Perinatal Nutrition. Disclosure Statement. Annual Meeting of the NASPGHAN. Keynote Lecture: Nutrients in the Perinatal Environment: Lessons Learned
|
|
|
- Poppy Holmes
- 5 years ago
- Views:
Transcription
1 Annual Meeting of the NASPGHAN Chicago, ILL October 10-13, 2013 Keynote Lecture: Nutrients in the Perinatal Environment: Lessons Learned Allan Walker, M.D. Boston, MA Disclosure Statement Dr. Allan Walker has disclosed the information listed below. Any real or apparent conflict of interest related to the content of the presentation has been resolved Organization Name Dannon/Yakult International Mead Johnson Nutritionals NUTEK Inc. Affiliation/financial interest Scientific Advisory Board Research Grant & Scientific Advisory Board Scientific Advisory Board Perinatal Nutrition Diet and microbiota Microbiota and disease Preconception and intrauterine nutrition Neonatal nutrition Clinical consequences Summary and conclusions 1
2 Perinatal Nutrition The Hygiene Hypothesis has Evolved Into A New Paradigm Western Society Nutrition and the effects it has on gut colonization and immune responses are an increasingly likely explanation for the greater incidence of inflammatory diseases such as asthma and type-1 diabetes in developed countries Nature Immunology 12:5-9, 2011 Perinatal nutritional programming: A convergence of the hygiene and fetal programming hypotheses Accumulating evidence suggests that nutrition during pregnancy and early postnatal life is one of the most important environmental cues that programs microbiological, metabolic and immunologic development which in turn influences long-term health from Utrecht, Netherlands Symposium Bringing Science to Early Life Nutrition Am J Clin Nutr. 2013; 98(suppl):586S-593S 2
3 Perinatal Nutrition Does Diet Affect Disease Burden? Immune disorders Obesity/ Metabolic Syndrome New Engl J Med 2002;347: Science September 2012 Am J Clin Nutr. 1996;63:741-5 Acquired Western Lifestyle (Nutrition) Affects Disease Expression In Immigrants Nat Rev Gastroenterol Hepatol. 2012;9:
4 Perinatal Nutrition Diet and microbiota Diet And Its Effects On Gut Microbiota PNAS. 2010;107: Science 2011;333:101 Diet And Its Effects On Gut Microbiota Three predominate enterotypes Composition Enterotypes and Diet Nature 2011;473:176 Science 2011;334:107 4
5 Perinatal Nutrition Diet and microbiota Microbiota and disease Trialogue Between Commensals, Gut Associated Immune Tissue And Intestinal Epithelium Trialogue Metabolic Effect Nat Rev Gastroenterol Hepatol. 2012;9: Immunological Effect Science. 2010;328: Nat Med. 2011;17: Dybiosis in Clinical Disease Pediatrics. 2012;129:
6 Microbiota As An Intermediate In Disease Expression Obesity Nat Rev Gastroenterol Hepatol. 2012;9: Metabolic Syndrome Nature. 2006;444: Kwashiorkor Science. 2010;328: Science. 2013;339: Inflammatory Links Between Obesity And Metabolic Disease J Clin Invest. 2011;121: Relationship Between Obesity And Allergic Disease Mechanism Leptin Allergy. 2007;62: J Allergy Clin Immunol. 2005;115:103-9 Adiponectin Leptin and Treg J Clin Endocrinol Metab. 2005;90: Immunity. 2007;26:
7 Perinatal Nutrition Diet and microbiota Microbiota and disease Preconception and intrauterine nutrition What Is The Impact Of Maternal Pre-conception BMI On Childhood Obesity? Odd Ratio of Childhood Overweight Int J Obes (Lond). 2011;35:522-9 Gut Microbiota In Pregnant Women: Role Of Weight Gain and BMI Microbiota and Weight Gain Microbiota and BMI Br J Nutr. 2010;104:
8 Role Of High Fat Obesogenic Diet On Placental Hemodynamics And Stillbirth Placental Volume Blood Flow Inflammatory Mediator TLR-4 MCP-1 IL-1 Endocrinology. 2011;152: Metabolic Syndrome In Childhood: Role of Birth Weight and Gestational Diabetes LGA Large For Gestational Age MS Metabolic Syndrome AGA Appropriate For Gestational Age GDM Gestational Diabetes Mellitus Pediatrics. 2005;115:e290-6 Diet-Induced Obesity During Pregnancy Results In Offspring Obesity And Hypertension Offspring Obesity Offspring Hypertension Metabolic Changes Hypertension. 2008;51:
9 Intrauterine Nutrition: Immunoprogramming effect Vitamin D Omega 3 FA Probiotics Farm animal exposure and unpasteurized cow s milk ingestion Intrauterine Nutrition : Immunoprogramming Vitamin D and wheezing Prenatal Vit. D and tolerogenic dendritic cells Am J Clin Nutr. 2007;85: Clin. & Exp Allergy 2009;40: Intrauterine nutrition : immunoprogramming -3FA and allergy Acta Paediatr. 2009;98: J All. Clin Immun. 2003;112:
10 Polyunsaturated Fatty Acid (W6/W3 Ratio) Effect During Pregnancy And Lactation On Immune Responses DTH- Th1 Allergic Response Th2 J. Dev. Origins of Health and Diseases 2011;2: Intrauterine Nutrition : immunoprogramming Immunobiology of farm exposure Nat Rev Immunol. 2010;10: Tregs in cord blood Percent demethylation FoxP3 demethylation (epigenetic effect) Pregnancy farm milk * Pregnancy no farm milk * p = 0.02 J All. Clin Immun. 2009;123: Prenatal Animal Contact And Non-pasteurized Cow Milk Ingestion On Innate Immune Function And Atopic Dermatitis (AT) Negative Association With TLRs in Cord Blood Prevalence of AT in First 2years J Allergy Clin Immunol. 2011;127:
11 Convergence Of The Hygiene And Fetal Programming Hypothesis Asthma Expression in Animal Model After Intrauterine Probiotic Exposure J Exp Med. 2009;206: Perinatal Nutrition Diet and microbiota Microbiota and disease Preconception and intrauterine nutrition Neonatal nutrition Breast Milk and Initial Colonization Standard Culture Techniques Genomic Analysis Bacteroides Bifidobacterium Pediatrics 1983; 72: PLoS One. 2012;7:e44595 SIgA at 6 months (ug/ml) siga Expression 25 r = 0.58, p = Number of Bifidobacterium species at 1 month IL-6 (pg/ml) LPS-induced IL r = -0.79, p = ND 1e-5 1e-4 1e-3 1e-2 1e Bacteroides fragilis at 1 month (relative %) Clin Exp Allergy. 2009;39:
12 Breast Milk and Initial Colonization Genome Biol. 2012;13:r32 What Is The Molecular Effect Of HMO s On Bacterial Gene Expression? HT-29 HMO Inulin Fold induction vs. LAC B. infantis ZO-1 Occludin JAM-A FOS GOS PLoS One. 2011;6:e17315 Fold induction vs. LAC Caco-2 SELPLG P-selectin glycoprotei n ligand-1 SERPING alpha-1 proteinase inhibitor B. infantis JPGN 2012; 55: Microbial Metabolites, SCFA, stimulates Treg Cells Science 2013:341;463 Science 2013:341;570 12
13 Perinatal Nutrition Diet and microbiota Microbiota and disease Preconception and intrauterine nutrition Neonatal nutrition Clinical consequences Clinical Disease Protection (longterm health effects) Obesity Type II diabetes Allergy Autoimmune disease Cardiovascular health 1. Initial weight gain Breastfeeding and Obesity 0.8 CDC WHO Age (months) 2. Longterm single effect on weight JAMA 2001;285:
14 Breast Feeding longterm health effects Type II Diabetes Study Martin, 71y (11) Fall, 64y (10) Rich-Ewards, 59y (14) Martin, 45-59y (18) Ravelli, 50y (6) Pettittt, 10-39y (21) Young, 13y (22) Overall Am J Clin Nutr. 2006;84(5): Cardiovascular Disease Hazard Ratio Odds of type 2 diabetes Breastfeeding lower Formula feeding lower Asthma Recurrent wheeze 1 y 2 y 4 y 8 y Overall effect 0-8 y Overall effect after exclusion Asthma 1 y 2 y Epidemiology. 2004;15:550-6 Celiac Disease Peters et al Faith Magnusson et al Inarsson et al Ascher et al Combined (fixed) 4 y 8 y Overall effect 0-8 y Overall effect after exclusion Adjusted odds ratios (95% CI) J Allergy Clin Immun. 2010;125: Odds ratio (95% confidence interval) Arch Dis Child. 2006;91:39-43 Perinatal Nutrition Diet and microbiota Microbiota and disease Preconception and intrauterine nutrition Neonatal nutrition Clinical consequences Summary and conclusions Summary and Conclusions A new hygiene hypothesis has evolved implicating perinatal diet in disease states Diet affects intestinal colonization which is associated with metabolic and immune-mediated disease Inflammation links obesity and metabolic disease There is a convergence of the hygiene and fetal programming hypothesis A healthy diet during the perinatal period may prevent disease in later life 14
Diet during pregnancy. and atopic disease
Diet during pregnancy and atopic disease 1. Elimination diet 2. Probiotics 3. LCPUFA 4. Conclusions Maternal elimination diet during pregnancy? NO! Prescription of of an an antigen avoidance diet to to
Intestinal Microbiota in Health and Disease
Intestinal Microbiota in Health and Disease February 27, 2015 Master s Course in Gastroenterology Prof. Kathy McCoy 1 Overview Overview of Gut Microbiota Microbiota in Health Microbiota in Disease 2 Gut
BREAST MILK COMPONENTS AND POTENTIAL INFLUENCE ON GROWTH
Note: for non-commercial purposes only CAMPUS GROSSHADERN CAMPUS INNENSTADT BREAST MILK COMPONENTS AND POTENTIAL INFLUENCE ON GROWTH Maria Grunewald, Hans Demmelmair, Berthold Koletzko AGENDA Breast Milk
Microbiome, allergy and inflammatory diseases
Microbiome, allergy and inflammatory diseases 1. NCDs & inflammation 2. Microbiome &GI inflammatory pathologies 3. Microbiome & autoimmunity 4. Microbiome & neurophaties 5. Microbiome & NAFLD 6. Microbiome
The Intestinal Microbiota and the Developing Immune System
The Intestinal Microbiota and the Developing Immune System 4 Feb 2016 The Intestinal Microbiota 10 fold more bacterial cells than human cells 100-1000 fold more bacterial genes than human genes Why does
Role of the Gut Microbiota in Autoimmunity
Role of the Gut Microbiota in Autoimmunity Pavan Bhargava, MD - Neuroimmunology Fellow Division of Neuroimmunology and Neurological Infections Johns Hopkins University, Baltimore, MD. May, 2015 None Disclosures
The role of nutrition in optimum gastrointestinal health
The role of nutrition in optimum gastrointestinal health Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor University Distinguished Teacher-Scholar University of Illinois
Gut microbiota, bacterial metabolites and metabolite sensing GPCRs protect against food allergy
Gut microbiota, bacterial metabolites and metabolite sensing GPCRs protect against food allergy Laurence Macia, PhD 5 th European Immunology & Innate Immunity Increased prevalence of inflammatory diseases
Allergy and Breast Feeding CON (?) Hugo Van Bever Department of Pediatrics NUHS Singapore
Allergy and Breast Feeding CON (?) Hugo Van Bever Department of Pediatrics NUHS Singapore WAC, Cancun, December 2011 As a pediatrician are you crazy? Breast milk is the best! 1. Nutritional 2. Psychological
The impact of the microbiome on brain and cognitive development
The Gut-Brain Axis The impact of the microbiome on brain and cognitive development Diane Stadler, PhD, RD Oregon Health & Sciences University, Portland, Oregon Lao-American Nutrition Institute With acknowledgements
The Epigenetics of Obesity: Individual, Social, and Environmental Influences. K. J. Claycombe, Ph.D.
The Epigenetics of Obesity: Individual, Social, and Environmental Influences K. J. Claycombe, Ph.D. What can happen to our gene(s) that would cause obesity? Modification via Epigenetic alterations C
Metabolic Programming. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD
Metabolic Programming Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD nutritional stress/stimuli organogenesis of target tissues early period critical window consequence of stress/stimuli are
Probiotics in Pediatric Health. AANP Annual Convention
Probiotics in Pediatric Health AANP Annual Convention Don Brown, ND July 12, 2017 Human Microbiome Richness and Metabolic Markers Human gut microbial composition was studied in 292 Danish adults Individuals
Gut Microbiome Essentials
CORE COMPONENTS I: Gut Microbiome Essentials 2016 Tom Fabian, PhD Module Outline 1. Microbiome overview: getting a sense of the microbiome, research, what we know 2. Bacteria: features, functions, communities
Persistent food allergy might present a more challenging situation. Patients with the persistent form of food allergy are likely to have a less
Iride Dello Iacono Food allergy is an increasingly prevalent problem in westernized countries, and there is an unmet medical need for an effective form of therapy. A number of therapeutic strategies are
Vishwanath Pattan Endocrinology Wyoming Medical Center
Vishwanath Pattan Endocrinology Wyoming Medical Center Disclosure Holdings in Tandem Non for this Training Introduction In the United States, 5 to 6 percent of pregnancies almost 250,000 women are affected
Mikrobiom und Ernährung. Ruth Ferstl
Mikrobiom und Ernährung Ruth Ferstl 18.09.2017 Gemeinsamkeiten? Zellen: - 10% Mensch - 90% Bakterien Gene: - 1% Mensch - 99% Bakterien Everything that we eat, drink, touch, and breathe is reflected in
Gut Lung Axis Implication of the Gut Microbiota beyond its niche
Gut Lung Axis Implication of the Gut Microbiota beyond its niche Reema Subramanian PhD Candidate (4 th year) Supervisor: Prof. Margaret Ip Department of Microbiology, CUHK Joint Graduate Student Seminar
March 30, ASN Comments and Additions to Select, Proposed Topics and Questions are in Red Below
March 30, 2018 The American Society for Nutrition (ASN) appreciates the opportunity to comment on the proposed topics and supporting scientific questions that will be considered during the development
Hygiene Hypothesis: 10 years later. Christina Ciaccio MD, MSc Assistant Professor The University of Chicago
Hygiene Hypothesis: 10 years later Christina Ciaccio MD, MSc Assistant Professor The University of Chicago none Disclosures Definitions Microbe: Microscopic organism Microbiota: Microbial community Definition
Exploration of the microbiota in inflammatory diseases. Matthew Stoll MD Research Computing Day September 13, 2012
Exploration of the microbiota in inflammatory diseases Matthew Stoll MD Research Computing Day September 13, 2012 We re surrounded by bugs Human body contains 100 trillion microbes Out-number human cells
Early Nutrition: the opportunity for childhood obesity prevention
Early Nutrition: the opportunity for childhood obesity prevention Prof. Cristina Campoy Department of Paediatrics. University of Granada. Spain Member of the ESPGHAN Committee on Nutrition HIGH LEVEL GROUP
The human microbiome. Shantelle Claassen-Weitz Division of Medical Microbiology Department of Pathology.
The human microbiome Shantelle Claassen-Weitz Division of Medical Microbiology Department of Pathology tellafiela@gmail.com Source: Hamzelou, J. (2012) New Sientist, 14 April 2012, 6-7 Initial acquisition
FOOD ALLERGY AND WHEEZING
FOOD ALLERGY AND WHEEZING Jarungchit Ngamphaiboon Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand The pattern of allergy in developed countries has been changing
Gut Immunology. goes Africa October 2015
Gut Immunology Michael J. Lentze Children s Hospital Medical Center University Hospitals Bonn/Germany and Givi Zhvania Academic Clinic of Pediatry Tbilisi/ Georgia goes Africa October 2015 History A 16
The importance of early complementary feeding in the development of oral tolerance: Concerns and controversies
The importance of early complementary feeding in the development of oral tolerance: Concerns and controversies Prescott SL, Smith P, Tang M, Palmer DJ, Sinn J, Huntley SJ, Cormack B. Heine RG. Gibson RA,
7/30/2018. Nutricia North America 1. Learning Objectives
Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease Kelly Tappenden, Ph.D, R.D. Kelly Tappenden, Ph.D, R.D. Professor and Department Head Department of
Diet and the Gut Microbiome
Diet and the Gut Microbiome Jean Kerver, PhD, MSc, RD March 15, 2018 COMMUNITY CAMPUSES & CLINICAL SITES Jean Kerver, PhD, MSc, RD kerverje@msu.edu 1 Diet and the Gut Microbiome Does the type and amount
Feed those babies some peanut products!!!
Disclosures Feed those babies some peanut products!!! No relevant disclosures Edward Brooks Case presentation 5 month old male with severe eczema starting at 3 months of age. He was breast fed exclusively
Are Fake Sugars Contributing to the Obesity Epidemic? Prenatal and early-life exposure to non-nutritive sweeteners and cardiometabolic health
Are Fake Sugars Contributing to the Obesity Epidemic? Prenatal and early-life exposure to non-nutritive sweeteners and cardiometabolic health Meghan Azad, PhD Children s Hospital Research Institute of
Supporting improved nutrition for appropriate growth and improved long-term health outcomes
Supporting improved nutrition for appropriate growth and improved long-term health outcomes ZTC831/07/2015 The first 1000 days are a critical period for growth and development Achieving optimal nutrition
Professor, of Human Nutrition
ω-3 fatty acids: The Effects during Pregnancy and Breast feeding Antonis Zampelas Professor, of Human Nutrition Director, Laboratory of Food Chemistry and Human Nutrition, Department of Food Science and
Maternal Child Health and Chronic Disease
Maternal Child Health and Chronic Disease The Odd Couple or A Marriage Made in Heaven? AMCHP Women and Perinatal Health Information Series July 17, 2008 Joan Ware, MSPH, RN, Consultant, Women s s Health
Food Allergy in Turkey
Food Allergy in Turkey Isil B Barlan Pediatric Allergy/ Immunology Marmara University Istanbul Brussels/ 07 Age distribution in Turkey over 65 % 65 %5 % 30 0-14 15-64 Median age 50 45 40 35 30 25 20 15
OHSU Moore Institute for Nutrition & Wellness OHSU School of Medicine. Diane Stadler, PhD, RD Graduate Programs in Human Nutrition
OHSU Moore Institute for Nutrition & Wellness OHSU School of Medicine Diane Stadler, PhD, RD Graduate Programs in Human Nutrition Moore Institute for Nutrition & Wellness There is no question that a nutritious,
Early life determinants of Non-Alcoholic Fatty Liver Disease and NASH DR JULIANA MUIVA-GITOBU KENYA PAEDIATRIC ASSOCIATION CONFERENCE APRIL 2016.
Early life determinants of Non-Alcoholic Fatty Liver Disease and NASH DR JULIANA MUIVA-GITOBU KENYA PAEDIATRIC ASSOCIATION CONFERENCE APRIL 2016. Outline Definition NAFLD and NASH Magnitude of the problem
Pro/Con: Pets Prevent Allergies and Asthma
Slide 1 Pro/Con: Pets Prevent Allergies and Asthma Slide 2 Special thanks to: n Dr. Dennis Ownby n Dr. Matt Perzanowski n Dr. Erica von Mutius and Dr. Charlotte Braun-Fahrlander n Dr. Andy Liu n Colleagues
Microbiome and Asthma
제 12 차천식연구회 COPD 연구회공동심포지엄 Microbiome and Asthma 한양대학교병원호흡기알레르기내과 김상헌 Disclosure 내용 1 Lung Microbiome 2 Lung Microbiome and Asthma 3 Gut Microbiome and Asthma Microbiome and Microbiota human microbiome
Breastfeeding and the Microbiome
Breastfeeding and the Microbiome JENNY WALTERS MPH, IBCLC Objectives At the conclusion of this session, participants will be able to: Identify ways the microbiota is passed from mother to baby Identify
Prevalence and predicted ongoing rise of obesity among preschool children
Prevalence and predicted ongoing rise of obesity among preschool children de Onis M et al. Am J Clin Nutr 2010;92:1257-1264 Lakshman R, et al. Circulation 2012;126:1770-9. persistence of obesity from childhood
Developmental Origins of Health and Disease
Developmental Origins of Health and Disease Roles of Maternal Nutrition Matthew W. Gillman, MD, SM Harvard University Thanks to Faculty, Trainees, & Staff Obesity Prevention Program Department of Population
Early life nutrition and Inflammation
Early life nutrition and Inflammation Harry J McArdle and Graham Devereux Rowett institute of Nutrition and Health, University of Aberdeen. Aberdeen Royal Infirmary. The process of development Critical
VITAMINS, MINERALS AND THE GUT
VITAMINS, MINERALS AND THE GUT Nutrients Looking at individual nutrients that are involved with gut health can be misleading This is not about taking individual nutrients It supports more a whole food
Immunity & Metabolism Human Microbiome Systems Nutrition. Food Bioactives Asian Consumers
INFANT HEALTH Clare Wall, PhD, Assoc. Professor, The University of Auckland, and Martin Kussmann, PhD, Professor, The Liggins Institute, The University of Auckland. Chief Scientist HVN On behalf of the
A CENTRAL ROLE FOR MICROBIOTA IN PREGNANCY AND EARLY LIFE? Sacha Sidani, MD, FRCPC NASOM/GÉMOQ Annual Conference 2016
A CENTRAL ROLE FOR MICROBIOTA IN PREGNANCY AND EARLY LIFE? Sacha Sidani, MD, FRCPC NASOM/GÉMOQ Annual Conference 2016 Disclosure 2 Objectives Review the basic concepts of microbiota structure and function
Tolerance 2. Regulatory T cells; why tolerance fails. Abul K. Abbas UCSF. FOCiS
1 Tolerance 2. Regulatory T cells; why tolerance fails Abul K. Abbas UCSF FOCiS 2 Lecture outline Regulatory T cells: functions and clinical relevance Pathogenesis of autoimmunity: why selftolerance fails
Vitamina D: un ormone multifunzione
Vitamina D: un ormone multifunzione Introduction And Infections Diego Peroni Clinica Pediatrica Universita di Ferrara Food Allergy Asthma Conclusions diego.peroni@unife.it Holick, M. F. J. Clin. Invest.
Comparison of cow-milk, breast milk and formula: nutritional, immunologic and developmental considerations
Comparison of cow-milk, breast milk and formula: nutritional, immunologic and developmental considerations Eugene Dinkevich, MD Downstate Healthy Lifestyles Program Department of Pediatrics SUNY-Downstate
The New GDM Screening Guidelines. Jennifer Klinke MD, FRCPC Endocrinologist and Co director RCH Diabetes in Pregnancy Program
The New GDM Screening Guidelines Jennifer Klinke MD, FRCPC Endocrinologist and Co director RCH Diabetes in Pregnancy Program Disclosures Current participant (RCH site) for MiTy study Metformin in women
Maternal and Infant Nutrition Briefs
Maternal and Infant Nutrition Briefs A research-based newsletter prepared by the University of California for professionals interested in maternal and infant nutrition March/April 2003 New Guidelines on
Asthma. In Europe ~30 million children and adults under 45 have asthma. On average 3 people a day die from asthma in the UK
Dr Neil Williams Nottingham Trent University College of Science and Technology Department of Sport Science Email: neil.williams@ntu.ac.uk @NeilW_ExPhys 1 Asthma In Europe ~30 million children and adults
Probiotic action and health and well-being of children. Seppo Salminen Functional Foods Forum Finland
Probiotic action and health and well-being of children Seppo Salminen Functional Foods Forum Finland DEFINITION OF A PROBIOTIC Probiotic:...a living microbial preparation, which beneficially influences
PROBIOTICS IN THE FIRST 1000 DAYS
PROBIOTICS IN THE FIRST 1000 DAYS 25 TH APRIL 2018 Rocio Martin Director Danone Nutricia Research Singapore 1 OUTLINE Probiotics Relevance of the first 1000 days Microbiota and health during the 1000 days
Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease. Kelly Tappenden, Ph.D, R.D.
Probiotics, Prebiotics and the Role of the Infant Intestinal Microbiota in Health and Allergic Disease Kelly Tappenden, Ph.D, R.D. Kelly Tappenden, Ph.D, R.D. Professor and Department Head Department of
Today s talk 21/05/2017. Microbiota: the consequence of evolution! Probiotics and mucosal immunity interactions in early life.
Europe Probiotics and mucosal immunity interactions in early life Almere, 09 Mei, 2017 Today s talk The dynamics of the microbiota The required signals from the environment Not all signals (probiotics!)
Reply: Gut microbiota diversity and atopic disease: Does breast-feeding play a role?
Reply: Gut microbiota diversity and atopic disease: Does breast-feeding play a role? Thomas Abrahamsson, Hedvig E. Jakobsson, Anders F. Andersson, Bengt Bjorksten, Lars Engstrand and Maria Jenmalm Linköping
Gestational Diabetes: Long Term Metabolic Consequences. Outline 5/27/2014
Gestational Diabetes: Long Term Metabolic Consequences Gladys (Sandy) Ramos, MD Associate Clinical Professor Maternal Fetal Medicine Outline Population rates of obesity and T2DM Obesity and metabolic syndrome
CLN Students' graduation projects
Academic year Semester CLN Students' graduation projects Program Section # Project Title supervisor Female 2 Female 2 30- Female and breast cancer 2 3 H (2009- Female 2 Eating habbits of breast cancer
Evaluating next generation ingredients to support immune health. Dr Carrie Ruxton Freelance Dietitian
Evaluating next generation ingredients to support immune health Dr Carrie Ruxton Freelance Dietitian What is the immune system? Innate Physical barriers i.e. skin Natural killer cells Macrophages Acquired
Necrotizing Enterocolitis: The Role of the Immune System
Necrotizing Enterocolitis: The Role of the Immune System Patricia Denning, M.D. Associate Professor in Pediatrics Division of Neonatology Emory University School of Medicine What is NEC? What is NEC? Necrotizing
Healthy Nutrition & Life style Let us start at the beginning!
Faculty of Science Departement Pharmaceutical Sciences Healthy Nutrition & Life style Let us start at the beginning! Irene LENOIR-WIJNKOOP P.I.Lenoir-Wijnkoop@uu.nl Disclosures Director Public Health &
Prof C.S. Yajnik MD,FRCP KEM HOSPITAL, PUNE, INDIA
Trans-generational impact of the double burden of malnutrition A case study from India Prof C.S. Yajnik MD,FRCP KEM HOSPITAL, PUNE, INDIA www.kemdiabetes.org Life can only be understood backwards - Soren
The Milk of Paradise?: New Research on Maternal Obesity, Breast Milk Quality, and Infant Metabolic Health
The Milk of Paradise?: New Research on Maternal Obesity, Breast Milk Quality, and Infant Metabolic Health Ellen W. Demerath, PhD Associate Professor, Division of Epidemiology and Community Health School
Like mother, like offspring Does maternal overweight predict health outcomes?
Like mother, like offspring Does maternal overweight predict health outcomes? Patricia Iozzo, MD, PhD Institute of Clinical Physiology National Research Council (CNR), Pisa, Italy Brussels 16 October 2017
Feeding the Small for Gestational Age Infant. Feeding the Small for Gestational Age Infant
Feeding the Small for Gestational Age Infant Feeding the Small for Gestational Age Infant What s the right strategy? Infants born small-for-gestational age (SGA) are at higher risk for adult diseases.
Links between gut, allergy and obesity?
Centre for Environment and Toxicology, DHI Links between gut, allergy and obesity? Anders Permin, HoD, DVM, PhD The consortium DanORC Background Background Obesity: Globally > 1 billion overweight, at
Follow-up of Celiac Disease
Follow-up of Celiac Disease Benjamin Lebwohl MD, MS Director of Clinical Research Celiac Disease Center Columbia University celiacdiseasecenter.org BL114@columbia.edu @BenjaminLebwohl Disclosures None
Cynthia Belew, CNM, WHNP C Associate Clinical Professor University of California San Francisco
Cynthia Belew, CNM, WHNP C Associate Clinical Professor University of California San Francisco cynthia.belew@ucsf.edu Be educated about and have index of suspicion for gluten sensitivity disorders Be alert
Gut microbiota, metabolic syndrome, obesity and the nutrient sensor pathways
Gut microbiota, metabolic syndrome, obesity and the nutrient sensor pathways Department of Gastroenterology, Endocrinology & Metabolism Medical University Innsbruck Herbert Tilg Nothing to disclose Fig.
Gut microbiota at 16 weeks and future hypertensive disorders of pregnancy
Gut microbiota at 16 weeks and future hypertensive disorders of pregnancy Marloes Dekker Nitert m.dekker@uq.edu.au Blood pressure (mmhg) Butyrate producing capacity (centroid value) Blood pressure and
N-3 polyunsaturated fatty acids and allergic disease
N-3 polyunsaturated fatty acids and allergic disease Current Opinion in Clinical Nutrition and Metabolic Care Volume 7(2) March 2004 pp 123-129 Susan Prescott and Philip Calder Abbreviations DHA: EPA:
GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH?
GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? Corrie Whisner, PhD School of Nutrition and Health Promotion Arizona State University Center for Research on Ingredient Safety Annual Meeting
METABOLIC SYNDROME IN REPRODUCTIVE FEMALES
METABOLIC SYNDROME IN REPRODUCTIVE FEMALES John J. Orris, D.O., M.B.A Division Head, Reproductive Endocrinology & Infertility, Main Line Health System Associate Professor, Drexel University College of
Human breast milk mirna, maternal probiotic supplementation and atopic dermatitis in offsrping
Human breast milk mirna, maternal probiotic supplementation and atopic dermatitis in offsrping Melanie Rae Simpson PhD candidate Department of Public Health and General Practice Norwegian University of
The prevalence of atopic diseases in childhood
Paediatrica Indonesiana VOLUME 54 March NUMBER 2 Original Article Caesarean delivery and risk of developing atopic diseases in children Anak Agung Tri Yuliantini 1, Mohammad Juffrie 2, Ketut Dewi Kumara
HUMAN GUT MICROBIOTA
HUMAN GUT MICROBIOTA Patrizia Brigidi Department of Pharmaceutical Sciences, University of Bologna, Italy patrizia.brigididi@unibo.it The Gut-Liver axis: a bidirectional relation in health and disease
Epatite B: fertilità, gravidanza ed allattamento, aspetti clinici e terapeutici. Ivana Maida
Epatite B: fertilità, gravidanza ed allattamento, aspetti clinici e terapeutici Ivana Maida Positivity for HBsAg was found in 0.5% of tested women In the 70s and 80s, Italy was one of the European countries
COMPLICATIONS OF PRE-GESTATIONAL AND GESTATIONAL DIABETES IN SAUDI WOMEN: ANALYSIS FROM RIYADH MOTHER AND BABY COHORT STUDY (RAHMA)
COMPLICATIONS OF PRE-GESTATIONAL AND GESTATIONAL DIABETES IN SAUDI WOMEN: ANALYSIS FROM RIYADH MOTHER AND BABY COHORT STUDY (RAHMA) Prof. Hayfaa Wahabi, King Saud University, Riyadh Saudi Arabia Hayfaa
CIRCULAR OF INFORMATION PASTEURIZED HUMAN MILK
CIRCULAR OF INFORMATION PASTEURIZED HUMAN MILK PLEASE READ CAREFULLY 1. General Information This circular supplements the information contained on the labels of bottles of pasteurized human milk. The Public
The Gut Microbiome: 101 Justin Carlson University of Minnesota
The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C. 2003 Human Gut Microbes Associated With Obesity Ley et al., Nature. 2006. Consumer Driven Science For Better of
Breast, Bottle & Childhood Obesity
Breast, Bottle & Childhood Obesity Disclosure: I earn royalties from book & app sales Nancy Mohrbacher, IBCLC, FILCA Overweight 85 th percentile; obesity 95 th percentile % of overweight children 20 18
The Enigma of the Infant Microbiome
The Enigma of the Infant Microbiome 3 rd Microbiome R&D and Business Collaboration Forum Europe London, April 2016 David J. Kyle, CEO, Evolve Biosystems Inc Microbiome diversity is a good thing. Modern
How Gut Microbes Alter the Risks of RSV Infection and Asthma in Mice and Men
How Gut Microbes Alter the Risks of RSV Infection and Asthma in Mice and Men Dennis R. Ownby MD Medical College of Georgia at Augusta University Disclosures No commercial financial relationships No discussion
Prevention of MTCT OF HTLV
Prevention of MTCT OF HTLV Sasan.ms May 2018 Determinants of HTLV-1 MTCT Studies on HTLV-1 MTCT determinants have focused mainly on 1. genetic host factors, 2. immunological host factors, 3. lactation
Why Obese People are Unable to Keep Weight Off After Losing It
Why Obese People are Unable to Keep Weight Off After Losing It Robert E. Ratner, MD Chief Scientific and Medical Officer American Diabetes Association I have no Pertinent Financial Disclosures Change in
LA GESTIONE DELLA GRAVIDANZA OGGI. Enrico Ferrazzi. Direttore -MANGIAGALLI CENTER IRCCS CA GRANDA POLICLINICO University of Milan, School of Medicine,
LA GESTIONE DELLA GRAVIDANZA OGGI Enrico Ferrazzi Direttore -MANGIAGALLI CENTER IRCCS CA GRANDA POLICLINICO University of Milan, School of Medicine, 1 Gravidanza a basso rischio: counselling e sorveglianza
Human milk components and infant growth
Note: for non-commercial purposes only CAMPUS GROSSHADERN CAMPUS INNENSTADT Human milk components and infant growth Maria Grunewald, Martina Weber, Franca F. Kirchberg, Hans Demmelmair, M. Luisa Mearin,
Over the last 2 decades, the incidence of obesity in reproductive-age women
Catalano Impact of Maternal GDM and Obesity on Mother and Fetus Patrick Catalano, MD Over the last 2 decades, the incidence of obesity in reproductive-age women has increased significantly. The increase
Early Origins of Metabolic Disease and Aging
1 Early Origins of Metabolic Disease and Aging Janet C. King, Ph.D. Senior Scientist, Children s Hospital Oakland Research Institute And Professor Emeritus, UC Berkeley & Davis 2 The Maternal Nutrition-Offspring
9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives
The Physiological Roles of the Intestinal Microbiota Kelly A. Tappenden, Ph.D., R.D., FASPEN Professor and Head, Kinesiology and Nutrition University Distinguished Teacher-Scholar University of Illinois
S304- Emerging Treatments of Nutritional Disorders
S304- Emerging Treatments of Nutritional Disorders Erick Hernandez, MD Division of Pediatric Gastroenterology Miami Children s Hospital Miami, Florida Disclosure of Relevant Relationship Dr. Hernandez(or
WEBINAR Microbial Metabolism Associated with Health. 12 April 2018; CET
WEBINAR Microbial Metabolism Associated with Health 12 April 2018; 15.00-16.30 CET PROGRAMME Brief Introduction of Both Organisations and Scientific Background Dr Bettina Schelkle (ILSI Europe, BE) Dr
India is one of the diabetes capitals of the world and at the same time the capital
Yajnik Undernutrition and Overnutrition During Pregnancy in India: C. S. Yajnik, MD, FRCP India is one of the diabetes capitals of the world and at the same time the capital for low birth weight (LBW)
Developing the potential of prebiotics and probiotics as immune health ingredients
Developing the potential of prebiotics and probiotics as immune health ingredients ARTHUR OUWEHAND ACTIVE NUTRITION DUPONT NUTRITION & HEALTH 20 th November 2014, The gut microbiome The gut microbiota
Sarkis K Mazmanian, California Institute of Technology
Sarkis K Mazmanian, California Institute of Technology The human microbiota The human gut harbors 10 11-10 12 bacteria per gram colonic content (>10 14 total bacteria) Total bacteria outnumber human cells
Bifidobacterium animalis ssp. lactis Metagenics Institute. All Rights Reserved.
Bifidobacterium animalis ssp. lactis 420 Outline The clinical problem o BMI in Canadian population o Weight gain/regain patterns Microbiome and body weight regulation Development pathway of B420 B420 mechanisms
11/4/10. Making Sense of Infant Formulas, Milk Fortifiers and Additives. Components of infant formula. Goals of Growth.
Components of infant formula Making Sense of Infant Formulas, Milk Fortifiers and Additives Jae Kim, MD, PhD UCSD Medical Center Division of Neonatal-Perinatal Medicine Division of Pediatric Gastroenterology,
Early lifestyle intestinal microbiome
Session 4A Dietitians ensuring a healthy start in life 29/9/18 16.05 16.30 Early lifestyle intestinal microbiome Dr Emilia Vassilopoulou Assistant Professor of Diet and Nutrition Clinical Dietitian-Psychologist
Objectives. Diabetes in Pregnancy: A Growing Dilemma. Diabetes in the US 10/6/2015. Disclosure. The presenter has no conflicts to disclose
Diabetes in Pregnancy: A Growing Dilemma Kathy O Connell, MN RN Perinatal Clinical Nurse Specialist University of Washington Medical Center Seattle, WA koconnll@uw.edu Objectives Describe pathophysiologic
The Primary Prevention of Asthma
The Primary Prevention of Asthma Risk Factors Associated with Asthma Onset Ted Schettler Science and Environmental Health Network Collaborative on Health and Environment June, 2013 Asthma: a complex disease(s)