Clinical Policy Title: Robotic assisted surgery
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1 Clinical Policy Title: Robotic assisted surgery Clinical Policy Number: Effective Date: March 1, 2014 Initial Review Date: September 18, 2013 Most Recent Review Date: September 17, 2017 Next Review Date: September 2018 Policy contains: Robotic assisted surgery. DaVinci surgical system. ZEUS robotic system. Related policies: CP# Radiofrequency (RF) Ablation of Uterine Fibroids ABOUT THIS POLICY: Select Health of South Carolina has developed clinical policies to assist with making coverage determinations. Select Health of South Carolina s clinical policies are based on guidelines from established industry sources, such as the Centers for Medicare & Medicaid Services (CMS), state regulatory agencies, the American Medical Association (AMA), medical specialty professional societies, and peer-reviewed professional literature. These clinical policies along with other sources, such as plan benefits and state and federal laws and regulatory requirements, including any state- or plan-specific definition of medically necessary, and the specific facts of the particular situation are considered by Select Health of South Carolina when making coverage determinations. In the event of conflict between this clinical policy and plan benefits and/or state or federal laws and/or regulatory requirements, the plan benefits and/or state and federal laws and/or regulatory requirements shall control. Select Health of South Carolina s clinical policies are for informational purposes only and not intended as medical advice or to direct treatment. Physicians and other health care providers are solely responsible for the treatment decisions for their patients. Select Health of South Carolina s clinical policies are reflective of evidence-based medicine at the time of review. As medical science evolves, Select Health of South Carolina will update its clinical policies as necessary. Select Health of South Carolina s clinical policies are not guarantees of payment Coverage policy Select Health of South Carolina considers the use of robotic assistance in surgery to be investigational and, therefore, not medically necessary (Ind 2017, Ielpo 2017, Albright 2016, Tan 2016, Fonseka 2015, Lang 2015, Cundy 2014, Robertson 2013, Close 2013, Wright (2013). Limitations: Robotic assistance is not separately reimbursable from the primary surgical procedure. Alternative covered services: Surgeon consultation for approved standard or minimally invasive surgery without the assistance of robotic technology. Background Robotic assisted surgery has become increasingly common in the United States and in the world, rising from 80,000 to 500,000 procedures between 2007 and The new technology has rapidly expanded. In 1
2 2010, 9.5% of hysterectomies in U.S. hospitals were performed using robotic technology, up from just 0.5% three years earlier. In hospitals that introduced robotic surgery for hysterectomy, 22.4% of the procedures were performed using a robot three years lager (Wright, 2013). The use of computer assistance allows the surgeon to take advantage of the miniaturization possible that leads to smaller incisions, less pain and somewhat reduced hospitalization time. The robotic assistance devices allow the surgeon to operate from a console with three dimensional viewing. Computer technology translates surgeons hand motions into precise manipulation of surgical instruments inserted into the patients bodies through cannulas. This allows the surgeon to operate remotely. Much of the original work on robot assisted surgery was performed through grants by the U.S. military looking for ways to operate remotely on soldiers injured on the battlefield. The greatest use of robotics occurs within hospitals where the surgeon is in close proximity to the patient but taking advantage of miniaturization of the incision. Perhaps the most commonly used model of robotic assisted surgery is the davinci system, made by Intuitive Surgical. It is often used for prostatectomies, hysterectomies, bypass surgeries, and removing cancerous tissue (Carlson, 2016). The U.S. Food and Drug Administration approved the device in Another common model is the ZEUS Robotic Surgical System (also owned by Intuitive Surgical). The Consensus document from the Society for American Gastrointestinal and Endoscopic Surgeons (SAGES) lists four elements of advantages for robotic surgeries (Herron, 2008): Superior visualization, including 3-dimensional imaging of the operative field. Stabilization of instruments within the surgical field. Mechanical advantages over traditional laparoscopy. Improved ergonomics for the operating surgeon. SAGES further indicates the optimal use of robotics for intra-abdominal surgery is where the procedure is in a defined space within the abdomen and in which fine dissection and micro-suturing is needed. The application of robotic assisted surgery is now found in the following fields. The majority of these procedures are performed without the use of such computer assistance: Specialty Procedures Cardiology Ablation of aberrant conduction systems. Cardiothoracic surgery Interventional cardiac procedures. Atrial septal defect closure. General surgery Bariatric surgery. Endoscopic coronary artery bypass. Cholecystectomy. Colectomy. Gastrectomy. Heller myotomy. 3-D cardiac mapping. MIDCAB. Valve repair or replacement. Incisional hernia repair. Nissan fundoplication. Pancreatectomy. Rectopexy. Splenectomy. 2
3 Specialty Gynecology Hysterectomy. Myomectomy. Sacrocolpopexy. Procedures Staging for cancer. Tubal anastomosis. Vesicovaginal fistula repair. Orthopedic surgery Total hip replacement. Total knee replacement. Pediatric surgery Anal pull-through for imperforate anus. Appendectomy. Cholecystectomy. Fundoplication. Thoracic surgery Lobectomy. Thymectomy. Urology Cystectomy. Donor nephrectomy. Partial/radical nephrectomy. Gastric banding. Heminephrectomy. Pyeloplasty. Vascular ring repair. Transthoracic. esophagectomy. Pyeloplasty. Radical prostatectomy. The large number of procedures for which robotic assistance has been used further indicates the technology is in its infancy, with efforts to find optimal outcomes for patients. Most of the above listed procedures have been performed a small number of times and have not been subjected to randomized controlled clinical trials. Searches Select Health of South Carolina searched PubMed and the databases of: UK National Health Services Centre for Reviews and Dissemination. Agency for Healthcare Research and Quality s National Guideline Clearinghouse and other evidence-based practice centers. The Centers for Medicare & Medicaid Services. We conducted searches on August 30, Search terms were robotic systems, robotic assisted surgery, and da Vinci surgery. We included: Systematic reviews, which pool results from multiple studies to achieve larger sample sizes and greater precision of effect estimation than in smaller primary studies. Systematic reviews use predetermined transparent methods to minimize bias, effectively treating the review as a scientific endeavor, and are thus rated highest in evidence-grading hierarchies. Guidelines based on systematic reviews. Economic analyses, such as cost-effectiveness, and benefit or utility studies (but not simple cost studies), reporting both costs and outcomes sometimes referred to as efficiency studies which also rank near the top of evidence hierarchies. 3
4 Findings Researchers have assessed a variety of outcomes of robotically-assisted surgery. Those measures (typically in studies comparing robotic surgery to laparoscopic surgery) include length of stay, blood loss, anesthesia required, recovery time, time in the operating room, complications, and costs. Because many procedures using robotic technology having been performed, the literature contains a large number of controlled trials (along with meta-analyses and systematic reviews). While some researchers conclude that robotic surgery is superior to traditional laparotomy or laparoscopy, a number of others strongly believe that the superiority of robotic surgery is unproven. On March 14, 2013, American College of Obstetrics and Gynecology (ACOG) president James T. Breeden MD issued a statement on the College s web site. Breeden stated that studies have shown that adding this expensive technology for routine surgical care does not improve patient outcomes... there is no good data proving that robotic hysterectomy is even as good as let alone better than existing, and far less costly, minimally invasive alternatives. Breeden cited aggressive direct-to-consumer marketing of the latest medical technologies may mislead the public into believing that they are the best choice. In March 2016, Project Hope Senior Fellow and former Health Care Financing Administration director Gail Wilensky PhD published a peer-reviewed journal article echoing these conclusions. Evidence of effective outcomes of robotic surgery patients compared to laparoscopy patients is considerably less compelling, she wrote. Wilensky also focused on the cost of robotic surgery. The purchase price of a single machine is around $2 million, and thus the average incremental cost of robotic surgery compared to laparoscopy is about $3,000 to $6,000 per patient. She did acknowledge that the greatest efficacy has been found in those procedures that are most difficult to reach with a laparoscope, such as prostatectomy and some head and neck surgeries; but concluded that there is no indication that these robotic procedures are likely to become more cost-effective over time (Wilensky, 2016). Both Breeden and Wilensky cited a large 2013 JAMA study published by Columbia University researchers covering 264,758 women undergoing hysterectomy in 441 hospitals between 2007 and The study found similar rates of complications, long lengths of stay, transfusions, and nursing home discharges for the two groups, but also cited concern over the higher average costs associated with robotic surgery, especially as the percent of hysterectomies performed with a robot soared (Wrignt, 2013). Meta-analyses and systematic reviews have failed to establish a pattern of improved long-term efficacy of this procedure. In addition to the seminal Columbia research, the following were published in the first half of 2016: A meta-analysis by researchers at the Geisel School of Medicine at Dartmouth College found no difference in complications, length of stay, operating time, conversions to laparotomy, and blood loss between robotic vs. laparoscopic hysterectomies, leading to the conclusion that robotic surgery s role in benign gynecological surgery remains unclear (Albright, 2016). 4
5 In patients affected by sleep apnea undergoing tongue reduction, failure rates of trans-oral robotic surgery and coblation tongue surgery were not significantly different (34.4% and 38.5%). However, complication rates were significantly higher in the robotic group (21.3% vs. 8.4%) (Camaroto, 2016). A large meta analysis (99 articles, 14,448 patients) comparing outcomes for robotic vs. minimally invasive surgery for various types of procedures documented robotic groups had reduced blood loss, and a lower transfusion rate. However, robotic groups had similar LOS and 30 day complication rates, and a higher average operative time. The report noted that many studies suffered from high risk of bias and inadequate statistical power (Tan, 2016). A meta-analysis of sacrocolpopexy (treating prolapse of the apical segment of the vagina) compared results for patients undergoing laparoscopy vs. open surgery vs. robotic. In 9 studies of 1157 subjects, no difference was found in anatomical outcomes, mortality, LOS, and post-operative quality of life, but the robotic subjects experienced higher post-op pain and longer operating times (DeBouveia, 2016). In a review of 24 studies on radical prostatectomy (laparoscopy vs. robotic), the robotic subjects had less blood loss and a lower transfusion rate, along with better functional outcomes but there was no difference in perioperative and oncological outcomes (Huang, 2016). An analysis of 18 studies of 4878 patients undergoing thyroidectomy, comparing the conventional (open) approach vs. endoscopic vs. robotic documented a similar risk of post-operative complications, but a longer operative time (mean difference 43.5 minutes) for robotic-assisted surgery procedures than conventional surgery (Kandil, 2016). Some articles have analyzed additional costs for treating patients with robotic assisted surgery. As mentioned, average incremental costs per procedure are estimated at $3,000 to $6,000 (Wilensky, 2016). Trials of sacrocolpopexy, in addition to finding robotic procedures had longer time in the operating room and caused more pain than laparoscopic surgery, calculated that average cost per patients was nearly twice as high for robotic surgery when cost of purchase and maintenance was factored in, i.e. $19,616 vs. $11,573 (Callewaert, 2016). A study of 10,347 U.S. women diagnosed with uterine cancer from who underwent hysterectomies from found that robotic surgery had higher median charges than laparoscopic surgery, i.e. $38,161 vs. $31,476 (Zakhari, 2015). Policy updates: Two (2) new peer-reviewed references have been added to this policy, both published in Both have been added to the Summary of Clinical Evidence section. A systematic review (Ind 2017) compared robotic with standard laparoscopy for treatment of endometrial cancer. Thirty-six papers including 33 retrospective studies, two matched case-control studies and one randomized controlled study were used in the meta-analysis. Information from a further seven 5
6 registry/database studies were assessed descriptively. There were no differences in the duration of surgery but days spent in the hospital were shorter in the robotic arm (0.46 days, 95%CI 0.26 to 0.66) than with standard laparoscopy. A robotic approach had less blood loss (57.74 ml, 95%CI to 77.20), less conversions to laparotomy (RR = 0.41, 95%CI 0.29 to 0.59), and less overall complications (RR = 0.82, 95%CI 0.72 to 0.93). The authors cited the robotic approach for treatment of endometrial cancer has favorable clinical outcomes. An observational, comparative study (Ielpo 2017) abstracted data retrospectively on patients who underwent laparoscopic and robotic rectal resection from October 2010 to March 2017, at Sanchinarro University Hospital, Madrid. A total of 86 robotic and 112 laparoscopic rectal resections were included. The mean operative time was significantly lower in the laparoscopic approach (336 versus 283 min; p = 0.001). The main pre-operative data, overall morbidity, hospital stay and oncological outcomes were similar in both groups, except for the readmission rate (robotic: 5.8%, laparoscopic: 11.6%; p = 0.001). The authors concluded that robotic rectal resection has similar clinical outcomes to that of the conventional laparoscopic approach. Summary of clinical evidence Citation Ind (2017) Content, Methods, Recommendations A comparison of operative outcomes between standard and robotic laparoscopic surgery for endometrial cancer: A systematic review and metaanalysis. A systematic review (Ind 2017) compared robotic with standard laparoscopy for treatment of endometrial cancer. Thirty-six papers including 33 retrospective studies, two matched case-control studies and one randomized controlled study were used in the meta-analysis. Information from a further seven registry/database studies were assessed descriptively. There were no differences in the duration of surgery but days spent in the hospital were shorter in the robotic arm (0.46 days, 95%CI 0.26 to 0.66) than with standard laparoscopy. A robotic approach had less blood loss (57.74 ml, 95%CI to 77.20), less conversions to laparotomy (RR = 0.41, 95%CI 0.29 to 0.59), and less overall complications (RR = 0.82, 95%CI 0.72 to 0.93). The authors cited the robotic approach for treatment of endometrial cancer has favorable clinical outcomes. Ielpo (2017) Robotic versus laparoscopic surgery for rectal cancer: a comparative study of clinical outcomes and costs. An observational, comparative study (Ielpo 2017) abstracted data retrospectively on patients who underwent laparoscopic and robotic rectal resection from October 2010 to March 2017, at Sanchinarro University Hospital, Madrid. A total of 86 robotic and 112 laparoscopic rectal resections were included. The mean operative time was significantly lower in the laparoscopic approach (336 versus 283 min; p = 0.001). The main pre-operative data, overall morbidity, hospital stay and oncological outcomes were similar in both groups, except for the readmission rate (robotic: 5.8%, laparoscopic: 11.6%; p = 0.001). The authors concluded that robotic rectal resection has similar clinical outcomes to that of the conventional laparoscopic approach. 6
7 Citation Albright (2016) Content, Methods, Recommendations Complications in hysterectomy, laparoscopic vs. robotic 41 complications among 326 patients No significant differences in rates of class complications No significant differences in mean length of stay, operating time, conversions to laparotomy, or blood loss Concludes the role of robotic surgery in benign gynecology remains unclear Tan (2016) Outcomes, robotic vs. minimally invasive surgery 99 studies, 14,448 subjects, variety of procedures Robotic subjects had less blood loss, lower transfusion rate Robotic subjects had similar LOS and 30 day complication rates Robotic subjects had longer operative time Many studies had high risk of bias or inadequate statistical power Fonseka (2015) Comparing methods of cystectomy 24 studies, 2104 cases Robot assisted vs laparoscopic vs. open cystectomy Robot assisted had outcomes superior to open Robot = longer operative time vs. laparoscopic, same LOS, blood loss, complications Lang (2015) Thyroidectomy via robotic and nonrobotic assisted methods 10 studies, 2205 cases (differentiated thyroid carcinoma) Open vs. robotic-assisted thyroidectomy Robotic resulted in fewer central lymph nodes, less-complete thyroid resections, otherwise similar outcomes Cundy (2014) Pyeloplasty in children 12 studies, 679 participants Open vs. laparoscopic vs. robotic-assisted pyeloplasty Robotic had shorter LOS, lower anesthesia required, lower blood loss Robotic had higher cost, longer operating time Robertson (2013) Treatment of localized prostate cancer Close (2013) Treatment of localized prostate cancer Wright (2013) Meta-analysis of 58 studies (only 1 RCT) of 19,064 men with prostate surgery Fewer significant complications with robotic (0.4%) vs. laparoscopic (2.9%) Lower incidence residual tumor invading margins of resected tissue by robot. Meta-analysis of patients with prostate cancer for up to 10 years. Higher cost of robotic prostatectomy may be offset by lower risk of early harms and positive margin, if > 150 cases are performed each year. 7
8 Citation Content, Methods, Recommendations Benign gynecology surgery 441 U.S. hospitals, 264,758 procedures, , robotic vs. laparoscopic Similar rates of complications, LOS > 2 days, transfusions, discharge to nursing home Average additional costs of robotic patients was $2189 References Professional society guidelines/other: American Association of Gynecologic Laparoscopists. Guidelines for privileging for robotic-assisted gynecologic laparoscopy. J Min Invasive Gynecol. 2014;21(2): American College of Obstetrics and Gynecology. Committee opinion no. 628: robotic surgery in gynecology. Obstet Gynecol. 2015;125(3): Carlson A. Trends in medical robots & robotic surgery companies. Kaleidoscope. April 5, Accessed August 30, Herron DM, Marohn M; SAGES-MIRA Robotic Surgery Consensus Group. A consensus document on robotic surgery. Surg Endosc. 2008;22(2): Ind T, Laios A, Hacking M, Nobbenhuis M. A comparison of operative outcomes between standard and robotic laparoscopic surgery for endometrial cancer: A systematic review and meta-analysis. Int J Med Robot. 2017; 1. doi: /rcs Ielpo B, Duran H, Diaz E, Fabra I, Caruso R, Malavé L, Ferri V, Nuñez J, Ruiz-Ocaña A, Jorge E, Lazzaro S, Kalivaci D, Quijano Y, Vicente E. Robotic versus laparoscopic surgery for rectal cancer: a comparative study of clinical outcomes and costs. Int J Colorectal Dis doi: /s Milowsky MI, Rumble RB, Booth CM, et al. Guideline on muscle-invasive and metastatic bladder cancer (European Association of Urology Guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement. J Clin Oncol. 2016;1;34(16): Stenzl A, Cowan NC, De Santis M, et al. The updated EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol. 2009;55(4): U.S. Food and Drug Administration (FDA). Center for Devices and Radiological Health. ZEUS Robotic Surgical System. 501(k) Premarket Notification. October 5, Accessed August 30, US Food and Drug Administration (FDA). Center for Devices and Radiological Health. Intuitive Surgical da 8
9 Vinci. 501(k) Premarket Notification. December 16, Accessed August 30, Peer-reviewed references Albright BB, Witte T, Tofte AN, et al. Robotic versus laparoscopic hysterectomy for benign disease: A systematic review and meta-analysis of randomized trials. J Minim Invasive Gynecol. 2016;23(1): Callewaert G, Bosteels J, Housmans S, et al. Laparoscopic versus robotic-assisted sacrocolpopexy for pelvic organ prolapse: a systematic review. Gyecol Surg. 2016;13: Cammaroto G, Montevecchi F, D Agostino G, et al. Tongue reduction for OSAHS: TORSs vs coblations, technologies vs techniques, apples vs oranges. Eur Arch Otorhinolaryngol. May 24, 2016 (Epub ahead of print). Close A, Robertson C, Rushton S, et al. Comparative cost-effectiveness of robot-assisted and standard laparoscopic prostatectomy as alternatives to open radical prostatectomy for treatment of men with localised prostate cancer: A health technology assessment from the perspective of the UK National Health Service. Eur Urol. 2013;64(3): Cundy TP, Harling L, Hughes-Hallett A et al. Meta-analysis of robot-assisted vs. conventional laparoscopic and open pyeloplasty in children. BJU Int. 2014;114(4): DeGouveia De Sa M, Claydon LS, Whitlow B, Dolcet Artahona MA. Robotic versus laparoscopic sacrocolpopexy for treatment of prolapse of the apical segment of the vagina: a systematic review and meta-analysis. Int J Urogynecol J. 2016;27(3): Fonseka T, Ahmed K, Froghi S. Comparing robotic, laparoscopic, and open cystectomy: A systemic review and meta-analysis. Arch Ital Urol Adrol. 2015;87(1): Huang X, Wang L, Zheng X, Wang X. Comparison of perioperative, functional, and oncologic outcomes between standard laparoscopic and robotic-assisted radical prostatectomy: a systemic review and metaanalysis. Surg Endosc. July 21, 2016 (Epub ahead of print) Jackson NR, Yao L, Tufano RP, Kandil EH. Safety of robotic thyroidectomy approaches: Meta-analysis and systematic review. Head Neck. 2014;36(1): Kandil E, Hammad AY, Walvekar RR, et al. Robotic thyroidectomy versus nonrobotic approaches: A metaanalysis examining surgical outcomes. Surg Innov. 2016;23(3): Klatte T, Shariat SF, Remzi M. Systematic review and meta-analysis of perioperative and oncologic outcomes of laparoscopic cryoablation versus laparoscopic partial nephrectomy for the treatment of small 9
10 renal tumors. J Urol. 2014;19(5): Lang BH, Wong CK, Tsang JS, Wong KP, Wan WY. A systemic review and meta-analysis in evaluating completeness and outcomes of robotic thyroidectomy. Laryngoscope. 2015;125(2): Liao G, Zhao Z, Lin S et al. Robotic-assisted versus laparoscopic colorectal surgery: a meta-analysis of four randomized controlled trials. World J Surg Oncol. 2014;12:122. Quass AM, Einarssen JI, Srouji S, Gargiulo AR, Robotic Myomectomy: A review of indications and techniques. Rev Obstet Gynecol. 2010;3(4): Robertson C, Close A, Fraser C, et al. Relative effectiveness of robot-assisted and standard laparoscopic prostatectomy as alternatives to open radical prostatectomy for treatment of localised prostate cancer: A systematic review and mixed treatment comparison meta-analysis. BJU Int. 2013;112(6): Shen WS, Xi HQ, Chen L, Wei B. A meta-analysis of robotic versus laparoscopic gastrectomy for gastric cancer. Surg Endosc. 2014;28(10): Shi G, Lu D, Liu Z, Liu D, Zhou X. Robotic Assisted Surgery for Gynaecological Cancer. Cochrane Database Syst Rev. December 11, Accessed August 30, Tan A, Ashrafian H, Scott AJ. Robotic surgery: disruptive innovation or unfulfilled promise? A systematic review and meta-analysis of the first 30 years. Surg Endosc. February 19, 2016 (Epub ahead of print) Wilensky GR. Robotic surgery: an example of when newer is not always better but clearly more expensive. Milbank Q. 2016;94(1):43 6. Wright JD, Ananth CV, Lewin SN, et al. Robotically assisted vs. laparoscopic hysterectomy among women with benign gynecologic disease. JAMA. 2013;309(7): Zakhari A, Czuzoj-Shulman N, Spence AR, Gotlieb WH, Abenhaim HA. Laparoscopic and robot-assisted hysterectomy for uterine cancer: a comparison of costs and complications. Am J Obstet Gynecol. 2015;213(5):665.e1 7. CMS National Coverage Determination (NCDs): No NCDs identified as of the writing of this policy. Local Coverage Determinations (LCDs): No LCDs identified as of the writing of this policy. 10
11 Commonly submitted codes Below are the most commonly submitted codes for the service(s)/item(s) subject to this policy. This is not an exhaustive list of codes. Providers are expected to consult the appropriate coding manuals and bill accordingly. CPT Code Description Comments S2900 Surgical techniques requiring use of robotic surgical system (list separately in NOT FOR USE WITH addition to code for primary procedure) MEDICARE CLAIMS Laparoscopy, surgical prostatectomy, retropubic, radical; including nerve sparing, includes robotic experience when performed ICD-10 Code Description Comments Diagnoses not specified HCPCS Level II Code N/A Description Comments 11
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