Blood Vessel Repair and Managing Immune Conditions through Polyphenolics Nature s solution to inflammation

Transcription

1 Blood Vessel Repair and Managing Immune Conditions through Polyphenolics Nature s solution to inflammation Supported by a grant from PIH, Ashburn VA 1

2 Housekeeping Audio Audio can be heard directly through your computer speakers OR you may call into the conference line for audio: When prompted Entry Code Note: Conference line is muted. Questions (Q&A) Please your questions to Dr. Jaffe will answer questions within 24 hours. 2

3 Dr. Russell Jaffe, MD, Ph.D., CCN FASCP, FACN, FACAAI, FOCIS, FAMLI, FRSM Fellow, Health Studies Collegium Director, PERQUE Integrative Health & ELISA/ACT Biotechnologies, LLC 3

4 Inflammation Rethought = Remove Repair Blocks Cardiovascular diseases Cancer Type 2 Diabetes Pulmonary Diseases Inflamma&on = Lack of Repair = Obstacle to recovery Alzheimers Neurologica l Diseases Arthritis Autoimmun e Diseases Modified from Grundy et al., 2005; Kahn et al.,

5 Inflammation: Repair deficits Cardiovascular: CAD, ASHD, PVD, & stroke risk Joint: Rheumatoid & Osteo Arthritis, tendonitis Liver: Infectious & non-infectious Hepatitis, Immune system: Allergies, sinusitis, asthma Gut: IBS, Crohn's disease, Ulcerative Colitis

6 Inflammation is Repair Deficit Predictive indices of risk: ESR: Erythrocyte Sedimentation Rate <3mm/hr for men and <7mm/hr for women hscrp: high sensitivity C reactive protein <0.5 Oxidation / Antioxidant status: Ox HDL/LDL & 8 oxo-guanine, N.D.

7 Inflammation = Repair deficit Inflammation = repair block = cumulative repair deficit or block Healthy = Seamless & complete repair

8 Innate Immune System Recycles, renews & repairs Supports as part of homeostasis Detoxifies xenotoxins & toxic metabolites Recycles infections to cell building blocks Rebuilds structure (collagen & elastin) Renews basement membrane nutrients Nutrient deficit & xenotoxins create need

9 Cells involved 1º Defense & Repair Innate: Dendritic / phagocytic 1-3. Macrophages / monocytes, & Granulocytes (blood & tissue) 4. Fibroblasts (muscles; organs) 5. Endothelial cells (blood vessels) 6. Glial cells (brain) 7. Kupfer cells (liver) 8. Sinusoidal cells of spleen Essentials of Clinical Immunology, H Chapel et al, Blackwell Pub, 2006

10 Dendritics Eat & Recycle Pathogens

11 Inflammation & Oxidative Stress Long term inflammation causes progressive damage due to cumulative deficits. Chronic systemic inflammation involves repair deficits in all distressed internal organs and systems. Inflammation causes free radical damage and oxidative stress

12 Oxidative Stress: Free Radical Damage

13 Oxidative Stress uses em up ä Antioxidants = ã Oxidative Stress (e.g. Vit C, E, Se, Zn ) (ã free radicals)

14 Polyphenolics Flavonoids & Flavonols Potent plant antioxidant promoters of repair Flavonoids: Quercetin Dihydrate Flavonols: soluble Oligomeric proanthocyanidins (OPC)

15 natural component of most fruits & vegetables hypoallergenic, potent, safer, effective

16 Anti-allergic & anti-inflammatory activities. Activate mast cells, basophils, neutrophils, eosinophils, T & B lymphocytes Promotes healthy blood clotting Prevents or reverses oxidative damage in the lens (cataract), blood vessel (ASHD,CAD) Augments NO production-endothelial function Middleton E Jr. Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol. 1998;439: Kim YJ, Park HJ, Yoon SH, Kim MJ, Leem KH, Chung JH, Kim HK.Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4 World J Gastroenterol Aug 14;11(30): Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr Oct;88(4):

17 Bioavailable powerful antioxidant > vitamins E, C & beta-carotene i blood pressure & HbA 1 C levels h vitamin C protect LDL & VLDL oxidation Bagchi D, et al., Oxygen Free Radical Scavenging Abilities of Vitamins C and E, and a Grape Seed Proanthocyanidin Extract In Vitro, Research Communications in Molecular Pathology and Pharmacology, 95: , Preuss HG, et al., Chromium, Zinc, and Grape seed Extract (Flavonoids) Can Overcome Age-Related Increases in SBP of Normotensive Rats, Journal of the American College of Nutrition, 16: Abstract 43, 481, 1997 Talpur NA, et al., Effects of Chromium and Grape Seed Extract on the Lipid Profile of Hypercholesterolemic Patients. The FASEB Journal, 14: Abstract 503.8, A727, 2000.

18 Polyphenolic Flavonol synergist Water extracted safer, soluble form not distilled w/ toxic chemicals: acetone, methylene chloride & xylene or toluene.

19 Cold-pressed juice (not skin or rind) Antioxidant & anti-inflammatory Prostate & hormone health promotion Blood vessel health properties Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L (2004). "Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia". J Med Food 7 (3): Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: laboratory and clinical evidence.nutr Cancer Nov;61(6): Talpur NA, et al., Effects of Chromium and Grape Seed Extract on the Lipid Profile of Hypercholesterolemic Patients. The FASEB Journal, 14: Abstract 503.8, A727, Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem Jun; 16(6):

20 Oxidative stress, inflammation, stop Free Radicals + Enhance Repair Unique flavonoid / flavonol protective combo: quercetin dihydrate & soluble OPC ± Organic cold-pressed Pomegranate juice, Transport activated Trophorestorative repair of body structure (collagen) & elasticity (elastin) Highest ORAC free-radical activity

21 Oxygen Radical Absorbance Capacity (ORAC) method of measuring antioxidant capacities in foods.

22 ORAC comparison

23 Typical Use Quercetin dihydrate Pomegran t juice powder Condition OPC Health Maintenance 1000mg 10mg 60mg Daily Duration Acute inflammation e.g., sprained ankle, back Chronic or persisting inflammation 2000mg 20mg 120mg ,000mg mg mg Every 15 minutes to comfort Daily as needed for comfort and to maintain hscrp <0.5

24 Nature s solution to inflammation Topic/Item Quercetin dihydrate + OPC + pomegranate juice powder Professional Anti- Inflammatory Cox-2 Inhibitor NSAID Ibuprofen ORAC highest high none none Heart better OK unhelpful unhelpful Vessels better OK unhelpful unhelpful Diabetes helpful unclear unhelpful unhelpful Brain better OK unhelpful unhelpful Aging better OK unhelpful unhelpful Vision helpful OK unhelpful unhelpful Skin helpful OK unhelpful unhelpful UTI helpful unclear unhelpful unhelpful Sugar helpful unclear unhelpful unhelpful

25 Ascorbates + polyphenolics synergy Buffered ascorbate & quercetin dihydrate are anti-histaminic: safer regulation Quercetin dihydrate enhances reduction of dehydroascorbic acid [oxidized ASC]; recycled back to reduced ascorbate by glutathione*. *Middleton, E. et al "The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer" Pharmacol Rev, 2000; 52 :

26 Ascorbates + polyphenolics Synergy Quercetin dihydrate g + soluble OPC ± pomegranate, tabsules, based on oxidative stress need Clinical pearl: Protect & Activate repair; recycles ascorbate Safer, synergistic flavonoid & flavonol anti-histaminic, steroid sparing Activate elective protectives, detox, recycling - Machha A, Achike FI, Mustafa AM, Mustafa MR.Nitric Oxide.Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas.2007 Jun;16(4): Middleton, E. et al. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev, 2000; 52 :

27 PERQUE Pain Guard Forté PERQUE Potent C Guard PERQUE Repair Guard

28 PERQUE Whey Guard Repair Essential Available Nutrients: Ultra Low Glycemic Load Novel Meal 15 grams of 100% Native Whey Protein Plus 500 mg each Quercetin dihydrate & Soluble OPC 28

29 Health Studies Collegium Evoking Human Healing THE ALKALINE WAY Responses 29

30 Health Studies Collegium Well Guard Program, Physiology 1 st Immune Tolerance Neurohormonal Balance Restore Competences Digestive and Detox 30

31 PERQUE Integrative Health (PIH Fundamentals) STEP1 Determine clients status via online or paper Health Assessment Questionnaire ( HAQ ). STEP2 LRA by ELISA/ACT tests find hidden allergens. STEP3 Personal PERQUE Supplementation program. The Alkaline Way Eat what you can digest, assimilate & eliminate within healthy homeostasis (immune tolerance); An Alkaline diet saves lives 31

32 Immune System: Enhance; Stop Burden 04 Hospitable host to pathogens Allergens provoke symptoms Repair deferred defense 1 st LRA by ELISA/ACT tests functional tests identifying causes of immune overload Innate immune system challenge underlies most metabolic syndrome. Contact ELISA/ACT Biotechnologies, LLC ; clientservices@elisaact.com 32

33 Alkaline Way Benefits 04 Neutralizes excess acids: sustains health Restores digestive & immune system health Regain tolerance to immune reactivities 33

34 Food & Chemical Effects 04 34

35 Alkaline Way Markers of Health & Risk 04 Inflammation = repair deficit: hscrp < 0.5 mg ESR <3mm/hr for men and <7mm/hr for women Detox & Methylation: Homocysteine < 6 mg/dl Oxidation / Antioxidant status: Ox HDL/LDL & 8 oxo-guanine, N.D. Stress Hormone balance: Cortisol/DHEA balance Acid/Alkaline metabolic status: 1 st AM Urine ph Alkaline Way restores, repairs & defends body 35

36 Health Studies Collegium 04 Questions Welcome You have been watching a pre-recorded presentation Please us your questions to clientservices2@perque.com and Dr. Jaffe will respond to them within 24 hours. 36

37 Health Studies Collegium 04 Thank You! We invite you to attend our upcoming webinars LRA by ELISA/ACT tests and Chronic Fatigue Syndrome Thursday, September 27, 2012 at 6 PM & 8 PM EST To register, contact ELISA/ACT Biotechnologies at or clientservices@elisaact.com Restoring Digestive Health Thursday, October 18, 2012 at 6 PM & 8 PM EST To register, contact: PERQUE Integrative Health at or clientservice2@perque.com 37