DEVELOPED BY SURGEONS

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2 DEVELOPED BY SURGEONS FOR SURGEONS Zimmer Biomet values our surgeon customers and the expertise and passion they bring to the field. The ROSA Knee System is a surgical assistant designed to adapt to each surgeon s workflow and support a wide range of surgical philosophies with features such as the soft tissue balancing and femoral rotation tools.

3 The ROSA Knee System is a culmination of market leading technology1 that Zimmer Biomet brings to the orthopaedic space and supports some of the most proven2 and distinguished knee implant systems in the world: Persona, Vanguard, and NexGen. By offering implant versatility and quantifiable patientspecific information, surgeons are equipped to personalize patient care.

4 Flexible imaging modalities, including x-ray based imaging and imageless options, allow surgeons and patients reduced imaging costs and convenience in preparing for surgeries. Preoperative planning with our 2D x-ray to 3D bone modeling X-Atlas technology limits instrumentation in the OR and facilitates custom plans based on a patient s unique anatomy.

5 The ROSA Knee System imaging modalities, combined with intraoperative data, allows surgeons to conduct a virtual knee replacement with predictive outcomes of balance and implant placement before performing any cuts.

6 With the platform, robotic intelligence is being combined with industry-leading implants 2 and materials, 3-10 all with the purpose of improving patient outcomes. The ROSA Knee System not only provides surgeons with real-time intraoperative data, but also the ability to analyze that data and link to post-operative long term outcomes.

7 References 1. Statement based on 1a. Zimmer b. Zimmer Statement based on: 5 million implantations12h,300+ Publications12g, 100% Survivorship at 17 Years12a, Lowest revision rate12b-e, Benchmark for PROMs12f, 10A* ODEP rating for CR and PS knees both with and without patella12g, Every 90 seconds a patient receives a NexGen knee12h, 1 in 5 knees implanted globally is a NexGen Kneev, 2a. Kim, Y.H., et al. Cementless and cemented total knee arthroplasty in patients, younger than fifty five years. Which is better? International Orthopaedics (SICOT), (2014) 38: b. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide.AOA 2016: Table KT9 Cumulative Percent Revision of Primary Total Knee Replacement with Cement Fixation. 2c. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide.AOA 2016: Table KT10 Cumulative Percent Revision of Primary Total Knee Replacement with Cementless Fixation. 2d. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide. AOA 2016: Table KT11 Cumulative Percent Revision of Primary Total Knee Replacement with Hybrid Fixation. 2e. Select variants from the 2016 Swedish National Registry available at (pgs 42-43). 2f. Baker, P.N., et al. The effect of surgical factors on early patient-reported outcome measures (PROMs) following total knee replacement. J Bone Joint Surg Br. 94:1058, g. Latest ODEP ratings can be found at 2h Sales data available at Zimmer Biomet. 2i. EMBASE search: «NexGen» AND «Knee». 3. Bobyn, JD., et al. Characterization of a New Porous Tantalum Biomaterial for Reconstructive Orthopaedics. 66th Annual AAOS, Zhang, Y., et al. Interfacial Frictional Behavior: Cancellous Bone, Cortical Bone, and a Novel Porous Tantalum Biomaterial. Journal of Musculoskeletal Research. 3:4, , Karageorgiou, V., et al. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 26: , Zimmer ZRR_WA_2409_ Zimmer ZRR_WA_2537_ Zimmer TM Zimmer ZRR_WA_2403_ Zimmer ZRR_WA_2551_12. All content herein is protected by copyright, trademarks and other intellectual property rights owned by or licensed to Zimmer Biomet or its affiliates unless otherwise indicated, and must not be redistributed, duplicated or disclosed, in whole or in part, without the express written consent of Zimmer Biomet. This material is intended for health care professionals. Distribution to any other recipient is prohibited. For indications, contraindications, warnings, precautions, potential adverse effects and patient counselling information, see the package insert or contact your local representative; visit for additional product information. Not for distribution in France. Check for country product clearances and reference product specific instructions for use Zimmer Biomet Authorized Representative Zimmer U.K. Ltd. 9 Lancaster Place, South Marston Park, Swindon, Wiltshire SN3 4FP, UK GLBL-en-REV0319 Legal Manufacturer Zimmer CAS 75 Queen Street Suite 3300 Montreal (Quebec) H3C 2N6 Canada Tel D.ORTHO or EC zimmerbiomet.com 0413 CE mark is not valid unless there is a CE mark on the product label.