The Chemistry and Use of 1,2-Alkanediols and Anti-oxidants for Product Protection
|
|
- Myron Smith
- 5 years ago
- Views:
Transcription
1 The Chemistry and Use of 1,2-Alkanediols and Anti-oxidants for Product Protection Ravi Pillai PAGE 1 1,2-ALKANEDIOLS CHEMISTRY Straight chain with two vicinal hydroxy groups CH 2 - CH - (CH 2 ) n - CH 3 OH OH Colorless and odourless to-low odor (depending on the chain length) 1,2-Pentanediol (INCI: Pentylene Glycol, colorless liquid) 1,2-Hexanediol (colorless liquid) 1,2-Octanediol (INCI: Caprylyl Glycol, liquid to waxy solid) 1,2-Decanediol (INCI: Decylene Glycol, waxy solid) PAGE 2 1
2 1,2-ALKANEDIOLS CHEMISTRY Chemically inert, compatible with most cosmetic ingredients Multi-functional ingredients: moisturiser, solubilizer (if liquid), preservative booster Different from other typical glycols like propylene and butylene glycols vs. 1,2-Hexanediol Amphiphilic Molecule 2-Methyl-2,4-pentanediol INCI: Hexylene Glycol PAGE 3 1,2-ALKANEDIOLS ANTI-MICROBIAL ACTIVITY MIC values (ppm) Microorganism 1,2-Pentanediol (Pentylene Glycol) 1,2-Hexanediol 1,2-Octanediol (Caprylyl Glycol) 1,2-Decanediol (Decylene Glycol) Staphylococcus epidermidis Corynebacterium xerosis Brevibacterium epidermidis NA NA Propionibacterium acnes Malassezia furfur Trichophyton mentagrophytes Candida albicans Aspergillus brasiliensis Escherichia coli Pseudomonas aeruginosa decreasing MIC values (increasing anti-mic activity) Anti-microbial activity increases with increasing chain length; what about preservative efficacy? PAGE 4 2
3 1,2-ALKANEDIOLS WATER SOLUBILITY Partition coefficient, log P o/w (calculated), of 1,2-alkanediols: 1,2-Alkanediol log P o/w 1,2-Propanediol ,2-Butanediol ,2-Pentanediol (Pentylene Glycol) 0.2 1,2-Hexanediol 0.7 1,2-Octanediol (Caprylyl Glycol) 1.7 1,2-Decanediol (Decylene Glycol) 2.7 increasing log P o/w (decreasing water solubility) Water solubility decreases with increasing chain length The insolubility of 1,2-Decanediol in water may explain its poor preservative efficacy PAGE 5 1,2-ALKANEDIOLS PRODUCT PROTECTION The MIC of 1,2-alkanediols show broad spectrum activity but the preservative efficacy shows weakness against mold, especially A. brasiliensis. Higher doses are necessary to protect against fungus. The most cost effective way to use alkanediols is to combine it with low doses of preservatives to make up for the weakness against mold. The mode of anti-microbial action of alkanediols is shown to be membrane disruption 1, 2. 1,2-Alkanediols can boost the activity of preservatives and other antimicrobials, providing a synergistic effect. 1 Use of 1,2-Alkanediols in Personal Care Formulations - Closer Look at Antimicrobial Activity, S. Schnittger, et al., Paper presented at SCC Annual Scientific Meeting, New York (2006) 2 Antimicrobial Activity of Aliphatic Diols and Their Esters, M. Akedo, J. Food Science Vol 42 No. 3 (1977) PAGE 6 3
4 PROTECTION WITH 1,2-ALKANEDIOLS SOME POSSIBLE OPTIONS Organic acids Caprylyl Glycol + Sodium Benzoate 1,2-Hexanediol + Dehydroacetic Acid Pentylene Glycol + Potassium Sorbate Caprylyl Glycol + 1,2-Hexanediol + Anisic Acid ph needs to be <5.5 Phenoxyethanol Caprylyl Glycol + Phenoxyethanol Decylene Glycol + 1,2-Hexanediol + Phenoxyethanol Works at a wider ph range Iodopropynyl Butylcarbamate (IPBC) Caprylyl Glycol + IPBC Caprylyl Glycol + 1,2-Hexanediol + IPBC PAGE 7 PROTECTION WITH 1,2-ALKANEDIOLS SOME POSSIBLE OPTIONS 0.5% Phenoxyethanol + 0.5% Caprylyl Glycol in Anionic Emulsion 1% phenoxyethanol kills bacteria in 2 days 1 log reduction of yeast & mold in 7 days kills all microbes in 14 days All challenge tests conducted as per Ph. Eur. guidelines PAGE 8 4
5 initial 2 days 7 days 14 days 28 days cfu/g PROTECTION WITH 1,2-ALKANEDIOLS SOME POSSIBLE OPTIONS 0.7% Phenoxyethanol + 0.2% Dec Glycol + 0.1% Hexanediol in Anionic Emulsion 1,200,000 1,000, , , , ,000 0 E. coli P. aeruginosa B. cepacia S. aureus C. albicans A. brasiliensis 1% phenoxyethanol kills bacteria & yeast in 2 days 1 log reduction of mold in 2 days kills all microbes in 7 days PAGE 9 PROTECTION WITH 1,2-ALKANEDIOLS SOME POSSIBLE OPTIONS 1.5% 1,2-Hexanediol + 0.2% Potassium Sorbate in Anionic Emulsion* kills bacteria in 2 days 1 log reduction of yeast & mold in 7 days kills all microbes in 14 days * ph PAGE 10 5
6 PROTECTION WITH 1,2-ALKANEDIOLS SOME POSSIBLE OPTIONS 0.4% 1,2-Hexanediol + 0.4% Cap Glycol + 0.4% Benzoate in Non-ionic Emulsion* kills all microbes in 2 days * ph - 5 PAGE 11 PROTECTION WITH 1,2-ALKANEDIOLS SOME FORMULATION TIPS Solubility varies: Pentylene Glycol is miscible in both water and cosmetic esters. Decylene Glycol is only soluble in cosmetic esters. When making emulsions, it is preferable to add the diols directly to water phase or at post emulsification 1,2-Alkanediols, especially the longer chain, can act as surfactants. Caprylyl Glycol Decylene Glycol Due to this, some emulsions tend to lose their viscosity or even break when these alkandiols are introduced. In such cases: addition of a viscosity modifier/stabilizer like carbomer may help increasing the emulsifier(s) is another option PAGE 12 6
7 cfu/g PROTECTION WITH 1,2-ALKANEDIOLS SOME FORMULATION TIPS 1,2-Alkanediols may form micelles in formulations with high surfactant content, losing part of their efficacy. They tend to lose some efficacy in SPF formulations due to migration to the lipophilic phase. Addition of solvents like butylene glycol or 1,3- propanediol helps to keep them in the water phase. As always, chelating agents are recommended to help boost the preservative efficacy. 1,2-Alkanediols are heat stable and works at a wide range of temperature (3-12) 1,2-Alkanediols comply with most global cosmetic regulations: 1,2-Pentanediol, 1,2-Hexanediol and 1,2-Octanediol appear in the Chinese FDA list 1,2-Decanediol appears in the 2004 PCPC/CTFA list PAGE 13 ANTI-OXIDANTS TROPOLONE INCI: Tropolone white to yellow powder nature identical compound Addition of % of Tropolone to Phenoxyethanol or 1,2-Alkanediols helps to make up their weakness against mold. O OH Challenge Test against Aspergillus brasiliens in Anionic Emulsion ' count 2d 7d 14d 28d 0.25% C % C % T % C % C days PAGE 14 7
8 PROTECTION WITH ANTI-OXIDANTS PHENOXYETHANOL + TROPOLONE 1% (Phenoxyethanol + Parabens) vs. 1% (Phenoxyethanol + Tropolone) SPF 30 Sunscreen Formulation Phenoxyethanol + Parabens vs. Phenoxyethanol + Tropolone weak against yeast & mold kills all microbes in 14 days Tropolone helps provide faster kill PAGE 15 PROTECTION WITH ANTI-OXIDANTS 1,2-ALKANEDIOLS + TROPOLONE 0.25% 1,2-Hexanediol % Cap Glycol % Tropolone in Aqueous Gel kills bacteria and yeast in 2 days 1 log reduction of mold in 2 days kills all microbes in 7 days PAGE 16 8
9 PROTECTION WITH TROPOLONE SOME FORMULATION TIPS Tropolone is a very active anti-oxidant that it could discolor many formulations/packaging materials. Stability tests on formulation and packaging is necessary. Presence of free metal ions also increase the chance of discoloration Stable at ph 3-8 Use level is very low: %, if combined with a preservative like Phenoxyethanol When making emulsions, it is preferable to add Tropolone during the cooling phase, below 50 o C. Complies with the cosmetic regulations of USA, Europe and Japan. PAGE 17 ANTI-OXIDANTS HYDROXYACETOPHENONE INCI: Hydroxyacetophenone white to off-white powder with very light odor nature identical compound found in Rubus chamaemorus (cloudberry, found in Alpine region) FEMA/GRAS listed multi-functional ingredient: anti-oxidant, anti-irritant, preservative booster PAGE 18 9
10 PROTECTION WITH ANTI-OXIDANTS PHENOXY + HYDROXYACETOPHENONE (HAP) 0.5% Phenoxyethanol + 0.5% Hydroxyacetophenone in Wet Wipes Lotion Base kills bacteria in 2 days kills all microbes in 7 days, even with re-inoculation PAGE 19 PROTECTION WITH ANTI-OXIDANTS CAP GLYCOL + HAP 0.25% Cap Glycol % Phenylpropanol + 0.5% Hydroxyacetoph in Shampoo kills bacteria and yeast in 2 days kills all microbes in 7 days PAGE 20 10
11 PROTECTION WITH ANTI-OXIDANTS 1,2-ALKANEDIOLS + HAP 0.25% Cap Glycol % Hexanediol + 0.5% Hydroxyacetoph in Aqueous Toner kills bacteria in 2 days kills all microbes in 7 days PAGE 21 PROTECTION WITH ANTI-OXIDANTS PHENOXY + 1,2-ALKANEDIOLS + HAP 0.2% Phenoxyethanol + 0.3% 1,2-Alkanediols + 0.5% HAP in SPF 64 Emulsion kills bacteria in 2 days kills all microbes in 7 days PAGE 22 11
12 PROTECTION WITH HYDROXYACETOPHENONE SOME FORMULATION TIPS Hydroxyacetophenone is soluble in water up to 1%, with stirring and heating to 60 o C. Recommended dose: up to 1% Excellent solubility in glycols and Glycerin Stable at ph 3-9 and up to 100 o C Not compatible with certain proteins When making emulsions, it is preferable to add Hydroxyacetophenone directly to the water phase. Advisable to have a good solvent like a glycol to help keep Hydroxyacetophenone in the water phase when using in formulations with high lipophilic content including SPF formulations Complies with the cosmetic regulations of USA, Europe and Japan. PAGE 23 1,2-ALKANEDIOLS AND ANTI-OXIDANTS SUMMARY 1,2-Alkanediols like Caprylyl Glycol and 1,2-Hexanediol are multifunctional ingredients that can protect cosmetic formulations Combination of 1,2-alkanediols with preservatives like organic acids, phenoxyethanol and IPBC helps to preserve many cosmetic formulations 1,2-Alkanediols comply with the cosmetic regulations of most countries; suitable for global formulations Anti-oxidants like Tropolone and Hydroxyacetophenone help boost the efficacy of common preservatives and other anti-microbial ingredients. Use of water soluble solvents like glycols increase the efficacy of alkanediols and anti-oxidants by helping to keep the anti-microbials in the water phase of emulsions PAGE 24 12
13 Acknowledgements: Dr. Manuel Pesaro and his group, Symrise Life Essentials R&D, Germany contact: Ravi Pillai THANK YOU! DISCLAIMER Symrise makes no warranties, either express or implied, as to the accuracy or completeness of the information set forth herein. Symrise expressly disclaims any implied warranty of merchantability and fitness for a particular purpose. Prospective users are requested to determine for themselves the suitability of Symrise materials and suggestions for any use prior to their utilization. Any necessary approvals from regulatory authorities for finished products must be obtained by the prospective user. Suggestions for applications involving our products or the reference to, or incorporation of, descriptive materials from patents and the citation of specific patents in this document may not be understood as recommendation for the use of Symrise products in violation of any patent or as a permission or licence to use any patent of Symrise or a third party. PAGE 25 13
Preservative A2 Plus. 1. INCI Composition. 2. Overview. 3. Specification data. Diazolidinyl Urea 99.0% Iodopropynyl Butylcarbamate 1.
Preservative A2 Plus Diazolidinyl Urea 99.0% Iodopropynyl Butylcarbamate 1.0% 1. ICI Composition 2. verview Preservative A2 Plus is a broad spectrum cosmetic preservative in powder. It is a synergistic
More informationMikrokill ECT. Broad Spectrum, Paraben-Free and Formaldehyde-Free Preservation System that meets the ECOCERT standards.
Mikrokill ECT (patent pending) Broad Spectrum, Paraben-Free and Formaldehyde-Free Preservation System that meets the ECOCERT standards. SAP Code#: 139650 Assigned INCI Designation: Benzyl Alcohol & Salicylic
More informationGlydant Plus Liquid (patented) Broad Spectrum Product Protection
Personal Care Consumer Care Glydant Plus Liquid (patented) Broad Spectrum Product Protection INCI Name: DMDM Hydantoin & Iodopropynyl Butylcarbanate (IPBC) Key Product Attributes: Highly cost-effective
More informationThe Good, The Bad & The Ugly: Formulation Tips for Traditional Preservatives. Personal Care Products Council Microbiology Seminar
The Good, The Bad & The Ugly: Formulation Tips for Traditional Preservatives Personal Care Products Council Microbiology Seminar October 24, 2013 Chuck Jones The Dow Chemical Company Lest You Think Preservative
More informationKemaben ME. 1. INCI composition. 2. Overview. 3. Specification data. 4. Chemical-physical data. Phenoxyethanol Methylparaben Ethylparaben
Kemaben ME 1. INCI composition Phenoxyethanol Methylparaben Ethylparaben 2. verview Kemaben ME is a liquid preservative system based on the shortest chain parabens in phenoxyethanol. It is well-balanced
More informationDEKABEN BL A welcome choice in a challenging world of preservation Value through expertise
www.imcdgroup.com DEKABEN BL A welcome choice in a challenging world of preservation Value through expertise CONFIDENCE Dekaben BL, a structural isomer of thymol, is an interesting preservative booster
More informationPreservative A15 Safe antimicrobial for cosmetics and pharmaceuticals
Safe antimicrobial for cosmetics and pharmaceuticals 1. Chemical structure Structural formula: Empirical formula: C 11 16 8 8 Molecular weight: 388,29 2. Codex and names CTFA/ICI name: Imidazolidinyl Urea
More informationPatent Pending: Application Number 62/139,908. Technical Data Sheet BACKGROUND
Technical Data Sheet BACKGROUND Fueled by the ever-changing regulations and the increasing safety concerns, among consumers, we must steer away from synthetics and focus on natural solutions. AMTicide
More informationGeogard 221 Broad Spectrum Preservation for Personal Care
Personal Care Geogard 221 Broad Spectrum Preservation for Personal Care Consumer Care INCI Name: Dehydroacetic Acid & Benzyl Alcohol & Water Key Product Attributes: Has a wide range of global regulatory
More informationADEKA NOL NHG. Product Properties. Antibacterial Properties. The minimum inhibitory concentration (MIC) for each bacterial strain. E.
TECHNICAL INFORMATION ADEKA NOL NHG ADEKA NOL NHG is a product that has an excellent balance of antibacterial effects, low skin irritation and water solubility, with bacteriostatic and moisturizing effects.
More informationNew England SCC. Natural Preservative Options. Rocco V. Burgo Chief Scientist. October 25, 2018
New England SCC Natural Preservative Options Rocco V. Burgo Chief Scientist October 25, 2018 Cosmetic Preservation Selection Method Drivers/Pulls Ethical Legal Technical Consumer Key Factors for Reliable
More information13th CSCC Meeting, Poreč SAFE AND EFFECTIVE ALTERNATIVES
SAFE AND EFFECTIVE ALTERNATIVES 1 Why use Alternative in Personal Care? 2 VERSTATIL product range Economy meets efficacy: safety first for low budgets! Page 3 Thomas Bussmann, Verstatil In-cosmetics Barcelona
More informationTechnical Data Sheet BACKGROUND
Technical Data Sheet BACKGROUND Fueled by the ever-changing regulations and the increasing safety concerns, among consumers, we must steer away from synthetics and focus on natural solutions. AMTicide
More informationN-(Hydroxymethyl) Glycine, Sodium salt
U Q UltraQuímica Ultracide FSM Talaíde Park (Lisboa) / PORTUGAL Armazém 9 Edifício A Tel: +351-21-423 1567 Estrada Octávio Pato Talaíde Fax: +351-21-423 1569 2785-601 São Domingos de Rana E-mail: ultraquimica@ultraquimica.pt
More informationFunctional Cosmetics Blends
Functional Cosmetics Blends Multi-Complex herb Ext. TM MCE-C Natural Preservatives for Cosmetics Functional Cosmetics Blends Product Name Composition Uses MCE-C Cinnamon extract, Scutellaria baicalensis
More informationKemaben 2. Broad spectrum cosmetic preservative system. 1. Composition. 2. General description. 3. Specifications data
Kemaben 2 Broad spectrum cosmetic preservative system INCI name % by weight Diazolidinyl Urea 30 Methylparaben 11 Propylparaben 3 Propylene Glycol 56 1. Composition 2. General description Kemaben 2 is
More informationProduct Information Dossier (PI)
Product Information Dossier (PI) Product P11-PD100 TRYLAGEN functional ingredient PCB Date June 2015 Revision 2 Contents PRODUCT INFORMATION Trade Name & Code 3 Manufacturer 3 INCI name 3 Composition 4
More informationConsiderations in Using Alternative Preservatives in Personal Care Products
Considerations in Using Alternative Preservatives in Personal Care Products D O N A L D J. E N G L I S H H E A D O F M I C R O B I O L O G Y AV O N P R O D U C T S, I N C. S U F F E R N, N E W Y O R K
More informationNatrlquest E30 INCI Name: Trisodium Ethylenediamine Disuccinate CAS No.: EINECS No.:
Biodegradable Chelant Natrlquest E30 INCI Name: Trisodium Ethylenediamine Disuccinate CAS No.: 178949-82-1 EINECS No.: 416-530-4 Natrlquest E30 H HN H N H Structure of EDDS free acid H H Chelating agents,
More informationJEECIDE AA AND JEECIDE AA PLUS
TECHNICAL BULLETIN JEECIDE AA AND JEECIDE AA PLUS Globally Approved Broad Spectrum Preservatives JEECIDE AA Introduction Jeecide AA is an easy to use liquid blend of Benzyl Alcohol, Benzoic Acid, and Sorbic
More informationProduct Information Dossier (PI)
Product Information Dossier (PI) Product PD090 DECORINYL functional ingredient Date September 2015 Revision 1 Contents PRODUCT INFORMATION Trade name & Code 3 Manufacturer 3 INCI name 3 Composition 4 Additional
More informationSteven Schnittger Executive Director, Microbiology The Estēe Lauder Companies, Inc
How to Preserve a Product in an Ever Changing Marketplace: The Shift from Conventional to Natural! Steven Schnittger Executive Director, Microbiology The Estēe Lauder Companies, Inc Overview The number
More informationKATHON LX Microbicide for Latex Preservation
Microbicide KATHON LX Microbicide for Latex Preservation Description KATHON LX microbicide is an aqueous based preservative formulated specifically for latex emulsion manufacturers. It has a long history
More informationBIORAN NP400 (Natural Preservative)
(Patent: 10-1532005) BIORAN NP400 (Natural Preservative) - Excellent Antimicrobial Activity - Natural Origin - No Praben, Phenoxyethanol and No Preservative labeling INKOS Co., Ltd. (67 Block 8Lot)96,
More informationProduct Information Antioxidants and Actives: dermofeel PA-3
Product Information Antioxidants and Actives: dermofeel PA-3 Product features: - Chelating agent - Readily biodegradable - Color stable, easy-to-use liquid - 100% naturally derived dermofeel PA-3 The product:
More informationLiquid Crystal System for Manufacture of Personal Care Cleansing Products
Liquid Crystal System for Manufacture of Personal Care Cleansing Products THIS PRODUCT IS A CONCENTRATE. IT MUST BE DILUTED AS BELOW BEFORE USE. The Liquid Crystal System provides a simple way of producing
More information1/ Can New Biodegradable Complexing Agents Replace Tetrasodium EDTA to Boost Preservatives? W. Siegert
1/2-2008 English Edition International Journal for Applied Science Personal Care Detergents Specialties W. Siegert Can New Biodegradable Complexing Agents Replace Tetrasodium EDTA to Boost Preservatives?
More informationCaprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics
Caprylyl Glycol/Phenethyl Alcohol Blend for Alternative Preservation of Cosmetics Paola Ziosi, * Stefano Manfredini, * Alberta Vandini, * Silvia Vertuani * and Massimo Fraternali * Department of Life Sciences
More informationTechnical Data Sheet SPI-305M
326 Exchange Drive Arlington, Texas 76011 817-469-7777 Technical Data Sheet SPI-305M INCI Name: Polyacrylamide & C13-14 Isoparffin & Laureth-7 Properties SPI-305M is a pre-neutralized polymer in ready
More informationother natural&ingredients Natural Preservative Systems
Paraben Free and many Natural Preservatives other natural&ingredients Natural Preservative ystems Innovation you canon feel U! YOU CAN COUNT, Fairfield, NJ 07004, UA Tel: 973-439-1401 Fax: 973-439-1402
More informationTaking inspiration from Nature: Biomimicry and Bioflavonoids from propolis
Taking inspiration from Nature: Biomimicry and Bioflavonoids from propolis Propolis is a mixture of substances secreted by plants in order to protect their buds from several exogenous factors like: weather
More informationTektamer 38 A.D. Product Information. Dibromodicyanobutane dispersion, VOC-free 1/9
Product Information Tektamer 38 A.D. Dibromodicyanobutane dispersion, VOC-free Tektamer is a registered trademark of LANXESS Corporation. Page 1 of 9: This document contains important information and must
More informationEnhanced delivery methods for greater efficacy
On-Line Formulation Training - Anywhere In The World - Enhanced delivery methods for greater efficacy Belinda Carli Director, Institute of Personal Care Science Image showing absorbance in the outer stratum
More informationProduct Information PREVENTOL CMK 40
Product Information PREVENTOL CMK 40 1/8 Uses For the preservation of concrete additives, metalworking fluids, textile auxiliaries, thickener solutions, adhesives (including protein-based formulations)
More informationPULLULAN as Cosmetic Ingredient. Hayashibara Biochemical Laboratories, Inc.
PULLULAN as Cosmetic Ingredient Hayashibara Biochemical Laboratories, Inc. What is Pullulan? Chemical Structure Maltotriose Natural polysaccharide derived from starch Manufactured by fermentation process
More informationProduct Information. Anti-Dandruff Agent. Pyrion - Disulfide. 3rd Issue: 15. Nov. 1999/Th
Product Information Anti-Dandruff Agent Pyrion - Disulfide 3rd Issue: 15. Nov. 1999/Th TABLE OF CONTENTS 1. Characteristics... 2 Structural formula... 2 2. Physical data... 3 Melting range... 3 Solubility...
More informationKem 30 A complete cosmetic preservative in liquid form 1. Chemical structure 2. Codex and names CTFA/INCI name: CAS number: EINECS number:
Kem 30 A complete cosmetic preservative in liquid form 1. Chemical structure Chemical name: Structural formula: N-(Hydroxymethyl) Glycine, Sodium salt H O Empirical formula: C 3 H 6 N O 3 Na Molecular
More informationEmulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance
Technical Information TEGO Carbomer 341 ER Emulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance Intended use Rheological additive Stabilizer Benefits at a glance
More informationWheat Amino acids & Peptides for Hair Care. INCI Name EU/USA CAS # EINECS # Hydrolyzed wheat protein
KELYAMIN Wheat Amino acids & Peptides for Hair Care Identification INCI Name EU/USA CAS # EINECS # Hydrolyzed wheat protein 70084-87-6 305-225-0 Composition % Liquid Powder Aqua Hydrolyzed wheat protein
More informationEmollient Esters with Anti-microbial Properties Multifunctional Molecules
Emollient Esters with Anti-microbial Properties Multifunctional Molecules Mild, Emollient, Microbiocidal ABITEC Corporation History of USA Organization Stokley Van Camp Capital City Products Karlshamns
More informationDefoaming Surfactants
TERGITOL L Series Biodegradable Surfactants TERGITOL L-61 E, L-62 E, L-64 E, L-81 E Defoaming Surfactants Trademark of The Dow Chemical Company ( Dow ) or an affiliated company of Dow. These surfactants
More informationConsumer product preservation
Specialty Chemicals by BASF BASF Biocides Consumer product preservation PAGE 2 BASF Biocides - protecting the world The biocide business for Specialty Chemicals, BASF AG BASF is one of the world s leading
More informationElementis Specialties
Elementis Specialties pure in cosmetics April 14, 2015 Presenting Rheoluxe Associative Thickeners for Personal Care The next big idea in rheology Market needs Product texture is a very important product
More informationACULYN 28 Rheology Modifier/Stabilizer
Technical Data Sheet A very efficient thickener for a wide array of Personal Care formulations. This bulletin focuses on our, a very efficient thickener for a wide array of personal care formulations.
More information1. NOMENCLATURE : 2,4-Hexadienoic Acid. : Hexadienoic acid. : 1,3- Pentadiene 1- Carboxylic Acid.
Chemical Preservatives (Approved by FSSAI) 1. Sorbic Acid (FCC IX) / E-200 2. Potassium Sorbate (FCC IX) / E-202) 3. D-Hydro Acetic Acid (DHA) (FCC IV) (E-265) 4. Sodium D-hydro Acetic Acid (E-266) FINESHED
More informationProduct Information Antioxidants and Actives: dermofeel enlight
Product Information Antioxidants and Actives: dermofeel enlight Product features: - Effective whitening blend - In vivo proven activity - Age spot correction - Skin tone harmonization - 100% naturally
More informationProduct overview. AROSURF Softness solutions for tissue and fluff pulp
Product overview AROSURF Softness solutions for tissue and fluff pulp ABOUT OUR PRODUCTS The product range of Evonik covers a variety of products with specific application profiles which address almost
More informationPreservation of Personal Care Products A Microbiologist s View
Preservation of Personal Care Products A Microbiologist s View PCPC Microbiological Workshop October 26, 2011 Deidre L. Mitchell Development Manager Microbiology Unilever Trumbull, CT Presentation Objectives
More informationConcentrate Appearance: colourless liquid * at 20 C miscible with water in any proportion Density: g/cm 3 *
P3-oxonia active Description: Product strengths: Properties Liquid, acidic disinfectant based on hydrogen peroxide/ peracetic acid for the food industry particularly effective against all types of microorganisms,
More informationProduct Information Antioxidants and Actives: dermofeel PA
Product Information Antioxidants and Actives: dermofeel PA Product features: - Chelating agent - Readily biodegradable - Easy-to-use liquid - 100% naturally derived The product: dermofeel PA This natural
More informationMIGLYOL Gel B, Gel T, 840 Gel B
MIGLYOL Gel B, Gel T, 840 Gel B INCI: Gel B: Caprylic/Capric Triglyceride, Stearalkonium Hectorite, Propylene Carbonate Gel T: Caprylic/Capric Triglyceride, Stearalkonium Bentonite, Propylene Carbonate
More informationFormulation Guidelines for Synovea HR
Formulation Guidelines for Synovea HR Synovea $ HR Hexylresorcinol is a well-defined material with a guaranteed purity of 99%. Generally speaking, Synovea $ HR is one of the very few phenolic skin lightening
More informationFormulation Guidelines for Synastol TC
Formulation Guidelines for Synastol TC Synastol TC is a standardized fruit extract of Terminalia Chebula with high content of hydrolysable tannins, typically 50-60%. Synastol TC is 100% natural and it
More informationDANTOGARD 2000 PRESERVATIVE High performance preservative for Household and Industrial applications DMDM Hydantoin
Product Information DANTOGARD 2000 PRESERVATIVE High performance preservative for Household and Industrial applications DMDM Hydantoin Active Matter: 1,3-Dimethylol-5,5-dimethylhydantoin H 3 C CH 3 O HOCH
More informationBIOBAN BP-40 Liquid Preservative Liquid Preservative For Water-Containing Systems EPA Reg. No
Product Information BIOBAN BP-40 Liquid Preservative Liquid Preservative For Water-Containing Systems EPA Reg. No. 464-676 General BIOBAN BP-40 liquid preservative contains the active ingredient 2-bromo-2-nitro-
More informationIndustrial Pharmacy (3) Solutions as a dosage form. DR.Saad.M.YACOUB
Industrial Pharmacy (3) Solutions as a dosage form DR.Saad.M.YACOUB Solutions: definition A solution is a homogenous one-phase system consisting of two or more components. The solvent, or mixture of solvents,
More informationKATHON CG Preservative
Product Information KATHON CG Preservative A Highly Effective, Broad Spectrum Preservative for Rinse-Off Haircare and Rinse-Off Skin Care Products General Dow has driven the progress of isothiazolinone
More informationAn Overview of Preservatives and their Modes of Action
An Overview of Preservatives and their Modes of Action Kevin Roden Thor Specialties What is a Preservative? A substance that maintains (preserves) the original performance/characteristics/integrity of
More informationVENTRIGUARD Technology Quadruple antimicrobial effect
Ventriguard ventriguard antimicrobial catheter for temporary ventricular drainage Long-term antimicrobial effect proved under practice-equivalent test conditions Prevents bacterial and mycotic infections
More informationCHEM 470 Surfactant Science
CHEM 470 Surfactant Science As a chemist recently recruited to cosmetic industry, or as a recent chemistry graduate, you may be surprised to discover that the technical foundation of the personal-care
More informationManufacturing use fungicide for formulation of preservatives for wood and other materials
Product Information PREVENTOL A 12-TK 50 Manufacturing use fungicide for formulation of preservatives for wood and other materials PREVENTOL is a registered trademark of LANXESS Deutschland GmbH. Page
More informationCREATING THE RIGHT BLEND, EVERY TIME.
CREATING THE RIGHT BLEND, EVERY TIME. With over 30 years experience, Sharon Labs has been effectively providing preservative solutions for the global personal care market. As one of the world s largest
More informationAlkyl Benzoate. Applications The multifunctional properties of Finsolv TPP allow it to be used for many applications in personal care areas:
Alkyl Benzoate Finsolv TPP INCI Name: C 12-15 Alkyl Benzoate (and) Dipropylene Glycol Dibenzoate (and) PPG-15 Stearyl Ether Benzoate CAS Nos.: 68477-27-8, 27138-31-4, 108347-90-6 EINECS Nos.: 270-112-4,
More informationIndustrial and Institutional Cleaning
Industrial and Institutional Cleaning Food and Beverage Processing Acidic cleaning for Dairy Industry 1 Introduction 2 Test Method -upon request- 3 Test Formulation 4 Summary Introduction Cleaning In Place
More informationDefoaming Surfactants
Defoaming Surfactants Surfadol -series DDTM-based surfactants Addinova High quality alternatives 1 Agenda 1. Introduction 2. Drop-ins 3. Generic Product Properties 4. Product List and Specific Features
More informationTEGO Carbomer 341 ER Emulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance
Emulsion stabilizer, viscosity enhancer for aqueous solutions with high electrolyte tolerance Thickener for mild (low active) personal cleansing formulations Stabilizer for cosmetic emulsions and gels
More informationEmulsions. Purpose of emulsions and of emulsification:
Pharmacist Ghada Hamid Emulsions Emulsion is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is immiscible. The dispersed
More informationFor over 40 years developing solutions that evolve the world
PERSONAL CARE For over 40 years developing solutions that evolve the world To the Personal Care market, Oxiteno offers innovations that promote beauty and wellness through mild and sustainable products.
More informationKolliphor P Grades. Technical Information. Poloxamers for Pharmaceutical Use. = Registered trademark of BASF Poloxamers Ph. Eur.
Technical Information Kolliphor P Grades June 2013 Supersedes issue dated February 2013 03_111136e-03/Page 1 of 8 WF-No. 122937 = Registered trademark of BASF Poloxamers Ph. Eur., Poloxamer USP/NF Poloxamers
More informationFlexaTrac -NTA C H E L A T I N G A G E N T
FlexaTrac -NTA C H E L A T I N G A G E N T KEY CHARACTERISTICS Readily biodegradable Completely water soluble Effective buffering agent Deflocculating properties Stable in acids and bases Stable over a
More informationMicrobiological Quality of Non-sterile Products Culture Media for Compendial Methods
Microbiological Quality of Non-sterile Products Culture Media for Compendial Methods The life science business of Merck operates as MilliporeSigma in the U.S. and Canada. Culture Media for Compendial Methods
More informationFinsolv EB. Ethylhexyl Benzoate. INCI Name: Ethylhexyl Benzoate CAS No.: EINECS No.:
Ethylhexyl Benzoate Finsolv EB INCI Name: Ethylhexyl Benzoate CAS No.: 5444-75-7 EINECS No.: 226-641-8 Finsolv EB Finsolv EB is a branched chain ester that provides excellent solubilisation for active
More informationEmollient for formulations with a light skin feel
Technical Information TEGOSOFT DEC Emollient for formulations with a light skin feel Intended use Liquid lipophilic emollient Benefits at a glance Low viscosity with a high spreadability Polarity Pour
More informationB. semisolid materials consisting of hydrophilic and hydrophobic portions
CHEM 470 Understanding Emulsions I. Definitions A. Any heterogeneous system which has at least one immiscible or barely miscible liquid dispersed in another liquid in the form of tiny droplets. A. Becher,
More informationNovel and Naturally Derived Water Resistance Agents for Sunscreens. Florida SCC Sunscreen Symposium September 12, 2009
Novel and Naturally Derived Water Resistance Agents for Sunscreens Florida SCC Sunscreen Symposium September 12, 2009 » Marketing Naturally derived» Functionality Benefits Sunscreen solubilizer Stability
More informationFormulation Guidelines for Synovea HR
Formulation Guidelines for Synovea HR Synovea HR Hexylresorcinol is a well-defined material with a guaranteed purity of 99%. Generally speaking, Synovea HR is one of the very few phenolic skin lightening
More informationDIGLYCEROL. Solvay Interox. Diglycerol General Overview. Product Data Sheet
Product Data Sheet DIGLYCEROL Diglycerol General Overview Polyglycerols have been known since the beginning of the 20th century, and polyglycerol fatty acid esters have been used in Europe and America
More informationParenteral products-definition
Parenteral products-definition Parenteral preparations are sterile, pyrogen-free liquids (solutions, emulsions, or suspensions) or solid dosage forms packaged in either single-dose or multidose containers.
More informationSURFONIC. Performance Emulsifiers for Metalworking Fluids
SURFONIC Performance Emulsifiers for Metalworking Fluids SURFONIC Performance Emulsifiers for Metalworking Fluids Metalworking Fluids Processes such as high-speed machining create increased pressure for
More informationDANOX LUCIEN LEUSINK 7G20. Marketing & Sales Manager SCA Barcelona, April 15th 2015 SURFACTANTS FOR CONSUMERS APPLICATIONS
DANOX HC-30 LUCIEN LEUSINK Marketing & Sales Manager SCA Barcelona, April 15th 2015 SURFACTANTS FOR CONSUMERS APPLICATIONS VISIT US AT BOOTH 7G20 CONTENTS 1. Cationic surfactants in hair conditioning 2.
More informationFIT TECHNICAL DATA. Summary of Research Studies and Production Trials
FIT TECHNICAL DATA Summary of Research Studies and Production Trials Fit Efficacy vs. Bacteria Pathogens Bacteria Pathogen Staphylococcus Aureus (ATCC 8) Listeria Monocytogenes (ATCC 9) Escherichia Coli
More informationCAPMUL + CAPTEX + ACCONON = SEDDS
OUR SOLUTIONS PORTFOLIO ABITEC products are specifically designed for meeting the solubility challenges of the pharmaceutical industry. Our products can be used alone or in conjunction with one another
More informationEUDRAGIT L 100 and EUDRAGIT S 100
Technical Information EUDRAGIT L 100 and EUDRAGIT S 100 Specification and Test Methods Ph. Eur. Methacrylic Acid - Methyl Methacrylate Copolymer (1:1) Methacrylic Acid - Methyl Methacrylate Copolymer (1:2)
More informationSOFTISAN Gel. INCI: Bis-Diglyceryl Polyacyladipate-1, Propylene Glycol Dicaprylate/Dicaprate, Stearalkonium Hectorite, Propylene Carbonate
INCI: Bis-Diglyceryl Polyacyladipate-1, Propylene Glycol Dicaprylate/Dicaprate, Stearalkonium Excellent co-emulsifier Stability improver Consistency regulator 1. Description: SOFTISAN Gel is an oleogel
More informationSUNZNO-NAS. SCCS * ZnO. *SCCS: Scientific Committee on Consumer Safety. Opinion SCCS/1518/13 on Zinc Oxide(nano form) COLIPA n o S76
SUNZNO-NAS SCCS * ZnO *SCCS: Scientific Committee on Consumer Safety Opinion SCCS/1518/13 on Zinc Oxide(nano form) COLIPA n o S76 SCCS * conformity summary for Zinc Oxide Purity >96% with impurities only
More informationAgro Ingredients. Velcis Formulated Performance for Plant Protection
Agro Ingredients Velcis Formulated Performance for Plant Protection Lonza Agro Ingredient Products A portfolio of products designed to help optimize crop protection formulations and help farmers deliver
More informationABIL Care 85 Emulsifier for O/W emulsions with a velvety-silky skin feel
ABIL Care 85 Emulsifier for O/W emulsions with a velvety-silky skin feel For sprayable emulsions, creams and lotions Cold processable emulsions are possible Long-lasting skin smoothing perception Low usage
More informationDevelopment of heavy-duty degreasers with low CLP labelling Microemulsions Part II
Development of heavy-duty degreasers with low CLP labelling Microemulsions Part II Alan Mortensen, Ph.D. 07-05-2015 1 Classification, Labelling and Packaging (CLP) New symbols and phrases (Hazard and Precautionary)
More informationACULYN 22 Rheology Modifier/Stabilizer
Technical Data Sheet A very efficient thickener for difficult to thicken surfactant systems This bulletin focuses on our, a very efficient thickener for difficult to thicken surfactant systems. Our ACULYN
More informationProduct Information PREVENTOL RI 80/RI 50
Product Information 1/7 Uses For the formulation of disinfectants or disinfecting cleaning agents for the medical, veterinary and cosmetic sectors, the food processing industry, agriculture and households.
More informationABIL Care XL 80 Excellence in Stability, Flexibility and Sensory Properties
ABIL Care XL 80 Excellence in Stability, Flexibility and Sensory Properties Silicone O/W emulsifier providing an outstanding combination of stabilization, flexibility and sensory benefits Formulations
More informationNaturally derived Alcohol free Proven efficiency
Naturally derived Alcohol free Proven efficiency The issue Indirect transmission commonly occurs by touching the eyes, nose or mouth after contact with surfaces contaminated by the virus. PFP Natural is
More informationTechnical Data Sheet
Technical Data Sheet MIGLYOL 829 ECO INCI: Caprylic/Capric/Succinic Triglyceride Non-greasy emollient Low spreadability Good absorption on skin Long playtime Personal Care 1. Description: MIGLYOL 829 ECO
More informationBALANCE RCF Polymer. INCI: Acrylates/Ceteareth-20 Methacrylate Crosspolymer. Cost Effective Fixative and Rheology Modifier
AkzoNobel Surface Chemistry INCI: Acrylates/Ceteareth-2 Methacrylate Crosspolymer Cost Effective Fixative and Rheology Modifier INTRODUCTION Traditionally, anionic polymers are not compatible with Carbomer.
More informationPharma Ingredients & Services. Kolliphor HS 15. Macrogol 15 Hydroxystearate Ph. Eur. Polyoxyl 15 Hydroxystearate USP. Technical Information
Technical Information March 2012 Supersedes issue dated December 2011 03_111149e-02/Page 1 of 8 WF-No. 118491 Kolliphor HS 15 Macrogol 15 Hydroxystearate Ph. Eur. Polyoxyl 15 Hydroxystearate USP = Trademark
More informationTEGOSOFT DEC Emollient for formulations with a light skin feel
TEGOSOFT DEC Emollient for formulations with a light skin feel Low viscosity with a high spreadability Easy to emulsify both in O/W and W/O emulsions Emollient for sprays, foams, creams, and lotions Emollient
More informationSilicone Polyether Surfactants and Derivatives
Siltech LLC 2170 Luke Edwards Road Dacula, Ga. 30019 (678) 442-0210 Technical Data (678) 4429624 (fax) Silicone Polyether Surfactants and Derivatives The products of this class have been known by a variety
More informationDelivery Systems. Glycospheres Softspheres 2/27/
Delivery Systems Glycospheres Softspheres 2/27/2018 Why Use Delivery Systems? Target certain areas of the skin Protect active ingredients from degradation when formulated Protect formula from degradation
More informationPhosphoric acid, tris (2-methylpropyl) ester
Product Safety Assessment Phosphoric acid, tris (2-methylpropyl) ester This document provides a brief description of phosphoric acid, tris (2-methylpropyl) ester, its uses, and the potential hazards associated
More informationIMWITOR 600. W/O emulsifier. Non ionic. PEG free. INCI: Polyglyceryl-3 Polyricinoleate
W/O emulsifier Non ionic PEG free 1. Description: is an ester from polyglycerin and plant derived condensed castor oil fatty acids. is a yellow-brownish waterless oil. Its appearance and consistency is
More information