UK Journal of Pharmaceutical and Biosciences Available at

Size: px
Start display at page:

Download "UK Journal of Pharmaceutical and Biosciences Available at"

Transcription

1 UK Journal of Pharmaceutical and Biosciences Vol. 2(2), 08-15, 2014 RESEARCH ARTICLE UK Journal of Pharmaceutical and Biosciences Available at Formulation and Assessment of Mouth Dissolving Tablets of Repaglinide-β- Cyclodextrin Complex Lakahan Chadar 1*, Vaibhav Shukla 1,2, S K Jain 3 1 Oriental College of Pharmacy, Bhopal , (M.P.), India 2 Department of Pharmaceutical Sciences, Dr. K.N. Modi University, Newai, Tonk , (Rajasthan), India 3 Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar , (M.P.), India Article Information Received 24 January 2014 Received in revised form 01 April 2014 Accepted 02 April 2014 Keywords: Repaglinide Crosscarmellose sodium Crosspovidone Sodium Starch Glycolate Mouth dissolving tablets * Corresponding Author: kidspharma@gmail.com Tel.: Abstract The present study was carried out to develop mouth dissolving tablets of Repaglinide with a rationale of providing better patient compliance, will serve to provide effective mode of treatment to elderly, impaired and noncooperative patient suffering from diabetes. The Repaglinide-βcyclodextrin was prepared in order to increase the solubility of drug. The inclusion efficiency of different ratios of Repaglinide-β-cyclodextrin was calculated, that shows the inclusion efficiency of 1:1 molar ratio is highest. The mouth dissolving tablets of Repaglinide (RCT1 to RCT5) were prepared by direct compression method using super disintegrants, for optimization of the diluents. The value of pre-compression of blends and postcompression tablets exhibited satisfactorily results. The formulation RCT3 complied with all the physical parameters such as hardness, friability and disintegration time, and taken for further studies. Nine different formulations (RCT6 to RCT14) were prepared by using various concentration of super disintegrant namely Crosscarmellose sodium, Crosspovidone and Sodium Starch Glycolate. Among all formulations studied, formulation RCT9 having crospovidone as disintegrant showed 56.5% drug release in 5 min. Therefore crospovidone is considered best superdisintegrant among Sodium starch glycolate and Crosscarmellose sodium. 1 Introduction Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance 1. To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets (ODT) has emerged as alternative oral dosage forms. These are novel types of tablets that disintegrate/dissolve/ disperse in saliva within few seconds. According to European Pharmacopoeia, the MDT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva. The target populations for these new Mouth dissolving dosage forms have generally been pediatric, geriatric, and bedridden or developmentally disabled patients. Patients with persistent nausea, who are traveling, or who have little or no access to water are also good candidates for mouth dissolving tablets 2. In the near future, other patient populations will also be targeted. A novel application for mouth dissolving tablets is in veterinary medicine, for example, to avoid pilling a cat. With Mouth dissolving dosage forms increasingly available, it will be likely that prescribers will recommend such products for their noncompliant patients. The ease of administration of a Mouth dissolving tablet, along with its pleasant taste, may encourage a patient to adhere to a daily medication regimen. Although a Mouth Dissolving Tablets may not solve all compliance issues, it may be enough of an advance to be of therapeutic significance.

2 Mouth dissolving tablets offering advantages over liquid and traditional dosage forms as it provides the convenience of a tablet formulation, while also allowing the ease of swallowing provided by a liquid formulation. Mouth dissolving tablets allow the luxury of much more accurate dosing than the primary alternative, oral liquids. A major claim of the some mouth dissolving tablets is increased bioavailability compared to traditional tablets. Because of dispersion in saliva while still in the oral cavity, there can be pre-gastric absorption from some formulations in those cases where the drug dissolves quickly. Buccal, pharyngeal and gastric regions are all areas of absorption of the many formulations 3. However, other formulations show nearly identical plasma-concentration profiles. Any pre-gastric absorption avoids first pass metabolism and can be a great advantage in drugs that undergo a great deal of hepatic metabolism. However, if the amount of swallowed drug varies, there is the potential for inconsistent bioavailability. While the claimed increase in bioavailability is disputable, it is clear that the major advantage of these formulations is convenience 1. Pharmaceutical marketing is another reason for the increase in available Mouth dissolving products. As a drug entity nears the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form. A new dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen. In this regard, Mouth dissolving tablet formulations are similar to many sustained release formulations that are now commonly available. An extension of market exclusivity, which can be provided by a mouth dissolving dosage form, leads to increased revenue, while also targeting underserved and under treated patient populations. Although the cost to manufacture these specialized dosage forms exceeds that of traditional tablets, this additional cost is not being passed on to the consumer. Therefore, cost is generally not an issue when recommending these new dosage forms. The present invention relates to the development of mouth dissolving tablet of Repaglinide-β-cyclodextrin. Repaglinide is an oral hypoglycemic agent especially useful for the treatment of diabetes type II. It induces the rapid onset short lasting insulin release. It acts in an analogous manner by binding to sulfonylurea receptor as well as to other distinct receptors. Repaglinide close the ATP dependant K channel into membrane of β cells which depolarizes the β cells and results in opening of the cell s calcium channel, which in turn induces calcium influx dependent insulin secretion. Repaglinide has poor aqueous solubility, which is the rate-limiting step for absorption of drug. Many attempts or means have been used to increase water solubility of Repaglinide. Solubility can be increased by forming a with cyclodextrin. Cyclodextrin enhances the aqueous solubility of drugs through inclusion ation which will be used to formulate mouth dissolving tablets. This will not only enhance the bioavailability of the drug but also reduce the onset of action due to fast absorption of drug from GIT as drug will be available as ready to absorption i.e. in solution form from the mouth cavity itself. 2 Materials and Methods 2.1 Materials Repaglinide gifted from Macleods Pharmaceutical Limited Mumbai, India, was off white, odourless powder. 2.2 Methods Preparation and characterization of Repaglinide-β Cyclodextrin Preparation of physical mixtures and the solid inclusion For physical mixtures, Repaglinide and β-cyclodextrin were weighed accurately at 1:1, 2:1 and 3:1 molar ratios mixed thoroughly by trituration in a mortar and sieved through 0.25 mm sieve. All physical mixtures were stored in dessicator until further evaluation. The inclusion of Repaglinide with β- cyclodextrin was prepared at 1:1, 2:1 and 3:1 molar ratios by wetting the physical mixture in a mortar with a minimum volume of ethanol and water (1:1 v/v) mixture and kneading thoroughly with a pestle to obtain a paste, which was then dried under vacuum at room temperature, sieved through 0.25 mm sieve and stored in a dessicator until further evaluation Inclusion efficiency The kneaded and its physical mixtures (25 mg) were placed in 25-mL volumetric flasks. Methanol (10 ml) was added, mixed thoroughly and sonicated for 30 min. The volume was made up to the mark with methanol. The solution was suitably diluted with the same solvent and spectrophotometrically assayed for drug content at nm Dissolution studies Dissolution studies were performed in phosphate buffer (ph 6.8, 900 ml) at 37±0.2 C, using USP XXIII apparatus (Electrolab, India) with a paddle rotating at 50 rpm. Solid products, each containing 50 mg of drug, were subjected to dissolution. At fixed time intervals, samples were withdrawn, filtered (Whatmann filter paper no. 41) and spectrophotometrically assayed for drug content at nm Preparation of mouth dissolving tablets containing a of Repaglinide with β-cyclodextrin UK J Pharm & Biosci, 2014: 2(2); 9

3 Mouth dissolving tablets were prepared by direct compression method using super disintegrants. Microcrystalline cellulose and lactose used as diluents. The equivalent to 1.5 mg of drug was taken and then mixed with directly compressible diluent and superdisintegrants in a container. Magnesium stearate and talc were mixed and blended with the initial mixture followed by compression of the blend. Compression was performed using 10 mm round, flat and plain single punch machine (Table 3) Pre-compression evaluation of powder blend Bulk density Bulk density was determined by placing the powders blend in a measuring cylinder and the total volume is noted. The weight of powder bed was determined by using digital weighing balance. Bulk density was calculated using the following formula: Bulk Density = Weight of the powder / Volume of the powder Tapped density Tapped density was determined by taking the dried powders in a measuring cylinder and measures the volume of powders after 100 tapping s and take weight of the total powders. Tapped Density = Weight of the powder / Tapped Volume of the powder Angle of repose Angle of repose was determined by measuring the height and radius of the heap of the powder bed. A cylindrical two side open tube of 6 cm length is place on graph paper. Powders are placed in the tube and slowly removed the tube vertically. With the help of scale the height and radius of the heap were measure and note. θ= tan -1 h / r Where, h = height of heap of granular bed, r = radius of heap of granular bed Compressibility index The compressibility was calculated using the equation: Percent compressibility or carr s index = [(tap - bulk)/tap] 100 Where bulk is the bulk density (g/ml) and tap is the tap density (g/ml) Evaluation of mouth dissolving tablets Friability test Friability of tablets was determined using Roche friabilator (Electolab, Mumbai). This device subjects the tablets to the combined effect of abrasions and shock in a plastic chamber revolving at 25 rpm and dropping the tablets at a height of six inches in each revolution. Preweighed sample of tablets was placed in the friabilator and were subjected to 100 revolutions. Tablets were dedusted using a soft muslin cloth and reweighed. The friability is given by the formula: F = (1 - Wo/W) x 100 Where, Wo is the weight of the tablets before the test and W is the weight of the tablet after the test Hardness Hardness or tablet crushing strength (Fc) (the force required to break a tablet in a diametric compression was measured using Monsanto hardness tester Drug content Four tablets were powdered and the blend equivalent to 6 mg of Repaglinide was weighed and dissolved in suitable quantity of phosphate buffer of ph 6.8. The solution was filtered, suitably diluted and the drug content was analyzed spectrophotometrically at 243 nm. Each sample was analyzed in triplicate Measurement of liquid uptake A glass petridish was partially filled with water and a tablet was placed on the surface of a band of filter paper supported on a glass slide. The uptake of water occurred from the lower surface of the tablet. The time required for water to reach the center of the upper surface of the tablet was noted as wetting time Disintegration Time The disintegration time (DT) was measured using a modified disintegration method, which is reported by Gohel et al. (2007) for mouth dissolving tablets. For this purpose, a petri dish (10-cm diameter) was filled with 10 ml of water. The tablet was carefully put in the center of the petridish and the time for the tablet to disintegrate completely into fine particles was noted In-vitro dissolution study The in-vitro dissolution study was carried out in the USP dissolution test apparatus (Dissolution tester USP) type 2 (paddle). The dissolution medium (900 ml, ph 6.8 buffer solution) was taken in a covered vessel and the temperature was maintained at 37±0.5 C. The speed of the paddle was set at 75 rpm. Sampling was performed at every 5-min interval. For each sample, 5 ml of the dissolution medium was withdrawn and immediately this volume was replaced with the same amount of fresh dissolution medium (Buffer ph 6.8, 37±0.5 C). The sample was withdrawn and diluted with buffer UK J Pharm & Biosci, 2014: 2(2); 10

4 solution (ph 6.8) and analyzed in the UV spectrophotometer (UV Shimadzu Corporation) at 243 nm. All the results were performed in triplicate Formulation of mouth dissolving tablets to assess effect of disintegrants Nine different formulations (RCT6 to RCT14) were prepared by using various concentration of super disintegrant namely Crosscarmellose sodium, Crosspovidone and Sodium Starch Glycolate (Table 8). It was decided to adopt the most simple direct compression process for manufacturing. All the excipients were mixed uniformly with drug as per the qualities given in table 3 and compressed as discussed in previous section. Tablets blends were evaluated for bulk density, tapped bulk density, compressibility index and angle of repose. The compressed tablets were then evaluated for various physical tests like friability, hardness, weight variation, wetting time, drug content and in-vitro dissolution study by using standard procedures Results and Discussions 3.1 Preparation and characterization of Repaglinide-β Cyclodextrin The Repaglinide-β-cyclodextrin was prepared in order to increase the solubility of drug. The and physical mixture of Repaglinide and β- cyclodextrin were prepared in different ratios of drug and β- cyclodextrin (1:1, 2:1 and 3:1) and inclusion efficiency of different ratios was calculated, that shows the inclusion efficiency of 1:1 molar ratio is highest (Table 1). Dissolution study of drug, physical mixture and Repaglinide - β- cyclodextrin have shown in table 2 that showed is more soluble than drug and physical mixture. 3.2 Preparation of mouth dissolving tablets containing a of Repaglinide with β-cyclodextrin The pharmacokinetic data revealed that Repaglinide is low permeable drug and less water soluble. Hence the basic aim of the formulation was to release the drug from the formulation instantly in water soluble form. The values of pre-compression parameters evaluated, were within prescribed limits and indicated a good free flowing property (Table 4). The data obtained from post-compression parameters such as weight variation, hardness, friability, wetting time, drug content and in vitro disintegration for prepared tablets were satisfactorily (Table 5 & Table 6). The results of pre-compression and post-compression indicate that product complied with the physical parameters. The formulation RCT3 exhibited good flow properties, less disintegration time (43 sec) and optimum dissolution rate (Table 7) compared to other formulations. Table 1: Inclusion efficiency of the drug and its preparation Type 1:1 molar ratio Inclusion Efficiency (%) 2:1 molar ratio 3:1 molar ratio Physical mixture 97.2 ± ± ±0.3 Kneaded 99.5 ± ± ± 0.4 Table 2: Dissolution profile of drug, physical mixture and Time (min) Cumulative % Drug Release Drug Physical Mixture Complex ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±1.02 Table 3: Composition of mouth dissolving tablets with different ratio of directly compressible diluents Ingredients (mg) RCT1 RCT2 RCT3 RCT4 RCT5 Repaglinide-cyclodextrin Lactose SD Microcrystalline cellulose Starch Crosscarmellose sodium Magnesium sterate Aspartame Vanillin flavour Sodium lauryl sulphate In order to have improved product performance several experiments were performed varying few of the functional excipients. Batch RCT3 UK J Pharm & Biosci, 2014: 2(2); 11

5 complied with all the physical parameters such as hardness, friability and disintegration time. So ratio of lactose and microcrystalline cellulose 3:4 was optimized and taken for further studies. 3.3 Formulation of mouth dissolving tablets to assess effect of disintegrants To point out disintegrants influence on the properties of directly compressible tablets among the various controls carried out throughout the operating procedure. The following parameters such as flow ability of blend, %compressibility of blend, physical properties of tablets were considered to optimize the formulation: Table 4: Precompressional parameters of powder blend used in the Optimization of directly compressible diluents The present investigation was undertaken to fabricate and evaluate a fast disintegration tablets of Repaglinide by direct compression method. Super disintegrants at different concentration levels were used to assist disintegration. Nine different formulations (RCT6 to RCT14) were prepared by using various concentration of super disintegrant namely Crosscarmellose sodium, Crosspovidone and Sodium Starch Glycolate, employing direct compression method. Bulk densities of various formulations were varied between 0.46 to 0.52 (gm/cm 3 ). The angle of repose values also varied from 26 to 34 (Table 9). Among all the formulation RCT6 and RCT9 exhibited good flow properties. In all the formulations, the hardness test indicated good mechanical strength, whereas friability is less than 1%, which indicated that the Formulation Angle of repose (θ) Bulk density (gm/cm 3 ) % Compress Flow property tablets had a good mechanical resistance (Table 10). Drug content was found to be high ( 98.11%) and uniform in all the tablets. Table 7: Drug release profile of tablets RCT1 33± ± ±0.25 Fair RCT2 30± ± ±0.17 Poor RCT3 26± ± ±0.65 Good RCT4 29± ± ±0.38 Fair RCT5 32± ± ±0.58 Poor Table 5: Post compression parameters of directly compressible diluents tablets Formulation % Friability Hardness (kg/cm 2 ) % Weight variation RCT1 1.2± ± ±5.82 RCT2 0.9± ± ±5.65 RCT3 0.6± ± ±4.48 RCT4 0.8± ± ±4.53 RCT5 1.0± ± ±5.62 Table 6: Post compression parameters of directly compressible diluents tablets Formulation Disintegration time (sec.) %Drug content (mg/tab) Wetting time (sec) RCT1 48± ± ±0.75 RCT2 45± ± ±0.54 RCT3 43± ± ±0.34 RCT4 46± ± ±0.47 RCT5 49± ± ±0.64 Time (min) Cumulative % drug release RCT1 RCT2 RCT3 RCT4 RCT ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.25 The tablets were subjected for evaluation of the in vitro disintegration time (Figure 1 and 2). After evaluation it was observed that the time for all the formulations varied from 40 to 56 sec. It was observed that when crospovidone was used as disintegrants, the tablet disintegrated rapidly within a short time due to the easy swelling ability of crospovidone when compared with other tablets prepared using Crosscarmellose sodium and Sodium starch glycolate. It is observed that the disintegration time of the tablets decreased with an increase in the level of Crosscarmellose sodium and crospovidone. However, the disintegration time increased with an increase in the level of Sodium starch glycolate in the tablets. It indicates that the increase in the level of Sodium starch glycolate had a negative effect on the disintegration of the tablets. At higher levels, formation of a viscous gel layer by Sodium starch glycolate 10 might have formed a thick barrier to the further penetration of the disintegration medium and hindered the disintegration or leakage of the tablet contents. Thus, tablet disintegration is retarded to some extent with tablets containing Sodium starch glycolate when compared with the UK J Pharm & Biosci, 2014: 2(2); 12

6 disintegration time of the tablets containing crospovidone 11. These results suggest that using wicking type of disintegrants like crospovidone can decrease the disintegration time. The dissolution of Repaglinide from the tablets is shown in (Table 7 and Table 11). The dissolution process of a tablet depends on the wetting followed by disintegration of the tablet. Table 8: Composition of mouth dissolving tablets with different ratio of super disintegrant Ingredients (mg) RCT6 RCT7 RCT8 RCT9 RCT10 RCT11 RCT12 RCT13 RCT14 Repaglinide-cyclodextrin Lactose SD Starch Microcrystalline cellulose Crosscarmellose sodium Crosspovidone Sodium Starch Glycolate Magnesium sterate Aspartame Sodium Lauryl Sulphate Vanillin Table 9: Precompressional parameters of blends using different ratio of super disintegrant Formulation Angle of repose ( ) Bulk density (gm/cm 3 ) % Compressibility Flowability RCT6 27± ± ±0.34 Good RCT7 29± ± ±0.55 Fair RCT8 30± ± ±0.84 Poor RCT9 26± ± ±0.47 Good RCT10 29± ± ±0.87 Fair RCT11 30± ± ±0.31 Fair RCT12 31± ± ±0.55 Fair RCT13 34± ± ±0.24 Poor RCT14 33± ± ±0.66 Poor Table 10: Post-compressional parameters of tablets using different ratio of super disintegrant Formulation % Friability Hardness (kg/cm 2 ) Disintegration time(sec.) %Weight variation %Drug content Wetting time(sec) RCT6 0.7± ± ± ± ± ±0.19 RCT7 0.9± ± ± ± ± ±0.33 RCT8 1.1± ± ± ± ± ±0.68 RCT9 0.7± ± ± ± ± ±0.49 RCT10 0.9± ± ± ± ± ±0.6 RCT11 1.1± ± ± ± ± ±0.59 RCT12 0.6± ± ± ± ± ±0.81 RCT13 0.9± ± ± ± ± ±0.67 RCT14 1.0± ± ± ± ± ±0.49 UK J Pharm & Biosci, 2014: 2(2); 13

7 Table 11: Tablet release profile of tablets prepared with different ratio of super disintegrant Time (min.) Cumulative % drug release RCT6 RCT7 RCT8 RCT9 RCT10 RCT11 RCT12 RCT13 RCT ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.95 superdisintegrant among Sodium starch glycolate and Crosscarmellose sodium. Fig. 1: Photographs showing disintegration of optimized (RCT9) tablets in water at 30, 60 and 90 seconds Physical parameters confirmed to the requirements. Weight variation was found with in the specifications of I.P 96. The Average percentage deviation of 20 tablets from each formulation was remained within ±7.5%. Hardness of the all tablet formulations were observed in the range of 2.2 to 3.6 (kg/cm 3 ). Friability of selected formulations was found in the range of 0.6 to 1.0%. Drug content of all formulations were found in the range of % (Table 10). Selected formulations had disintegration time of less than one minute. Among the combination of superdisintegrants of Microcrystalline cellulose and Crospovidone showed the highest efficiency. 4 Conclusions Fig. 2: Photographs showing disintegration of drug tablets in water at 30, 60 and 90 seconds The rapid increase in dissolution of Repaglinide with the increase in Crosscarmellose sodium may be attributed to rapid swelling and disintegration 10 of the tablet into apparently primary particles 12. However, tablets prepared with Sodium starch glycolate disintegrate by rapid uptake of water followed by rapid and enormous swelling into primary particle, but more slowly due to the formation of a viscous gel layer by Sodium starch glycolate. Crospovidone exhibit high capillary activity and pronounced hydration, with little tendency to gel formation 10 and disintegrate the tablets rapidly but into larger masses of aggregated particles 12. Among all formulations studied, formulation RCT9 having crospovidone as disintegrant showed 56.5% drug release in 5 min. Therefore crospovidone is best The major problem of Repaglinide is poor bioavailability and its limited aqueous solubility, which may hinder dissolution. Results revealed that it is possible to enhance the dissolution rate and the bioavailability by preparing with β- cyclodextrin and direct compression technique using different superdisintegrants. The overall results indicate that formulation RCT9, which contains 5% Crospovidone, was better and that it satisfies all the criteria as a fast dissolving tablet. 5 References 1. Habib W, Khankari R, Hontz J. Fast-dissolving drug delivery systems, critical review in therapeutics. Drug Carrier Systems. 2000; 17(1): Chang R, Guo, X, Burnside BA, Couch R. Fast-dissolving tablets. Pharm Tech. 2000; 24(6): UK J Pharm & Biosci, 2014: 2(2); 14

8 3. Seager H. Drug-deliver products and the zydis fastdissolving dosage form. J Pharm Pharmacol. 1998; 50: Sharma PP, Sharma S, Khokra SL, Sahu RK, Jangde R, Singh J. Formulation, development and evaluation of sustained release matrix tablets containing salbutamol sulphate. Pharmacologyonline, 2011; 2: Sharma V, Sharma S, Khokra SL, Sahu RK, Jangde R, Singh J. Formulation, development and evaluation of Pregabalin sustained release matrix tablets. Der Pharmacia Lettre. 2011; 3(5): Atri S, Sharma S, Khokra SL, Sahu RK, Jangde R. Design and evaluation of HPMC and xathan gum-based sustained release matrix tablets of Theophyllie. Pharmacologyonline. 2011; 2: Patel HM, Suhagia BN, Shah SA, Rathod IS, Parmar VK. Preparation and characterization of etoricoxib-bcyclodextrin es prepared by the kneading method. Acta Pharm. 2007; 57: Gohel MC, Bansal G, Bhatt N. Formulation and evaluation of orodispersible taste masked tablets of Famotidine. Pharma Biol World. 2005; 3: Masih D, Gupta R. Formulation and Evaluation of Mouth Dissolving Tablets of Tolperisone. UK Journal of Pharmaceutical and Biosciences. 2013; 1(1): Bolhuis GK, Zuurman K, Wierik GH. Improvement of dissolution of poorly soluble drugs by solid deposition on a superdisintegrant: II, The choice of superdisintegrants and effect of granulation. Eur J Pharm Sci. 1997; 5: Rowe RC, Sheskey PJ, Weeler PJ. Editors. Handbook of pharmaceutical excipients. 4 th ed. London and Washington DC: The Pharmaceutical Press Zhao N, Augsburger LL. Functionality comparison of 3 classes of superdisintegrants in promoting aspirin tablet disintegration and dissolution. AAPS Pharm. Sci. Tech. 2005; 6: E UK J Pharm & Biosci, 2014: 2(2); 15

Formulation and evaluation of fast dissolving tablet of aceclofenac

Formulation and evaluation of fast dissolving tablet of aceclofenac International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj

More information

Formulation and evaluation of oro-dispersible tablets of lafutidine

Formulation and evaluation of oro-dispersible tablets of lafutidine Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES Research Article Formulation, Development and Evaluation of Fast Dissolving Tablet of Salbutamol Sulphate by Using Superdisintegrants of Various Concentrations Santosh K 1 *, Meenakshi B 2 and Jyoti M

More information

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA

More information

B. Jayakar et. al. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CELECOXIB R. Margret Chandira, Shyam Sharma, Debjit Bhowmik, B.

B. Jayakar et. al. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CELECOXIB R. Margret Chandira, Shyam Sharma, Debjit Bhowmik, B. Page117 Online Available at www.thepharmaresearch.info THE PHARMA RESEARCH, A JOURNAL The Pharma Research (T. Ph. Res.), (2010), 4; 117-122. Published on- 15 Dec 2010 Copyright 2009 by Sudarshan Publication

More information

Formulation and Evaluation

Formulation and Evaluation Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the

More information

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012 STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college

More information

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast

More information

Available Online through

Available Online through ISSN: 0975-766X Available Online through Research Article www.ijptonline.com FORMULATION DESIGN AND OPTIMIZATION OF MOUTH DISSOLVE TABLETS OF GLIPIZIDE R.Shireesh Kiran 1*, B.Chander Shekar 1, Sharadha

More information

Formulation and evaluation of immediate release salbutamol sulphate

Formulation and evaluation of immediate release salbutamol sulphate 5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely

More information

Formulation and Evaluation of Mouth Dissolving Sublingual Tablets of Cimetidine to Treat Abdominal Cramps

Formulation and Evaluation of Mouth Dissolving Sublingual Tablets of Cimetidine to Treat Abdominal Cramps International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 3 Issue 9 September 2014 PP.41-46 Formulation and Evaluation of Mouth Dissolving Sublingual

More information

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets Research Article Vishakha S. Hastak*, Yogyata S. Pathare, Kiran C. Mahajan Department of Pharmaceutics, Shree Chanakya Education Society's Indira college of Pharmacy, Tathawade, Pune, Maharashtra, India.

More information

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Suppl 1, 2012 Research Article FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING

More information

Received on: Accepted on:

Received on: Accepted on: ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com FORMULATION, EVALUATION AND OPTIMIZATION OF ORODISPERSIBLE TABLET CONTAINING ANTI-EMETIC DRUG Imran AM* 1, Sudhakar

More information

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College

More information

Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil

Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (1):232-237 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.

More information

Optimization of valsartan tablet formulation by 2 3 factorial design

Optimization of valsartan tablet formulation by 2 3 factorial design Research Article ISSN: 0974-6943 K. P. R. Chowdary et al. / Journal of Pharmacy Research 2014,8(9, Available online through http://jprsolutions.info Optimization of valsartan tablet formulation by 2 3

More information

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on Research Article

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on  Research Article Available online on www.ijarpb.com Research Article Received on 15/01/2013; Revised on 23/01/2013; Accepted on 27/01/2013; Fast Dissolving Tablets Of Pioglitazone Hydrochloride By Use Of Various Superdisintegrants

More information

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.

More information

Formulation and evaluation of sublingual tablets of lisinopril

Formulation and evaluation of sublingual tablets of lisinopril Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets

More information

International Journal of Pharma and Bio Sciences V1(1)2010 FORMULATION AND EVALUATION OF ROSIGLITAZONE MOUTH DISSOLVING TABLET

International Journal of Pharma and Bio Sciences V1(1)2010 FORMULATION AND EVALUATION OF ROSIGLITAZONE MOUTH DISSOLVING TABLET G ARJUN 1*, M.SRAVAN PRASAD 1, D SANTHOSHA 1 AND G.ACHAIAH 2 1 Nalanda college of pharmacy, Osmania University, Nalgonda, India. 2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal,

More information

Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method

Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn:2278-3008, p-issn:2319-7676. Volume 11, Issue 2 Ver. III (Mar.- Apr.2016), PP 64-70 www.iosrjournals.org Formulation and Evaluation of

More information

EFFECT OF SUPERDISINTEGRANTS ON RELEASE OF DOMPERIDONE FROM FAST DISSOLVING TABLETS

EFFECT OF SUPERDISINTEGRANTS ON RELEASE OF DOMPERIDONE FROM FAST DISSOLVING TABLETS ISSN: 22-7346 B. Sujatha et al. / JGTPS/ 5(3)-(2014) 1973 1978 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com EFFECT OF SUPERDISINTEGRANTS ON RELEASE

More information

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES Research Article Deshmukh ND,, 2012; Volume 1(5): 364-378 ISSN: 2277-8713 FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES *N. D. DESHMUKH, R. R.

More information

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Formulation and In-Vitro evaluation of fast dissolving tablets of telmisartan Vishal Dhiman*, Gaurav Jain, Vaibhav Jagtap, R.V.Sheorey Department of Pharmaceutics,

More information

International Journal of Pharmacy

International Journal of Pharmacy International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF ZOLMITRIPTAN FAST DISSOLVING TABLET USING SYNTHETIC SUPERDISINTEGRANTS

More information

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN

More information

Available Online through Research Article

Available Online through Research Article ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,

More information

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS: 335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

Formulation and Development of Sustained Release Tablets of Valsartan Sodium

Formulation and Development of Sustained Release Tablets of Valsartan Sodium INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of

More information

ISSN: CODEN Code: PIHNBQ ZDB-Number: IC Journal No: Vol. 2 No Online Available at

ISSN: CODEN Code: PIHNBQ ZDB-Number: IC Journal No: Vol. 2 No Online Available at Received: 2-01-201 Accepted: 09-0-201 ISSN: 2277-795 CODEN Code: PIHNBQ ZDB-Number: 208-2 IC Journal : 7725 Vol. 2. 2 201 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION - JOURNAL Formulation

More information

M.Vijaya Laxmi et al., Asian Journal of Pharmaceutical Technology & Innovation, 03 (10); 2015; Research Article

M.Vijaya Laxmi et al., Asian Journal of Pharmaceutical Technology & Innovation, 03 (10); 2015; Research Article Asian Journal of Pharmaceutical Technology & Innovation ISSN: 2347-8810 Research Article Received on: 18-12-2014 Accepted on: 31-12-2014 Published on: 15-02-2015 Formulation and Evaluation of Rizatriptan

More information

International Journal of Pharma and Bio Sciences NOVEL CO-PROCESSED SUPERDISINTEGRANTS IN THE DESIGN OF FAST DISSOLVING TABLETS

International Journal of Pharma and Bio Sciences NOVEL CO-PROCESSED SUPERDISINTEGRANTS IN THE DESIGN OF FAST DISSOLVING TABLETS S.B.Shirsand*, R. G. Ramani, P.V.Swamy Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Sedam Road, Gulbarga-585 105, India * Correspondence Address shirsand@rediffmail.com

More information

Design and In-vitro Evaluation of Silymarin Bilayer Tablets

Design and In-vitro Evaluation of Silymarin Bilayer Tablets CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin

More information

Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet

Formulation and Evaluation of Amlodipine besylate orally disintegrating tablet Indo American Journal of Pharmaceutical Research. 2011:2(1);146-12. ISSN NO. 2231-6876 Journal home page: http://www.iajpr.com/index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH Formulation

More information

Int. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN:

Int. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(6):42-46 Research Article ENHANCEMENT OF SOLUBILITY

More information

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN:

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2014; 4(1):47-51 Research Article FORMULATION AND EVALUATION

More information

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Mayur V. Chinchore*, Sanjay P. Aher, Chetan P. Mahajan, Ghanshyam J. Yadav, Avish D. Maru Department of Pharmaceutics,

More information

Available online through ISSN

Available online through  ISSN Research Article Available online through www.ijrap.net ISSN 2229-3566 FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF METOPROLOL TARTRATE BY DIRECT COMPRESSION USING SUPER DISINTEGRANTS A. Senthil*

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY  ISSN Research Article INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VENLAFAXINE HCL TABLETS: COMPARATIVE STUDY OF SUPER DISINTEGRANT

More information

The purpose of the present investigation was to design a formulation of orodispersible tablets of Etoricoxib by adopting

The purpose of the present investigation was to design a formulation of orodispersible tablets of Etoricoxib by adopting Research ARTICLE Formulation design and optimization of orodispersible tablets of etoricoxib by response surface methodology S R Shahi, G R Agrawal, N V Shinde, S A Shaikh 1, S S Shaikh, A N Padalkar 3,

More information

Research Article. Formulation and in-vitro evaluation of levocetirizine dihydrochloride orodispersible tablets

Research Article. Formulation and in-vitro evaluation of levocetirizine dihydrochloride orodispersible tablets Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(4):792-799 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Formulation and in-vitro evaluation of levocetirizine

More information

Int. Res J Pharm. App Sci., 2012; 2(6): ISSN:

Int. Res J Pharm. App Sci., 2012; 2(6): ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(1): 269-273 Research Article FORMULATION DEVELOPMENT

More information

Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution

Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution ISSN 2395-3411 Available online at www.ijpacr.com 486 Research Article Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution Ghanshayma M. Patil*, Harshal K. Patil, Vipul

More information

FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD

FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD THAKKAR HARDIK R*, A.SENTHIL, RAVIKUMAR, V.B. NARAYANA SWAMY Karavali College of Pharmacy, Mangalore-575028,

More information

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE

More information

Int. J. Pharm. Sci. Rev. Res., 33(1), July August 2015; Article No. 12, Pages: 55-61

Int. J. Pharm. Sci. Rev. Res., 33(1), July August 2015; Article No. 12, Pages: 55-61 Research Article Sandeep Sathyanarayana D*, Narayana Charyulu R Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, Karnataka, India. *Corresponding

More information

Formulation and evaluation of oral dispersible tablets of aripiprazole

Formulation and evaluation of oral dispersible tablets of aripiprazole IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,

More information

FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE

FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE Vol 6, Suppl 3, 2013 ISSN - 0974-2441 Research Article FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE ABSTRACT SONALI J. SHAH *, RUPA MAZUMDER Department of

More information

Design and development of fast Melting Tablets of Terbutaline Sulphate

Design and development of fast Melting Tablets of Terbutaline Sulphate Design and development of fast Melting Tablets of Terbutaline Sulphate Mathew T and Agrawal S Swami Vivekanand College of Pharmacy, Khandwa Road, Indore (MP), INDIA Available online at: www.isca.in (Received

More information

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya

More information

FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER 407 - PVPK30 INCLUSION COMPLEXES K.P.R. Chowdary*, K. Surya Prakasa

More information

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Biresh Kumar Sarkar* 1, Devananda Jain 1, Mamta Parwal 2 1. Bhagwant University, Dept.of Pharmaceutical Tech and Sciences,

More information

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Pharmaceutics Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Remya KS, Beena P, Bijesh PV, Sheeba A Nazareth College

More information

Formulation and Optimization of Lamotrigin Fast Dissolving Tablet

Formulation and Optimization of Lamotrigin Fast Dissolving Tablet Formulation and Optimization of Lamotrigin Fast Dissolving Tablet Sachin S. Gupta 1, Hitesh Patel 2, B.G.Prajapati 2, Shreeraj Shah 1 1. L.J.Institute of Pharmacy.Sanand Cross road, Sarkhej-Gandhinagar

More information

FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX

FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Issue 1, 2012 Research Article FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE

More information

Asian Journal of Research in Pharmaceutical Sciences and Biotechnology

Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Research Article ISSN: 2349-7114 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com FORMULATION, IN VITRO DRUG RELEASE AND STABILITY STUDIES OF CLOPIDOGREL

More information

Formulation and evaluation of mouth dissolving tablets containing losartan potassium

Formulation and evaluation of mouth dissolving tablets containing losartan potassium Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (17):115-123 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Formulation and Evaluation of Fast Disintegrating Tablets of Caffeine by Using Effervescent Formulation Approach

Formulation and Evaluation of Fast Disintegrating Tablets of Caffeine by Using Effervescent Formulation Approach Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 212, 4 (5):149-1494 (http://scholarsresearchlibrary.com/archive.html) ISSN 975-571 USA CODEN: DPLEB4

More information

PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES

PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES FORMULATION AND OPTIMIZATION OF FAST DISINTEGRATING TABLET OF METFORMIN USING DISINTEGRANT BLENDS FOR IMPROVED EFFICACY N. R.Maniyar

More information

DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL

DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL Isha Shah, Alpesh Yadav, Shailendra Bhatt Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India-3000. Abstract

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Development and characterisation of oral fast dissolving tablet of nifedipine using camphor as a subliming material Shinde Anilkumar

More information

Pharmacologyonline 2: (2011) ewsletter Mehul et al. FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE

Pharmacologyonline 2: (2011) ewsletter Mehul et al. FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE DAVE MEHUL *, A.SENTHIL, THAKKAR HARDIK R, RAVIKUMAR, LAD TEJAS Karavali College of Pharmacy, Mangalore-575028, Karnataka, India.

More information

Scholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study

Scholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):24-30 (http:scholarsresearchlibrary.comarchive.html) ISSN 0974-248X USA CODEN: DPLEB4 Formulation

More information

Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences

Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences Formulation and Evaluation of Orodispersible Tablets of Salbutamol Sulphate. Prasanth VV 1, Sidhyartha Sarkar 2 *, Sourav Tribedi 1,

More information

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011 ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE

More information

372 J App Pharm Vol. 6; Issue 4: ; October, 2014 Moazzem et al, 2014

372 J App Pharm Vol. 6; Issue 4: ; October, 2014 Moazzem et al, 2014 372 J App Pharm Vol. 6; Issue 4: 372-379; October, 2014 Moazzem et al, 2014 Original Research Article EFFECT OF SUPERDISINTEGRATING AGENT ON THE RELEASE OF METFORMIN HCl FROM IMMEDIATE RELEASE TABLETS

More information

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS 211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability

More information

Scholars Research Library. Formulation and evaluation of rizatriptan benzoate orodispersible tablets

Scholars Research Library. Formulation and evaluation of rizatriptan benzoate orodispersible tablets Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):125-130 (http://scholarsresearchlibrary.com/archive.html) ISSN 0974-248X USA CODEN: DPLEB4

More information

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALSARTAN

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALSARTAN Research article FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALSARTAN ABSTRACT C.P. JAIN 1 AND P.S. NARUKA 2 1. Department of Pharmaceutical Sciences, M.L.S. University, Udaipur. 2. Department

More information

Formulation Development and Evaluation of Atorvastatin Calcium Tablets using Co-Processed Excipients

Formulation Development and Evaluation of Atorvastatin Calcium Tablets using Co-Processed Excipients Int. J. Pharm. Sci. Rev. Res., 36(1), January February 2016; Article No. 39, Pages: 217222 Research Article Formulation Development and Evaluation of Atorvastatin Calcium Tablets using CoProcessed Excipients

More information

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE Volume: I: Issue-2: Aug-Oct -2010 ISSN 0976-4550 NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE * Hindustan Abdul Ahad, Anuradha CM, Chitta Suresh

More information

A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS

A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Formulation And Invitro Evaluation Of Sustained Release Matrix Tablets Of Ibuprofen S Shanmugam, T Vetrichelvan and P Niranjan* Adhiparasakthi

More information

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE

More information

Development and characterization of orodispersible tablets of famotidine containing a subliming agent

Development and characterization of orodispersible tablets of famotidine containing a subliming agent Adisa et al Tropical Journal of Pharmaceutical Research, December 2008; 7 (4): 1185-1189 Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.

More information

Effect of superdisintegrants and their mode of incorporation on disintegration time and release profile of carbamazepine from immediate release tablet

Effect of superdisintegrants and their mode of incorporation on disintegration time and release profile of carbamazepine from immediate release tablet Journal of Applied Pharmaceutical Science Vol. 3 (5), pp. -84, May, 213 Available online at http://www.japsonline.com DOI: 1.7324/JAPS.213.3515 ISSN 2231-3354 Effect of superdisintegrants and their mode

More information

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and

More information

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS 5.1. AIM OF THE STUDY The pulsatile type press coated colon targeted atenolol tablet release drug after 6 hr lag time. The compression coated

More information

International Journal of Pharmacology and Pharmaceutical Sciences 2016; Vol: 3, Issue: 3, 14-18

International Journal of Pharmacology and Pharmaceutical Sciences 2016; Vol: 3, Issue: 3, 14-18 International Journal of Pharmacology and Pharmaceutical Sciences 2016; Vol: 3, Issue: 3, 14-18. Research Article ISSN: 2394-613X FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PERINDOPRIL USING

More information

Available online Research Article

Available online   Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 26, 8(2):7-7 Research Article ISSN : 975-7384 CODEN(USA) : JCPRC5 Optimization of directly compressible mixtures of microcrystalline

More information

FORMULATION & EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN FOR PAEDIATRIC USE

FORMULATION & EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN FOR PAEDIATRIC USE FORMULATION & EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN FOR PAEDIATRIC USE *Ashwini V.Jadhav, Vaishali R. Shinde, Sandip S. Kshirsagar and Swati. B. Suradakar Department of Pharmaceutics,

More information

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG M Seth *, DS Goswami,

More information

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT

More information

Adimoolam Senthil et al. IRJP 2 (1)

Adimoolam Senthil et al. IRJP 2 (1) INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN 2230 8407 Available online http://www.irjponline.com Research Article DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF METOPROLOL TARTRATE

More information

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online) Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101

More information

DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN

DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI

More information

Ajmer , India. * Correspondence rediffmail.com, Ph :

Ajmer , India. * Correspondence rediffmail.com, Ph : International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 910-914, Oct-Dec 2009 Formulation, Evaluation and Optimization of Fast-Dissolving Tablets Containing Nimesulide

More information

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants ISSN: 2231-3354 Received on: 13-11-2011 Revised on: 18:11:2011 Accepted on: 22-11-2011 Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants Leela

More information

COMPARATIVE EFFECT OF DIFFERENT HIGH FUNCTIONALITY EXCIPIENTS ON VARIOUS CHARACTERISTICS OF VARDENAFIL HCL TABLETS (BCS II DRUG)

COMPARATIVE EFFECT OF DIFFERENT HIGH FUNCTIONALITY EXCIPIENTS ON VARIOUS CHARACTERISTICS OF VARDENAFIL HCL TABLETS (BCS II DRUG) IJPSR (2014), Vol. 5, Issue 12 (Research Article) Received on 27 April, 2014; received in revised form, 28 July, 2014; accepted, 08 August, 2014; published 01 December, 2014 COMPARATIVE EFFECT OF DIFFERENT

More information

ISSN: Available online Journal of Global Trends in Pharmaceutical Sciences. Research Article

ISSN: Available online   Journal of Global Trends in Pharmaceutical Sciences. Research Article Research Article ISSN:2230-7346 Available online http://www.jgtps.com Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 1, pp 1-10, January March 2011 STUDIES ON DISSOLUTION RATE OF PARACETAMOL

More information

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

More information

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1119-1124, July-Sept 2011 Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with

More information

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE ISSN: 2395 1338 FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE B. Venkateswara Reddy *, K. Navaneetha Department of Pharmaceutics, St.Paul s College

More information

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*

More information

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET Gupta and Singh, IJPSR, 2013; Vol. 4(7): 2683-2690. ISSN: 0975-8232 IJPSR (2013), Vol. 4, Issue 7 (Research Article) Received on 05 March, 2013; received in revised form, 29 April, 2013; accepted, 29 June,

More information

OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105

OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105 Digest Journal of Nanomaterials and Biostructures Vol. 9, No. 3, July September 2014, p. 1077-1084 OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105

More information

ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE

ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.

More information

The present study deals with the formulation of fast dissolving tablets of poorly soluble carbamazepine by the direct

The present study deals with the formulation of fast dissolving tablets of poorly soluble carbamazepine by the direct Research ARTICLE Development and evaluation of carbamazepine fast dissolving tablets prepared with a complex by direct compression technique N G Raghavendra Rao, T Patel 1, S Gandhi 1 Department of Pharmaceutics,

More information