Pediatric Infectious Diseases
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1 Pediatric Infectious Diseases
2 Pediatric and Adolescent Medicine Vol. 4 Series Editor D. Branski, Jerusalem KAR.GER. Basel Freiburg Paris London New York. New Delhi Bangkok Singapore Tokyo Sydney
3 Pediatric Infectious Diseases Volume Editors D. Engelhard, Jerusalem M.I. Marks, Long Beach, Calif. D. Branski, Jerusalem 3 figures and 24 tables, 1993 KARGER Basel Freiburg Paris London New York. New Delhi Bangkok Singapore Tokyo Sydney
4 Pediatric and Adolescent Medicine Successor to 'Modem Problems in Paediatrics' and 'Monographs in Paediatrics' Library of Congress Cataloging-in-Publication Data Pediatric infectious diseases / volume editors, D. Engelhard, M.1. Marks, D. Branski. (Pediatric and adolescent medicine; vol. 4) Includes bibliographical references and index. 1. Communicable diseases in children. I. Engelhard, D. (Dan) II. Marks, Melvin I. III. Branski, D. IV. Series. [DNLM: 1. Communicable Diseases-in infancy & childhood. WI PEI63HLv.41993/WC JOOP ] ISBN Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. ~ Copyright 1993 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland) Printed on acid-free paper. ISBN
5 Contents Preface VII Liebermann, J.M. (Torrance, Calif.); Stutman, H.R. (Long Beach, Calif.): Advances in Pediatric Antibiotic Therapy Waner, J.L. (Oklahoma City, Okla.): Diagnosis of Viral Infections Morag, A. (Jerusalem); Gershon, A. (New York, N.Y.): Advances in Pediatric Infectious Diseases: Varicella zoster Virus. Biology and Epidemiology Janai, H.K. (Logan, Ohio); La Via, W.V. (Long Beach, Calif.); Bontrager, R. (Logan, Ohio); Stutman, H.R. (Long Beach, Calif.): Antiviral Therapy and Prophylaxis 37 Harari, M.D. (Jerusalem); Ephros, M.A. (Haifa): Treatment of Parasitic Diseases 49 Eidelman, L.A.; Weiss, Y.G.; Sprung, C.L. (Jerusalem): Adjunctive Therapy for Pediatric Infections Dennehy, P.H.; Peter, G. (Providence, R.I.): New Developments in Childhood Immunizations Novales, J.S. (Irvine, Calif.); Arrieta, A.e. (Orange County, Calif); Modanlou, H.D. (Irvine, Calif.): Infectious Diseases in the Neonatal Period Dagan, R. (Beer-Sheva); Branski, D. (Jerusalem): The Approach to the Febrile Child Under 24 Months of Age Ashkenazi, S. (Petah Tiqva); Pickering, L.K. (Norfolk, Va.): Current Concepts in Day Care Center Infections Katzman, D.K. (Toronto, Ont.); Prober, e.g. (Stanford, Calif.): Sexually Transmitted Diseases Kaplan, S.L. (Houston, Tex.): Central Nervous System Infections Arguedas, A.G. (San Jose); Marks, M.1. (Long Beach, Calif.lIrvine, Calif.): Lower Respiratory Tract Infection lsi Arrieta, A.e.; Marks, M.1. (Irvine, Calif.lLong Beach, Calif.): Urinary Tract Infection in Children Law, B.J.; Orr, P.H. (Winnipeg, Manitoba); Embree, J.E. (Winnipeg, Manitoba/ Nairobi): Communicable Diseases Subject Index
6
7 Preface Our understanding of the cause, pathogenesis and treatment of pediatric infectious diseases is increasing rapidly. In fact, the rate of acquisition of new knowledge seems beyond the ability of classic textboooks to keep readers up to date. The editors have attempted to respond with a collection of articles that highlight advances in pediatric infectious diseases. We are proud and honored to have had international participation in the authorship of this update. The topics chosen highlight advances in chemotherapy for viruses, bacteria, and parasites. Additionally, the role of adjunctive therapy has also been addressed. While recognizing that advances in therapy are most critical to pediatric practice, immunizations, day care center infections, and the approach to fever in the young child are also important to pediatric practitioners. Hospital-based physicians will appreciate the review of advances in the field of neuromuscular infections, sexually transmitted diseases, urinary tract, central nervous system and respiratory infections. The authors gratefully acknowledge the generous contributions of each of the authors who attempted to bridge the gap between scientific journal publications and textbooks. The present collection represents a scholarly treatment of the latest products of clinical research translated into practical advice for community and hospital-based practitioners. The editors also wish to recognize the work of Joyce Bagan and her staff in assisting the preparation, review and editing of this work. We hope that readers find these contributions stimulating and of practical value. The Editors
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