Minimally Invasive Aortic Arch Surgery:
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1 Minimally Invasive Aortic Arch Surgery: Where are we? Where are we headed? Jehangir J. Appoo Libin Cardiovascular Institute University of Calgary June 15, 2016 Cardiac Masters Day: Minimally Invasive Aortic and Endovascular Therapies ISMICS 16 th Annual Scientific Meeting Montreal, Canada
2 Disclosures: Consultant Gore Medical
3 Tasks Today: 1. Define why Min Invasive Arch is important 2. Current options for less invasive arch surgery : 1. Open Surgery 2. Closed Chest 3. Future Directions/Challenges
4 Case Example for today s tasks June y.o healthy female 5.5cm arch expanding 1-2mm/yr 2000: Mech AVR, Asc Ao & Hemiarch In 2016 what are the feasible MIS Approaches to this case? : Open Chest Options Closed Chest Options
5 Prep for this talk: What is M.I.S? Google Search (of interest, no defn on ISMICS website) minimizing surgical incisions to reduce trauma to the body one that is safe and is associated with a lower postoperative patient morbidity compared with a conventional approach for the same operation
6 M.I.S. = reduce trauma & decrease postoperative morbidity Historically, Arch Surgery used to be Maximally Invasive: Large incision: Full sternotomy, trapdoor, clamshell Trauma: Safety: Deep Hypothermic Circulatory Arrest with multisystem organ trauma Significant mortality and stroke risk
7 Perspective/Big Picture Innovation: Doing something different that matters Mark Allen, STS Presidential Address Jan 2016 Why is minimally invasive arch surgery important? are there a lot of cases? are we being innovative just because we can or does it matter?
8 Why is Minimally Invasive Arch Important? Descending thoracic aortic surgery has transitioned to endovascular treatment as first line therapy
9 Why is Minimally Invasive Arch Important? If closed chest arch can be solved Implications?
10 Ascending Aorta: large number of cases compared to descending! Final Frontier for Endovascular Surgery
11 Perspective/Big Picture Solving arch branches and angles is a critical piece of puzzle in current revolution of modular closed chest aortic reconstruction: TAVR Ascending Aorta Arch Descending Aorta Thoraco-abdominal Ao better not let this train leave the station...
12 M.I.S. = reduce trauma & decrease postoperative morbidity Open Chest Options: Full sternotomy can be less invasive: Mod hypothermia Continuous ACP
13 M.I.S. = reduce trauma & decrease postoperative morbidity Our full sternotomy strategy to reduce trauma : 25 0 Celsius NP temp ACP via R axillary or innominate Clamp each head vessel to keep cerebral circulation pressurized & capillary bed perfused & avoid embolic phenomenon Sequence of anastamosis: 1. distal arch with SACP 2. restart lower body perfusion 3. Bypass left carotid & then rewarm 4. ± left subclavian bypass 5. Proximal & take clamp off 6. Innominate whilst reperfusing HCA time: SACP time: 15-20mins mins
14 M.I.S. = reduce trauma & decrease postoperative morbidity Open Chest Options: 1. Full sternotomy Mod hypothermia with continuous ACP to reduce trauma to organs and decrease postop morbidity 2. Hemisternotomy with moderate hypothermia and continuous ACP Extension of our mini AVR approach
15 Hemi-Sternotomy Arch Example Jan y.o. male 5.8cm arch 2000 Mechanical Bentall
16 Hemi-sternotomy Arch Pearls I use 3 rd ICS for hemi arch & 4 th ICS for total arch Axillary vs. aorta/innominate cannulation Percutaneous fem venous cannulation Cool to 25 degrees Continuous ACP Sequence of anastamosis: 1. distal arch 2. left carotid & then rewarm 3. ± left subclavian 4. Proximal & take clamp off 5. Innominate whilst reperfusing
17 Redo hemi-sternotomy arch replacement Jan months post op HCA with continous ACP 18mins SACP 32 mins
18 What are the Closed Chest Options for our healthy 70 y.o patient? Single branch endografts off the shelf Multibranch Arch Endografts Grafts Custom Off the shelf
19 M.I.S. = reduce trauma & decrease postoperative morbidity Closed Chest Options in 2016: 1. Single branch arch grafts
20 Single Branch Arch Devices Off the shelf devices Designed for LSA or innominate artery Modular system Dual wire lumens Gore FDA study 6 sites enrolling in US First in man: Jan 2014 Medtronic Mona LSA FDA study First in man 2013
21 Single Branch Arch Grafts combined with extra-anatomic carotid carotid bypass for full arch reconstruction June 2016 Enrollment Gore FDA feasibility study: n=30 n=9 Feasibility trial completing moving to pivotal trial
22 As feasibility study finishes for arch aneurysms Dissections: 2016 Early Feasibility Study: Acute Type A Dissection 3 sites in Houston enrolling soon Technology is here.and future generations will improve on shortcomings...
23 In 2016, is single branch arch graft a good solution for our 70 y.o patient?
24 M.I.S. = reduce trauma & decrease postoperative morbidity Closed Chest Options in 2016: 1. Single branch arch grafts 2. Chimney/Snorkel
25 Closed Chest Arch Chimney Technique Off the shelf conventional devices Concern with gutter endoleaks & branch compression Main indication: emergencies when customized devices unavailable but being used electively in parts of world Not a good option for our patient today
26 M.I.S. = reduce trauma & decrease postoperative morbidity Closed Chest Options in 2016: 1. Single branch arch grafts 2. Chimney/Snorkel 3. Multibranch arch grafts
27 Cook Multibranch Arch Graft is custom made for alignment of patient s arch vessels Carotid-subclavian bypass preop Main body deployed transfemorally Head vessels cannulated from above Narrower body in arch
28 Closed Chest Total Arch: Cook Branched Arch >200 cases worldwide Largest published series 38 pts Reported early Stroke rate 10-15% Haulon et al. JTCVS 2014 Spear et al. Eur J of Vasc Endovasc Surg 2016
29 y.o male Type A repair 2009 Complicated course Aorta growing at rate of 1cm/year Arch dissected Large residual primary intimal tear in arch True lumen effaced Refused repeat sternotomy/thoracotomy
30
31
32 Complexity
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34 Pt. extubated on the table Transfused 1UPRBC VR images 3 months post op Stable 3 years post op
35 Z shape of the Main Module Fixation Continuous flow path to the brain Through and through access Off the shelf device Image courtesy of M. Lachat, Switzerland
36 NEXUS Modules Fenstration (optional) for an eptfe covered stent Image courtesy of M. Lachat, Switzerland
37
38 NEXUS Status June 2016: Human Feasibility study 6/10 patients enrolled Hradec Kralove, Czech Republic (Raupach J) Zurich, Switzerland (Lachat M) Rome, Italy (Mangialardi N) Compassionate Cases 8 patients ongoing Montreal, Canada (Cherrie ZA ) Rome, Italy (Mangialardi N) Modena, Italy (Coppi G ) Toronto, Canada (Lindsay T ) San Donato, Italy (Nano G) Data courtesy of M. Lachat, Switzerland
39 NEXUS Compassionate Cases Clinical Outcomes Clinical Events (N=9) Event # of Patients Details Technical success 9/9 Death 1/9 Stroke Spinal Cord Ischemia Stroke 2/9 Permanent Deficits 0/9 1/9 Compassionate #3 : 2 days post implantation, due to MI Compassionate #1 : Right side hemisyndrome Compassionate #4 : Right arm paresis Compassionate #4 : arch and descending aneurysms CSFD post implantation, patient recovered. Endoleak type Ia or III (after 1m) 1/9 Data courtesy of M. Lachat, Switzerland
40 Closed Chest Total Arch Najuta graft Precurved fenestrated arch graft in various configurations off the shelf Used in over 300 aneurysm cases in Japan Concern re: risk of stroke
41 In 2016 is a branched arch graft the best choice for our 70 y.o pt?
42 Case Example June y.o healthy female 5.5cm arch expanding 1-2mm/yr 2000: Mech AVR, Asc Ao & Hemiarch Discussed: Open Chest Options Closed Chest Options So, what did we do?
43 Hemisternotomy approach: Prox arch exposure via hemisternotomy R Axillary a. & fem vein cannulation 25 degrees C Continuous ACP
44 Distal Arch Exposure via Hemisternotomy
45 HCA SACP 16mins 38mins Post op VR image
46 In 2016 why choose Hemisternotomy in our healthy 70 y.o pt? Single branch arch graft safety single inflow?
47 In 2016 why choose Hemisternotomy in our healthy 70 y.o pt? Single branch arch graft safety single inflow? Multiple branch arch graft - stroke risk > open surgery??
48 In 2016 why choose Hemisternotomy in our healthy 70 y.o pt? Single branch arch graft safety single inflow? Multiple branch arch graft - stroke risk > open surgery?? 4 branch arch Healthy good surgical candidate?
49 In 2016 why choose Hemisternotomy in our healthy 70 y.o pt? Single branch arch graft safety single inflow? Multiple branch arch graft - stroke risk > open surgery?? 4 branch arch Healthy good surgical candidate Hemisternotomy & continuous ACP accomplished decreased trauma & post op morbidity Will open surgery be first line treatment in 2021??
50 Endovascular Revolution is in Evolution Arch & Asc Aorta not complete Future tasks: Stroke understanding pathophysiology and then targeted therapy Angulation control to land on inner curve of short ascending aorta Overcome lack of good proximal landing zone Lower profile devices Antegrade vs. retrograde cerebral blood flow
51 Future: Our preferred approach to Debakey Type I Dissection Zone 2 Arch Approach in near future?
52 Or will acute Type A Dissection be all percutaneous treatment?
53 Future: Endo Bentall? Platform of Aortic Valve and Ascending aortic graft followed by branched arch followed by.
54 Tasks Today: 1. Define why Min Invasive Arch is important Solving arch is a critical piece of puzzle in current revolution of modular closed chest aortic reconstruction
55 Tasks Today: 1. Define why Min Invasive Arch is important 2. Options for less invasive arch surgery in 2016: 1. Open Chest 2. Closed Chest
56 Tasks Today: 1. Define why Min Invasive Arch is important 2. Options for less invasive arch surgery in 2016: 1. Open Chest 2. Closed Chest 3. Future Issues to overcome
57 Good judgement comes from experience... Experience comes from bad judgement C. Walton Lillehei,
58 Calgary Thoracic Aortic Program,
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