K. Ravi Shankar et al. /BioMedRx 2013,1(3), Available online through
|
|
- Georgia Woods
- 5 years ago
- Views:
Transcription
1 Research Article K. Ravi Shankar et al. /BioMedRx 2013,1(3), Available online through Factorial Studies on Enhancement of Solubility and Dissolution Rate and Formulation Development of Efavirenz Tablets Employing ß Cyclodextrin and Soluplus *Corresponding author. Prof. K.P.R. Chowdary Former Principal, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam , Andhra Pradesh, India K. Ravi Shankar 1 and K. P. R. Chowdary* 2 1 A.KR.G College of Pharmacy, Nallajerla , Andhra Pradesh, India * 2 Former Principal, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam , Andhra Pradesh, India Received on: ; Revised on: ; Accepted on: ABSTRACT Efavirenz, a widely prescribed anti retroviral drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Its oral absorption is dissolution rate limited and it requires enhancement in the solubility and dissolution rate for increasing its oral bioavailability. The objective of the study is to enhance the solubility and dissolution rate of efavirenz by cyclodextrin complexation along with Soluplus and to evaluate the individual main effects and combined (or interaction) effects of ß cyclodextrin (ßCD) and surfactant (Soluplus) on the solubility and dissolution rate of efavirenz in a series of 2 2 factorial experiments. The solubility of efavirenz in four selected fluids containing ßCD and Soluplus as per 2 2 factorial study was determined. Solid inclusion complexes of efavirenz-ßcd were prepared with and without Soluplus by kneading method as per 2 2 -factorial design and were evaluated. The feasibility of formulating the drug- ßCD- Soluplus complexes into compressed tablets was also evaluated in a 2 2 factorial study. The individual and combined effects of ßCD and Soluplus in enhancing the solubility, dissolution rate and dissolution efficiency of efavirenz were highly significant (P < 0.01).ßCD alone gave a 2.14 fold increase in the solubility of efavirenz. Combination of ßCD with Soluplus resulted in a much higher enhancement in the solubility of efavirenz, fold than with ßCD alone. Soluplus alone gave a much higher enhancement ( folds) in the solubility of efavirenz. Combination of ßCD with Soluplus also gave significantly higher dissolution rates (K 1 ) when compared to ßCD alone. ßCD alone gave 2.00 fold increase and in combination with Soluplus, it gave 7.34 fold increase in the dissolution rate of efavirenz. Efavirenz ßCD, Efavirenz Soluplus and efavirenz ßCD Soluplus inclusion complexes could be formulated into compressed tablets by direct compression method. Efavirenz dissolution was rapid and higher from the tablets formulated employing drug- ßCD- Soluplus inclusion complexes when compared to the tablets containing efavirenz alone. The tablets formulated employing drug- ßCD- Soluplus inclusion complexes fulfilled the official (I.P 2010) dissolution rate test specification of NLT 70 % in 30 min prescribed for efavirenz tablets. The individual as well as combined effects of the two factors involved i.e., ßCD (factor A) and Soluplus (factor B) were highly significant (P< 0.01) in enhancing the dissolution ) and dissolution efficiency (DE 30 ) of efavirenz. Soluplus alone also gave a higher enhancement in the dissolution rate and dissolution efficiency of efavirenz and efavirenz tablets. Hence a combination of ßCD with Soluplus and / or Soluplus alone is recommended to enhance the solubility, dissolution rate and dissolution efficiency of efavirenz, a BCS class II drug and its tablet formulations. Key words: Efavirenz, ß Cyclodextrin, Soluplus, Solubility, Dissolution Rate, Efavirenz Tablets, Formulation development. INTRODUCTION Efavirenz, a widely prescribed HIV- 1 specific non nucleoside reverse transcriptase inhibitor drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It is practically insoluble in water and aqueous fluids. As such its oral absorption is dissolution rate limited and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. Several techniques 1 such as micronization, cyclodextrin complexation, use of surfactants and solubilizers, solid dispersion in water soluble and dispersible carriers, use of salts, prodrugs and polymorphs which exhibit high solubility, micro emulsions and self emulsifying micro and nano disperse systems have been used to enhance the solubility, dissolution rate and bioavailability of poorly soluble drugs. Among the various approaches complexation with cyclodextrins has gained good acceptance in recent years in industry for enhancing the solubility and dissolution rate of poorly soluble drugs. Cyclodextrins (CDs) are cyclic torus-shaped molecules with a hydrophilic outer surface and a lipophilic central cavity which can accom-
2 K. Ravi Shankar et al. /BioMedRx 2013,1(3), modate a variety of lipophilic drugs. As a consequence of inclusion process many physico-chemical properties such as solubility, dissolution rate, stability and bioavailability can be favourably affected 2, 3. Cyclodextrins have been receiving increasing application in pharmaceutical formulation in recent years due to their approval by various regulatory agencies 4, 5. Soluplus is a polymeric solubiliser with an amphiphilic chemical nature, which was particularly developed for solid solutions 6. Soluplus is polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft co- polymer. Soluplus increased the solubility and enhanced the bioavailability of actives in solid solutions. Itraconazole and fenofibrate showed significant increase in the bioavailability with Soluplus 6. The solubility and dissolution rate of valsartan was effectively enhanced by using Soluplus in the form of solid dispersions 7. Poly vinyl pyrrolidone (PVP K 30) is also reported 8, 9 to enhance the solubility and dissolution rate of poorly soluble drugs. Though cyclodextrin complexation and use of surfactants and PVP for enhancing the solubility and dissolution rate of poorly soluble drugs have been investigated individually, no reports are available on their combined use in enhancing the solubility and dissolution rate. In the present investigation the individual main effects and combined (or interaction) effects of ß cyclodextrin (ßCD) and surfactant (Soluplus) on the solubility and dissolution rate of efavirenz, a BCS class II drug were evaluated in a 2 2 factorial study. The feasibility of formulating the drug- ßCD- Soluplus complexes into compressed tablets was also evaluated in a 2 2 factorial study. EXPERIMENTAL Materials Efavirenz was a gift sample from M/s. Eisai Pharmatechnology and Manufacturing Pvt. Ltd., Visakhapatnam. ß Cyclodextrin was gift sample from M/s. Cerestar Inc., USA. Soluplus was a gift sample from BASF, the chemical company, Hyderabad. Methanol (Qualigens), Avicel PH 102 and poly vinyl pyrrolidone (PVP K30) were procured from commercial sources. All other materials used were of pharmacopoeial grade. Methods Estimation of Efavirenz A UV Spectrophotometric method based on the measurement of absorbance at 245 nm in water containing 2 % Sodium lauryl sulphate (SLS) was used for the estimation of efavirenz. The method was validated for linearity, accuracy, precision and interference. The method obeyed Beer s law in the concentration range of 0-10 µg/ml. When a standard drug solution was repeatedly assayed (n=6), the relative error and coefficient of variance were found to be 0.85% and 1.20 % respectively. No interference by the excipients used in the study was observed. temperature (28±1 o C) on Rotary Flask Shaker. After 24 h of shaking, 2 ml aliquots were withdrawn at 2 h interval and filtered immediately using a 0.45 µ disk filter. The filtered samples were diluted suitably and assayed for efavirenz by measuring absorbance at 245 nm. Shaking was continued until two consecutive estimations are the same. The solubility experiments were replicated for three times each (n=3). Preparation of Efavirenz - ßCD Complexes Solid inclusion complexes of efavirenz ßCD - Soluplus were prepared as per 2 2 factorial study by kneading method. Efavirenz, ßCD and Soluplus were triturated in a mortar with a small volume of solvent consisting of a blend of dichloromethane: methanol (1:1). The thick slurry formed was kneaded for 45 min and then dried at 55 o C until dry. The dried mass was powdered and sieved to mesh No Preparation of Efavirenz- ßCD Soluplus tablets Compressed tablets each containing 50 mg of efavirenz were prepared as per 2 2 factorial study by direct compression method employing efavirenz- ßCD - Soluplus inclusion complexes as per the formulae given in Table 3. All ingredients as per the formula were blended in a closed polyethylene bag and were compressed into tablets on a 16- station tablet punching machine (M/s Cadmach machineries Pvt. Ltd., Ahmedabad) to a hardness of 5-6 kg/cm 2 using 9 mm flat punches. In each case 100 tablets were compressed. Evaluation of tablets: Hardness of the tablets was tested using a Monsanto hardness tester. Friability of the tablets was determined in a Roche friabilator. Disintegration time of the tablets prepared was determined using a Thermonic tablet disintegration test machine using water as test fluid. Dissolution rate study: The dissolution rate of efavirenz from the ßCD - Soluplus inclusion complexes and tablets prepared was studied in 900 ml water containing 1 % Sodium lauryl sulphate (SLS) using Disso 2000 (Labindia) 8- station dissolution test apparatus with a paddle stirrer at 50 rpm. A temperature 37±1 o C was maintained throughout the study. Inclusion complex equivalent to 50 mg of efavirenz or one tablet containing 50 mg of efavirenz was used in each test. Samples of dissolution media (5 ml) were withdrawn through a filter (0.45 µ) at different intervals of time, suitable diluted and assayed for efavirenz at 245 nm. The sample of dissolution fluid withdrawn at each time was replaced with fresh fluid. The dissolution experiments were replicated three times each (n=3). Analysis of results: Dissolution data were subjected to analysis as per zero order and first order kinetics and the corresponding dissolution rates were calculated. Dissolution efficiency (DE 30 ) values were calculated as suggested by Khan 10. Solubility and dissolution data were also analyzed by Analysis of Variance (ANOVA) as per 2 2 factorial study. Solubility Determination Excess drug (50 mg) was added to 15 ml of each fluid taken in a 25 ml stoppered conical flask and the mixtures were shaken for 24 h at room RESULTS AND DISCUSSION The objective of the study is to enhance the solubility and dissolution rate of efavirenz by cyclodextrin complexation along with Soluplus
3 K. Ravi Shankar et al. /BioMedRx 2013,1(3), and to evaluate the individual main effects and combined (or interaction) effects of ß cyclodextrin (ßCD), and surfactant (Soluplus) on the solubility and dissolution rate of efavirenz in a series of 2 2 factorial experiments. The feasibility of formulating the drug- ßCD- Soluplus complexes into compressed tablets was also evaluated in a 2 2 factorial study. The individual main effects and combined (interaction) effects of ßCD (Factor A), and Soluplus (Factor B) on the aqueous solubility of efavirenz were evaluated in a series of 2 2 -factorial experiments. For this purpose, two levels of ßCD (0, 5 mm), and two levels of Soluplus (0, 1%) were selected in each case and the corresponding four treatments involved in the factorial study were purified water (1); water containing 5 mm ßCD (a); water containing 1% Soluplus (b); and water containing 5 mm ßCD and 1% Soluplus (ab). The solubility of efavirenz in the above mentioned fluids was determined (n=3) and the results are given in Table-1. The solubility data were subjected to Analysis of variance (ANOVA) to find out the significance of main and combined effects of ßCD and Soluplus on the solubility of efavirenz. The results of ANOVA indicated that the individual and combined effects of ßCD and Soluplus in enhancing the solubility of efavirenz were highly significant (P < 0.01). ßCD alone gave a 2.14 fold increase in the solubility of efavirenz. Combination of ßCD with Soluplus resulted in a much higher enhancement in the solubility of efavirenz (86.96 fold) than with ßCD alone. Soluplus alone gave a much higher enhancement ( folds) in the solubility of efavirenz. Table1: Solubility of Efavirenz in Various Fluids as per 2 2 -Factorial Study Table 2: Dissolution Parameters of Efavirenz- ßCD-Soluplus Inclusion Complexes Prepared as per 2 2 Factorial Study. EF- ß Composition PD 10 Dissolution Increase Dissolution Increase CD (%) Rate (min -1 ) in K 1 Efficiency in DE 20 Complex (K 1 x 10 2 ) (no of (DE 20 ) (%) (no of ( x) (sd)) folds) (x) (sd) folds) E EF (0.56) (1.7) EF EF- ßCD (1:2) a (4.5) (10.37) EF EF-Soluplus (1%) b (1.35) (1.16) EF EF- ßCD (1:2) ab Soluplus (1%) (0.55) (1.85) Fluid (code as per Solubility Increase in solubility factorial experiment) (mg/ml) (number of folds) Distilled water(1) Water containing 5mM ßCD (a) Water containing 1% Soluplus (b) Water containing 5mM ßCD And 1% Soluplus (ab) Fig.1: Dissolution Profiles of Efavirenz ßCD Inclusion Complexes Prepared by Employing ßCD and Soluplus as per 2 2 Factorial Design To evaluate the individual and combined effects of ßCD and Soluplus on the dissolution rate of efavirenz, solid inclusion complexes of efavirenz- ßCD were prepared with and without Soluplus as per factorial design. For this purpose two levels of ßCD (0 and 1:2 ratio of drug : ßCD) and two levels of Soluplus (0 and 1%) were selected and the corresponding four treatments involved in the 2 2 -factorial study were efavirenz pure drug (1); efavirenz- ßCD (1:2) inclusion binary complex (a); efavirenz - Soluplus (1%) binary complex (b); and efavirenz- ßCD (1:2) - Soluplus (1%) ternary complex (ab). The CD complexes were prepared by kneading method. All the solid inclusion complexes of efavirenz- ßCD - Soluplus prepared were found to be fine and free flowing powders. Low coefficient of variation (c.v.) values (< 1.2 %) in the percent drug content indicated uniformity of drug content in each batch of solid inclusion complexes prepared. The dissolution rate of efavirenz alone and from ßCD complexes was studied in water containing 1 % SLS as prescribed in IP The dissolu- tion of efavirenz followed first order kinetics with r (correlation coefficient) above Dissolution efficiency (DE 20 ) values were calculated as suggested by Khan 10. The dissolution parameters are given in Table-2. The dissolution of efavirenz was rapid and higher in the case of efavirenz- ßCD and efavirenz- ßCD - Soluplus complex systems prepared when compared to efavirenz pure drug as such. The dissolution profiles of various inclusion complexes prepared are given in Fig-1. The dissolution ) values were subjected to ANOVA to find out the significance of the main and combined effects of ßCD and Soluplus on the dissolution rate of efavirenz. ANOVA indicated that the individual main effects of ßCD and Soluplus and their combined effects in enhancing the dissolution )and dissolution efficiency (DE 20 ) were highly significant (P < 0.01). ßCD alone gave a 2.00 fold increase in the dissolution rate of (K 1 ) of efavirenz. When ßCD is combined with Soluplus the dissolution ) was significantly enhanced (4.41 fold). Soluplus ( )
4 K. Ravi Shankar et al. /BioMedRx 2013,1(3), alone also gave higher dissolution rates, 7.34 fold increase in the dissolution ) of efavirenz. DE 20 values were also much higher in the case of ßCD Soluplus solid complexes when compared to efavirenz pure drug. The feasibility of formulating efavirenz- ßCD - Soluplus solid inclusion complexes into tablets was evaluated by preparing efavirenz tablets employing the solid inclusion complexes by direct compression method. To evaluate the individual and combined effects of ßCD and Soluplus on the dissolution rate and efficiency of efavirenz tablets, tablets each containing 50 mg of efavirenz were formulated employing solid inclusion complexes of drug- ßCD - Soluplus as per 2 2 factorial design. For this purpose two levels of ßCD (0 and 1: 2 ratio of Drug : ßCD) and two levels of each of Soluplus ( 0 and 1%) were selected and the corresponding four treatments involved in the formulation of tablets as per 2 2 -factorial study were efavirenz pure drug (1); EF- ßCD (1:2) inclusion binary complex (a); EF - Soluplus (1%) binary mixture (b) and EF - ßCD (1:2) Soluplus (1%) ternary complex (ab). Table 3: Formulae of Efavirenz Tablets Prepared by Direct Compression Method Employing Drug- ßCD Soluplus Inclusion complexes Table 5.All the tablets prepared were found to contain efavirenz within 100 ± 2% of the labeled claim. Hardness of the tablets was in the range Kg/cm 2. Percentage weight loss in the friability test was less than 0.5 % in all the cases. All the tablets formulated employing efavirenz - ßCD - Soluplus inclusion complexes disintegrated rapidly within 2 min. The dissolution rate of efavirenz from the tablets prepared was studied in 900 ml of water containing 1 % SLS as prescribed in I.P Dissolution of efavirenz from all the tablets prepared followed first order kinetics with the correlation coefficient (r) values above Ingredient (mg / tablet) Efavirenz Tablet Formulation Efavirenz (1)** EF- ßCD (1:2) (a) EF Soluplus (1%) (b) EF - ßCD (1:2) Soluplus (1%) (ab) PVP K Crasscarnellose sodium Talc Magnesium Stearate Aerosil Avicel PH Total weight (mg) EF: Efavirenz; ßCD: ß cyclodextrin; ** Figures in parentheses are codes as per 2 2 Factorial Design All the prepared tablets were evaluated for drug content, hardness, friability and disintegration time and dissolution rate of efavirenz. The physical properties of the tablets prepared are given in Table 4. The dissolution profiles of various tablets formulated are shown in Fig. 2.The dissolution parameters of the tablets prepared are summarized in Table 4: Physical Properties of Efavirenz Tablets Prepared Employing Drug- ßCD Soluplus by Direct Compression Method as per 2 2 Factorial Study Formulation Hardness Friability DT Drug code as per (Kg/sq. cm) (% weight (min- Content 2 2 factorial loss) sec) (mg/tablet) design Fig.2: Dissolution Profiles of Efavirenz ßCD tablets Prepared by Employing ßCD and Soluplus as per 2 2 Factorial Design Table 5: Dissolution Parameters of Efavirenz Tablets Prepared as per 2 2 Factorial Study Employing Drug-ßCD-Soluplus Inclusion Complexes EF- ß Composition PD 10 Dissolution Increase Dissolution Increase CD (%) Rate (min -1 ) in K 1 Efficiency in DE 20 Complex (K 1 x 10 2 ) (no of (DE 20 ) (%) (no of ( x) (sd)) folds) (x) (sd) folds) EF (0.015) (1.24) - EF- ßCD (1:2) (0.04) (4.67) 2.38 EF-Soluplus (1%) (0.02) (11.2) 1.79 EF- ßCD (1:2) (0.015) (4.15) 2.33 Soluplus (1%) Efavirenz dissolution was rapid and higher from the tablets formulated employing drug- ßCD- Soluplus inclusion complexes when compared to the tablets containing efavirenz alone. Dissolution parameters, K 1 and DE 30 were subjected to ANOVA to find out the significance of the individual and combined effects of the two factors (ßCD, Soluplus) in enhancing the dissolution rate and efficiency of efavirenz tablets. The individual as well as combined effects of the two factors
5 K. Ravi Shankar et al. /BioMedRx 2013,1(3), involved i.e., ßCD (factor A) and Soluplus ( factor B ) were highly significant (P< 0.01) in enhancing the dissolution ) and dissolution efficiency (DE 30 ) of efavirenz. Formulation formulated with ßCD alone gave higher enhancement in the dissolution rate (9.21 fold) when compared to control formulation formulated with efavirenz alone. Formulations containing Soluplus i.e. and gave relatively low dissolution when compared to formulation. The low dissolution observed with tablet formulations containing Soluplus is due to its binding nature reported earlier 6. I.P 2010 prescribed a dissolution rate specification of NLT 70% in 30 min for efavirenz tablets. All the efavirenz tablets formulated employing with drug- ßCD ( ), drug Soluplus ( ) and drug- ßCD Soluplus ( ) inclusion complexes fulfilled the official (I.P) dissolution rate specification of efavirenz tablets. Whereas plain tablets formulated employing efavirenz alone did not fulfill the official dissolution rate specification. Hence Soluplus alone or a combination of ßCD with Soluplus is recommended to enhance the dissolution rate and dissolution efficiency of efavirenz tablets. CONCLUSIONS 1. The individual and combined effects of ßCD and Soluplus in enhancing the solubility, dissolution rate and dissolution efficiency of efavirenz were highly significant (P < 0.01). 2. ßCD alone gave a 2.14 fold increase in the solubility of efavirenz. Combination of ßCD with Soluplus resulted in a much higher enhancement in the solubility of efavirenz, fold than with ßCD alone. 3. Soluplus alone gave a much higher enhancement ( folds) in the solubility of efavirenz. 4. Combination of ßCD with Soluplus also gave significantly higher dissolution rates (K 1 ) when compared to ßCD alone. ßCD alone gave 2.00 fold increase and in combination with Soluplus, it gave 7.34 fold increase in the dissolution rate of efavirenz. 5. Efavirenz ßCD, Efavirenz Soluplus and efavirenz ßCD Soluplus inclusion complexes could be formulated into compressed tablets by direct compression method. 6. Efavirenz dissolution was rapid and higher from the tablets formulated employing drug- ßCD- Soluplus inclusion complexes when compared to the tablets containing efavirenz alone. Source of support: Nil, Conflict of interest: None Declared 7. The tablets formulated employing drug- ßCD- Soluplus inclusion complexes fulfilled the official (I.P 2010) dissolution rate test specification of NLT 70 % in 30 min prescribed for efavirenz tablets. 8. The individual as well as combined effects of the two factors involved i.e., ßCD ( factor A) and Soluplus ( factor B) were highly significant (P< 0.01) in enhancing the dissolution ) and dissolution efficiency (DE 30 ) of efavirenz. 9. Soluplus alone also gave a higher enhancement in the dissolution rate and dissolution efficiency of efavirenz and efavirenz tablets. 10. Hence a combination of ßCD with Soluplus and / or Soluplus alone is recommended to enhance the solubility, dissolution rate and dissolution efficiency of efavirenz, a BCS class II drug and its tablet formulations. REFERENCES 1. Chowdary, K. P. R and Madhavi, BLR, Novel Drug Delivery Technologies for Insoluble Drugs, Indian Drugs, (9), Fromming, K.H. and Szejtli, J. Cyclodextrins in Pharmacy. Kluwer Academic Publications, Dordrecghi, 1994, p Duchene, D., Woussidjewe, D. and Dumitriu, S. Polysaccharides in Medical Applications. Marcel Dekker, New York, 1996, Thompson, D.O. Crit Rev Therapeutic Drug Carrier System. 1997, 14 (1), Hedges, A.R. Chemical Review. 1998, 98, Hendrik Hardung, Dejan Djuric, Shaukat Ali, Drug Delivery Technology, 2010,10 (3), XX. 7. Raja Rajeswari.K, Abbulu. K and Sudhakhar.M, J. Chem. Pharm. Res., 2011, 3(1): Giri, T. K., Badwaik, H., Alexander, A., and Tripathi, D. K., Int. J. Applied Biology and Pharmaceutical Tech., 2010, 1 (2), Aejaz, A., Jafar, M. Dehghan, M. H. G., and Adil Shareef, S.,. Int. J. Pharm. and Pharmaceutical Sci., 2010, 2 (1), Khan, K.A., Journal of Pharmacy and Pharmacology. 1975, 27,
Int. Res J Pharm. App Sci., 2013; 3(4): ISSN:
International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(4):110-115 Research Article FORMULATION DEVELOPMENT
More informationAvailable online at
Available online at www.jgtps.com Research Article ISSN:2230-7346 Journal of Global Trends in Pharmaceutical Sciences Vol.3, Issue 4, pp -923-928, October December 202 ENHANCEMENT OF DISSOLUTION RATE OF
More informationInt. Res J Pharm. App Sci., 2012; 2(6): ISSN:
International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(1): 269-273 Research Article FORMULATION DEVELOPMENT
More informationA FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN AND SOLUTOL HS15
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN
More informationFORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES
Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.
More informationENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP
Int. J. Chem. Sci.: 9(2), 20, 637-646 ISSN 0972-768X www.sadgurupublications.com ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP K. P. R. CHOWDARY *, K.
More informationScholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):24-30 (http:scholarsresearchlibrary.comarchive.html) ISSN 0974-248X USA CODEN: DPLEB4 Formulation
More informationFORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES
Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER 407 - PVPK30 INCLUSION COMPLEXES K.P.R. Chowdary*, K. Surya Prakasa
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS
Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar
More informationFACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS
JChrDD Vol 2 Issue 2 2011: 89-93 ISSN 2249-6785 Journal of Chronotherapy and Drug Delivery Received: August 06, 2011 Accepted: Sep 12, 2011 Original Research Paper FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY
More informationInt. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN:
International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(6):42-46 Research Article ENHANCEMENT OF SOLUBILITY
More informationChemate and Chowdary, IJPSR, 2012; Vol. 3(7): ISSN:
IJPSR (2012), Vol. 3, Issue 07 (Research Article) Received on 18 March, 2012; received in revised form 25 April, 2012; accepted 22 June, 2012 A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION
More informationENHANCEMENT OF SOLUBILITY, DISSOLUTION RATE AND BIOAVAILABILITY OF RITONAVIR BY CYCLODEXTRINS AND SOLUTOL HS15 - A FACTORIAL STUDY
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article ENHANCEMENT OF SOLUBILITY, DISSOLUTION RATE AND BIOAVAILABILITY OF RITONAVIR BY CYCLODEXTRINS
More informationOptimization of valsartan tablet formulation by 2 3 factorial design
Research Article ISSN: 0974-6943 K. P. R. Chowdary et al. / Journal of Pharmacy Research 2014,8(9, Available online through http://jprsolutions.info Optimization of valsartan tablet formulation by 2 3
More informationEFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION RATE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article EFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION
More informationFORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD
Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA
More informationInt. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN:
International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2014; 4(1):47-51 Research Article FORMULATION AND EVALUATION
More informationSTUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS
Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College
More informationCHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR
CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF ACECLOFENAC BY SOLID DISPERSION IN STARCH PHOSPHATE AND GELUCIRE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF ACECLOFENAC BY SOLID DISPERSION
More informationAsian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012
STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college
More informationIJRPC 2014, 4(2), Vinod Kumar et al. ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY
IJRPC 2014, 4(2), 415422 Vinod Kumar et al. ISSN: 2231 2781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FACTORIAL STUDY ON THE EVALUATION
More informationAvailable online at
Available online at www.jgtps.com Research Article ISSN:2230-7346 Journal of Global Trends in Pharmaceutical Sciences Vol.3, Issue 4, pp -909-916, October December 2012 PRECLINICAL PHARMACOKINETIC EVALUATION
More informationFormulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch
Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,
More informationA Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac
Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*
More informationPREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE
More informationFormulation Development of Nimesulide Tablets by Wet Granulation and Direct Compression Methods Employing Starch Citrate
Asian Journal of Chemistry; Vol. 24, No. 8 (2012), 3362-3366 Formulation Development of Nimesulide Tablets by Wet Granulation and Direct Compression Methods Employing Starch Citrate K.P.R. CHOWDARY *,
More informationIJRPC 2012, 2(3) Chowdary et al ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION, CHARACTERIZATION AND EVALUATION OF PGS - PVP CO-PROCESSED EXCIPIENT AS DIRECTLY
More informationFormulation Development of Etoricoxib Tablets by Wet Granulation and Direct Compression Methods Employing Starch Phosphate
International Journal of Pharmacology and Technology 3(1), June 2011, pp. 9-15 Formulation Development of Etoricoxib Tablets by Wet Granulation and Direct Compression Methods Employing Starch Phosphate
More informationFORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam
More informationFABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS
Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.
More informationPreparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release
Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5901-5907 Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release K.P.R. CHOWDARY* and MALLURU SUBBA
More informationSTABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS
Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN
More informationFormulation and evaluation of immediate release salbutamol sulphate
5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely
More informationFormulation and evaluation of sublingual tablets of lisinopril
Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com COMPARARISSION OF SOLUBILITY IMPROVEMENT OF CEFIXIME
More informationPreparation and Evaluation of Ethylene Vinyl Acetate Copolymer Coated Microcapsules of Glipizide for Controlled Release
Asian Journal of Chemistry Vol. 21, No. 8 (2009), 5838-5842 Preparation and Evaluation of Ethylene Vinyl Acetate Copolymer Coated Microcapsules of Glipizide for Controlled Release K.P.R. CHOWDARY* and
More informationFormulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution
ISSN 2395-3411 Available online at www.ijpacr.com 486 Research Article Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution Ghanshayma M. Patil*, Harshal K. Patil, Vipul
More informationAvailable Online through Research Article
ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,
More informationEvaluation of Ethyl Cellulose as Microencapsulating Agent for Controlled Release of Glimepiride
Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5924-5930 Evaluation of Ethyl Cellulose as Microencapsulating Agent for Controlled Release of Glimepiride K.P.R. CHOWDARY* and SRINIVAS PANGULURI University
More informationFormulation and Evaluation
Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the
More informationDESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN
Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI
More informationPREPARATION, CHARACTERIZATON AND DISSOLUTION KINETICS OF CELECOXIB : β AND HP β -CYCLODEXTRIN COMPLEXES
Int. J. Chem. Sci : 6(2), 2008, 887-902 PREPARATION, CHARACTERIZATON AND DISSOLUTION KINETICS OF CELECOXIB : β AND HP β -CYCLODEXTRIN COMPLEXES K. P. R. CHOWDARY and LINGARAJ S. DANKI a Department of Pharmaceutical
More informationJournal of Pharmaceutical and Scientific Innovation
Journal of Pharmaceutical and Scientific Innovation www.jpsionline.com Research Article ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ROSUVASTATIN BY USING SOLID DISPERSION TECHNIQUE Swathi T 1 *,
More informationJournal of Advanced Scientific Research. Formulation and Evaluation of Glimepiride Solid Dispersion Tablets for Their Solubility Enhancement
Wagh V.T. et al, J Adv Sci Res, 2012, 3(4): 36-41 36 Journal of Advanced Scientific Research Available online through http://www.sciensage.info/jasr ISSN 0976-9595 Research Article Formulation and Evaluation
More informationPatel B et al. IRJP 1 (1)
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY Available online http://www.irjponline.com Research Article IMPROVEMENT OF SOLUBILITY OF CINNARIZINE BY USING SOLID DISPERSION TECHNIQUE Patel Bipin*, Patel Jayvadan,
More informationPreparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums
1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(4):150-158 Effect of losartan potassium on the solubility
More informationGlobal College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India
IJPSR (2012), Vol. 3, Issue 09 (Research Article) Received on 19 May, 2012; received in revised form 25 June, 2012; accepted 27 August, 2012 IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(3):159-164 Studies on formulation and in vitro evaluation
More informationISSN: X CODEN: IJPTFI Available Online through Research Article
ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com NEW SPECTROPHOTOMETRIC ESTIMATION OF NAPROXEN TABLETS FORMULATIONS EMPLOYING MIXED SOLVENCY CONCEPT (AT 331NM)
More informationFormulation and Development of Sustained Release Tablets of Valsartan Sodium
INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of
More informationJournal of Pharmaceutical and Scientific Innovation
Journal of Pharmaceutical and Scientific Innovation www.jpsionline.com (ISSN : 2277 4572) Research Article ASSESSING THE BEST POLY VINYL PYRROLIDONE AS A CARRIER FOR ETORICOXIB SOLID DISPERSIONS: FABRICATION
More informationInternational Journal of Pharma and Bio Sciences
STUDIES ON THE PREPARATION, CHARACTERIZATION AND SOLUBILITY OF SK.MAJAHAR*, R.M.RAO KUSUMANCHI, B.N.GAYATRI Formulation Research and Development, Hetero Drugs Ltd., Hyderabad, India. *Corresponding Author:
More informationFORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX
Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Issue 1, 2012 Research Article FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE
More informationKarnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:
335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY
More informationVolume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL
Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya
More informationMEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON
Page67 Available Online through IJPBS Volume 1 Issue 2 APRIL- JUNE 2011 SIMPLE QUANTITATIVE METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN PUREFORM AND PHARMACEUTICAL DOSAGE FORMS BYUV SPECTROSCOPY
More informationComparative evaluation of modified starches in different tablet formulations as disintegrants
Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 12, 4 (6):16-1684 (http://scholarsresearchlibrarycom/archivehtml) ISSN 975-571 USA CODEN: DPLEB4 Comparative
More informationFormulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology
Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology Sunita Shakya Department of Pharmacy, Kathmandu University, Kavre, Nepal. Email: sunita95@gmail.com
More informationFORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS
International Journal of PharmTech Research CODEN( USA): IJPRIF ISSN : 0974-4304 Vol.1, No.3, pp 634-638, July-Sept 2009 FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS K. Reeta Vijaya
More informationFormulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium
Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast
More informationThe objective of the present investigation is to design and evaluate controlled release tablets of carvedilol, employing
Research Article Preparation and evaluation of controlled release tablets of carvedilol M L Varahala Setti, J Vijaya Ratna Division of Pharmaceutical Technology, University College of Pharmaceutical Sciences,
More informationOptimization of Valsartan SR Floating Tablet Formulation by 2 2 Factorial Design and Multiple Regression Technique
Optimization of Valsartan SR Floating Tablet by 2 2 Factorial Design and Multiple Regression Technique K. Srinivasa Reddy 1, Surya Kanta Swain 2, K. P. R. Chowdary *3, S. V. U. M. Prasad 4 1 School of
More informationInternational Journal of Medicine and Pharmaceutical Research
International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating
More informationResearch Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form
Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Gowekar NM, Lawande YS*, Jadhav DP, Hase RS and Savita N. Gowekar Department
More informationDesign and In-vitro Evaluation of Silymarin Bilayer Tablets
CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin
More informationDesign and development of fast Melting Tablets of Terbutaline Sulphate
Design and development of fast Melting Tablets of Terbutaline Sulphate Mathew T and Agrawal S Swami Vivekanand College of Pharmacy, Khandwa Road, Indore (MP), INDIA Available online at: www.isca.in (Received
More informationCombining HME & Solubilization: Soluplus - The Solid Solution By: Hendrik Hardung, PhD; Dejan Djuric, PhD; and Shaukat Ali, PhD
Combining HME & Solubilization: Soluplus - The Solid Solution By: Hendrik Hardung, PhD; Dejan Djuric, PhD; and Shaukat Ali, PhD INTRODUCTION Drug solubilization has drawn attention in recent years because
More informationAsian Journal of Pharmacy and Life Science ISSN Vol. 1 (4), Oct-Dec, 2011
Asian Journal of Pharmacy and Life Science ISSN 223 4423 Vol. (4), OctDec, 20 Preparation, Evaluation and Characterization of Solid Dispersion of Piroxicam Priya Jain*, Dheeraj Jain 2, Prasoon Dwivedi,
More informationInternational Journal of Pharma Sciences and Scientific Research
Research Article International Journal of Pharma Sciences and Scientific Research ISSN 2471-6782 Open Access Formulation, development and evaluation of rivaroxaban tablets by using solubility enhancement
More informationISSN: PREPARATION AND EVALUATION OF CONTROLLED RELEASE CARBAMAZEPINE MICROCAPSULES USING NATURAL POLYMER. Visakhapatnam , India
Research Article ISSN:2230-7346 Journal of Global Trends in Pharmaceutical Sciences Vol.3, Issue 2, pp 597-607, April June 2012 PREPARATION AND EVALUATION OF CONTROLLED RELEASE CARBAMAZEPINE MICROCAPSULES
More informationIJRPC 2011, 1(4) Rohan et al. ISSN: INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article ABSORPTION CORRECTION METHOD AND SIMULTANEOUS EQUATION METHOD FOR THE SIMULTANEOUS ESTIMATION
More informationskim milk as carrier by kneading method. They were evaluated for percentage yield, drug content, FT-IR
Available Online through ISSN: 0975-766X CODEN: IJPTFI Research Article www.ijptonline.com ENHANCEMENT OF SOLUBILITY & DISSOLUTION RATE OF LAMOTRIGINE BY KNEADING METHOD Gadhave M.V*, Mahakal A. J., Gaikwad
More informationJournal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011
ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE
More informationBioavailability enhancement of poorly soluble APIs. Enhanced solubilization out of solid glassy solutions prepared by Hot-Melt Extrusion
Pharma Ingredients & Services. Welcome to more opportunities. Custom Synthesis Excipients Active Ingredients ExActConcepts Example: Itraconazole Bioavailability enhancement of poorly soluble APIs Enhanced
More information7. SUMMARY, CONCLUSION AND RECOMMENDATIONS
211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research J. Chem. Pharm. Res., 2010, 2(5): 45-51 ISSN No: 0975-7384 CODEN(USA): JCPRC5 Simultaneous U.V. Spectrophotometric estimation
More informationFORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS
More informationFormulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique
35 Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique Bhumi B. Patel 1 *, Chainesh N. Shah 2, Rumit M. Shah 3 1 Department
More informationBiopharmaceutics Dosage form factors influencing bioavailability Lec:5
Biopharmaceutics Dosage form factors influencing bioavailability Lec:5 Ali Y Ali BSc Pharmacy MSc Industrial Pharmaceutical Sciences Dept. of Pharmaceutics School of Pharmacy University of Sulaimani 09/01/2019
More informationInternational Journal of Chemistry and Pharmaceutical Sciences
Ramesh Naik M et al IJCPS, 2014, Vol.2(11): 1259-1264 Research Article ISSN: 2321-3132 International Journal of Chemistry and Pharmaceutical Sciences Fabrication and Evaluation of Montelukastsodium Sustained
More informationFORMULATION AND EVALUATION OF GLIMEPIRIDE SOLID DISPERSIONS AND THEIR TABLET FORMULATIONS FOR ENHANCED BIOAVAILABILITY
FORMULATION AND EVALUATION OF GLIMEPIRIDE SOLID DISPERSIONS AND THEIR TABLET FORMULATIONS FOR ENHANCED BIOAVAILABILITY ABSTRACT S.Vidyadhara*, J.Ramesh Babu, RLC.Sasidhar, A.Ramu, S.Siva Prasad and M.Tejasree
More informationA STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE FORMS
International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009 Research Article A STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE
More informationMaisammaguda, Dulapally, Secundrabad.
121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY
More informationAsian Journal of Biochemical and Pharmaceutical Research
ISSN: 2231-2560 Research Article Asian Journal of Biochemical and Pharmaceutical Research Design and Evaluation of Gastroretentive Floating Tablets of Dipyridamole: Influence of Formulation Variables A.
More informationDESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS
Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and
More informationAvailable Online through
ISSN: 0975-766X Available Online through Research Article www.ijptonline.com FORMULATION DESIGN AND OPTIMIZATION OF MOUTH DISSOLVE TABLETS OF GLIPIZIDE R.Shireesh Kiran 1*, B.Chander Shekar 1, Sharadha
More informationComparative Dissolution Study of Glipizide by Solid Dispersion Technique
Comparative Dissolution Study of Glipizide by Solid Dispersion Technique Dehghan M H G 1, Saifee M 1, Hanwate R M 2 1 Y.B.Chavan College of Pharmacy,Dr. Rafiq Zakaria campus, Aurangabad-431001, Maharashtra,
More informationINTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES
International Journal of Institutional Pharmacy and Life Sciences 5(1): January-February 215 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Pharmaceutical Sciences Research Article!!!
More informationJournal of Chemical and Pharmaceutical Research, 2012, 4(6): Research Article. Studies on Carica Papaya Starch as a Pharmaceutical Excipient
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2012, 4(6):3134-3138 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Studies on Carica Papaya Starch as a Pharmaceutical
More informationFORMULATION STUDIES ON SOLID DISPERSIONS OF CELECOXIB IN SUPERDISINTEGRANTS ALONE AND WITH PVP
http://www.rasayanjournal.com Vol.2, No.3 (2009), 691-698 ISSN: 0974-1496 CODEN: RJCABP FORMULATION STUDIES ON SOLID DISPERSIONS OF IN SUPERDISINTEGRANTS ALONE AND WITH PVP Department of Pharmaceutics,
More informationStudies on Curcuma angustifolia Starch as a Pharmaceutical Excipient
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.2, No.4, pp 2456-2460, Oct-Dec 2010 Studies on Curcuma angustifolia Starch as a Pharmaceutical Excipient P.RAJEEVKUMAR
More informationFormulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting
Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Biresh Kumar Sarkar* 1, Devananda Jain 1, Mamta Parwal 2 1. Bhagwant University, Dept.of Pharmaceutical Tech and Sciences,
More informationFORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF AMLODIPINE
More informationVenkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)
Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101
More informationDESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL
DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL Isha Shah, Alpesh Yadav, Shailendra Bhatt Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India-3000. Abstract
More informationDesign and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets
Research Reviews: Pharmacy & Pharmaceutical Sciences e-issn: 2320-1215 www.rroij.com Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Sowjanya Battu*, Madhavi K, Bhikshapathi
More informationComparative study of different solubility enhancement techniques on dissolution rate of zaltoprofen
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More information