The Pathology of Germ Cell Tumours of the Ovary

Size: px
Start display at page:

Download "The Pathology of Germ Cell Tumours of the Ovary"

Transcription

1 The Pathology of Germ Cell Tumours of the Ovary Professor Mike Wells University of Sheffield Amman, Jordan November 2013

2 Professor Francisco Paco Nogales

3

4 I. Primitive germ cell tumors A. Dysgerminoma B. Yolk sac tumour 1. Polyvesicular vitelline tumour 2. Glandular variant 3. Hepatoid variant C. Embryonal carcinoma D. Polyembryoma E. Nongestational choriocarcinoma F. Mixed germ cell tumour, specify components II. Biphasic or triphasic teratoma A. Immature teratoma B. Mature teratoma III. Monodermal teratoma Modified from Nogales FF et al in Tavassoli FA, Devillee P: WHO pathology and genetics of tumours of the breast and female genital organs. Lyon, France, International Agency for Research on Cancer, 2003.

5 Embryonic stem (ES) and induced pluripotent stem (ips) cells Regulatory network controlled by master transcriptional regulators POU5F1 (OCT3/4), SOX2, and NANOG. Further regulators include Lin28 and KLF4 BOHELER KR. J. Cell. Physiol. 221: 10 17, Somatic cells can be reprogrammed to ips cells by the expression of key pluripotency factors

6 OCT3/4 aka POU5F1, OCT3 or OTF3 Nuclear transcription factor - chromosome 6p21.3 Blastocyst differentiation gastrulation Embryonal stem cells of the inner cell mass epiblast Primordial germ cells Inducing pluripotency Chemically induced pluripotency of fibroblasts into embryonal stem cells

7 SOX2 factor SRY-box2 Nuclear transcription factor- chromosome 3q26.33 Responsible for Development of the inner cell mass epiblast Differentiation of the trophectoderm Not expressed by primordial germ cells gastrulation Neural plate cells mouse embryos that do not express the gene (knock-out) - do not progress from morula stage

8 SALL4 Family of three genes SALL - chromosome 20q13 Expressed by cells of epiblast Mandatory for endodermal differentiation Not implicated in trophectoderm differentiation Primordial germ cells Interacts with different other nuclear transcription factors (ie CDX2) differentiating: -Anorectal region -Kidney -Heart -Limbs -Brain

9 PRIMORDIAL GERM CELLS OCT3/4, SALL4 DYSGERMINOMA OCT3/4, SALL4 S O X 2 EMBRYONAL CARCINOMA SOX2, OCT3/4, SALL4 YOLK SAC TUMOUR SALL4 CHORIOCARCINOMA TERATOMA - SALL4, -SOX2, -OCT3/4 SALL4, SOX2, -OCT3/4

10 SALL4 14 week ovary

11 Ovarian dysgerminoma mutated c-kit gene usually unilateral 3% - syncytiotrophoblastic cells 5% - anaplastic granulomas in > 20%

12

13

14 Dysgerminoma

15 Dysgerminoma

16 Dysgerminoma

17 Dysgerminoma

18 Dysgerminoma

19 Dysgerminoma

20

21 Dysgerminoma Immuno 20% CK

22 Dysgerminoma - Immuno INESPECIFICA NON-SPECIFIC PLAP

23 CD117 NON-SPECIFIC

24 OCT3/4

25 Dysgerminoma - Immuno D2-40 OCT3/4 SALL4

26 PYS AC Day 17

27 AP SHYS Day 17

28 AFP 7th wk

29 Histology of yolk sac tumours Endodermal extraembryonal patterns - reticular-microcystic - endodermal sinuses (Schiller-Duval) - parietal - polyvesicular - tubular Endodermal somatic patterns - glandular - hepatic - solid YSTs with overgrown components

30 Murine

31

32

33 AFP

34

35 Tubular YST Day 33 SHYS

36 Histology of yolk sac tumours Endodermal extraembryonal patterns - reticular-microcystic - endodermal sinuses (Schiller-Duval) - parietal - polyvesicular - tubular Endodermal somatic patterns - glandular - hepatic - solid YSTs with overgrown components

37

38

39 Glypican 3 (GLP3) Expressed in 8 th and 11 th week SHYS, developing liver, lung, pancreas acinary cells, neuroectodermal epithelium and syncytiotrophoblast. + in embryonal tumours neuro-, medullo- and nephroblastoma + marker for liver cell neoplasia. Serum marker, combined with AFP levels, increases diagnostic sensitivity. GLP3 is a sensitive marker for YSTs and to a certain extent, it parallels their AFP distribution.

40 Yolk sac tumours - Immuno NON-SPECIFIC FOCAL >50% GLY3 GLY3 Preda O, Nicolae A, Aneiros-Fernández J, Borda A, Nogales FF. Glypican 3 is a sensitive, but not a specific, marker for the diagnosis of yolk sac tumours. Histopathology Jan;58:

41 Choriocarcinoma

42 Choriocarcinoma hcg,hpl,cd10,α-inh GLP3

43 Gonadoblastoma OCT3/4 α-inh

44 Immature teratoma of the ovary stage 1 in 70% of cases solid and cystic subjective grading preponderance of neuroectodermal tissues gliomatosis peritonei commonest complication

45 O Connor DM & Norris HJ Int J Gynecol Pathol 1994; 13: Low grade (grade 1) High grade (grades 2 & 3)

46

47

48

49 GLY3

50 SOX2

51

Testicular Germ Cell Tumors; A Simplistic Approach

Testicular Germ Cell Tumors; A Simplistic Approach Testicular Germ Cell Tumors; A Simplistic Approach Merce Jorda, MD, PhD, MBA Professor and Vice Chair, Director of Anatomic Pathology Director of Genitourinary Pathology Service Interim Director of Cytopathology

More information

Unilateral ovarian metastases of gastric adenocarcinoma simulating primary ovarian yolk sac tumours

Unilateral ovarian metastases of gastric adenocarcinoma simulating primary ovarian yolk sac tumours Unilateral ovarian metastases of gastric adenocarcinoma simulating primary ovarian yolk sac tumours Francisco F Nogales, Elvira Stacher (*), Ovidiu Preda, Pablo Goyenaga, José Aneiros-Fernandez, Farid

More information

Germ cell tumours UK SH. Ivo Leuschner. Kiel Pediatric Tumor Registry, Institute of Pathology University Hospital of Schleswig-Holstein Campus Kiel

Germ cell tumours UK SH. Ivo Leuschner. Kiel Pediatric Tumor Registry, Institute of Pathology University Hospital of Schleswig-Holstein Campus Kiel Germ cell tumours Ivo Leuschner Kiel Pediatric Tumor Registry, Institute of Pathology University Hospital of Schleswig-Holstein Campus Kiel UK SH Old histogenetic Concept of Germ cell tumours Pluripotent

More information

Male Genital Cancers in the US in Frequency of Types

Male Genital Cancers in the US in Frequency of Types Germ Cell Tumors of the Testis Pathology, Immunohistochemistry, and the Often Confusing Appearance of Their Metastases Charles Zaloudek, MD Department of Pathology UCSF Male Genital Cancers in the US in

More information

Genetic Studies of Dysgerminoma

Genetic Studies of Dysgerminoma Genetic Studies of Chromosome 12p abnormalities are characteristic of germ cell tumors isochromosome 12p and 12p overrepresentation Some can be detected by karyotyping FISH study of 21 dysgerminomas showed

More information

New Developments in Immunohistochemistry for Gynecologic Pathology

New Developments in Immunohistochemistry for Gynecologic Pathology New Developments in Immunohistochemistry for Gynecologic Pathology Michael T. Deavers, M.D. Professor, Departments of Pathology and Gynecologic Oncology Immunohistochemistry in Gynecologic Pathology Majority

More information

Testicular Tumors: What s New, True, Important Cristina Magi-Galluzzi, MD, PhD

Testicular Tumors: What s New, True, Important Cristina Magi-Galluzzi, MD, PhD Testicular Tumors: What s New, True, Important Cristina Magi-Galluzzi, MD, PhD Director, Genitourinary Pathology R.J. Tomsich Pathology & Laboratory Medicine Institute Professor of Pathology, Lerner College

More information

International Journal of Medical and Health Sciences

International Journal of Medical and Health Sciences International Journal of Medical and Health Sciences Journal Home Page: http://www.ijmhs.net ISSN:2277-4505 Case Report Histomorphological Specrtum of Malignant Germ Cell Tumours: An Overview and Report

More information

Adenocarcinoma of the Cervix

Adenocarcinoma of the Cervix Question 1. Each of the following statements about cervical adenocarcinoma is true except: Adenocarcinoma of the Cervix SAMS a) A majority of women with cervical adenocarcinoma have stage I tumors at diagnosis.

More information

Analysis of Germ Cell Tumors of Ovary in a Tertiary Care Hospital: A Two Year Retrospective Study

Analysis of Germ Cell Tumors of Ovary in a Tertiary Care Hospital: A Two Year Retrospective Study Original Article DOI: 10.17354/ijss/2016/212 Analysis of Germ Cell Tumors of Ovary in a Tertiary Care Hospital: A Two Year Retrospective Study Muktanjalee Deka 1, Chandan Jyoti Saikia 2, Rukmini Bezbaruah

More information

Note: The cause of testicular neoplasms remains unknown

Note: The cause of testicular neoplasms remains unknown - In the 15- to 34-year-old age group, they are the most common tumors of men. - Tumors of the testis are a heterogeneous group of neoplasms that include: I. Germ cell tumors : 95%; all are malignant.

More information

-The cause of testicular neoplasms remains unknown

-The cause of testicular neoplasms remains unknown - In the 15- to 34-year-old age group, they are the most common tumors of men. - include: I. Germ cell tumors : (95%); all are malignant. II. Sex cord-stromal tumors: from Sertoli or Leydig cells; usually

More information

N-cadherin Expression in Testicular Germ Cell and Gonadal Stromal Tumors

N-cadherin Expression in Testicular Germ Cell and Gonadal Stromal Tumors 381 Ivyspring International Publisher Research Paper Journal of Cancer 2012; 3: 381-389. doi: 10.7150/jca.5017 N-cadherin Expression in Testicular Germ Cell and Gonadal Stromal Tumors Daniel J. Heidenberg

More information

Springer Healthcare. Understanding and Diagnosing Ovarian Cancer. Concise Reference: Krishnansu S Tewari, Bradley J Monk

Springer Healthcare. Understanding and Diagnosing Ovarian Cancer. Concise Reference: Krishnansu S Tewari, Bradley J Monk Concise Reference: Understanding and Diagnosing Ovarian Cancer Krishnansu S Tewari, Bradley J Monk Extracted from: The 21 st Century Handbook of Clinical Ovarian Cancer Published by Springer Healthcare

More information

The aging of the population in Western countries has. Germ Cell Tumors of the Ovary. An Update

The aging of the population in Western countries has. Germ Cell Tumors of the Ovary. An Update Germ Cell Tumors of the Ovary An Update Francisco F. Nogales, MD, PhD; Isabel Dulcey, MD; Ovidiu Preda, MD, PhD Context. The field of ovarian germ cell tumors (OGCTs) has remained relatively unchanged

More information

Ovarian Germ Cell Tumor Histopathological and statistical analysis

Ovarian Germ Cell Tumor Histopathological and statistical analysis Nepal Medical Association Building Exhibition Road, Kathmandu Journal of Pathology of Nepal (23) Vol. 3, 44 446 Association of Clinical Pathologist of Nepal2 Journal of PATHOLOGY of Nepal www.acpnepal.com

More information

Adnexal ovarian cyst icd 10 Adnexal ovarian cyst icd 10

Adnexal ovarian cyst icd 10 Adnexal ovarian cyst icd 10 Adnexal ovarian cyst icd 10 Adnexal ovarian cyst icd 10 Be a part of an industry leading organization that drives the business side of healthcare. The survival rates for dysgerminomas presenting at early

More information

Strategic delivery: Setting standards Increasing and. Details: Output: Demonstrating efficiency. informing choice.

Strategic delivery: Setting standards Increasing and. Details: Output: Demonstrating efficiency. informing choice. Strategic delivery: Setting standards Increasing and informing choice Demonstrating efficiency economy and value Details: Meeting Scientific and Clinical Advances Advisory Committee Agenda item 6 Paper

More information

Single-cell RNA-Seq profiling of human pre-implantation embryos and embryonic stem cells

Single-cell RNA-Seq profiling of human pre-implantation embryos and embryonic stem cells Single-cell RNA-Seq profiling of human pre-implantation embryos and embryonic stem cells Liying Yan,2,5, Mingyu Yang,5, Hongshan Guo, Lu Yang, Jun Wu, Rong Li,2, Ping Liu, Ying Lian, Xiaoying Zheng, Jie

More information

Pathology of Ovarian Tumours. Dr. Jyothi Ranganathan MD ( Path) AFMC Pune PDCC (Cytopathology) PGI Chandigarh

Pathology of Ovarian Tumours. Dr. Jyothi Ranganathan MD ( Path) AFMC Pune PDCC (Cytopathology) PGI Chandigarh Pathology of Ovarian Tumours Dr. Jyothi Ranganathan MD ( Path) AFMC Pune PDCC (Cytopathology) PGI Chandigarh Outline Incidence Risk factors Classification Pathology of tumours Tumour markers Prevention

More information

Research programs involving human early embryos

Research programs involving human early embryos Research programs involving human early embryos 1. Understanding normal mammalian embryo development 2. Understanding errors in genetic and epigenetic programs 3. Providing research and therapeutic tools

More information

Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features 1

Ovarian Malignant Germ Cell Tumors: Cellular Classification and Clinical and Imaging Features 1 Note: This copy is for your personal non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, contact us at www.rsna.org/rsnarights. Ovarian Malignant

More information

Testis. Protocol applies to all malignant germ cell and malignant sex cord-stromal tumors of the testis, exclusive of paratesticular malignancies.

Testis. Protocol applies to all malignant germ cell and malignant sex cord-stromal tumors of the testis, exclusive of paratesticular malignancies. Testis Protocol applies to all malignant germ cell and malignant sex cord-stromal tumors of the testis, exclusive of paratesticular malignancies. Protocol revision date: January 2005 Based on AJCC/UICC

More information

SALL4 Is a Novel Sensitive and Specific Marker for Metastatic Germ Cell Tumors, With Particular Utility in Detection of Metastatic Yolk Sac Tumors

SALL4 Is a Novel Sensitive and Specific Marker for Metastatic Germ Cell Tumors, With Particular Utility in Detection of Metastatic Yolk Sac Tumors Original Article SALL4 Is a Novel Sensitive and Specific Marker for Germ Cell Tumors, With Particular Utility in Detection of Yolk Sac Tumors Dengfeng Cao, MD, PhD 1 ; Peter A. Humphrey, MD, PhD 1 ; and

More information

Ovarian Clear Cell Carcinoma

Ovarian Clear Cell Carcinoma Ovarian Clear Cell Carcinoma Rouba Ali-Fehmi, MD Professor of Pathology The Karmanos Cancer Institute, Wayne State University School of Medicine 50 year old woman with chief complaint of shortness of breath

More information

More than 90% testicular tumors are of germ cell

More than 90% testicular tumors are of germ cell ORIGINAL ARTICLE SALL4 Is a Novel Diagnostic Marker for Testicular Germ Cell Tumors Dengfeng Cao, MD, PhD,* Jianping Li, BS,* Charles C. Guo, MD,w Robert W. Allan, MD,z and Peter A. Humphrey, MD, PhD*

More information

OVARIES. MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L13 Dr: Ali Eltayb.

OVARIES. MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L13 Dr: Ali Eltayb. OVARIES MLS Basic histological diagnosis MLS HIST 422 Semester 8- batch 7 L13 Dr: Ali Eltayb. OBJECTIVES Recognize different disease of ovaries Classify ovarian cyst Describe the pathogenesis, morphology

More information

Patient Information. Age: 8 y/o Sex: Female. Date of Admission: Date of Discharge:

Patient Information. Age: 8 y/o Sex: Female. Date of Admission: Date of Discharge: Patient Information Age: 8 y/o Sex: Female Date of Admission: 92-10-08 Date of Discharge: 92-10-18 Chief Complaint Severe admominal pain and vomiting with dysuria since last afternoon Present Illness Lower

More information

Uncommon secondary tumour of the stomach

Uncommon secondary tumour of the stomach Uncommon secondary tumour of the stomach B. Bancel, Hôpital CROIX ROUSSE LYON Bucharest Nov 2013 Case report 33-year old man Profound mental retardation and motor disturbances (sequelae of neonatal meningeal

More information

DOWNLOAD OR READ : PRINCIPLES OF OOCYTE AND EMBRYO DONATION PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : PRINCIPLES OF OOCYTE AND EMBRYO DONATION PDF EBOOK EPUB MOBI DOWNLOAD OR READ : PRINCIPLES OF OOCYTE AND EMBRYO DONATION PDF EBOOK EPUB MOBI Page 1 Page 2 principles of oocyte and embryo donation principles of oocyte and pdf principles of oocyte and embryo donation

More information

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology bs_bs_banner doi:10.1111/jog.12596 J. Obstet. Gynaecol. Res. Vol. 41, No. 2: 167 177, February 2015 Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology

More information

3/28/2017. Disclosure of Relevant Financial Relationships. Clinical History. Pathology

3/28/2017. Disclosure of Relevant Financial Relationships. Clinical History. Pathology Disclosure of Relevant Financial Relationships Monalisa Sur MBBS, FCPath(S.A), MMED(WITS), FRCPath(U.K), FRCP( C) Professor, Department of Pathology and Molecular Medicine Division of Anatomical Pathology

More information

3 cell types in the normal ovary

3 cell types in the normal ovary Ovarian tumors 3 cell types in the normal ovary Surface (coelomic epithelium) the origin of the great majority of ovarian tumors 90% of malignant ovarian tumors Totipotent germ cells Sex cord-stromal cells

More information

Diseases of the penis & testis

Diseases of the penis & testis Diseases of the penis & testis Done by : Saef B AL-Abbadi Diseases of penis, Condyloma Acuminatum A benign tumor *Tend to recur but only rarely progress into in situ or invasive cancers read this = genital

More information

Gynaecological Malignancies

Gynaecological Malignancies Gynaecological Malignancies Dr Rodney Itaki Lecturer Anatomical Pathology Discipline University of Papua New Guinea Division of Pathology School of Medicine & Health Sciences Overview Genital tract tumors

More information

Extragonadal germ cell tumors represent approximately 1% Unusual Presentations of Gynecologic Tumors. Extragonadal Yolk Sac Tumor of the Vulva

Extragonadal germ cell tumors represent approximately 1% Unusual Presentations of Gynecologic Tumors. Extragonadal Yolk Sac Tumor of the Vulva Special Article Unusual ations of Gynecologic Tumors Extragonadal Yolk Sac Tumor of the Vulva Extragonadal germ cell tumors are uncommon, and although they morphologically resemble their gonadal counterparts,

More information

Int J Clin Exp Pathol 2014;7(8): /ISSN: /IJCEP Shujie Pang, Lin Zhang, Yiquan Shi, Yixin Liu

Int J Clin Exp Pathol 2014;7(8): /ISSN: /IJCEP Shujie Pang, Lin Zhang, Yiquan Shi, Yixin Liu Int J Clin Exp Pathol 2014;7(8):5259-5266 www.ijcep.com /ISSN:1936-2625/IJCEP0001129 Case Report Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young

More information

Histological pattern of ovarian tumors and their age distribution

Histological pattern of ovarian tumors and their age distribution Original Article Nepal Med Coll J 2008; 10(2): 81-85 Histological pattern of ovarian s and their age distribution R Jha and S Karki Department of Pathology, TUTH, Maharajgunj, Kathmandu, Nepal Corresponding

More information

International Journal of Research and Review E-ISSN: ; P-ISSN:

International Journal of Research and Review   E-ISSN: ; P-ISSN: International Journal of Research and Review www.ijrrjournal.com E-ISSN: 2349-9788; P-ISSN: 2454-2237 Case Report Rare Combinations of Testicular Mixed Germ Cell Tumors - 2 Case Reports Dr. Byna Syam Sundara

More information

Pelvic tumor in childhood Classification, imaging approach and radiological findings

Pelvic tumor in childhood Classification, imaging approach and radiological findings Pelvic tumor in childhood Classification, imaging approach and radiological findings M. Mearadji International Foundation for Pediatric Imaging Aid Rotterdam, The Netherlands Solid pelvic masses in childhood

More information

Mediastinal Germ Cell Tumors

Mediastinal Germ Cell Tumors Mediastinal Germ Cell Tumors Anja C. Roden, M.D. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA 2018 MFMER slide-1 Disclosure I have no relevant financial relationships

More information

CODING TUMOUR MORPHOLOGY. Otto Visser

CODING TUMOUR MORPHOLOGY. Otto Visser CODING TUMOUR MORPHOLOGY Otto Visser INTRODUCTION The morphology describes the tissue of the tumour closest to normal tissue Well differentiated tumours are closest to normal Undifferentiated tumours show

More information

Annual report of Gynecologic Oncology Committee, Japan Society of Obstetrics and Gynecology, 2013

Annual report of Gynecologic Oncology Committee, Japan Society of Obstetrics and Gynecology, 2013 bs_bs_banner doi:10.1111/jog.12360 J. Obstet. Gynaecol. Res. Vol. 40, No. 2: 338 348, February 2014 Annual report of Gynecologic Oncology Committee, Japan Society of Obstetrics and Gynecology, 2013 Daisuke

More information

Institute of Pathology First Faculty of Medicine Charles University. Ovary

Institute of Pathology First Faculty of Medicine Charles University. Ovary Ovary Barrett esophagus ph in vagina between 3.8 and 4.5 ph of stomach varies from 1-2 (hydrochloric acid) up to 4-5 BE probably results from upward migration of columnar cells from gastroesophageal junction

More information

Dr Sanjiv Manek Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust

Dr Sanjiv Manek Oxford. Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust Dr Sanjiv Manek Oxford Oxford Pathology Course 2010 for FRCPath Illustration-Cellular Pathology. Oxford Radcliffe NHS Trust Ovarian Endometrial Vulvo-vaginal Cervical Illustration-Cellular Pathology. Oxford

More information

2% of all malignancies Male predominance Patients usually more than 60 years old

2% of all malignancies Male predominance Patients usually more than 60 years old Benign Bladder Tumors Transitional Cell Papilloma 2-3% Inverted Papilloma Rare Malignant Transitional (Urothelial) Carcinoma 90% Carcinoma In-Situ (By Itself) 5-10% Squamous Cell Carcinoma 3-7% Adenocarcinoma

More information

New Immunohistochemical Markers in the Evaluation of Primary Non-Glial Central Nervous System Tumors

New Immunohistochemical Markers in the Evaluation of Primary Non-Glial Central Nervous System Tumors New Immunohistochemical Markers in the Evaluation of Primary Non-Glial Central Nervous System Tumors Suzanne Z. Powell, M.D. The Methodist Hospital Houston, TX The Methodist Hospital Research Institute

More information

Morphologic Aspects Aspects

Morphologic Aspects Aspects Testicular Testicular Germ Germ Cell Cell Neoplasia: Neoplasia: Molecular Molecular Pathways Pathways & Challenging Morphologic Aspects Aspects George George J. J. Netto, Netto, M.D. M.D. Johns Johns Hopkins

More information

Recently, there has been an increasing incidence among women and younger persons

Recently, there has been an increasing incidence among women and younger persons Bladder Tumors Benign Transitional Cell Papilloma 2-3% Inverted Papilloma Rare Malignant Transitional (Urothelial) Carcinoma 90% Carcinoma In-Situ (By Itself) 5-10% Squamous Cell Carcinoma 3-7% Adenocarcinoma

More information

Leukaemia 35% Lymphoma 14%

Leukaemia 35% Lymphoma 14% Distribution ib ti of Cancers in Children under 15 years Leukaemia 35% Lymphoma 14% Neuroblastoma 9% Other 5% Liver 1% Retinoblastoma 3% Bone and STS 15% CNS 20% Wilms' 8% 30-40% Mortality Germ Cell Tumours

More information

A Rare Case of Immature Ovarian Teratoma with Gliomatosis Peritonei

A Rare Case of Immature Ovarian Teratoma with Gliomatosis Peritonei [Downloaded free from http://www.jbcrs.org on Monday, March 13, 2017, IP: 220.227.255.125] Case Report A Rare Case of Immature Ovarian Teratoma with Gliomatosis Peritonei Shruti A Heda, Anjali D Patrikar,

More information

Tinh hoàn

Tinh hoàn Tinh hoàn Tinh hoàn Tinh hoàn Tiền liệt tuyến Tiền liệt tuyến Mào tinh hoàn Mào tinh hoàn Túi tinh Túi tinh Túi tinh Túi tinh So-called cystadenoma of seminal vesicle. Gross appearance of granulomatous

More information

Gynecologic Cancer Surveillance and Survivorship: Informing Practice and Policy

Gynecologic Cancer Surveillance and Survivorship: Informing Practice and Policy Gynecologic Cancer Surveillance and Survivorship: Informing Practice and Policy Stephanie Yap, M.D. University Gynecologic Oncology Northside Cancer Institute Our Learning Objectives Review survival rates,

More information

Vulva Inflammatory Disorders Lichen Planus Fixed Drug Eruption Erythema Multiforme Plasmacytosis Mucosae (Zoon) Lichen Sclerosus Allergic Contact

Vulva Inflammatory Disorders Lichen Planus Fixed Drug Eruption Erythema Multiforme Plasmacytosis Mucosae (Zoon) Lichen Sclerosus Allergic Contact Vulva Inflammatory Disorders Lichen Planus Fixed Drug Eruption Erythema Multiforme Plasmacytosis Mucosae (Zoon) Lichen Sclerosus Allergic Contact Dermatitis Psoriasis Lichen Simplex Chronicus Foreign Body

More information

3 cell types in the normal ovary

3 cell types in the normal ovary Ovarian tumors 3 cell types in the normal ovary Surface (coelomic epithelium) the origin of the great majority of ovarian tumors (neoplasms) 90% of malignant ovarian tumors Totipotent germ cells Sex cord-stromal

More information

Malignant Ovarian Germ Cell Tumours: Is there any clue for its diagnosis?

Malignant Ovarian Germ Cell Tumours: Is there any clue for its diagnosis? Malignant Ovarian Germ Cell Tumours: Is there any clue for its diagnosis? Poster No.: C-0485 Congress: ECR 2014 Type: Educational Exhibit Authors: M. Horta, T. M. Cunha; Lisbon/PT Keywords: Cancer, Diagnostic

More information

Ovarian Tumors. Andrea Hayes-Jordan MD FACS, FAAP Section Chief, Pediatric Surgery/Surgical Onc. UT MD Anderson Cancer Center

Ovarian Tumors. Andrea Hayes-Jordan MD FACS, FAAP Section Chief, Pediatric Surgery/Surgical Onc. UT MD Anderson Cancer Center Ovarian Tumors Andrea Hayes-Jordan MD FACS, FAAP Section Chief, Pediatric Surgery/Surgical Onc. UT MD Anderson Cancer Center Case 13yo female with abdominal pain Ultrasound shows huge ovarian mass Surgeon

More information

Bi-potent Gonads. Sex Determination

Bi-potent Gonads. Sex Determination יצירת הגונדות Primordial Germ Cells (PGCs) Somatic cells Genital ridge Bi-potent Gonads Sex Determination Testis and Sperm Ovary and Oocyte Migration of Primordial Germ Cells in the Chick Embryo The

More information

Methoden / Methods inc. ICCC-3 105

Methoden / Methods inc. ICCC-3 105 Methoden / Methods inc. ICCC-3 105 Internationale Klassifikation der Krebserkrankungen bei Kindern (ICCC-3) Zuordnung von ICD-O-3-Codes für Morphologie und Topographie zu diagnostischen Kategorien International

More information

Protocol for the Examination of Lymphadenectomy Specimens From Patients With Malignant Germ Cell and Sex Cord-Stromal Tumors of the Testis

Protocol for the Examination of Lymphadenectomy Specimens From Patients With Malignant Germ Cell and Sex Cord-Stromal Tumors of the Testis Protocol for the Examination of Specimens From Patients With Malignant Germ Cell and Sex Cord-Stromal Tumors of the Testis Version: Testis 4.0.1.1 Protocol Posting Date: February 2019 Accreditation Requirements

More information

Histopathological Study of Ovarian Lesions

Histopathological Study of Ovarian Lesions Histopathological Study of Ovarian Lesions Nirali N. Thakkar 1, Shaila N. Shah 2 1 Resident doctor, Pathology department, Government Medical College, Bhavnagar-364001, India 2 Head of the department, Pathology

More information

International Society of Gynecological Pathologists Symposium 2007

International Society of Gynecological Pathologists Symposium 2007 International Society of Gynecological Pathologists Symposium 2007 Anais Malpica, M.D. Department of Pathology The University of Texas M.D. Anderson Cancer Center Grading of Ovarian Cancer Histologic grade

More information

Prof. Dr. med. Beata BODE-LESNIEWSKA Institute of Pathology and Molecular Pathology University Hospital; Zurich

Prof. Dr. med. Beata BODE-LESNIEWSKA Institute of Pathology and Molecular Pathology University Hospital; Zurich Prof. Dr. med. Beata BODE-LESNIEWSKA Institute of Pathology and Molecular Pathology University Hospital; Zurich 32 year old man 2 months history of growing left supraclavicular lymph nodes Antibiotic treatment

More information

MPB333:Molecular Endocrinology of Obesity and Diabetes

MPB333:Molecular Endocrinology of Obesity and Diabetes MPB333:Molecular Endocrinology of Obesity and Diabetes The Use of Stem Cells as a Cure for Type 1 Diabetes January 15, 2010 Trish Labosky 9415C MRBIV trish.labosky@vanderbilt.edu In theory. 2. ~Easy and

More information

7 Mousa. Obada Zalat. Mohammad Badi

7 Mousa. Obada Zalat. Mohammad Badi 7 Mousa Obada Zalat Mohammad Badi Tumors of the ovaries Last lecture we talked about surface epithelial tumors of the ovaries (the most common type). But there are many other types of tumors of germ cell

More information

Transitional Cell Papilloma 2-3% Inverted Papilloma Rare

Transitional Cell Papilloma 2-3% Inverted Papilloma Rare BLADDER TUMORS Benign Transitional Cell Papilloma 2-3% Inverted Papilloma Rare Malignant Transitional (Urothelial) Carcinoma90% Carcinoma In-Situ (By Itself) 5-10% Squamous Cell Carcinoma 3-7% Adenocarcinoma

More information

Protocol for the Examination of Biopsy Specimens From Patients With Extragonadal Germ Cell Tumors

Protocol for the Examination of Biopsy Specimens From Patients With Extragonadal Germ Cell Tumors Protocol for the Examination of Specimens From Patients With Extragonadal Germ Cell Tumors Version: Germ Cell 4.0.0.0 Protocol Posting Date: February 2019 Includes the Children s Oncology Group staging

More information

Best Practice & Research Clinical Endocrinology & Metabolism

Best Practice & Research Clinical Endocrinology & Metabolism Best Practice & Research Clinical Endocrinology & Metabolism 24 (2010) 291 310 Contents lists available at ScienceDirect Best Practice & Research Clinical Endocrinology & Metabolism journal homepage: www.elsevier.com/locate/beem

More information

CARCINOMA OF UNKNOWN PRIMARY: DIAGNOSTIC APPROACH USING IMMUNOHISTOCHEMISTRY

CARCINOMA OF UNKNOWN PRIMARY: DIAGNOSTIC APPROACH USING IMMUNOHISTOCHEMISTRY CARCINOMA OF UNKNOWN PRIMARY: DIAGNOSTIC APPROACH USING IMMUNOHISTOCHEMISTRY Jason L Hornick, MD, PhD Director of Surgical Pathology Director of Immunohistochemistry Brigham and Women s Hospital Associate

More information

Christian Marth, MD, PhD Department of Obstetrics and Gynecology Innsbruck Medical University Innsbruck, Austria

Christian Marth, MD, PhD Department of Obstetrics and Gynecology Innsbruck Medical University Innsbruck, Austria Christian Marth, MD, PhD Department of Obstetrics and Gynecology Innsbruck Medical University Innsbruck, Austria Classification of Ovarian Neoplasms Origin Surface Epithelial Cells Germ Cells Sex Cord

More information

The Panel Approach to Diagnostics. Lauren Hopson International Product Specialist Cell Marque Corporation

The Panel Approach to Diagnostics. Lauren Hopson International Product Specialist Cell Marque Corporation The Panel Approach to Diagnostics Lauren Hopson International Product Specialist Cell Marque Corporation Cell Marque Rocklin, California About Cell Marque: IVD primary antibody manufacturer Distributors

More information

2/9/2015. Bartholin Cyst. Vulva: Squamous epithelium skin. Vagina: Squamous epithelium mucosa. Cervix: Ectocervix: squamous Endocervix: glandular

2/9/2015. Bartholin Cyst. Vulva: Squamous epithelium skin. Vagina: Squamous epithelium mucosa. Cervix: Ectocervix: squamous Endocervix: glandular Vulva: Squamous epithelium skin Bartholin Cyst Vagina: Squamous epithelium mucosa Cervix: Ectocervix: squamous Endocervix: glandular Slide courtesy of Dr. Lodge Rigal Slide courtesy of Dr. Lodge Rigal

More information

Disclosure of Relevant Financial Relationships

Disclosure of Relevant Financial Relationships Evening Specialty Conference - Genitourinary Pathology Case 2 Disclosure of Relevant Financial Relationships Sean R Williamson, MD Henry Ford Health System, Detroit, MI @Williamson_SR USCAP requires that

More information

ipsc genomic instability and impact on product safety Prof Peter Andrews, University of Sheffield, UK

ipsc genomic instability and impact on product safety Prof Peter Andrews, University of Sheffield, UK ipsc genomic instability and impact on product safety Prof Peter Andrews, University of Sheffield, UK PSC genomic instability and impact on product safety Peter W Andrews variability PSC genomic instability

More information

GUIDELINES ON TESTICULAR CANCER

GUIDELINES ON TESTICULAR CANCER 38 (Text updated March 2005) P. Albers (chairman), W. Albrecht, F. Algaba, C. Bokemeyer, G. Cohn-Cedermark, A. Horwich, O. Klepp, M.P. Laguna, G. Pizzocaro Introduction Compared with other types of cancer

More information

Journal of Rawalpindi Medical College (JRMC); 2016;20(4):

Journal of Rawalpindi Medical College (JRMC); 2016;20(4): Original Article Morphological Profile of Ovarian Tumours Bilquis Begum, Iram Nadeem Rana, Nadeem Ikram Department of Pathology, Rawalpindi Medical College, Rawalpindi Abstract Background: To study the

More information

Transcriptional repression of Xi

Transcriptional repression of Xi Transcriptional repression of Xi Xist Transcription of Xist Xist RNA Spreading of Xist Recruitment of repression factors. Stable repression Translocated Xic cannot efficiently silence autosome regions.

More information

Clinicopathological and Histological Features of Ovarian Tumour- A Study

Clinicopathological and Histological Features of Ovarian Tumour- A Study IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 16, Issue 9 Ver. IX (September. 2017), PP 56-60 www.iosrjournals.org Clinicopathological and Histological

More information

Ovarian Tumors: A Study of 2146 Cases at AFIP, Rawalpindi, Pakistan.

Ovarian Tumors: A Study of 2146 Cases at AFIP, Rawalpindi, Pakistan. Ovarian Tumors: A Study of 2146 Cases at AFIP, Rawalpindi, Pakistan. 1 Muhammad Zubair, 2 Shoaib Naiyar Hashmi, 3 Saeed Afzal, 4 Iqbal Muhammad, 5 Hafeez Ud Din, 6 Syed Naeem Raza Hamdani, 7 Rabia Ahmad.

More information

GERM CELL TUMORS 3/21/2017. Disclosure of Relevant Financial Relationships. Disclosure of Relevant Financial Relationships

GERM CELL TUMORS 3/21/2017. Disclosure of Relevant Financial Relationships. Disclosure of Relevant Financial Relationships Eyas M Hattab, MD Department of Pathology and Laboratory Medicine University of Louisville eyas.hattab@louisville.edu Disclosure of Relevant Financial Relationships USAP requires that all planners (Education

More information

Case E1. Female aged 63 years Right Nephrectomy Two separate tumours Section of each tumour

Case E1. Female aged 63 years Right Nephrectomy Two separate tumours Section of each tumour Case E1 Female aged 63 years Right Nephrectomy Two separate tumours Section of each tumour Tumour 1 Upper pole tumour 28mm macro diameter Circumscribed Friable cut surface Tumour 2 Middle pole Part solid

More information

ICD-O Morphology code. R=Rare Tier Tumour ICD-O Topography code C30.0, C31

ICD-O Morphology code. R=Rare Tier Tumour ICD-O Topography code C30.0, C31 R=Rare Tier Tumour ICD-O Topography code ICD-O Morphology code EPITHELIAL TUMOURS OF NASAL CAVITY AND SINUSES R 2 Squamous cell carcinoma with variants of nasal cavity and sinuses C30.0, C3 C30.0, C3 8000,

More information

Higher Human Biology Unit 1: Human Cells

Higher Human Biology Unit 1: Human Cells Higher Human Biology Unit 1: Human Cells Key Area 1.1: Division & differentiation in human cells Learning Outcomes Somatic stem cells divide by mitosis to form more somatic cells. Germline stem cells divide

More information

See the latest estimates for new cases of ovarian cancer and deaths in the US and what research is currently being done.

See the latest estimates for new cases of ovarian cancer and deaths in the US and what research is currently being done. About Ovarian Cancer Overview and Types If you have been diagnosed with ovarian cancer or are worried about it, you likely have a lot of questions. Learning some basics is a good place to start. What Is

More information

8 years later! Next Generation Sequencing. Pathogenic Findings: HNF1A c.864delinscc, p.g292rfs*25 (NM_ ) (VAF: 59%) HNF1A Loss

8 years later! Next Generation Sequencing. Pathogenic Findings: HNF1A c.864delinscc, p.g292rfs*25 (NM_ ) (VAF: 59%) HNF1A Loss 8 years later! Next Generation Sequencing Pathogenic Findings: HNF1A c.864delinscc, p.g292rfs*25 (NM_000545.6) (VAF: 59%) HNF1A Loss Interpretation HNF1A c.864delinscc, p.g292rfs*25 (NM_000545.6) This

More information

Malignant Ovarian Germ Cell Tumours: Experience in the National University Hospital of Singapore

Malignant Ovarian Germ Cell Tumours: Experience in the National University Hospital of Singapore 657 Malignant Ovarian Germ Cell Tumours: Experience in the National University Hospital of Singapore F K Lim,*MBBS, M Med, MRCOG, B Chanrachakul,**MBBS, S M Chong,***MBBS, FRCPath, FRCPA, S S Ratnam,****MD,

More information

A 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy.

A 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy. November 2015 Case of the Month A 53 year-old woman with a lung mass, right hilar mass and mediastinal adenopathy. Contributed by: Rasha Salama, M.D., IU Department of Pathology and Laboratory Medicine

More information

FINALIZED SEER SINQ QUESTIONS

FINALIZED SEER SINQ QUESTIONS 0076 Source 1: WHO Class CNS Tumors pgs: 33 MP/H Rules/Histology--Brain and CNS: What is the histology code for a tumor originating in the cerebellum and extending into the fourth ventricle described as

More information

Cluster Dendrogram. dist(cor(na.omit(tss.exprs.chip[, c(1:10, 24, 27, 30, 48:50, dist(cor(na.omit(tss.exprs.chip[, c(1:99, 103, 104, 109, 110,

Cluster Dendrogram. dist(cor(na.omit(tss.exprs.chip[, c(1:10, 24, 27, 30, 48:50, dist(cor(na.omit(tss.exprs.chip[, c(1:99, 103, 104, 109, 110, A Transcriptome (RNA-seq) Transcriptome (RNA-seq) 3. 2.5 2..5..5...5..5 2. 2.5 3. 2.5 2..5..5...5..5 2. 2.5 Cluster Dendrogram RS_ES3.2 RS_ES3. RS_SHS5.2 RS_SHS5. PS_SHS5.2 PS_SHS5. RS_LJ3 PS_LJ3..4 _SHS5.2

More information

Histopathological diagnosis of CUP

Histopathological diagnosis of CUP Histopathological diagnosis of CUP Dr Karin Oien karin.oien@glasgow.ac.uk Disclosure slide Dr Karin Oien has no financial interests in any company mentioned in this presentation. Dr Karin Oien is conducting

More information

Bibliography. Serous Tumors of the Ovary. Nomenclature

Bibliography. Serous Tumors of the Ovary. Nomenclature Bibliography Serous Tumors of the Ovary Nomenclature 1. Allison KH, Swisher EM, Kerkering KM, et al. Defining an appropriate threshold for the diagnosis of serous borderline tumor of the ovary: when is

More information

NEOPLASIA. 3. Which of the following tumour is benign a. Chondrosarcoma b. Osteochondroma c. Chondroblastoma d. Ewing s tumour e.

NEOPLASIA. 3. Which of the following tumour is benign a. Chondrosarcoma b. Osteochondroma c. Chondroblastoma d. Ewing s tumour e. NEOPLASIA 1. malignant neoplasms a. are independent of hormonal influence b. are always composed of homogenous cell lines c. arise from differentiated cells by a process of anaplasia d. display abnormal

More information

Manipulating the Mouse Embryo

Manipulating the Mouse Embryo Manipulating the Mouse Embryo A LABORATORY MANUAL Second Edition Brigid Hogan Rosa Beddington Frank Costantini Elizabeth La~y Preface to First Edition, v Preface to Second Edition, vii Developmental Genetics

More information

Tumours of the Prostate and Testis update on WHO classification, IHC and molecular Morphology

Tumours of the Prostate and Testis update on WHO classification, IHC and molecular Morphology Tumours of the Prostate and Testis update on WHO classification, IHC and molecular Morphology Glen Kristiansen Professor and Chairman Institute of Pathology, University Hospital Bonn January 2016 WHO GU-Pathology

More information

Application of induced pluripotent stem (ips) cells in intractable childhood disorders

Application of induced pluripotent stem (ips) cells in intractable childhood disorders 10th Annual World Congress on Pediatrics Application of induced pluripotent stem (ips) cells in intractable childhood disorders Lessons from Dravet synd. patient-derived ipscs Shinichi Hirose, MD, PhD

More information

Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors

Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors ORIGINAL ARTICLE Embryonic Stem Cell Transcription Factor Signatures in the Diagnosis of Primary and Metastatic Germ Cell Tumors Sandro Santagata, MD, PhD,* Keith L. Ligon, MD, PhD,*w and Jason L. Hornick,

More information

L/O/G/O. Ovarian Tumor. Xiaoyu Niu Obstetrics and Gynecology Department Sichuan University West China Second Hospital

L/O/G/O. Ovarian Tumor. Xiaoyu Niu Obstetrics and Gynecology Department Sichuan University West China Second Hospital L/O/G/O Ovarian Tumor Xiaoyu Niu Obstetrics and Gynecology Department Sichuan University West China Second Hospital Essentials classification of ovarian tumor clinical manifestation of ovarian tumor metastatic

More information