NS219: Basal Ganglia Anatomy
|
|
- Moris Jenkins
- 6 years ago
- Views:
Transcription
1 NS219: Basal Ganglia Anatomy
2 Human basal ganglia anatomy
3 Analagous rodent basal ganglia nuclei
4 Basal ganglia circuits: the classical model of direct and indirect pathways + Glutamate + - GABA -
5 Gross anatomy of the striatum: gateway to the basal ganglia rodent Dorsomedial striatum: -enriched in PLTS interneurons -Increased calbinden immunoreactivity Striatal subregions: Dorsomedial (caudate) Dorsolateral (putamen) Ventral (nucleus accumbens) Dorsolateral striatum: -enriched in FS interneurons -increased CB1 immunoreactivity
6 Gross anatomy of the striatum: patch and matrix compartments Patch/Striosome: -substance P -mu-opioid receptor Matrix: -ChAT and AChE -somatostatin
7 Microanatomy of the striatum: cell types Projection neurons: MSN: medium spiny neuron (GABA) striatonigral projecting direct pathway striatopallidal projecting indirect pathway Interneurons: FS: fast-spiking interneuron (GABA) LTS: low-threshold spiking interneuron (GABA) LA: large aspiny neuron (ACh) 30 um Striatal afferents: (Intralaminar nuclei) (glutamate) (Layer II/III, V) (glutamate) Substantia nigra (dopamine)
8 Microanatomy of the striatum: striatal microcircuits Feedforward inhibition (mediated by fast-spiking interneurons) Lateral feedback inhibition (mediated by MSN collaterals)
9 External Globus Pallidus (): interneuron of the basal ganglia neurons have long dendrites (up to 1.5 mm) receive highly convergent striatal GABAergic inputs (70-80%) collateral inhibitory inputs (10-20%) excitatory inputs from (10%) 2 major cell types: PV+ neurons send axons to ENK+ neurons send axons to striatum and SNr form basket-like perisomatic GABAergic synapses
10 Microanatomy of the Subthalamic Nucleus () Subthalamic nucleus (): the only glutamatergic basal ganglia nucleus receives inhibitory inputs from the ( classical circuit) receives excitatory inputs from the sends axons to basal ganglia output nuclei (SNr, GPi/EP)
11 Microanatomy of basal ganglia output nuclei (SNr, GPi/EP) Substantia Nigra pars reticulata (SNr) intermingled DA neurons/dendrites from neighboring major excitatory inputs from, major inhibitory inputs from striatum (direct pathway MSNs) and project to thalamus Globus Pallidus pars interna (GPi)/Entopeduncular Nucleus (EP) major excitatory inputs from, major inhibitory inputs from striatum (direct pathway MSNs) and project to thalamus
12 The simplified classical model of basal ganglia circuit function Information encoded as firing rate Basal ganglia circuit is linear and unidirectional exerts opposing effects on direct and indirect pathway MSNs
13 Basal ganglia motor circuit: direct pathway Glutamate + GABA Direct pathway MSNs express: D1, M4 receptors, Sub. P, dynorphin
14 Basal ganglia motor circuit: direct pathway Glutamate + GABA
15 Basal ganglia motor circuit: direct pathway Glutamate + GABA
16 Basal ganglia motor circuit: direct pathway Glutamate + GABA
17 Basal ganglia motor circuit: direct pathway Glutamate + GABA
18 Basal ganglia motor circuit: indirect pathway Glutamate GABA - Indirect pathway MSNs express: D2 receptors, enkephalin
19 Basal ganglia motor circuit: indirect pathway Glutamate GABA -
20 Basal ganglia motor circuit: indirect pathway Glutamate GABA -
21 Basal ganglia motor circuit: indirect pathway Glutamate GABA -
22 Basal ganglia motor circuit: indirect pathway Glutamate GABA -
23 Basal ganglia motor circuit: indirect pathway Glutamate GABA -
24 Basal ganglia motor circuit: indirect pathway Glutamate GABA -
25 Summary of the classical model of basal ganglia circuit function Activation of the direct pathway facilitates/selects/initiates proper movements Activation of the indirect pathway inhibits/terminates unwanted movements normally inhibits the indirect pathway and potentiates the direct pathway
26 Anatomical revisions to the classical model + -
27 Functional revisions to the classical model Thalamic lesions do not cause bradykinesia lesions do not cause dyskinesia Patterns of activity may be more important than rate in regulating thalamocortical motor circuits
Basal Ganglia Anatomy, Physiology, and Function. NS201c
Basal Ganglia Anatomy, Physiology, and Function NS201c Human Basal Ganglia Anatomy Basal Ganglia Circuits: The Classical Model of Direct and Indirect Pathway Function Motor Cortex Premotor Cortex + Glutamate
More informationAnatomy of the basal ganglia. Dana Cohen Gonda Brain Research Center, room 410
Anatomy of the basal ganglia Dana Cohen Gonda Brain Research Center, room 410 danacoh@gmail.com The basal ganglia The nuclei form a small minority of the brain s neuronal population. Little is known about
More informationBasal Ganglia George R. Leichnetz, Ph.D.
Basal Ganglia George R. Leichnetz, Ph.D. OBJECTIVES 1. To understand the brain structures which constitute the basal ganglia, and their interconnections 2. To understand the consequences (clinical manifestations)
More informationTeach-SHEET Basal Ganglia
Teach-SHEET Basal Ganglia Purves D, et al. Neuroscience, 5 th Ed., Sinauer Associates, 2012 Common organizational principles Basic Circuits or Loops: Motor loop concerned with learned movements (scaling
More informationBasal Ganglia. Introduction. Basal Ganglia at a Glance. Role of the BG
Basal Ganglia Shepherd (2004) Chapter 9 Charles J. Wilson Instructor: Yoonsuck Choe; CPSC 644 Cortical Networks Introduction A set of nuclei in the forebrain and midbrain area in mammals, birds, and reptiles.
More informationGBME graduate course. Chapter 43. The Basal Ganglia
GBME graduate course Chapter 43. The Basal Ganglia Basal ganglia in history Parkinson s disease Huntington s disease Parkinson s disease 1817 Parkinson's disease (PD) is a degenerative disorder of the
More informationConnections of basal ganglia
Connections of basal ganglia Introduction The basal ganglia, or basal nuclei, are areas of subcortical grey matter that play a prominent role in modulating movement, as well as cognitive and emotional
More informationCOGNITIVE SCIENCE 107A. Motor Systems: Basal Ganglia. Jaime A. Pineda, Ph.D.
COGNITIVE SCIENCE 107A Motor Systems: Basal Ganglia Jaime A. Pineda, Ph.D. Two major descending s Pyramidal vs. extrapyramidal Motor cortex Pyramidal system Pathway for voluntary movement Most fibers originate
More informationBasal Ganglia. Steven McLoon Department of Neuroscience University of Minnesota
Basal Ganglia Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Graduate School Discussion Wednesday, Nov 1, 11:00am MoosT 2-690 with Paul Mermelstein (invite your friends)
More informationDamage on one side.. (Notes) Just remember: Unilateral damage to basal ganglia causes contralateral symptoms.
Lecture 20 - Basal Ganglia Basal Ganglia (Nolte 5 th Ed pp 464) Damage to the basal ganglia produces involuntary movements. Although the basal ganglia do not influence LMN directly (to cause this involuntary
More informationMaking Things Happen 2: Motor Disorders
Making Things Happen 2: Motor Disorders How Your Brain Works Prof. Jan Schnupp wschnupp@cityu.edu.hk HowYourBrainWorks.net On the Menu in This Lecture In the previous lecture we saw how motor cortex and
More informationComputational cognitive neuroscience: 8. Motor Control and Reinforcement Learning
1 Computational cognitive neuroscience: 8. Motor Control and Reinforcement Learning Lubica Beňušková Centre for Cognitive Science, FMFI Comenius University in Bratislava 2 Sensory-motor loop The essence
More informationThe Wonders of the Basal Ganglia
Basal Ganglia The Wonders of the Basal Ganglia by Mackenzie Breton and Laura Strong /// https://kin450- neurophysiology.wikispaces.com/basal+ganglia Introduction The basal ganglia are a group of nuclei
More informationBasal ganglia macrocircuits
Tepper, Abercrombie & Bolam (Eds.) Progress in Brain Research, Vol. 160 ISSN 0079-6123 Copyright r 2007 Elsevier B.V. All rights reserved CHAPTER 1 Basal ganglia macrocircuits J.M. Tepper 1,, E.D. Abercrombie
More informationA. General features of the basal ganglia, one of our 3 major motor control centers:
Reading: Waxman pp. 141-146 are not very helpful! Computer Resources: HyperBrain, Chapter 12 Dental Neuroanatomy Suzanne S. Stensaas, Ph.D. March 1, 2012 THE BASAL GANGLIA Objectives: 1. What are the main
More informationBasal Ganglia. Today s lecture is about Basal Ganglia and it covers:
Basal Ganglia Motor system is complex interaction between Lower motor neurons (spinal cord and brainstem circuits) and Upper motor neurons (pyramidal and extrapyramidal tracts) plus two main regulators
More informationA. General features of the basal ganglia, one of our 3 major motor control centers:
Reading: Waxman pp. 141-146 are not very helpful! Computer Resources: HyperBrain, Chapter 12 Dental Neuroanatomy Suzanne S. Stensaas, Ph.D. April 22, 2010 THE BASAL GANGLIA Objectives: 1. What are the
More informationBasal Ganglia General Info
Basal Ganglia General Info Neural clusters in peripheral nervous system are ganglia. In the central nervous system, they are called nuclei. Should be called Basal Nuclei but usually called Basal Ganglia.
More informationBASAL GANGLIA. Dr JAMILA EL MEDANY
BASAL GANGLIA Dr JAMILA EL MEDANY OBJECTIVES At the end of the lecture, the student should be able to: Define basal ganglia and enumerate its components. Enumerate parts of Corpus Striatum and their important
More informationBrain anatomy and artificial intelligence. L. Andrew Coward Australian National University, Canberra, ACT 0200, Australia
Brain anatomy and artificial intelligence L. Andrew Coward Australian National University, Canberra, ACT 0200, Australia The Fourth Conference on Artificial General Intelligence August 2011 Architectures
More information神經解剖學 NEUROANATOMY BASAL NUCLEI 盧家鋒助理教授臺北醫學大學醫學系解剖學暨細胞生物學科臺北醫學大學醫學院轉譯影像研究中心.
神經解剖學 NEUROANATOMY BASAL NUCLEI 盧家鋒助理教授臺北醫學大學醫學系解剖學暨細胞生物學科臺北醫學大學醫學院轉譯影像研究中心 http://www.ym.edu.tw/~cflu OUTLINE Components and Pathways of the Basal Nuclei Functions and Related Disorders of the Basal Nuclei
More information1/2/2019. Basal Ganglia & Cerebellum a quick overview. Outcomes you want to accomplish. MHD-Neuroanatomy Neuroscience Block. Basal ganglia review
This power point is made available as an educational resource or study aid for your use only. This presentation may not be duplicated for others and should not be redistributed or posted anywhere on the
More informationSTRUCTURE AND CIRCUITS OF THE BASAL GANGLIA
STRUCTURE AND CIRCUITS OF THE BASAL GANGLIA Rastislav Druga Department of Anatomy, Second Faculty of Medicine 2017 Basal ganglia Nucleus caudatus, putamen, globus pallidus (medialis et lateralis), ncl.
More informationFor more information about how to cite these materials visit
Author(s): Peter Hitchcock, PH.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Non-commercial Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/
More informationVL VA BASAL GANGLIA. FUNCTIONAl COMPONENTS. Function Component Deficits Start/initiation Basal Ganglia Spontan movements
BASAL GANGLIA Chris Cohan, Ph.D. Dept. of Pathology/Anat Sci University at Buffalo I) Overview How do Basal Ganglia affect movement Basal ganglia enhance cortical motor activity and facilitate movement.
More informationPETER PAZMANY CATHOLIC UNIVERSITY Consortium members SEMMELWEIS UNIVERSITY, DIALOG CAMPUS PUBLISHER
PETER PAZMANY CATHOLIC UNIVERSITY SEMMELWEIS UNIVERSITY Development of Complex Curricula for Molecular Bionics and Infobionics Programs within a consortial* framework** Consortium leader PETER PAZMANY
More informationDevelopmental regulation of Medium Spiny Neuron dendritic arborization. Lorene M. Lanier Department of Neuroscience
Developmental regulation of Medium Spiny Neuron dendritic arborization Lorene M. Lanier Department of Neuroscience Diversity in dendritic arbors Pyramidal Purkinje Medium Spiny http://youtu.be/_tqpca6wx84
More informationEmbryological origin of thalamus
diencephalon Embryological origin of thalamus The diencephalon gives rise to the: Thalamus Epithalamus (pineal gland, habenula, paraventricular n.) Hypothalamus Subthalamus (Subthalamic nuclei) The Thalamus:
More informationThe motor regulator. 1) Basal ganglia/nucleus
The motor regulator 1) Basal ganglia/nucleus Neural structures involved in the control of movement Basal Ganglia - Components of the basal ganglia - Function of the basal ganglia - Connection and circuits
More informationBiological Bases of Behavior. 8: Control of Movement
Biological Bases of Behavior 8: Control of Movement m d Skeletal Muscle Movements of our body are accomplished by contraction of the skeletal muscles Flexion: contraction of a flexor muscle draws in a
More informationChapter 2: Studies of Human Learning and Memory. From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.
Chapter 2: Studies of Human Learning and Memory From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D. Medium Spiny Neuron A Current Conception of the major memory systems in the brain Figure
More informationBasal ganglia Sujata Sofat, class of 2009
Basal ganglia Sujata Sofat, class of 2009 Basal ganglia Objectives Describe the function of the Basal Ganglia in movement Define the BG components and their locations Describe the motor loop of the BG
More informationPII: S (99) COMMENTARY
Pergamon www.elsevier.com/locate/neuroscience Connections of the dopaminergic system with the striatum Neuroscience Vol. 96, No. 3, pp. 451 474, 2000 451 Copyright 2000 IBRO. Published by Elsevier Science
More informationThe Basal Ganglia and Motor Control
NEURAL PLASTICITY VOLUME 10, NO. 1-2, 2003 The Basal Ganglia and Motor Control Henk J. Groenewegen Department ofanatomy, Research Institute Neurosciences Vrije Universiteit, Medical Center, Amsterdam,
More informationParkinsonism or Parkinson s Disease I. Symptoms: Main disorder of movement. Named after, an English physician who described the then known, in 1817.
Parkinsonism or Parkinson s Disease I. Symptoms: Main disorder of movement. Named after, an English physician who described the then known, in 1817. Four (4) hallmark clinical signs: 1) Tremor: (Note -
More informationVisualization and simulated animations of pathology and symptoms of Parkinson s disease
Visualization and simulated animations of pathology and symptoms of Parkinson s disease Prof. Yifan HAN Email: bctycan@ust.hk 1. Introduction 2. Biochemistry of Parkinson s disease 3. Course Design 4.
More informationBasal Nuclei (Ganglia)
Doctor said he will not go deep within these slides because we will take them in physiology, so he will explain the anatomical structures, and he will go faster in the functions sheet in yellow Basal Nuclei
More informationMotor System Hierarchy
Motor Pathways Lectures Objectives Define the terms upper and lower motor neurons with examples. Describe the corticospinal (pyramidal) tract and the direct motor pathways from the cortex to the trunk
More informationThe Basal Ganglia in Parkinson s Disease: Current Concepts and Unexplained Observations
The Basal Ganglia in Parkinson s Disease: Current Concepts and Unexplained Observations Jose A. Obeso, PhD, MD, 1,2 Concepcio Marin, PhD, MD, 2,3 C. Rodriguez-Oroz, PhD, MD, 1,2 Javier Blesa, 1,2 B. Benitez-Temiño,
More informationDynamic Behaviour of a Spiking Model of Action Selection in the Basal Ganglia
Dynamic Behaviour of a Spiking Model of Action Selection in the Basal Ganglia Terrence C. Stewart (tcstewar@uwaterloo.ca) Xuan Choo (fchoo@uwaterloo.ca) Chris Eliasmith (celiasmith@uwaterloo.ca) Centre
More informationnucleus accumbens septi hier-259 Nucleus+Accumbens birnlex_727
Nucleus accumbens From Wikipedia, the free encyclopedia Brain: Nucleus accumbens Nucleus accumbens visible in red. Latin NeuroNames MeSH NeuroLex ID nucleus accumbens septi hier-259 Nucleus+Accumbens birnlex_727
More informationYou submitted this quiz on Sun 19 May :32 PM IST (UTC +0530). You got a score of out of
Feedback Ex6 You submitted this quiz on Sun 19 May 2013 9:32 PM IST (UTC +0530). You got a score of 10.00 out of 10.00. Question 1 What is common to Parkinson, Alzheimer and Autism? Electrical (deep brain)
More informationNetwork Effects of Deep Brain Stimulation for Parkinson s Disease A Computational. Modeling Study. Karthik Kumaravelu
Network Effects of Deep Brain Stimulation for Parkinson s Disease A Computational Modeling Study by Karthik Kumaravelu Department of Biomedical Engineering Duke University Date: Approved: Warren M. Grill,
More information9 Group Report: Microcircuits, Molecules, and Motivated Behavior
9 Group Report: Microcircuits, Molecules, and Motivated Behavior Microcircuits in the Striatum J. P. BOLAM, Rapporteur H. BERGMAN, A. M. GRAYBIEL, M. KIMURA, D. PLENZ, H. S. SEUNG, D. J. SURMEIER, andj.
More informationDr. Farah Nabil Abbas. MBChB, MSc, PhD
Dr. Farah Nabil Abbas MBChB, MSc, PhD The Basal Ganglia *Functions in association with motor cortex and corticospinal pathways. *Regarded as accessory motor system besides cerebellum. *Receive most of
More informationThis article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution
More informationThe basal forebrain: Questions, chapter 29:
The basal forebrain: Questions, chapter 29: 7) What is the "basal forebrain", and what is its involvement in Alzheimer' s Disease? The acetylcholine-containing neurons of the nucleus basalis of Meynart
More informationChapter 8. Control of movement
Chapter 8 Control of movement 1st Type: Skeletal Muscle Skeletal Muscle: Ones that moves us Muscles contract, limb flex Flexion: a movement of a limb that tends to bend its joints, contraction of a flexor
More informationMODULE 6: CEREBELLUM AND BASAL GANGLIA
MODULE 6: CEREBELLUM AND BASAL GANGLIA This module will summarize the important neuroanatomical and key clinical concepts from Chapters 15 and 16 of the textbook for the course. The first part of this
More informationThe basal ganglia work in concert with the
Corticostriatal circuitry Suzanne N. Haber, PhD Introduction Corticostriatal connections play a central role in developing appropriate goal-directed behaviors, including the motivation and cognition to
More informationModeling the interplay of short-term memory and the basal ganglia in sequence processing
Neurocomputing 26}27 (1999) 687}692 Modeling the interplay of short-term memory and the basal ganglia in sequence processing Tomoki Fukai* Department of Electronics, Tokai University, Hiratsuka, Kanagawa
More informationTHE BRAIN HABIT BRIDGING THE CONSCIOUS AND UNCONSCIOUS MIND
THE BRAIN HABIT BRIDGING THE CONSCIOUS AND UNCONSCIOUS MIND Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD How did I get here? What did I do? Start driving home after work Aware when you left
More informationRole of excitatory serotonergic signaling in the. pathway-specific neuromodulation of striatal. synaptic plasticity
DIPARTIMENTO DI BIOSCIENZE Doctoral School in Physiology Cycle XXVIII Role of excitatory serotonergic signaling in the pathway-specific neuromodulation of striatal synaptic plasticity Author: Marta Gritti,
More informationThis is a repository copy of Basal Ganglia. White Rose Research Online URL for this paper:
This is a repository copy of. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/114159/ Version: Accepted Version Book Section: Prescott, A.J. orcid.org/0000-0003-4927-5390,
More informationPHY3111 Mid-Semester Test Study. Lecture 2: The hierarchical organisation of vision
PHY3111 Mid-Semester Test Study Lecture 2: The hierarchical organisation of vision 1. Explain what a hierarchically organised neural system is, in terms of physiological response properties of its neurones.
More informationLack of GPR88 enhances medium spiny neuron activity and alters. motor- and cue- dependent behaviors
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue- dependent behaviors Albert Quintana, Elisenda Sanz, Wengang Wang, Granville P. Storey, Ali D. Güler Matthew J. Wanat, Bryan
More informationStrick Lecture 4 March 29, 2006 Page 1
Strick Lecture 4 March 29, 2006 Page 1 Basal Ganglia OUTLINE- I. Structures included in the basal ganglia II. III. IV. Skeleton diagram of Basal Ganglia Loops with cortex Similarity with Cerebellar Loops
More informationThe Nucleus Accumbens Core Dopamine D1 and Glutamate AMPA/NMDA Receptors Play a Transient Role in the Performance of Pavlovian Approach Behavior
City University of New York (CUNY) CUNY Academic Works Dissertations, Theses, and Capstone Projects Graduate Center 9-2017 The Nucleus Accumbens Core Dopamine D1 and Glutamate AMPA/NMDA Receptors Play
More informationSystems Neuroscience Dan Kiper. Today: Wolfger von der Behrens
Systems Neuroscience Dan Kiper Today: Wolfger von der Behrens wolfger@ini.ethz.ch 18.9.2018 Neurons Pyramidal neuron by Santiago Ramón y Cajal (1852-1934, Nobel prize with Camillo Golgi in 1906) Neurons
More informationLOCAL CIRCUIT NEURONS IN THE FRONTAL CORTICO-STRIATAL SYSTEM
8 LOCAL CIRCUIT NEURONS IN THE FRONTAL CORTICO-STRIATAL SYSTEM Y. Kawaguchi 1. INTRODUCTION The neostriatum is the principal recipient of afferents to basal ganglia from the cerebral cortex, especially,
More informationThe role of intra-thalamic and thalamocortical circuits in action selection
The role of intra-thalamic and thalamocortical circuits in action selection M D Humphries and K N Gurney Department of Psychology, University of Sheffield, Sheffield, S10 2TP,UK E-mail: m.d.humphries@shef.ac.uk,k.gurney@shef.ac.uk
More informationCOGNITIVE SCIENCE 107A. Sensory Physiology and the Thalamus. Jaime A. Pineda, Ph.D.
COGNITIVE SCIENCE 107A Sensory Physiology and the Thalamus Jaime A. Pineda, Ph.D. Sensory Physiology Energies (light, sound, sensation, smell, taste) Pre neural apparatus (collects, filters, amplifies)
More informationNeocortex. Cortical Structures in the Brain. Neocortex Facts. Laminar Organization. Bark-like (cortical) structures: Shepherd (2004) Chapter 12
Neocortex Shepherd (2004) Chapter 12 Rodney Douglas, Henry Markram, and Kevan Martin Instructor: Yoonsuck Choe; CPSC 644 Cortical Networks Cortical Structures in the Brain Bark-like (cortical) structures:
More informationLecture : Basal ganglia & Cerebellum By : Zaid Al-Ghnaneem
Lecture : Basal ganglia & Cerebellum By : Zaid Al-Ghnaneem Some notes in the beginning : #1 : there is a slides file contains the sheet info as notes for those who love slides more than word papers. #2
More informationThe ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.
The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Mark D. Humphries,a,b, Tony Prescott a a Adaptive Behaviour Research Group, Department of Psychology,
More informationLevodopa vs. deep brain stimulation: computational models of treatments for Parkinson's disease
Levodopa vs. deep brain stimulation: computational models of treatments for Parkinson's disease Abstract Parkinson's disease (PD) is a neurodegenerative disease affecting the dopaminergic neurons of the
More informationThe control of spiking by synaptic input in striatal and pallidal neurons
The control of spiking by synaptic input in striatal and pallidal neurons Dieter Jaeger Department of Biology, Emory University, Atlanta, GA 30322 Key words: Abstract: rat, slice, whole cell, dynamic current
More informationReview Article How Basal Ganglia Outputs Generate Behavior
Advances in Neuroscience Volume 214, Article ID 768313, 28 pages http://dx.doi.org/1.1155/214/768313 Review Article How Basal Ganglia Outputs Generate Behavior Henry H. Yin Department of Psychology and
More informationPSY 315 Lecture 11 (2/23/2011) (Motor Control) Dr. Achtman PSY 215. Lecture 11 Topic: Motor System Chapter 8, pages
Corrections: No Corrections Announcements: Exam #2 next Wednesday, March 2, 2011 Monday February 28, 2011 we will be going over the somatosensory system, and there will be time left in class to review
More informationUNIVERSITY OF JORDAN FACULTY OF MEDICINE DEPARTMENT OF PHYSIOLOGY & BIOCHEMISTRY NEUROPHYSIOLOGY (MEDICAL) Spring, 2014
UNIVERSITY OF JORDAN FACULTY OF MEDICINE DEPARTMENT OF PHYSIOLOGY & BIOCHEMISTRY NEUROPHYSIOLOGY (MEDICAL) Spring, 2014 Textbook of Medical Physiology by: Guyton & Hall, 11 th edition 2006 Eman Al-Khateeb,
More informationResearch Article A Biologically Inspired Computational Model of Basal Ganglia in Action Selection
Computational Intelligence and Neuroscience Volume 25, Article ID 8747, 24 pages http://dx.doi.org/.55/25/8747 Research Article A Biologically Inspired Computational Model of Basal Ganglia in Action Selection
More informationBASAL GANGLIA: A "pit stop" that integrates the movement, cognition and emotion.
BASAL GANGLIA: A "pit stop" that integrates the movement, cognition and emotion. Poster No.: C-0795 Congress: ECR 2011 Type: Educational Exhibit Authors: V. M. González Montaño, T. M. Zamorano Pozo, R.
More informationAn in vitro analysis of striatal microcircuitry
An in vitro analysis of striatal microcircuitry By Rasha ElGhaba A thesis submitted to the University of Sheffield in fulfilment of the requirements for the degree of Doctor of Philosophy July 2015 Page
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,350 108,000 1.7 M Open access books available International authors and editors Downloads Our
More informationSYNAPTIC TRANSMISSION AND SYNAPTIC PLASTICITY IN THE MOUSE STRIATUM
From DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY Karolinska Institutet, Stockholm, Sweden SYNAPTIC TRANSMISSION AND SYNAPTIC PLASTICITY IN THE MOUSE STRIATUM Sietske Schotanus Stockholm 2008 Supervisor Docent
More information2 CNS & Neurological Disorders - Drug Targets, 2011, Vol. 10, No. 7 Pierucci et al. topographically and functionally segregated pathways. The cortical
CNS & Neurological Disorders - Drug Targets, 2011, 10, 000-000 1 Nitric Oxide Modulation of the Basal Ganglia Circuitry: Therapeutic Implication for Parkinson s Disease and Other Motor Disorders Massimo
More informationarxiv: v1 [math.fa] 18 Jun 2009
Averaging Transformations of Synaptic Potentials on Networks H. R. Noori,a arxiv:0906.3404v1 [math.fa] 18 Jun 2009 Abstract a Interdisciplinary Center for Scientific Computing, University of Heidelberg,
More informationMotor Functions of Cerebral Cortex
Motor Functions of Cerebral Cortex I: To list the functions of different cortical laminae II: To describe the four motor areas of the cerebral cortex. III: To discuss the functions and dysfunctions of
More informationBasal nuclei, cerebellum and movement
Basal nuclei, cerebellum and movement MSTN121 - Neurophysiology Session 9 Department of Myotherapy Basal Nuclei (Ganglia) Basal Nuclei (Ganglia) Role: Predict the effects of various actions, then make
More informationThis is a repository copy of Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease.
This is a repository copy of Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/110882/
More informationExtrapyramidal Motor System. Basal Ganglia or Striatum. Basal Ganglia or Striatum 3/3/2010
Extrapyramidal Motor System Basal Ganglia or Striatum Descending extrapyramidal paths receive input from other parts of motor system: From the cerebellum From the basal ganglia or corpus striatum Caudate
More informationDOPAMINE DA NEURON ANATOMY AND PHYSIOLOGY
9 DOPAMINE ANTHONY A. GRACE Studies into the regulation of the dopamine (DA) system and its postsynaptic actions are often stymied by the myriad of actions that this neurotransmitter can produce. Thus,
More informationChapter 2: Studies of Human Learning and Memory. From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.
Chapter 2: Studies of Human Learning and Memory From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D. Definitions Learning: The acquisition of an altered behavioral response due to an environmental
More informationMovement Disorders. Psychology 372 Physiological Psychology. Background. Myasthenia Gravis. Many Types
Background Movement Disorders Psychology 372 Physiological Psychology Steven E. Meier, Ph.D. Listen to the audio lecture while viewing these slides Early Studies Found some patients with progressive weakness
More informationExam 2 PSYC Fall (2 points) Match a brain structure that is located closest to the following portions of the ventricular system
Exam 2 PSYC 2022 Fall 1998 (2 points) What 2 nuclei are collectively called the striatum? (2 points) Match a brain structure that is located closest to the following portions of the ventricular system
More informationLecture XIII. Brain Diseases I - Parkinsonism! Brain Diseases I!
Lecture XIII. Brain Diseases I - Parkinsonism! Bio 3411! Wednesday!! Lecture XIII. Brain Diseases - I.! 1! Brain Diseases I! NEUROSCIENCE 5 th ed! Page!!Figure!!Feature! 408 18.9 A!!Substantia Nigra in
More informationDISORDERS OF THE MOTOR SYSTEM. Jeanette J. Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine
DISORDERS OF THE MOTOR SYSTEM Jeanette J. Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine THE MOTOR SYSTEM To understand disorders of the motor system, we need to review how a
More informationSpinal Interneurons. Control of Movement
Control of Movement Spinal Interneurons Proprioceptive afferents have a variety of termination patterns in the spinal cord. This can be seen by filling physiologically-identified fibers with HRP, so their
More informationStriatal Plasticity and Basal Ganglia Circuit Function
Striatal Plasticity and Basal Ganglia Circuit Function Anatol C. Kreitzer 1,2,3, * and Robert C. Malenka 4 1 Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA 2 Department of Physiology
More informationTHE ROBOT BASAL GANGLIA: Action selection by an embedded model of the basal ganglia
To appear in Nicholson, L. F. B. & Faull, R. L. M. (eds.) Basal Ganglia VII, Plenum Press, 2002 THE ROBOT BASAL GANGLIA: Action selection by an embedded model of the basal ganglia Tony J. Prescott, Kevin
More informationExplorative Analysis and Data Mining in Big Neural Data
Explorative Analysis and Data Mining in Big Neural Data Jennifer Linge 2015 Master s Thesis Biomedical Engineering Faculty of Engineering LTH Department of Biomedical Engineering Supervisors: Frida Sandberg
More informationIntroduction to Computational Neuroscience
Introduction to Computational Neuroscience Lecture 7: Network models Lesson Title 1 Introduction 2 Structure and Function of the NS 3 Windows to the Brain 4 Data analysis 5 Data analysis II 6 Single neuron
More informationOutline of the next three lectures
Outline of the next three lectures Lecture 35 Anatomy of the human cerebral cortex gross and microscopic cell types connections Vascular supply of the cerebral cortex Disorders involving the cerebral cortex
More informationThe Neuroscience of Addiction: A mini-review
The Neuroscience of Addiction: A mini-review Jim Morrill, MD, PhD MGH Charlestown HealthCare Center Massachusetts General Hospital Disclosures Neither I nor my spouse/partner has a relevant financial relationship
More informationSymbolic Reasoning in Spiking Neurons: A Model of the Cortex/Basal Ganglia/Thalamus Loop
Symbolic Reasoning in Spiking Neurons: A Model of the Cortex/Basal Ganglia/Thalamus Loop Terrence C. Stewart (tcstewar@uwaterloo.ca) Xuan Choo (fchoo@uwaterloo.ca) Chris Eliasmith (celiasmith@uwaterloo.ca)
More informationThe Neuropathology of Huntington s Disease
The Neuropathology of Huntington s Disease Henry J. Waldvogel, Eric H. Kim, Lynette J. Tippett, Jean-Paul G. Vonsattel and Richard LM Faull Abstract The basal ganglia are a highly interconnected set of
More informationNeuroanatomy. Dr. Maha ELBeltagy. Assistant Professor of Anatomy Faculty of Medicine The University of Jordan
Neuroanatomy Dr. Maha ELBeltagy Assistant Professor of Anatomy Faculty of Medicine The University of Jordan 2018 Prof Yousry 10/15/17 Types of brain fibers THE WHITE MATTER OF THE BRAIN The white matter
More informationOrganization of Motor Functions 4.
Organization of Motor Functions 4. Dr. Attila Nagy 2018 Sensory-motor system Limbic cortex Structure Subcortical Motivational sub areas Frontal cortex Task Motivation Sequence Plan Tim e Ascending system
More informationTHE BRAIN HABIT BRIDGING THE CONSCIOUS AND UNCONSCIOUS MIND. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD
THE BRAIN HABIT BRIDGING THE CONSCIOUS AND UNCONSCIOUS MIND Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD Linking thought and movement simultaneously! Forebrain Basal ganglia Midbrain and
More informationNeurodegenerative Disease. April 12, Cunningham. Department of Neurosciences
Neurodegenerative Disease April 12, 2017 Cunningham Department of Neurosciences NEURODEGENERATIVE DISEASE Any of a group of hereditary and sporadic conditions characterized by progressive dysfunction,
More information