Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized controlled trials in reproductive medicine: Disclosing the caveats

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1 UvA-DARE (Digital Academic Repository) Randomized controlled trials in reproductive medicine Braakhekke, M.W.M. Link to publication Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized controlled trials in reproductive medicine: Disclosing the caveats General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 25 Dec 2018

2 Randomized Controlled Trials in Reproductive Medicine: Disclosing the Caveats Miriam Braakhekke

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4 Randomized Controlled Trials in Reproductive Medicine Disclosing the Caveats Miriam Braakhekke

5 Randomized Controlled Trials in Reproductive Medicine Disclosing the Caveats PhD thesis, University of Amsterdam, the Netherlands 2017 Miriam Braakhekke All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system of any nature, or transmitted to any form or by any means, without prior permission of the author. Financial support for printing this thesis was kindly provided by: Universiteit van Amsterdam (UvA), OLVG Oost, ChipSoft, IM Services BV, Ferring BV and Memidis Pharma BV. Printed by: Gildeprint - Enschede ISBN:

6 Randomized Controlled Trials in Reproductive Medicine Disclosing the Caveats ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op donderdag 21 september 2017, te 14:00 uur door Miriam Willeke Marloes Braakhekke geboren te Heumen

7 Promotiecommissie: Promotores: Prof. dr. F. van der Veen AMC-UvA Prof. dr. B.W.J. Mol AMC-UvA copromotor: Dr. F. Mol AMC-UvA overige leden: Prof. dr. P.M.M. Bossuyt AMC-UvA Prof. dr. H.R. Büller AMC-UvA Dr. W.J. Dondorp Universiteit van Maastricht Prof. dr. J.L.H. Evers Universiteit van Maastricht Prof. dr. M. Goddijn AMC-UvA Prof. dr. S. Repping AMC-UvA Faculteit der Geneeskunde

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9 contents chapter 1 Introduction and outline of the thesis 9 chapter 2 equipoise and the rct 19 chapter 3 chapter 4 chapter 5 chapter 6 chapter 7 chapter 8 Braakhekke M, Mol F, Mastenbroek S, Mol BW, van der Veen F Human Reproduction 2017;32(2): Reporting multiple cycles in trials on medically assisted reproduction Scholten I, Braakhekke M, Limpens J, Hompes PGA, van der Veen F, Mol BW, Gianotten J Reproductive BioMedicine online 2016;33(5): How are neonatal and maternal outcomes reported in randomised trials in reproductive medicine? Braakhekke M, Kamphuis EM, van Rumste M, Mol F, van der Veen F, Mol BW Human Reproduction 2014;29(6): Ongoing pregnancy qualifies best as the primary outcome measure of choice in trials in reproductive medicine: an opinion paper Braakhekke M, Kamphuis EM, Dancet EAF, Mol F, van der Veen F, Mol BW Fertility and Sterility 2014;101(5): Effectiveness versus safety in reproductive medicine Braakhekke M, Kamphuis E, Norman R, Bhattacharya S, Mol F, van der Veen F, Mol BW Human Reproduction 2015;30(10): Selective outcome reporting and sponsorship in randomized controlled trials on ivf and icsi Braakhekke M, Scholten I, Mol F, Mol BW, van der Veen F Accepted for publication, Human Reproduction, August 2017 Consistency of information provided on websites of fertility clinics in europe Braakhekke M, Sent D, Feddouli S, Mol F, van der Veen F, Mol BW Submitted chapter 9 Summary and implications for the future

10 APPeNDices Nederlandse samenvatting 127 List of co-authors and affiliations 137 Author contributions 140 PhD portfolio 145 Dankwoord 151 curriculum Vitae 157

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