Klippel - Trenaunay Syndrome (KTS) When and What to do? Dr. Ayhan ŞENOL SBU.Gazi Yasargil ETH. Diyarbakır /TURKEY
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1 Klippel - Trenaunay Syndrome (KTS) When and What to do? Dr. Ayhan ŞENOL SBU.Gazi Yasargil ETH. Diyarbakır /TURKEY
2 Disclosure Speaker name: Ayhan ŞENOL I have the following potential conflicts of interest to report: Consulting Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) x I do not have any potential conflict of interest
3 Klippel - Trenaunay Syndrome (KTS) In 1900, Klippel and Trenaunay first described capillary hemangiomas in one or more extremities as a congenital syndrome characterized by varicose veins, soft tissue and bone hypertrophy [1]
4 Klippel - Trenaunay Syndrome (KTS) The incidence of this syndrome is equal in men and women. Whether it is hereditary transition is unknown BUT Autosomal dominant inheritance was observed in some cases. [2]
5 KTS Most, if not all, cases of KTS are caused by somatic mutations in the PIK3CA gene. PIK3CA-related overgrowth spectrum (PROS)
6 KTS Capillary malformations 98% Varicose veins venous malformation 72% 63% Hypertrophy 67% [3]
7 symptoms Capillary malformation Varicose vein Hypertrophy + + ± ±. Popliteal vein Agenesis-Anomaly + + Aneurysmal dilatation + Agenesis - Bone malformation Port wine stain
8 Capillary malformations This is the most common cutaneous manifestation of KTS. Typically, capillary malformations involve the enlarged limb. It is seen 98% of patients. Hypertrophy, hemorrhage, and color changes in the extremities are often the first conspicuous in patients due to venous malformation and varicosities at the skin.
9 Varicose veins-venous Can occur in both the superficial and deep venous systems. malformations Superficial venous abnormalities : ectasia of small veins or large venous malformations. Deep venous abnormalities aneurysmal dilatation, aplasia, hypoplasia, duplications, and venous incompetence.
10 Hypertrophy Enlargement of the extremity: may be caused by bone abnormality, circumferential soft-tissue Hypertrophy or lymphatic malformation. xtremity growth usually stops at the end of the Adeloson period.
11 Port - wine stain port-wine stain
12 KTS,
13 22 y.o female Popliteal vein agenesis Minimal hypertrophy Port-wine stain
14 55 y.o male Port wine stain and multiple varicose veins on right leg. Aneurysms were detected in the popliteal and femoral vein.
15 KTS Treatment How can we do for this patients And What is the purpose of treatment in KTS
16 KTS Treatment There is no cure for KTS Treatment is symptomatic and supportive. Reduce symptoms and risk of complications. Conservative treatments most effective for undesired side effects.
17 What can we do
18 What to do? conservatively -Elastic Socks Protects the extremity from trauma Used to reduce the effects of venous insufficiency.
19 What to do? -Surgery -Ligation and Stripping a small incision to prevent pooling of blood. Ligation and striping can be used for removal of the vein. should be known that deep veins are normal
20 What to do? Ambulatory phlebectomy should be known that deep veins are normal
21 What to do? Sclerotherapy Sclerotherapy can eliminate the pain and discomfort of varicose veins can prevent complications such as venous hemorrhage and ulceration
22 What to do? Sclerotherapy Foaming agent pushes blood in the vein so the sclerosing agent will have better contact with the vein wall.
23 -Sclerotherapy What to do? Several sclerotherapy treatments usually are required to achieve the desired results. under ultrasound guidance
24 What can we do And sometimes we can't do anything
25 What to do? Sometime Nothing no right leg complaints and happy Loves his right leg more than his left.
26 KTS References 1) Spencer L, Quarmby JW. Klippel-Trenaunay Syndrome and left iliac vein agenesis EJVES Extra 2007;13: ) Whelan AJ, Watson MS, Porter FD, Steiner RD. Klippel- Trenaunay-Weber syndrome associated with a 5:11 balanced translocation. Am J Med Genet 1995;59: ) Jacob AG, Driscoll DJ, Shaughnessy WJ, Stanson AW, Clay RP, Gloviczki P. Klippel-Trénaunay syndrome: spectrum and management. Mayo Clin Proc 1998;73: ) Cherry KJ, Gloviczki P, Stanson AW. Persistent sciatic vein: Diagnosis and treatment of a rare condition. J Vasc Surg 1996;23: ) Collins PS, Villavicencio JL, Abreu SH, et al. Abnormalities of lymphatic drainage in lower extremities: a lymphoscintigraphic study. J Vasc Surg 1989;9: ) Gloviczki P, Hollier LH, Telander RL, et al. Surgical implications of Klippel Trenaunay syndrome, Ann Surg 1983; 197: )
27 Thanks
28 , Can it be seen in the upper extremity Limited number of cases have been reported in the literature
29 Klippel - Trenaunay Syndrome (KTS) When and What to do? Dr. Ayhan ŞENOL SBU.Gazi Yasargil ETH. Diyarbakır /TURKEY
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