ABLATHERM HIFU THE CANADIAN EXPERIENCE. WILLIAM L. OROVAN McMASTER UNIVERSITY MAPLE LEAF HIFU
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1 ABLATHERM HIFU THE CANADIAN EXPERIENCE WILLIAM L. OROVAN McMASTER UNIVERSITY MAPLE LEAF HIFU
2 PROCEDURE 1. Spinal Anaesthetic/IV Sedation 2. Right Lateral Decubitus Position 3. Transrectal Probe 4. Catheter Intra/Post Op 5. Ambulatory
3 I. PROCEDURE
4
5
6 ABLATHERM HIFU: Position
7
8 HIFU: Probe Ablatherm U/S 7.5 MHZ IMAGING U/S 3.0 MHZ FIRING Treatment port: Power: 41.5 W
9 HIFU: Prostatic Image
10 HIFU: Treatment
11
12
13 PROBE POSITIONING
14 PUBLISHED DATA: ABLATHERM: BLANA 146 PATIENTS 22 MONTHS MEDIAN F/U ASTRO Criteria 84% Success (Other publications Chaussy, Gelet, Thurhoff, Poissonier) UROLOLGY 2004 Feb 63(2)
15 EUROPEAN 8 YEAR RESULTS BLANA ET AL EUROPEAN UROLOGY 140 PATIENTS MEAN FOLLOW UP 6.4 YEARS BOCHEMICAL FAILURE FREE SURVIVAL: 60 MONTHS - 77% 84 MONTHS - 69% UROLOGY 2008 Dec : 72(6)
16 MAPLE LEAF RESULTS SINGLE TREATMENT NO PRIOR TURP VOL < 40 cc AMBULATORY SPINAL ANAESTHETIC/IV SEDATION URETHRAL CATHETER
17 INCLUSION CRITERIA TOTAL PATIENTS TREATED 507 HIGH RISK GROUP/PRIOR Rx 144 < 6 MONTH F/U OR < 2 DATA POINTS 131 ANALYZED COHORT 232
18 PATIENT CHARACTERISTICS PATIENT AGE MEAN 61 (45-82) PRE Rx PSA 6.6 ug ug/l Bx # / Bx +ve 8 / 3 PROSTATE VOL (CALC) 25.2 cc
19 RISK CATEGORY LOW 97 INTERMEDIATE 134
20 TREATMENT DATA Rx TIME 122 minutes (85-142) Rx LESIONS VOL Rx/VOL CALC 1.4 AVERAGE POWER 41.4 WATTS
21 Biochemical failure-free rate BCF free rates by Horwitz definition 89% (82, 96%) 81% (74, 88%) 82% (76, 89%) Risk group Intermediate Low Time (months) At Risk Intermediate Low
22 BCF free rate by Phoenix definition Biochemical failure-free rate % (96, 100%) P = % (81, 95%) 78% (63, 92%) Risk group Intermediate Low Time (months) At Risk Intermediate Low
23 BCF free rate by Stuttgart definition Biochemical Failure-free rate P = % (75, 91%) 89% (80, 99%) 84% 731, 97%) 72% (57,87%) 58% (30, 86%) Risk group Intermediate Low Time (months) At Risk Intermediate Low
24 BCF free rates using Stephenson definiiton Biochemical Failure-free rate % (60, 76%) 65% (55, 73%) 56% (45, 67%) 62% (52, 72%) Risk group Intermediate Low Time (months) At Risk Intermediate Low
25 COMPLICATIONS PROLONGED CATHETER DEPENDENCE 25% (>2 WEEKS) STRICTURE 11% (DILATATION/TVU) URETHRA/RECTAL FISTULA < 0.4%
26 QOL (110) PRE QOL 3/12 6/12 9/12 12/12 15/
27 Mean % changes from pre-op QoL % Changes from baseline (Mean and 95% CI) Pre QOL 3mth QOL 6mth QOL 9mth QOL 12mth QOL 15mth QOL 18mth QOL
28 INCONTINENCE (110) PRE INCONTINENCE 3/12 6/12 9/12 12/12 15/
29 Mean % changes from pre-op incontinence % Chnages from baseline (Mean and 95% CI) Pre Incontinence 6mth Incontinence 12mth Incontinence 18mth Incontinence 3mth Incontinence 9mth Incontinence 15mth Incontinence
30 50 Incontinence (range published in the literature) 49% 5 40 Occurrence (%) % % 1 2.3% 2 0% 4 HIFU Beam RT 5% 6 Radical Prostatectomy excluding grade I, pad rate. 1. Ficarra et al, BJU Int Dec;98(6): Chaussy and Thuroff Curr Urol Rep. 2003;4(3): Zelefsky et al, Int J Radiat Oncol Biol Phys Aug 1;53(5):1111-6; 4. Brabbins et al, Int J Radiat Oncol Biol Phys Feb 1;61(2): Steineck et al, N Engl J Med Sep 12;347(11):790-6; 6. Abou-Elela et al, Eur J Surg Oncol. 2007; 33:96-101
31 IPSS (40) PRE Rx 3/12 6/12 9/12 12/12 15/
32 Mean % changes from pre-op IPSS % Chnages from baseline (Mean and 95% CI)100 Pre IPSS 3mth IPSS 6mth IPSS 9mth IPSS 12mth IPSS 15mth IPSS 18mth IPSS
33 IIEF (75) (NO NERVE SPARING) N1 = 58 Pre 3/12 6/12 9/12 12/12 MEAN (NERVE SPARING) N2 = 44 Pre 3/12 6/12 9/12 12/12 MEAN
34 Mean % changes from pre-op IIEF % Changes from baseline (Mean and 95% CI) Pre IIEF 3mth IIEF 6mth IIEF 9mth IIEF 12mth IIEF 15mth IIEF 18mth IIEF
35 100 Impotence (range published in the literature) 91% 5 80 Occurrence (%) % 1 63% 3 41% % 2 14% 6 0 HIFU Beam RT Radical Prostatectomy 1. Blana et al Urology Feb;63(2): Thuroff et al. J Endourol Oct;17(8): Potosky et al, J Natl Cancer Inst Oct 4;92(19): ; 4. Matalinska et al, J Clin Oncol Mar 15;19(6): ; 5. Matalinska et al, J Clin Oncol Mar 15;19(6): ; 6. Walsh et al, J Urol Jun;163(6):
36 Negative Biopsy Rate (%) % 1 75% n= n= n=120 Gelet, Poissonnier Lyon 2007 n=227 Negative Biopsy Rate 86% 3 86% 4 87% 5 88%6 82% 6 93% (multi center) n= n= n=175 Chaussy, Thuroff Munich 2004 n=146 Blana Regensburg 77% 8 83% n=30 Ficarra Verona 2006 n=58 Lee Seoul 1. Gelet et al, J Endourol. 2000;14(6):519-28; 2. Gelet et al, Eur Urol. 2001;40(2):124-9; 3. Poissonnier et al Prog Urol. 2003;13(1):60-72; 4. Poissonnier et al Eur Urol. 2007;51(2):381-7; 5. Thuroff et al J Endourol. 2003;17(8):673-7; 6. Chaussy et al Curr Urol Rep. 2003;4(3):248-52; 7. Urology. 2004;63(2): ; 8. Ficarra et al BJU Int. 2006;98(6):1193-8; 9. Prostate Cancer Prostatic Dis. 2006;9(4):
37 Ne gative Biopsy Rate (%) %3 86%4 87%5 88%6 82% 6 78% 1 75% n= n= n=120 Gelet, Poissonnier Lyon 2007 n=227 Negative Biopsy Rate 2003 (multi center) n= n= n=175 Chaussy, Thuroff Munich 93% n= n=30 Blana Ficarra Regensburg Verona 77% 8 83% n=58 Lee Seoul 100% n=20 68% (multi center) n=72 87% n=63 Uchida Toyko 69% 13 66% n= n=96 Ablatherm Sonablate 1. Gelet et al, J Endourol. 2000;14(6):519-28; 2. Gelet et al, Eur Urol. 2001;40(2):124-9; 3. Poissonnier et al Prog Urol. 2003;13(1):60-72; 4. Poissonnier et al Eur Urol. 2007;51(2):381-7; 5. Thuroff et al J Endourol. 2003;17(8):673-7; 6. Chaussy et al Curr Urol Rep. 2003;4(3):248-52; 7. Urology. 2004;63(2): ; 8. Ficarra et al BJU Int. 2006;98(6):1193-8; 9. Prostate Cancer Prostatic Dis. 2006;9(4):439-43; 10. Uchida et al Urology Mar;59(3):394-8; 11. Uchida et al Hinyokika Kiyo Oct;51(10):651-8; 12. Uchida et al Int J Urol Mar;13(3):228-33; 13. Uchida et al BJU Int Oct;98(4):770-2.
38 FDA TRIAL (ENLIGHT) T-11 or T-2T > 50 Years Gleason score 3+3 Prostate volume < 40 cc AP Diameter < 25 mm
39 FDA TRIAL LOCATIONS (HIFU) University of Colorado Hospital and Health Science Center Aurora, Colorado Florida Foundation for Healthcare Research Inc Ocala, Florida Hackensack University Medical Center Hackensack, New Jersey Memorial Sloan-Kettering Institute New York, New York Duke University Medical Center Durham North Carolina
40 FDA TRIAL LOCATIONS (HIFU) Thomas Jefferson University Philadelphia, Pennsylvania Vanderbilt University Medical Center Nashville, Tennessee Urology Associates Of North Texas Arlington, Texas The University of Texas M.D. Anderson Cancer Center Houston, Texas
41 FDA TRIAL LOCATIONS (HIFU) Virginia Urology Center Richmond, Virginia Medical College of Wisconsin, Inc Milwaukee, Wisconsin Maple Leaf HIFU Hamilton, Ontario, Canada
42 CONCLUSIONS: ABLATHERM HIFU IS A SAFE AND EFFECTIVE TREATMENT FOR LOCALIZED PROSTATE CA MORE STUDY WITH LONGER FOLLOW UP NEEDED
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