4146 Women's Health Profile

Transcription

1 Ordering Physician: Metametrix 1234 Main St. Anywhere, GA Reference Number: Age: 50 Sex: Female Date of Birth: 02/05/1962 Date Collected: 6/12/12 Date Received: 6/13/12 Report Date: Telephone: Fax: 6/22/12 (770) (770) /15/12

2 Ordering Physician: Metametrix 1234 Main St. Anywhere, GA Reference Number: Age: 50 Sex: Female Date of Birth: 02/05/1962 Date Collected: 6/12/12 Date Received: 6/13/12 Report Date: Telephone: Fax: 6/22/12 (770) (770) /15/12 Summary of abnormal results: Findings Intervention Options Metabolic Association Endocrine Insulin Sensitivity HDL Cholesterol Low Cr, V, Lipoate, n-3 FA balance Suppressed hepatic function Triglycerides High Cr, V, Lipoate, n-3 FA balance Insulin-stimulated lipogenesis Cell Regulation Nitric Oxide Inhibition Asymmetric Dimethylarginine (ADMA) High Folate, antioxidants Low rate of ADMA clearance Arginine/ADMA Low Arginine Poor nitric oxide production Eicosanoid Balance Docosahexaenoic acid (22:6n3) Low Add fish oil n-3 Fatty acid insufficiency Index of Omega-3 Fatty Acids Low Fish oils or extracts Omega-3 insufficiency Cell Protection No Abnormality Found Metabolic Markers (Organic Acids) B-Vitamin Insufficiency a-ketoglutarate High CoQ10, Lipoic Acid, B1, B2, B3, Citric acid cycle B5 a-ketoisovalerate High Lipoic Acid, B1, B2, B3, B5 Impaired Valine metabolism Cellular Energy a-ketoglutarate High CoQ10, Lipoic Acid, B1, B2, B3, Citric acid cycle B5 Neural Function 5-Hydroxyindoleacetate Very Low 5-HTP Serotonin turnover inhibition Detoxification Pyroglutamate Very Low Free-form amino acids Amino Acid insufficiency A

3 Endocrine Insulin Sensitivity 1 Insulin 2 Glucose 3 HDL Cholesterol 4 LDL Cholesterol (Direct) 5 Triglycerides Results Low Limit High Limit Reference Limits µiu/ml mg/dl 45 L >= 50 mg/dl 102 < 130 mg/dl 180 H < 150 mg/dl Estrogen Metabolism 2/16 Hydroxyestrogen Ratio Reference Limits All Females (2-OHE1 + 2-OHE2) / 16a-OHE Hydroxyestrone and Methylation Ratio 7 4-Hydroxyestrone (4-OHE1) 8 2-OHE1 / 2-OMeE1 Hydroxyestrogens 2-Hydroxyestrone (2-OHE1) 2-Hydroxyestradiol (2-OHE2) 2-OHE1 + 2-OHE2 16a-Hydroxyestrone (16a-OHE1) Methoxyestrogens 2-Methoxyestrone (2-OMeE1) 4-Methoxyestrone (4-OMeE1) Results 1.5 <0.067 <= <= 10.4 ng/mg creatinine <0.23 Pre-Menopausal Females <= % Reference Limits Post-Menopausal Females (no hormone therapy) <= 0.4 Post-Menopausal Females (on hormone therapy) Hydroxyestrone (4-OHE1) <0.067 <= 3.2 <= 2.1 <= <= 0.3 ng/mg creatinine *UC = Unable to calculate Creatinine =165 mg/dl Page 1

4 Cell Regulation Nitric Oxide Regulation Results 95% Reference Interval 15 Asymmetric Dimethylarginine (ADMA) 16 Arginine 17 Arginine/ADMA Eicosanoid Balance H L µmol/l µmol/l Ranges: Ages 13 and over 18 Eicosapentaenoic (20:5n3) 19 Docosahexaenoic (22:6n3) 20 Arachidonic (20:4n6) 21 AA/EPA Index of Omega-3 Fatty Acids (EPA + DHA %) µm L µm µm L >80.00 µm Sears, B. Toxic Fat: When Good Fat Turns Bad. 1st ed. Nashville, TN: Thomas Nelson; Harris, WS. Omega - 3 fatty acids and cardiovascular disease: A case for omega-3 index as a new risk factor. Pharmacological Research 2007; 55: Cell Protection Cell Membrane Oxidation 22 Lipid Peroxides <= 2.60 nmol/ml Elemental Cofactor Status Erythrocytes (packed cells) Magnesium Plasma Zinc ,594 ppm ppb Page 2

5 Ranges: Ages 13 and over Metabolic Markers B-Vitamin Insufficiency Results mcg/mg creatinine 95% Reference Interval 25 Pyruvate 26 a-ketoglutarate 27 a-ketoisovalerate 28 a-ketoisocaproate 29 a-keto-β-methylvalerate 30 Xanthurenate 31 β-hydroxyisovalerate 32 Methylmalonate 33 Formiminoglutamate H H <= 6.4 <= 35.0 <= <= <= <= <= <= <DL* <= 2.2 Cellular Energy 34 Adipate 35 Suberate 36 Ethylmalonate 37 β-hydroxybutyrate 38 Succinate 39 Fumarate 40 Malate 41 Hydroxymethylglutarate <= <= <= <DL* <= <= <DL* <= <= <= 5.1 Page 3

6 Ranges: Ages 13 and over Results mcg/mg creatinine 95% Reference Interval Neural Function 42 Vanilmandelate 43 Homovanillate 44 5-Hydroxyindoleacetate 45 Kynurenate 46 Quinolinate 47 Picolinate <DL* L <= <= Detoxification 48 Citrate 49 Cis-Aconitate 50 Isocitrate 51 2-Methylhippurate 52 Orotate 53 Glucarate 55 Pyroglutamate <DL* <= <= <= L Creatinine =165 mg/dl * <DL = less than detection limit Page 4

7 Supplement Recommendation Summary With knowledge of a patient's full medical history and concerns, the Organix Basic Profile laboratory results may be used to help healthcare professionals create an individually optimized nutritional support program. Based strictly on the results from this test, the summary table below shows estimates of nutrient doses that may help to normalize nutrient-dependent metabolic functions. All amounts are adult doses that should be adjusted for children according to body weight and indication of need. Customized Vitamin and Mineral Formulation Nutrients listed in this section are normally contained in a multi-vitamin preparation. "Base" amounts may be used to ensure health even when no abnormalities are found. Customized preparations of the multi-vitamin/mineral formula shown below may be produced by compounding pharmacies. If such a product is made according to these specifications each dose should be thoroughly stirred into a few ounces of water or diluted fruit juice to allow bubbles to form and avoid stomach bloating effects. Daily Amounts Nutrient Vitamin A ß-Carotene Vitamin C Vitamin D Vitamin E Vitamin K* Thiamin (B1) Riboflavin (B2) Niacin (B3) Pyridoxine (B6) Folic Acid (or 5-Methyl-THF) Vitamin B12 Biotin Base 2500 IU 5500 IU 250 mg 400 IU 100 IU 100 mcg 5 mg 5 mg 25 mg 15 mg 400 mcg 50 mcg 100 mcg Units Added 2000 mg 400 IU 5 mg 10 mg 20 mg 800 mcg Pantothenic Acid (B5) 25 mg 25 mg Calcium citrate 500 mg Iodine* 75 mcg Magnesium 250 mg Zinc 15 mg Selenium 100 mcg Copper 1 mg Manganese* 5 mg Chromium 200 mcg Molybdenum* 25 mcg Boron* 1 mg * Nutrients with an asterisk are not modified based on the Organix Basic test results. MM02 Page 5

8 Other Items Indicated for Individual Supplementation Various conditionally essential nutrients and other potentially beneficial interventions appear in this section only if relevant abnormalities are present. These ingredients are not included in the customized vitamin formula on the previous page. Nutrient 5-Hydroxytryptophan Arginine Coenzyme Q10 Fish Oil Lipoic Acid Need for Other Antioxidants Amount 200 mg 1000 mg 30 mg 6 gm 100 mg Strong If orotate is elevated, amino acid supplementation may be contraindicated, except for arginine. These guidelines are intended as a starting point for the clinician who requested the test and are based only on the laboratory results included in this report. Final recommendations should be implemented by the clinician with consideration of medical history and current clinical observations. Page 6