How to avoid common problems in research and manuscripts Dr. Bill Summerskill Senior executive editor, The Lancet
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1 How to avoid common problems in research and manuscripts Dr. Bill Summerskill Senior executive editor, The Lancet
2 Statement of interests Dr. Summerskill is an employee of and holds stock in RELX Group, a company that publishes scientific journals. He has received hospitality, accommodation, and travel from academic organisations, health charities, government agencies, and non-governmental organisations.
3 Aims Review Taiwan s publications in The Lancet Show common errors in worldwide submissions to The Lancet and how to avoid them To reaffirm The Lancet family of journal s commitment to improve health in Asia and to publish the best research from Taiwan
4 Objectives Reflect on research goals and strategies Empower you to submit more competitive manuscripts to scientific journals Help to strengthen Taiwan s research presence
5 Publications from Taiwan, Accepted Articles Total Submissions Accepted - Other 0 PR China Hong Kong Taiwan
6 Publications from Taiwan, 2013 Original research articles 6 (3%) Seminars and Reviews 2 Clinical pictures 3 Correspondence 2
7 Publications from Taiwan, research submissions 0 accepted How / Why have things changed? I would like to work with you to understand and correct the recent under-representation of Taiwan in The Lancet
8 Avoiding 14 avoidable problems There are many aspects of research that influence publication which you cannot control There are others which you can control, but that are commonly ignored and weaken a submission
9 1) Wrong research question Formulate a clear research question Meaningful Specific Answerable PICO
10 Clinical questions P I C O Population Intervention (Comparator) Outcome Age Gender Co-morbidity etc. Test Treatment Exposure (aetiology) etc. None Placebo Gold standard etc. Survival Symptoms Complication etc.
11 2) Poor planning How is this study going to make a contribution to the understanding or practice of health care? REWARD (Reducing research Waste And Rewarding Diligence)
12 Reducing research waste and rewarding diligence (REWARD)
13 3) Wrong methods Apply the correct methods to answer your research question Involve a statistician
14 3) Wrong methods Involve a statistician to advise on Power calculation Analyses Endpoints Data collection
15 4) Weak administration Registration Ethical / institutional approval Funding (retain right to publish)
16 5) Lax conduct Failure to recruit Missing data Reporting delays No independent monitoring
17 6) No consent Written Informed By participant If not required, explain
18 7) Post-hoc analysis Analysis guided by protocol Pre-specified endpoints Pre-specified methods (importance of a sound protocol) Let the data speak for themselves
19 8) Sloppy reporting Follow reporting guidelines Report all pre-specified endpoints in order Major journals will be interested in your science, not your language Avoid jargon Limit abbreviations
20
21
22 9) Text recycling Unattributed to other authors Even if written by yourself Do not be tempted by what might seem better use of English to convey the same idea use your own words Constitutes scientific misconduct
23 10) Failure to declare interests All potential competing interests should be disclosed It is up to readers, not authors, to determine what constitutes a competing interest
24 11) Wrong journal Who is your audience? Where does your manuscript fit (references)? Does journal have a relevant section? Type of research (eg animal research)
25 12) Unfamiliar with journal Be familiar with your chosen journal Philosophy Interests Landmark papers Calls for papers
26 12) Unfamiliar with journal Be familiar with the journal s requirements Format (structure, length) Supporting material (protocols, signatures) If in doubt, ask (and mention in cover letter)
27
28 13) Weak cover letter Does not explain why the manuscript is important for that journal or its readers Does not convey enthusiasm Length words (as short as necessary to interest, but do not overwhelm the reader)
29 14) Not revising seriously An invitation to revise does not imply acceptance Engage wholeheartedly with the process Be respectful, rely on the science
30 Why are the 14 points important? Often occur together Suggest a lack of awareness about research Undermine confidence in other parts of the study of paper that may have been done well Many can be easily fixed
31 What do editors look for? Research that is going to change thinking Interest to a wide audience First and last publication Ethically sound Methodologically robust Reported fully
32
33 1) Right research question Meaningful Specific Answerable
34
35 2) Good planning Make a contribution to the understanding or practice of health care
36
37 3) Right methods Power calculation Analyses Endpoints Data collection
38
39 4) Strong administration Registration Ethical / institutional approval Funding (retain right to publish)
40
41 5) Strict conduct
42
43 6) Include consent Written Informed By participant If not required, explain
44
45 7) Pre-planned analysis Guided by protocol Pre-specified endpoints Pre-specified methods (importance of a sound protocol) Let the data speak for themselves
46
47 8) Careful reporting Follow reporting guidelines Report all pre-specified endpoints in order Major journals will be interested in your science, not your language Avoid jargon Limit abbreviations
48
49
50 9) No text recycling Unattributed to other authors Even if written by yourself Do not be tempted by what might seem better use of English to convey the same idea use your own words Constitutes scientific misconduct
51
52 10) Clearly declare interests Statement on data sharing
53 11) Right journal Important clinical topic Substantial disease burden Ability to change practice Multi-centre Well-done RCT
54 RCTs and total research published in RCTs Articles % (60%) 59% (55%) 43% (40%) NEJM Lancet JAMA
55 12) Familiarity with journal Philosophy Sections Content Requirements Calls for papers
56 13) Convincing cover letter Does not explain why the manuscript is important for that journal or its readers Does not convey enthusiasm Length words (as short as necessary to interest, but do not overwhelm the reader)
57
58 13) Convincing cover letter EV71 infection is an important public health issue in Asia-Pacific region and beyond, including Brazil, Western Australia, Malaysia, Singapore, Taiwan, Hong Kong, Japan, South Korea, Vietnam and mainland China.
59 13) Convincing cover letter The clinical spectrum of EV71 infection ranges from asymptomatic infection, to mild hand-footmouth disease, and severe complications with central nervous system, and cardiopulmonary involvement. From 2010 through 2011, 1*6 million cases and 509 deaths were reported in China.
60 13) Convincing cover letter The development of vaccine against EV71 is currently a dynamic topic with paramount relevance for public health. The phase II clinical trial (ClinicalTrials.gov number: NCT ) reported here written according to CONSORT guideline
61 14) Revise seriously An invitation to revise does not imply acceptance Engage wholeheartedly with the process Be respectful, rely on the science
62 What do editors look for? Research that is going to change thinking
63 What do editors look for? Research that is going to change thinking Interest to a wide audience
64
65 What do editors look for? Research that is going to change thinking Interest to a wide audience First and last
66
67 What do editors look for? Research that is going to change thinking Interest to a wide audience First and last Ethically sound
68
69 What do editors look for? Research that is going to change thinking Interest to a wide audience First and last Ethically sound Robust methods
70
71 What do editors look for? Research that is going to change thinking Interest to a wide audience First and last Ethically sound Robust methods Reported fully
72
73 Conclusion Taiwan is a world-leader in science The Lancet family of journals want to bring excellent research from Taiwan to the world Observing the 14 details discussed today can strengthen your manuscript and increase your chance of publication in The Lancet
74 Taiwan s expertise Methodological rigour Gastroenterology: H pylori, hepatitis, HCC Oncology: lung cancer Health registries Health systems
75 The Lancet Digital Medicine
76
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