Prior Authorization Criteria Update: Calcium/Vitamin D Replacement, Oral
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1 Copyright 2012 Oregon State University. All Rights Reserved Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35 Salem, Oregon Phone Fax Prior Authorization Criteria Update: Calcium/Vitamin D Replacement, Oral Purpose of Update: The calcium/vitamin D class was last reviewed in March of At that time prior authorization (PA) criteria was created to designate specific vitamin D and calcium supplements as preferred and provide coverage for the following patients: pregnant, nutrient deficient, diagnosis of osteopenia or osteoporosis, and patients 65 years of age or older who are at risk for falls (see Appendix 1). The purpose of this update is to determine the appropriateness of designating a vitamin D solution (drops) as a preferred drug. Guidelines recommend that infants receive supplemental vitamin D to ensure adequate levels for proper growth. Guidelines recommend vitamin D 400 IU daily for infants from birth up to 12 months and IU daily for infants months. 1 3 Human breast milk contains small amounts of vitamin D, and therefore, supplementation is recommended. Infants who receive formula may require vitamin D supplementation dependent upon the micronutrient composition of the formula. Fortification of foods with vitamin D and increased exposure to sunlight contributes to appropriate vitamin D levels in children as they age. 2 Currently, multi vitamin pediatric formulations, including drops, with 400 IU vitamin D are available without a prior authorization (PA). Recommendation: It is recommended that a vitamin D solution suitable for infants is added to the preferred drug list. Evaluate costs in executive session. References: 1. Centers for Disease Control and Prevention. Vitamin D. Available at: special circumstances/diet andmicronutrients/vitamin d.html. Accessed 1/15/ Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. In: Ross AC, Taylor CL, Yaktine AL, et al., editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); Available at: ncbinlm nih gov.liboff.ohsu.edu/books/nbk56070/. doi: / Accessed 1/15/ Holick MF, Binkley NC, Bischoff Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011;96: Accessed 1/16/ Wagner CL, Greer FR. Section on breastfeeding and committee on nutrition 2008 prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122: Author: Kathy Sentena, PharmD March 2019
2 Appendix 1. Current Preferred Drug List Status Generic Brand FormDesc PDL calcium carbonate CALCI-MIX CAPSULE Y calcium carbonate CALCIUM CARBONATE ORAL SUSP Y calcium carbonate CALCIUM TABLET Y calcium carbonate CALCIUM 500 TABLET Y calcium carbonate CALCIUM CARBONATE TABLET Y calcium carbonate OYSCO-500 TABLET Y calcium carbonate OYSTER SHELL CALCIUM TABLET Y calcium carbonate/vitamin D3 CALCIUM TAB CHEW Y calcium carbonate/vitamin D3 CALCIUM VIT D TAB CHEW Y calcium carbonate/vitamin D3 OS-CAL 500+D TAB CHEW Y calcium carbonate/vitamin D3 CALCIUM 500-VIT D3 TABLET Y calcium carbonate/vitamin D3 CALCIUM VIT D TABLET Y calcium carbonate/vitamin D3 OS-CAL 500-VIT D3 TABLET Y cholecalciferol (vitamin D3) DECARA CAPSULE Y cholecalciferol (vitamin D3) MAXIMUM D3 CAPSULE Y cholecalciferol (vitamin D3) VITAMIN D3 CAPSULE Y cholecalciferol (vitamin D3) DIALYVITE VITAMIN D3 MAX TABLET Y cholecalciferol (vitamin D3) VITAMIN D TABLET Y cholecalciferol (vitamin D3) VITAMIN D3 TABLET Y ergocalciferol (vitamin D2) DRISDOL CAPSULE Y ergocalciferol (vitamin D2) VITAMIN D2 CAPSULE Y calcium carb/d3/magnesium/zinc CAL MAG ZINC-D3 TABLET N calcium carb/magnesium oxid/d3 CALCIUM MAGNESIUM + D TABLET N calcium carb/vit D3/minerals CALCIUM +D & MINERALS TAB CHEW N calcium carb/vit D3/minerals CALCIUM 600+MINERALS TABLET N calcium carb/vitamin D3/vit K1 CALCIUM SOFT CHEW TAB CHEW N calcium carbonate CALCI-CHEW TAB CHEW N calcium carbonate CALCIUM TAB CHEW N calcium carbonate CORAL CALCIUM TABLET N calcium carbonate/vitamin D2 CALCIUM CARBONATE W/VITAMIN D TABLET N calcium carbonate/vitamin D3 CALCIUM 250-VIT D3 TABLET N calcium carbonate/vitamin D3 CALCIUM VIT D TABLET N calcium carbonate/vitamin D3 CALCIUM 500-VIT D3 TABLET N calcium carbonate/vitamin D3 CALCIUM VIT D TABLET N calcium carbonate/vitamin D3 CALCIUM 600-VIT D3 TABLET N calcium carbonate/vitamin D3 OS-CAL 500-VIT D3 TABLET N calcium carbonate/vitamin D3 OYSCO 500-VIT D3 TABLET N calcium carbonate/vitamin D3 OYSCO D TABLET N
3 calcium carbonate/vitamin D3 OYSTER SHELL + D TABLET N calcium carbonate/vitamin D3 OYSTER SHELL CALCIUM W-VIT D TABLET N calcium carbonate/vitamin D3 OYSTER SHELL CALCIUM-VIT D3 TABLET N calcium citrate CALCITRATE TABLET N calcium citrate CITRACAL LIQUITAB TABLET EFF N calcium citrate/vitamin D3 CALCET TAB CHEW N calcium citrate/vitamin D3 CALCITRATE + VIT D TABLET N calcium citrate/vitamin D3 CALCIUM CITRATE - VITAMIN D TABLET N calcium citrate/vitamin D3 CALCIUM CITRATE - VITAMIN D3 TABLET N calcium citrate/vitamin D3 CALCIUM CITRATE-VITAMIN D3 TABLET N calcium citrate/vitamin D3 CITRUS CALCIUM + D TABLET N calcium citrate/vitamin D3 CITRUS CALCIUM-VITAMIN D3 TABLET N calcium glubionate CALCIONATE SYRUP N calcium gluconate CALCIUM GLUCONATE TABLET N calcium lactate CALCIUM LACTATE TABLET N calcium phosphate dibas/vit D3 CALVITE P&D TABLET N calcium phosphate dibas/vit D3 RISACAL-D TABLET N calcium/mag/d3/b12/fa/b6/boron FOLGARD OS TABLET N calcium/mag/d3/b12/fa/b6/boron TL G-FOL OS TABLET N calcium/mag/d3/b12/fa/b6/boron CALCIUM-FOLIC ACID PLUS D WAFER N calcium/magnesium/zinc CALCIUM/MAGNESIUM/ZINC TABLET N calcium/magnesium/zinc CALCIUM-MAGNESIUM-ZINC TABLET N cholecalciferol (vitamin D3) DIALYVITE VITAMIN D CAPSULE N cholecalciferol (vitamin D3) VITAMIN D3 CAPSULE N cholecalciferol (vitamin D3) D-VI-SOL DROPS N cholecalciferol (vitamin D3) D-VITA DROPS N cholecalciferol (vitamin D3) VITAMIN D3 DROPS N cholecalciferol (vitamin D3) VITAMIN D3 TABLET N cholecalciferol (vitd3)/vit K2 DOSOQUIN TABLET N ergocalciferol (vitamin D2) CALCIDOL DROPS N ergocalciferol (vitamin D2) CALCIFEROL DROPS N ergocalciferol (vitamin D2) DRISDOL DROPS N ergocalciferol (vitamin D2) ERGOCALCIFEROL DROPS N vitamin D3/folic acid DERMACINRX PUREFOLIX TABLET N calcium HI-CAL TABLET calcium carb/mag ox/zinc sulf CALCIUM-MAGNESIUM-ZINC TABLET calcium carb/vitamin D3/soyb SOY FORMULA TABLET calcium carbonate CALCIUM CARBONATE TABLET calcium carbonate/vitamin D2 LIQUID CALCIUM CAPSULE calcium carbonate/vitamin D2 CALCIUM CARBONATE W/VITAMIN D TABLET
4 calcium carbonate/vitamin D2 OYSTER + D TABLET calcium carbonate/vitamin D2 OYSTER SHELL CALCIUM TABLET calcium carbonate/vitamin D2 OYSTER SHELL CALCIUM W/VIT D TABLET calcium carbonate/vitamin D2 OYSTER SHELL CALCIUM W-VIT D TABLET calcium/magnesium/zinc CALCIUM-MAGNESIUM-ZINC TABLET dihydrotachysterol DHT TABLET Appendix 2. Proposed Prior Authorization Criteria Calcium and Vitamin D Supplements Goal(s): Restrict use of calcium and vitamin D supplements to patients who are pregnant; have a documented nutritional deficiency; have a diagnosis of osteopenia or osteoporosis; infants 0-24 months or elderly patients at risk for falls. Length of Authorization: Up to 12 months Requires PA: Non-preferred calcium and vitamin D products Covered Alternatives: Current PMPDP preferred drug list per OAR at Searchable site for Oregon FFS Drug Class listed at
5 Approval Criteria 1. What diagnosis is being treated? Record ICD10 code 2. Is this an OHP-funded diagnosis? Yes: Go to #3 No: Pass to RPh. Deny; not funded by the OHP 3. Does the patient meet any of the following criteria: Pregnancy; Documented nutrient deficiency; Diagnosis of osteopenia or osteoporosis; Infants 0-24 months of age OR Age 65 years or older and at risk for falls Yes: Approve for up to 12 months. Request that a 90 day s supply be filled at a time. No: Pass to RPh. Deny; medical appropriateness P&T Review: 3/19 (KS), 3/16 (KS) Implementation: 5/1/16
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