Statistical approaches to explore clinical heterogeneity in psychosis Islam, Atiqul
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1 University of Groningen Statistical approaches to explore clinical heterogeneity in psychosis Islam, Atiqul IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Islam, A. (2017). Statistical approaches to explore clinical heterogeneity in psychosis [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:
2 Statistical approaches to explore clinical heterogeneity in psychosis Md. Atiqul Islam
3 Uitgave in de RGOc-reeks, nummer 37. The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (Zon-Mw, grant number ), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organizations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical center The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGZ Eindhoven en De Kempen, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta. The research and publication of this thesis was financially supported by Research Institute SHARE (Science in Healthy Ageing and healthcare), University Medical Center Groningen (UMCG), University of Groningen, Department of Epidemiology, Rob Giel Research center (RGOc) and GROUP-project. ISBN: (printed version) ISBN: (electronic version) Design: Rukhsana Rushmi Cover: Loes kema, GVO drukkers & vormgevers B.V. Lay-out: Md. Atiqul Islam Printed by: GVO drukkers & vormgevers B.V., Ede, the Netherlands Copyright Md. Atiqul Islam, No part of this publication may be reproduced or transmitted in any form or by any means without the permission of the author.
4 Statistical approaches to explore clinical heterogeneity in psychosis PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 5 July 2017 at hours by Md. Atiqul Islam born on 1 January 1981 in Pabna, Bangladesh
5 Supervisor Prof. E.R. van den Heuvel Co-supervisors Dr. R. Bruggeman Dr. B.Z. Alizadeh Assessment Committee Prof. E.C. Wit Prof. A.J. Oldehinkel Prof. A.C. Krabbendam
6 To my parents, wife & daughter
7 Paranimfen Sanne Y. Smith-Apeldoorn Jan van Bebber
8 CONTENTS Chapter 1 General Introduction 9 Part A Statistical Analysis for Heterogeneity 27 Chapter 2 Chapter 3 Chapter 4 A comparison of indices for identifying the number of clusters in hierarchical clustering: A study on cognition in schizophrenia patients Long-term cognitive trajectories in patients with schizophrenia and their unaffected siblings Long-term course of negative symptom subdomains and relationship with outcome in patients with a psychotic disorder Part B Statistical Analysis for Associations 99 Chapter 5 Chapter 6 The predictive value of neurocognition and social cognition for the development of psychotic experiences in siblings of people with psychotic disorders Familial liability to psychosis is a risk factor for multimorbidity in people with psychotic disorders and their unaffected siblings Chapter 7 Factors contributing to the duration of untreated psychosis 163 Chapter 8 Summary and General Discussion 177 Addendums Nederlandse Samenvatting (Dutch summary) List of publications Co-authors List of RGOc dissertations List of SHARE dissertations Acknowledgements About the author
9
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