Material Safety Data Sheet

Transcription

1 Material Safety Data Sheet MSDS Update: 04/17/2012 Version: 1.0 Date Printed: SECTION 1 - Chemical Product & Company Identification Product Name Solubility and Stability Screen HT Product Number HR2-072 Company Hampton Research Street Address 34 Journey City, State, Zip, Country Aliso Viejo, CA , U.S.A. Technical Phone Fax Emergency Phone For CHEMTREC Assistance, call: For International CHEMTREC Assistance, call: SECTION 2 - Composition / Information on Ingredient Substance Name Formula M r CAS # EC No SARA RTECS LD50 (2-Hydroxypropyl)-β-cyclodextrin 1, No 1,2-Propanediol C 3 H 8 O No TY Butyl-3-methylimidazolium chloride 1-Ethyl-3-methylimidazolium acetate C 8 H 15 ClN No C 8 H 14 N 2 O No 4-Aminobutyric acid (GABA) C 4 H 9 NO No ES Aminovaleric acid C 5 H 11 NO No 20,000 mg/kg mg/kg 12,680 mg/kg 6-Aminohexanoic acid C 6 H 13 NO No MO ,300 mg/kg 6-O-α-D-Maltosyl-β-cyclodextrin C 54 H 90 O 45 1, No Acetamide C 2 H 5 NO Yes AB Adipic acid C 6 H 10 O AU ,000 mg/kg 11 g/kg Ammonium acetate C 2 H 7 NO No AF Ammonium chloride NH 4 Cl Yes BP ,650 mg/kg Solubility and Stability Screen HT - HR Page 1 of 13

2 (CONTINUED) - SECTION 2 - Composition / Information on Ingredient Substance Name Formula M r CAS # EC No SARA RTECS LD50 Ammonium sulfate H 8 N 2 O 4 S Yes BS Benzamidine hydrochloride C 7 H 8 N 2 HCl No CV Intraperitoneal - mouse mg/kg Betaine monohydrate C 5 H 11 NO 2 H 2 O No Cadmium chloride hydrate CdCl 2 xh 2 O Yes Calcium chloride dihydrate CaCl 2 2H 2 O No EV Cesium chloride CsCl No FK ,600 mg/kg Cholin acetate C 7 H 17 NO No Cobalt(II) chloride hexahydrate CoCl 2 6H 2 O Yes GG D-(+)-Trehalose dihydrate C 12 H 22 O 11 2H 2 O No DL-Malic acid ph 7.0 C 4 H 6 O No ON D-Sorbitol C 6 H 14 O No LZ mg/kg 4,600 mg/kg 1,600 mg/kg 15,900 mg/kg Ethylammonium nitrate C 2 H 9 N 2 O Ethylene glycol C 2 H 6 O Yes KW Ethylenediamine dihydrochloride C 2 H 8 N 2 2HCl No KV Ethylenediaminetetraacetic acid disodium salt dihydrate C 10H 14 N 2 Na 2 O 8 2H 2 O No AH Formamide CH 3 NO No LQ Gadolinium(III) chloride hexahydrate Cl 3 Gd 6H 2 O No LW Glutaric acid C 5 H 8 O No MA ,700 mg/kg 1,620 mg/kg > 2,000 mg/kg 5,577 mg/kg Intraperitoneal - mouse mg/kg 6,000 mg/kg Glycerol C 3 H 8 O No MA Glycine C 2 H 5 NO No MB ,930 mg/kg Gly-gly C 4 H 8 N 2 O No Gly-gly-gly C 6 H 11 N 3 O No GSH (L-Glutathione reduced) GSSG (L-Glutathione oxidized) C 10 H 17 N 3 O 6 S No MC C 20 H 32 N 6 O 12 S No 5,000 mg/kg > 5,000 mg/kg Solubility and Stability Screen HT - HR Page 2 of 13

3 (CONTINUED) - SECTION 2 - Composition / Information on Ingredient Substance Name Formula M r CAS # EC No SARA RTECS LD50 Guanidine hydrochloride CH 5 N 3 HCl No Hydroxyectoine C 6 H 10 N 2 O No Hypotaurine C 2 H 7 NO 2 S No L-Argininamide dihydrochloride C 6 H 15 N 5 O 2HCl Yes L-Arginine C 6 H 14 N 4 O No CF L-Arginine ethyl ester dihydrochloride C 8 H 18 N 4 O 2 2HCl No L-Glutamic acid C 5 H 9 NO No L-Histidine C 6 H 9 N 3 O No MS Lithium chloride LiCl No OJ Lithium citrate tribasic tetrahydrate C 6 H 5 Li 3 O 7 4H 2 O No Lithium nitrate LiNO No QU > 30,000 mg/kg > 15,000 mg/kg 526 mg/kg L-Proline C 5 H 9 NO No TW L-Serine C 3 H 7 NO No VT Magnesium chloride hexahydrate MgCl 2 6H 2 O No OM ,100 mg/kg Magnesium sulfate hydrate MgSO 4 aq No Methyl-β-cyclodextrin No Methyl α-d-glucopyranoside C 7 H 14 O No N-Ethylurea C 3 H 8 N 2 O No YT N-Methylformamide C 2 H 5 NO No LQ ,000 mg/kg N-Methylurea C 2 H 6 N 2 O No YT Non Detergent Sulfobetaine 195 (NDSB-195) Non Detergent Sulfobetaine 201 (NDSB-201) Non Detergent Sulfobetaine 211 (NDSB-211) Non Detergent Sulfobetaine 221 (NDSB-221) C 7 H 17 NO 3 S No C 8 H 11 NO 3 S No C 7 H 17 NO 4 S No C 9 H 19 NO 3 S No Solubility and Stability Screen HT - HR Page 3 of 13

4 (CONTINUED) - SECTION 2 - Composition / Information on Ingredient Substance Name Formula M r CAS # EC No SARA RTECS LD50 Non Detergent Sulfobetaine 256 (NDSB-256) C 12 H 19 NO 3 S No Oxalic acid dihydrate C 2 H 2 O 4 2H 2 O No Pentaerythritol ethoxylate (15/4 EO/OH) C 7 H 18 O 6 ~ No Polyethylene glycol 200 (C 2 H 4 O) n H 2 O ~ No TQ Polyethylene glycol 3,350 Polyethylene glycol 8,000 Polyethylene glycol monomethyl ether 550 Polyethylene glycol monomethyl ether 750 Polyethylene glycol monomethyl ether 1,900 (C 2 H 4 O) n H 2 O (C 2 H 4 O) n H 2 O 3,300-3,400 7,000-8, No No TQ CH 3 (OCH 2 CH 2 ) n OH ~ No PE ~ ~ 1, Polypropylene glycol P 400 C 3 H 8 O No TR Polyvinylpyrrolidone K 15 (C 6 H 9 NO) n ~ 10, No TR Potassium chloride KCl No TS ,200 mg/kg > 50,000 mg/kg ul/kg > 2,000 mg/kg mg/kg Potassium phosphate dibasic K 2 HPO No Potassium thiocyanate KSCN No XL Sodium benzenesulfonate C 6 H 5 NaO 3 S No DB Sodium bromide NaBr No VZ Sodium chloride NaCl No VZ mg/kg 9,378 mg/kg 3,500 mg/kg 3,000 mg/kg Sodium malonate ph 7.0 C 3 H 4 O No OO Sodium phosphate monobasic monohydrate NaH 2 PO 4 H 2 O No Sodium p-toluenesulfonate CH 3 C 6 H 4 SO 3 Na No XT Sodium sulfate decahydrate Na 2 SO 4 10H 2 O No 1310 mg/kg Intravenous - mouse - 1,700 mg/kg Spermidine C 7 H 19 N No EJ Spermine tetrahydrochloride C 10 H 26 N 4 4HCl No EJ Succinic acid ph 7.0 C 4 H 6 O No WM ,260 mg/kg Solubility and Stability Screen HT - HR Page 4 of 13

5 (CONTINUED) - SECTION 2 - Composition / Information on Ingredient Substance Name Formula M r CAS # EC No SARA RTECS LD50 Sucrose C 12 H 22 O No WN ,700 mg/kg Tacsimate ph 7.0 Taurine C 2 H 7 NO 3 S No WX TCEP hydrochloride C 9 H 15 O 6 P HCl No Tetraethylammonium bromide (CH 3 CH 2 ) 4 NBr No BS ,000 mg/kg 3,500 mg/kg 2,000 mg/kg Trichloroacetic acid Cl 3 CCOOH No Triethylene glycol C 6 H 14 O No YE Trimethylamine N-oxide dihydrate C 3 H 9 NO 2H 2 O No YH ,000 mg/kg 8,700 mg/kg Tryptone No Urea CH 4 N 2 O No YR ,471 mg/kg Water Xylitol C 5 H 12 O No α-cyclodextrin C 36 H 60 O No 16,500 mg/kg Intravenous - rat mg/ kg β-alanine C 3 H 7 NO No β-cyclodextrin C 42 H 70 O 35 1, No 18,800 mg/kg = NOT AVAILABLE SECTION 3 - Hazards Identification HMIS RATING HAZARD RATINGS HEALTH HAZARD: LEAST FLAMMABILITY: SLIGHT REACTIVITY: MODERATE 3 - HIGH NFPA RATING 4 - EXTREME HEALTH HAZARD: 0 FLAMMABILITY: 0 REACTIVITY: 0 For additional information on toxicity, please refer to SECTION 11. Solubility and Stability Screen HT - HR Page 5 of 13

6 SECTION 4 - First Aid Measures GENERAL ADVICE Consult a physician. Show this safety data sheet to the doctor in attendance. ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. DO NOT INDUCE VOMITING. Call a physician. INHALATION EXPOSURE If inhaled, remove to fresh air. If breathing is difficult, GIVE OXYGEN. Call a physician. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water for at least 15 minutes. Take off contaminated clothing and shoes immediately. Call a physician. EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. SECTION 5 - Fire Fighting Measures FLASH POINT AUTOIGNITION TEMPERATURE FLAMMABILITY EXTINGUISHING MEDIA Suitable: Water spray, Carbon dioxide, dry chemical powder, or appropriate foam. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): SECTION 6 - Accidental Release Measures PROCEDURE(S) OF PERSONAL PRECAUTIONS Exercise appropriate precautions to minimize direct contact with skin or eyes and prevent inhalation of dust. Solubility and Stability Screen HT - HR Page 6 of 13

7 (CONTINUED) - SECTION 6 - Accidental Release Measures PROCEDURE(S) OF PERSONAL PRECAUTIONS Exercise appropriate precautions to minimize direct contact with skin or eyes and prevent inhalation of dust. METHODS FOR CLEANING UP Wash spill site with soap solution. Flush spill area with copious amounts of water. Place in appropriate container. Ventilate area and wash spill site after material pickup is complete. SECTION 7 - Handling & Storage HANDLING User Exposure - Ensure adequate inhalation. Avoid inhalation. - Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. STORAGE Suitable: Keep container tightly closed. Store between minus 20 and 4 C -20 C - Best if used within 12 months of receipt. See User Guide for additional storage options SECTION 8 - Exposure Controls / PPE ENGINEERING CONTROLS Contains no substances with occupational exposure limit values. Safety shower and eye bath PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as (NIOSH) or CEN (EU). Respiratory protection is not required. Where protection from nuisance levels of dust are desired, use type N95 (US) or type (P1) (EN 143) dust masks. Hand: Handle with protective gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove s outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Eye: Tightly fitting safety goggles. Face shield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Skin and Body Protection: Complete suit protecting against chemicals, Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Hygiene Measures: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. GENERAL HYGIENE MEASURES Wash thoroughly before and after handling. Solubility and Stability Screen HT - HR Page 7 of 13

8 SECTION 9 - Physical / Chemical Properties APPEARANCE PHYSICAL STATE: Solution PROPERTY VALUE AT TEMPERATURE OR PRESSURE MP / MP Range Freezing Point Vapor Pressure Vapor Density Saturated Vapor Concentration SG / Density Bulk Density Volatile % VOC Content Water Content Solvent Content Evaporation Rate Viscosity Surface Tension Partition Coefficient Decomposition Temperature Flash Point Explosion Limits Flammability Autoignition Temperature Refractive Index Optical Rotation Miscellaneous Data Solubility = NOT AVAILABLE SECTION 10 - Stability & Reactivity STABILITY Stable: Stable under recommended storage conditions. See SECTION 7 regarding suitable storage. HAZARDOUS DECOMPOSITION PRODUCTS No data available. HAZARDOUS EXOTHERMIC REACTIONS Will not occur. HAZARDOUS POLYMERIZATION Will not occur. Solubility and Stability Screen HT - HR Page 8 of 13

9 SECTION 11 - Toxicological Information ACUTE TOXICITY No data available. IRRITATION AND CORROSION No data available. SENSITISATION No data available. CHRONIC EXPOSURE No data available. ROUTE OF EXPOSURE Skin Contact: May cause skin irritation Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: May be harmful if swallowed. SIGNS & SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have NOT been thoroughly investigated. SECTION 12 - Ecological Information No data available. SECTION 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and a scrubber. Observe all federal, state, and local environmental regulations. SECTION 14 - Transportation Information DOT (US) UN- Number: 3316 Class: Proper Shipping Name: Chemical kits or First aid kits Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport. IATA UN- Number: 3316 Class: Proper Shipping Name: Chemical kits or First aid kits Non-Hazardous for Transport: Non-hazardous for air transport. Solubility and Stability Screen HT - HR Page 9 of 13

10 SECTION 15 - Regulatory Information OSHA HAZARDS TSCA STATUS EU ADDITIONAL INFORMATION Substance Name CAS # HAZARD Code R-Phrase S-Phrase (2-Hydroxypropyl)-β-cyclodextrin ,2-Propanediol Butyl-3-methylimidazolium chloride T, N 25-36/37/38-51/ Ethyl-3-methylimidazolium acetate Aminobutyric acid (GABA) Xi 36/37/ Aminovaleric acid / Aminohexanoic acid Xi 36/37/ WGK Germany 6-O-α-D-Maltosyl-β-cyclodextrin Acetamide Xn 40 36/37 1 Adipic acid /37/38 Ammonium acetate Ammonium chloride Xn Ammonium sulfate Benzamidine hydrochloride /37/38 Betaine monohydrate Cadmium chloride hydrate T+, N /23/25-50/ Calcium chloride dihydrate Xi Cesium chloride Cholin acetate Cobalt(II) chloride hexahydrate T, N /43-50/ D-(+)-Trehalose dihydrate DL-Malic acid ph Xn 22-37/ D-Sorbitol Ethylammonium nitrate Xi 36/37/38 24/25/37/39 Ethylene glycol Xn 22 1 Ethylenediamine dihydrochloride Xn 22-36/37/38-42/ / Ethylenediaminetetraacetic acid disodium salt dihydrate Formamide T Gadolinium(III) chloride hexahydrate Xi 36/37/ Glutaric acid Xi Glycerol Glycine /25 1 Solubility and Stability Screen HT - HR Page 10 of 13

11 (CONTINUED) - SECTION 15 - Regulatory Information EU ADDITIONAL INFORMATION Substance Name CAS # HAZARD Code R-Phrase S-Phrase Gly-gly Xi Gly-gly-gly GSH (L-Glutathione reduced) GSSG (L-Glutathione oxidized) Xi 36/37/ Guanidine hydrochloride Xn 22-36/ Hydroxyectoine Xi 36/37/ Hypotaurine Xi 36/37/ L-Argininamide dihydrochloride T 20/21/22-39/23/24/25 1 L-Arginine L-Arginine ethyl ester dihydrochloride L-Glutamic acid L-Histidine Lithium chloride Xn 22-36/37/ /37/39 3 Lithium citrate tribasic tetrahydrate Xi 36/37/ Lithium nitrate Xi, O 8-36/37/ /37/39 3 L-Proline WGK Germany L-Serine Magnesium chloride hexahydrate Magnesium sulfate hydrate Methyl-β-cyclodextrin Methyl α-d-glucopyranoside N-Ethylurea /25 2 N-Methylformamide T N-Methylurea Non Detergent Sulfobetaine 195 (NDSB-195) C /37/ Non Detergent Sulfobetaine 201 (NDSB-201) /25 3 Non Detergent Sulfobetaine 211 (NDSB-211) C /37/39-45 Non Detergent Sulfobetaine 221 (NDSB-221) C /37/ Non Detergent Sulfobetaine 256 (NDSB-256) Oxalic acid dihydrate Xn 21/22 24/25 1 Pentaerythritol ethoxylate (15/4 EO/OH) Polyethylene glycol Polyethylene glycol 3, Polyethylene glycol 8, Polyethylene glycol monomethyl ether 1, Polyethylene glycol monomethyl ether Polyethylene glycol monomethyl ether Polypropylene glycol P Polyvinylpyrrolidone K Solubility and Stability Screen HT - HR Page 11 of 13

12 (CONTINUED) - SECTION 15 - Regulatory Information EU ADDITIONAL INFORMATION Substance Name CAS # HAZARD Code R-Phrase S-Phrase WGK Germany Potassium chloride /25 Potassium phosphate dibasic /25 3 Potassium thiocyanate Xn 20/21/ / Sodium benzenesulfonate Xn 22-36/37/ Sodium bromide Sodium chloride Sodium malonate ph Xn 20/ /39 1 Sodium phosphate monobasic monohydrate Sodium p-toluenesulfonate Xi 36/37/ Sodium sulfate decahydrate Spermidine C /37/ Spermine tetrahydrochloride Xi 36/ Succinic acid ph Xi 37/ /37/39 1 Sucrose Tacsimate ph 7.0 Taurine Xi 36/37/ TCEP hydrochloride C /37/39 2 Tetraethylammonium bromide Xi 36/37/ Trichloroacetic acid C, N 35-50/ /37/ Triethylene glycol Xi 36/37/ Trimethylamine N-oxide dihydrate Xi 36/ Tryptone Urea Water Xylitol α-cyclodextrin β-alanine β-cyclodextrin = NOT AVAILABLE UNITED STATES REGULATORY INFORMATION SARA LISTED: SARA LISTED: For additional information on toxicity, please refer to SECTION 2. TSCA INVENTORY ITEM: CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. Solubility and Stability Screen HT - HR Page 12 of 13

13 SECTION 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household, or other use. WARRANTY The above information is believed to be correct but does no purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of this product. Hampton Research Corp., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. License granted to make unlimited paper copies for internal use only Hampton Research Corp. Solubility and Stability Screen HT - HR Page 13 of 13