATENT APPLICATIONS, TABLE 45 GLOBAL CATHETER PATENT APPLICATIONS, CATHETER PATENT ACTIVITY BY ASSIGNEE TABLE 46 CATHETER PATENT APPLICATION ACTIVITY BY ASSIGNEE, JANUARY 2008-SEPTEMBER 2011 (NUMBER OF PATENTS)

11 TABLE 46 (CONTINUED) CARDIOVASCULAR CATHETER PATENTS TABLE 47 CARDIOVASCULAR CATHETER PATENTS BY TYPE, JANUARY 2008-SEPTEMBER TABLE 48 CARDIAC CATHETER PATENTS, NOVEMBER JANUARY TABLE 48 (CONTINUED) TABLE 48 (CONTINUED) TABLE 48 (CONTINUED) TABLE 49 BALLOON CATHETER PATENTS, APRIL 2011-JANUARY TABLE 49 (CONTINUED) TABLE 50 CARDIAC GUIDE CATHETER PATENTS, NOVEMBER 2011-JANUARY TABLE 51 CARDIAC GUIDEWIRE PATENTS, UROLOGY CATHETER PATENTS IV CATHETER PATENTS TABLE 52 IV CATHETER PATENTS BY TYPE, JANUARY SEPTEMBER TABLE 53 IV CATHETER PATENTS, JUNE 2009-SEPTEMBER SPECIALTY CATHETER PATENTS TABLE 54 SPECIALTY CATHETER PATENTS BY TYPE, JANUARY 2008-SEPTEMBER TABLE 55 SPECIALTY CATHETER PATENTS, OCTOBER JANUARY TABLE 55 (CONTINUED) CATHETER COATINGS TABLE 56 CATHETER COATING PATENTS, JANUARY SEPTEMBER TABLE 57 CATHETER COATING PATENTS, JULY 2011-JUNE TABLE 57 (CONTINUED) CHAPTER ELEVEN: COMPANY DIRECTORY ABBOTT LABORATORIES BUSINESS OVERVIEW FINANCIAL PRODUCTS TABLE 58 ABBOTT LABORATORIES CATHETER PRODUCTS ANGIODYNAMICS BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 59 ANGIODYNAMICS CATHETER PRODUCTS ASTRA TECH INC., UROLOGY DIVISION BUSINESS OVERVIEW

12 FINANCIALS PRODUCTS TABLE 60 ASTRA TECH CATHETER PRODUCTS B. BRAUN MELSUNGEN AG BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 61 B. BRAUN CATHETER PRODUCTS TABLE 61 (CONTINUED) BECTON DICKINSON & CO BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 62 BD CATHETER PRODUCTS BOSTON SCIENTIFIC BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 63 BOSTON SCIENTIFIC CATHETER PRODUCTS TABLE 63 (CONTINUED) CARDINAL HEALTH BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 64 CARDINAL HEALTH CATHETER PRODUCTS CAREFUSION CORP BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 65 CAREFUSION CATHETER PRODUCTS CODMAN & SHURTLEFF (DEPUY) BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 66 CODMAN & SHURTLEFF CATHETER PRODUCTS COLOPLAST GROUP FINANCIALS PRODUCTS TABLE 67 COLOPLAST CATHETER PRODUCTS COOK MEDICAL BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 68 COOK MEDICAL CATHETER PRODUCTS

13 TABLE 68 (CONTINUED) COVIDIEN BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 69 COVIDIEN CATHETER PRODUCTS C. R. BARD BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 70 C. R. BARD CATHETER PRODUCTS TABLE 70 (CONTINUED) TABLE 70 (CONTINUED) EDWARDS LIFESCIENCES BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 71 EDWARDS LIFESCIENCES CATHETER PRODUCTS EV3 ENDOVASCULAR INC. (COVIDIEN) BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 72 EV3 CATHETER PRODUCTS GOODMAN CO. LTD BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 73 GOODMAN CATHETER PRODUCTS HOLLISTER BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 74 HOLLISTER CATHETER PRODUCTS HOSPIRA INC BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 75 HOSPIRA CATHETER PRODUCTS ICU MEDICAL BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 76 ICU MEDICAL CATHETER PRODUCTS INTEGRA LIFE SCIENCES

14 BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 77 INTEGRA LIFESCIENCES CATHETER PRODUCTS JOHNSON & JOHNSON BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 78 JOHNSON & JOHNSON CATHETER PRODUCTS TABLE 78 (CONTINUED) KIMBERLY CLARK HEALTHCARE BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 79 KIMBERLY CLARK HEALTHCARE CATHETER PRODUCTS MEDCOMP BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 80 MEDCOMP CATHETER PRODUCTS MEDLINE INDUSTRIES BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 81 MEDLINE CATHETER PRODUCTS MEDRAD (BAYER AG) BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 82 MEDRAD CATHETER PRODUCTS MEDTRONIC BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 83 MEDTRONIC CATHETER PRODUCTS MERIT MEDICAL SYSTEMS BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 84 MERIT MEDICAL CATHETER PRODUCTS TABLE 84 (CONTINUED) NAVILYST MEDICAL BUSINESS OVERVIEW FINANCIALS

15 PRODUCTS TABLE 85 NAVILYST MEDICAL CATHETER PRODUCTS PULSION MEDICAL AG BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 86 PULSION MEDICAL SYSTEMS CATHETER PRODUCTS ROCHESTER MEDICAL BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 87 ROCHESTER MEDICAL CATHETER PRODUCTS SMITHS MEDICAL BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 88 SMITHS MEDICAL CATHETER PRODUCTS ST. JUDE MEDICAL BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 89 ST. JUDE MEDICAL CATHETER PRODUCTS TABLE 89 (CONTINUED) STRYKER BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 90 STRYKER CATHETER PRODUCTS TELEFLEX MEDICAL (FORMERLY ARROW INTERNATIONAL) BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 91 TELEFLEX CATHETER PRODUCTS TERUMO MEDICAL CORP BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 92 TERUMO CATHETER PRODUCTS TABLE 92 (CONTINUED) VASCULAR SOLUTIONS BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 93 VASCULAR SOLUTIONS CATHETER PRODUCTS

16 VOLCANO CORPORATION BUSINESS OVERVIEW FINANCIALS PRODUCTS TABLE 94 VOLCANO CORPORATION CATHETER PRODUCTS APPENDIX: CATHETER PRODUCTS AND THEIR MANUFACTURERS TABLE 95 CATHETER PRODUCTS BY APPLICATION, TYPE, BRAND NAME, AND MANUFACTURER TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED) TABLE 95 (CONTINUED)