Actisaf Advanced management in horse nutrition for better performance. phileo-lesaffre.com LESAFFRE ANIMAL CARE

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1 Advanced management in horse nutrition for better performance phileo-lesaffre.com LESAFFRE ANIMAL CARE

2 improves feed utilization In trials carried out in various locations, has repeatedly and consistently demonstrated that it can improve horses ability to digest fibers, enabling the animals to use energy from forage better, and therefore utilize the daily ration more efficiently. Giving at 1 g/day secures benefits on feed utilization. Neutral Detergent Fiber digestibility % France 1 5 g/d (5 1 1 CFU) 1 days Germany 5 g/d (5 1 1 CFU) 33 days (different dosages) United Kingdom 3 1 g/d (1 1 1 CFU) 1 days p <.5 Hemicellulose digestibility Dry matter digestibility % % France 1 5 g/d (5 1 1 CFU) 1 days 5 Germany 5 g/d (5 1 1 CFU) 33 days United Kingdom 3 1 g/d (1 1 1 CFU) 1 days (different dosages) p <.1 1. France, 17. Effect of SC47 supplementation on total apparent digestibility coefficients and the fecal ecosystem in horses. Internal data.. Germany, 6. Trial for European Union registration. 3. United Kingdom,. Trial for European Union registration.

3 favors fibrolytic microflora Two recent digestibility studies in France used different doses of (5 g/day and 1 g/day) on 6 and 8 horses respectively, confirming improved fiber digestibility. The underlying mode of action of can be eplained using the latest metagenomic technologies. Rations were individually calculated to provide 1% of energy requirements: hay (5% Dry Matter Ingested), alfalfa pellets (% DMI) and commercial feed pellets (3% DMI). : Positive shift in the bacterial community The diagram below shows the different bacterial families that constitute the microbiota in horses that were fed diets supplemented with during the two digestibility studies. These microbiota are typical of healthy horses. Taonomic distribution of the bacteria found in fecal samples Study 1 Study : 1 g/day 1 : 5 g/day Prevo. Prevo. Prevo. Prevo. Rikenellaceae R. Prevotellaceae Rikenellaceae R. Por. Bac. Bac. Bacteroidales Bacteroidales S4-7 Bacteria Bacteroidetes Bacteroidia Fibrobac. Fibrobac. Fibrobac. Trepo. Spiro. Spiro. Spiro. Ana. Farm. Defl. Defl. Chris. Chris. Ruminoc. Ruminococcaceae Clostridiales Clostridia Firmicutes Ruminoc. Multi. Eub. Multiaffiliation Lachnospiraceae Sac. Prev. Por. Prev. Prev. Prev. Bac. Prevotellaceae Bac. Unk. genus Fibrobac. Fibrobac. Fibrobac. Fibrobac. Fibrobac. Bac. Bacteroidales Trepo. Spiro. Bacteroidia Bacteroidales Rikenellaceae Spiro. Spiro. Rikenellaceae RC9 Bacteria Bacteroidetes Eub. Defl. Defl. Ruminococcaceae Farm. Clostridiales Clostridia Firmicutes Ana. Chris. Chris. Lachnospiraceae Multi. Multiaffiliation increases fibrolytic bacteria Sequencing the microbiota reveals shifts in the microbial population in the hindgut, as illustrated by the population of fecal bacteria. Significant increases were observed in 6 species. These studies confirm that supplementation benefits the intestinal microbiota in the horse, improving fiber digestion. Bacterial species Family > gennus Gap factor between and. Spirochaetes > Treponema.3 Bacteroidales S4-7 > unknown. Lachnospiraceae > UCG-9.9 Prevotellaceae > UGC Ruminococcaceae > NK4A14 1. Bacteroidales BS11 gut > unknown.7 Total 1.6 LS Means of bacterial species France, 15. Effect of SC47 supplementation on total apparent digestibility coefficients and gastrointestinal ecosystems in horses fed a highstarch diet. Internal data. France, 16. Effect of SC47 supplementation on total apparent digestibility coefficients and the fecal ecosystem in horses. Internal data

4 improves metabolism during training Metabolic status was better in horses fed a diet supplemented with 1 g/day (1 1 1 CFU) of for 9 days during a period of intensive training than horses in the control group. Horses were fed daily 5 to 6 kg of commercial feed pellets and ad libitum hay. Detoification 1 ΔUrea D to D9 A rapid reduction in urea (nitrogen waste) levels in the horses indicates improved protein metabolism and detoification. 3 1 mmol/l p <.1 Oygenation 1 ΔHemoglobin D to D9 Red blood cell production is stimulated by supplementation, raising significantly more hemoglobin levels in the blood than in the control group. This increase improves the horse s ability to supply the organs with oygen during periods of increased effort. g/dl p <.5 Inflammation 1 ΔFibrinogen D to D9 The level of fibrinogen in the blood is an indicator of inflammation and stress. Fibrinogen levels decreased more significantly in horses fed than horses in the control group, revealing a reduction in the inflammatory stress caused by intensive training. g/l p < France, 17. Double-blind placebo-controlled randomized study: influence of an oral supplementation in SC47 in trotters in training. Internal data.

5 improves body condition and training performance During intensive race training, horses fed a diet supplemented with 1 g/day (1 1 1 CFU) of for 9 days maintained better body condition than horses in the group. supplementation also improved speed in relation to heart rate. Weight loss during training 1 Weight loss in young horses during periods of intensive activity is detrimental to health and performance. improves fitness and increases training success by maintaining body weight during periods of work. This benefit is related to the effect of on the balance of the microbiota, improving fiber digestibility and feed utilization. kg Δweight D to D9-3 p <.5 Heart function during training 1 ΔV D to D45 V (race speed reached at heart beats per minute) is a recognized marker for performance during training. Supplementation with significantly increases V. This could be related to the metabolic effects of, such as increased hemoglobin levels, better energy use, and improved body detoification. km/h p < France, 17. Double-blind placebo-controlled randomized study: influence of an oral supplementation in SC47 in trotters in training. Internal data.

6 ACT47-H-SH-BR6P-188E1-en The information provided in this document is, to the best of out knowledge, true and accurate. However, products must only be used in compliance with local laws and regulations; we cannot guarantee freedom of use for every intended application or country. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. BETTER RESISTANCE No weight loss Less inflammatory stress Sport horses Foal to Adult horse Pregnant and lactating mare 137, rue Gabriel Péri - BP Marcq-en-Barœul - France Tel.: Fa: info@phileo.lesaffre.com BETTER FEED VALORIZATION Better use of energy Better fiber digestibility BETTER PERFORMANCE Improved V Better blood oygenation Life stage Regulations vary by region and country. Consult local regulations for specific applications. IMPROVED METABOLISM Better detoification And use of proteins 1 g/head/day 5-1 g/head/day 15 g/head/day LESAFFRE ANIMAL CARE