the minispec mq series TD-NMR Analyzers Innovation with Integrity TD-NMR TD-NMR General Principles the minispec International Standard Methods

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the minispec mq series TD-NMR Analyzers Versatile Time-Domain NMR Analyzer from the NMR Experts.

Chemometric calibration option 21 CFR part 11, IQ/OQ/PQ and GLP compliance Low maintenance Sample temperature range from -100 C to +200 C for unique R&D applications Fully developed magnet design for

and fluorine. In response, RF signals are generated by the sensitive nuclei and the signals are detected by the minispec.

1 the minispec mq series TD-NMR Analyzers Versatile Time-Domain NMR Analyzer from the NMR Experts. Relaxation and diffusion analysis Rapid, non-destructive, solvent free technology No sample preparation Replaces wet chemical and physical tests Simple linear calibration with 3 or more samples Chemometric calibration option 21 CFR part 11, IQ/OQ/PQ and GLP compliance Low maintenance Sample temperature range from -100 C to +200 C for unique R&D applications Fully developed magnet design for utmost speed of analysis Innovation with Integrity TD-NMR General Principles TD-NMR uses a permanent magnetic field and radio frequency (RF) energy to look at NMR sensitive nuclei such as hydrogen and fluorine. In response, RF signals are generated by the sensitive nuclei and the signals are detected by the minispec. The amplitude and duration of these signals are related to the properties of the sample. Unlike other spectroscopic techniques, TD-NMR is unaffected by sample color and surface properties. The minispec is perfectly suited to both QA/QC labs and R&D facilities because it is a nondestructive and non-invasive measurement that requires no sample preparation. the minispec International Standard Methods There are several published and well established methods for the minispec, including a number of international standard methods. In the food industry, Solid Fat Content (SFC) measurements are described in official methods by several organizations, including ISO, IUPAC and AOCS. In agriculture, oil and moisture in oilseeds and residues is determined by international standard methods. In the petrochemical industry, percent hydrogen in hydrocarbons like jet fuel and diesel are the subject of ASTM methods. TD-NMR

Bruker BioSpin 06/12 T137089 minispec Plus m + Software for Routine Applications the minispec Droplet Size Analysis Food Industry Solid Fat Content in fat compositions (AOCS Cd 16b-93, ISO 8292 &

150 methods) Oil and moisture in seeds and oilseed residues (AOCS Ak4-95, ISO 10565 & 10632 methods, USDA GIPSA approved) Solid Fat Content as well as total fat content in chocolate and chocolate

Xylene soluble content in polypropylene Density and crystallinity in polyethylene Rubber content in polymers like ABS or polystyrene Cross-link density of elastomers Petrochemical Industry Hydrogen

determination Moisture and solvents in powders and tablets Contrast agent investigations near MRI fields: 0.25 T, 0.5 T, 0.75 T, 1.0 T and 1.

studies Diffusion experiments Single-Sided NMR Typical minispec Configurations mq60: 1.41 T / 60 MHz mq40: 0.94 T / 40 MHz mq20: 0.47 T / 20 MHz mq10: 0.23 T / 10 MHz mq7.5: 0.17 T / 7.

2 Bruker BioSpin 06/12 T minispec Plus m + Software for Routine Applications the minispec Droplet Size Analysis Food Industry Solid Fat Content in fat compositions (AOCS Cd 16b-93, ISO 8292 & IUPAC methods) Oil and moisture in seeds and oilseed residues (AOCS Ak4-95, ISO & methods, USDA GIPSA approved) Solid Fat Content as well as total fat content in chocolate and chocolate related products Droplet size analysis in O/W and W/O emulsions Oil, water and protein in dry and wet food and feed Textile Industry Spin Finish on Fibres (OPU) Coatings on Polymers Polymer Industry Xylene soluble content in polypropylene Density and crystallinity in polyethylene Rubber content in polymers like ABS or polystyrene Cross-link density of elastomers Petrochemical Industry Hydrogen content in hydrocarbons (ASTM D 7171 method) Oil content in paraffin and wax the minispec Contrast Agent Analysis Pharmaceutical Industry Fat and lean in live mice and rats Contactless weight determination Moisture and solvents in powders and tablets Contrast agent investigations near MRI fields: 0.25 T, 0.5 T, 0.75 T, 1.0 T and 1.5 T Healthcare Industry Fluorine content in toothpaste Melting properties of cosmetics R&D and Academics the minispec Cross Link Density Analysis All types of temperature dependent relaxation time studies Diffusion experiments Single-Sided NMR Typical minispec Configurations mq60: 1.41 T / 60 MHz mq40: 0.94 T / 40 MHz mq20: 0.47 T / 20 MHz mq10: 0.23 T / 10 MHz mq7.5: 0.17 T / 7.5 MHz For QC/QA and R&D applications, the minispec can be delivered with: autosamplers & barcode readers all types of accessories likes baths and blocks sample tubes with sizes from 7.5 to 50 mm, thus perfectly suited also for inhomogenous samples Software for R&D Users Highlights of R&D features: TD-NMR from 2 to 65 MHz a wide selection of intelligent Plug & Play probes for fast and tool-free exchange, e.g. for hydrogen and fluorine analysis a variety of magnet/probe combinations for special needs fully remote temperature control from -100 C to +200 C relaxation time determination with a large number of echoes/ data points diffusion-type experiments with state-of-the-art gradient technology shaped RF pulses and linear transmitter for selective and spin lock experiments powerful experiment editor (ExpSpel) for application development Bruker BioSpin is ISO 9001 certified. Bruker BioSpin cmr@bruker-biospin.com Magnetic safety measures apply to the operation of the minispec. Bruker BioSpin is continually improving its products and reserves the right to change specifications without notice.

3 Food & Feed Industry Fast and Reliable Quality Control by Time Domain NMR Innovation with Integrity TD-NMR

4 Solutions for the Food & Feed Industries QA / QC and Research with Ease To determine the essential properties of food and feed, Bruker developed a powerful device for fast and reliable answers throughout all production and processing steps: the minispec based on Time Domain (TD)-NMR. This method is well recognized due to its time saving qualities and simplicity of operation. No chemicals and consumables are required. Moreover, a large variety of food can be analyzed with minimal sample preparation. TD-NMR is an inherently quantitative method, insensitive to matrix effects that occur in many complex foods and food intermediates. TD-NMR provides clear advantages over wet-chemical and other spectroscopic methods. It has been adapted in various AOCS, ISO, and IUPAC standard methods as well. Bruker started its development in close partnership with major food companies in the 1970 s and continues to innovate to this day. Our strong commitment to the food and feed industries has led to many dedicated applications. The most notable is the Solid Fat Content determination (SFC) in fat compositions. The Range of Applications International standard applications Solid Fat Content (SFC) Determination ISO 8292 AOCS Cd 16b-93; AOCS Cd IUPAC Oil & Moisture Determination in Seeds and Residues ISO 10565; ISO AOCS Ak4-95 USDA GIPSA approved Key applications Droplet Size Distribution of Oil in Water / Water in Oil Emulsions Total Fat Content in Chocolate Further applications Total Fat and Moisture Content in in Chips in Milk Powder in Food Snacks Flavor / Oil Content Determination Oil and Moisture Determination (> 10 % moisture content) The Key Advantages Fast and accurate The measurement takes typically less than one minute. Minimal sample preparation and high accuracy (e.g % for total fat determination) make the minispec analysis the method of choice for Quality Control (QC) in the food industry. Reproducible & non-destructive The repeatability and reproducibility of the minispec analysis are significantly better compared to wetchemical methods. The measurement is non-invasive, non-destructive and allows heterogeneous samples to be analyzed without grinding or homogenization. Safe & simple Raw materials and foodstuffs are measured without grinding, cutting, or any other sample preparation. No chemicals such as solvents are required. Compact and robust The small footprint of the minispec unit allows flexible placement anywhere in the production facility. No dedicated supplies or consumables are required. 2

Application Examples Oil & Moisture Determination in Seeds and Residues This method is the international standard to measure the

The oil content determines the value of the crop and thus, it is of utmost importance to farmers and oil mills.

Droplet Size Distribution of Water in Oil and Oil in Water Emulsions With the minispec NMR method, the droplet size distribution in

For example, this is an important parameter since the water content and droplet size distribution influence shelf life, taste, and

Oil and Moisture Determination (>10 % moisture) For foodstuffs like meat with moisture contents exceeding 10 %, a TD-NMR

5 Application Examples Oil & Moisture Determination in Seeds and Residues This method is the international standard to measure the oil and moisture content in seeds and seed residues. The oil content determines the value of the crop and thus, it is of utmost importance to farmers and oil mills. The moisture influences the shelf life and is therefore controlled frequently. Droplet Size Distribution of Water in Oil and Oil in Water Emulsions With the minispec NMR method, the droplet size distribution in water in oil emulsions such as margarine or mayonnaise are measured conveniently and noninvasively. For example, this is an important parameter since the water content and droplet size distribution influence shelf life, taste, and oral sensation. Solid Fat Content (SFC) Determination This international standard method is used to measure the melting profile of fat composition. It is important to characterize it in detail to ensure proper performance of many final customer products, such as margarine or chocolate. Total Fat Content in Chocolates The total fat content in chocolate can be measured quickly and conveniently without the need for any chemicals or sample preparation. The method can be applied to chocolate liquors, intermediate products and final chocolate products, too. Oil and Moisture Determination (>10 % moisture) For foodstuffs like meat with moisture contents exceeding 10 %, a TD-NMR application is available that uses a chemo-metric data analysis to determine the fat content of the sample. This way, time-consuming predrying of the sample can be avoided. Total Fat and Moisture Content in Food Snacks The minispec provides an easy analysis of fat and moisture content (moisture <10 %) in a wide range of foods such as chips, crisps, pretzels, etc. Total Fat and Moisture in Milk and Cacao Powder In these economically important foodstuffs, the fat and moisture content is routinely measured with Bruker s minispec in QC. Total Fat Content in Feeds The total fat content of pet food can be determined in a rapid and easy manner; for example with dog and cat food. 3

the minispec mq one TD-NMR Analyzers

the minispec mq one TD-NMR Analyzers The best minispec TD-NMR just got better. The mq one offers unparalleled performance in an all-in-one design for dedicated industrial quality control applications.