Anatomical applicability of current off-the-shelf branched endografts in thoracoabdominal aortic aneurysms managed by open surgery.
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1 Leipzig Interventional Course Update on clinical trials Tuesday, January 30 th, 2018 Anatomical applicability of current off-the-shelf branched endografts in thoracoabdominal aortic aneurysms managed by open surgery Tommaso Cambiaghi Vascular Surgery, Vita-Salute - San Raffaele University Scientific Institute Ospedale San Raffaele, Milan Italy Chair: Prof. Roberto Chiesa
2 Disclosure Speaker name: Tommaso Cambiaghi... I have the following potential conflicts of interest to report: Consulting Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) I do not have any potential conflict of interest
3 Endovascular TAAA management
4 Off-the-shelf solutions Cook T-Branch Endologix Ventana Cook P-Branch Gore TAMBE Illustrations by David Factor, taken from «Endovascular Aortic Repair» by G. Oderich
5 Off-the-shelf limitations Cook T-Branch
6 Original graft design considered suitable for endovascular repair using a customized multi-branched thoracoabdominal stent-graft 88%
7 Early applicability study patients referred for treatment in a single-center, nonrandomized, prospective clinical trial of MBEVAR 47%
8 Real life applicability
9 Study population 562 TAAA pararenal AAA treated by OPEN SURGERY, pre-op CTA slice thickness 1.0mm Inadequate CTA resolution 100 TAAA extent II 100 TAAA extent III 100 TAAA extent IV + pararenal
10 Study design Software analysis: 3Mensio Reference point: top of CT ostium; Distance to LSA Distance to proximal and distal aneurysm neck; Distance to aortic bifurcation and bilateral iliac bifurcations; Diameter at 0mm, 10mm and 20mm above proximal neck, Diameter at CT, at 45mm and 65mm above CT origin, Diameter at SMA and renal arteries origin, Diameter at aortic bifurcation, and at common iliac artery bilaterally.
11 Study design Software analysis: 3Mensio Reference point: top of CT ostium; Distance to the top of SMA, LRA, RRA; Radial orientation of the target vessels; Direction of the target vessels wrt aortic axis Anatomical variations of visceral vessels
12 Results
13 5mm Access vessels One iliac axis 7mm One upper extremity access 96%
14 Access vessels One iliac axis 7mm One upper extremity access Acceptable access tortuosity 91%
15 Proximal sealing Parallel, healthy neck, 24-30mm diameter Extent IV and pararenals 43% 14%
16 Proximal sealing + TEVAR Healthy arch Zone > 2 87%
17 Visceral vessels revascularization Correct number of visceral vessels No upward visceral vessel 55% -8% upward -22% -19%
18 Visceral vessels revascularization Correct number of visceral vessels No upward visceral vessel Target vessel diameter 5mm 50%
19 Visceral vessels revascularization Correct number of visceral vessels No upward visceral vessel Target vessel diameter 5mm No aneurysm/stenosis >75%/early branching 41%
20 Visceral vessels distribution 5-10% Chuter T.A.M. Chiesa R.
21 Strict applicability 42%
22 Overall applicability Proximal extension up to Zone 2 Embolization of inadequate vessels Occlusion of supernumerary branches 80-85%
23 Conclusions Waiting for final data Good applicability with adjunctive procedures Further off-the-shelf designs
24 Leipzig Interventional Course Update on clinical trials Tuesday, January 30 th, 2018 Anatomical applicability of current off-the-shelf branched endografts in thoracoabdominal aortic aneurysms managed by open surgery Tommaso Cambiaghi Vascular Surgery, Vita-Salute - San Raffaele University Scientific Institute Ospedale San Raffaele, Milan Italy Chair: Prof. Roberto Chiesa
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